290 results about "Support matrix" patented technology

A method for the effective treatment of articulating joint surface cartilage in an animal by the transplantation of an implantable article including chondrocyte cells retained to an absorbable support matrix. An instrument for placing and manipulating the implantable article at the site of implantation, and a retention device for securing the implantable article to the site of implantation. An implantable article for cartilage repair in an animal, the implantable article including chondrocyte cells retained on an absorbable support matrix, and a method of making same. An article comprising an absorbable flexible support matrix for living cells grown and adhered thereto.

The invention uses recombinant parvoviruses, and particularly recombinant adeno-associated virus (rAAV) to deliver genes and DNA sequences for gene therapy following manipulation of the therapeutic virus for packaging and transport. The invention delivers therapeutic viral vectors via rAAV affixed to support matrixes (i.e., sutures, surgically implantable materials, grafts, and the like).

The present invention relates to compositions including nano-particles and a nano-structured support matrix, methods of their preparation and applications thereof. The compositions of the present invention are particularly suitable for use as anode material for lithium-ion rechargeable batteries. The nano-structured support matrix can include nanotubes, nanowires, nanorods, and mixtures thereof. The composition can further include a substrate on which the nano-structured support matrix is formed. The substrate can include a current collector material.

This invention provides a method and system for analyzing and deriving analytical insights from textual information. The information structuration process determines the structure in which the text information is rendered. A cyclical extraction process using the parameters of co-frequency, co-dependency, and co-relatedness and parts of speech, determines various textual aspects and their subcomponents such as themes and dimensions. Using the subcomponents of the textual aspects, relationship maps are built, disambiguated and ranked. A text analytics and decision support matrix is created using the ranked relations, thereby providing a highly relevant result set to the user's information need. A multidimensional navigation matrix is created that helps a user navigate across dimensions.

Composite hydrogen transport membranes, which are used for extraction of hydrogen from gas mixtures are provided. Methods are described for supporting metals and metal alloys which have high hydrogen permeability, but which are either too thin to be self supporting, too weak to resist differential pressures across the membrane, or which become embrittled by hydrogen. Support materials are chosen to be lattice matched to the metals and metal alloys. Preferred metals with high permeability for hydrogen include vanadium, niobium, tantalum, zirconium, palladium, and alloys thereof. Hydrogen-permeable membranes include those in which the pores of a porous support matrix are blocked by hydrogen-permeable metals and metal alloys, those in which the pores of a porous metal matrix are blocked with materials which make the membrane impervious to gases other than hydrogen, and cermets fabricated by sintering powders of metals with powders of lattice-matched ceramic.

A cylindrical body is produced which is composed of a fiber structure with a basis weight of 1-50 g / m2 and having a diameter of 0.5-50 mm and a bellows-shaped section, wherein the crest-to-crest spacing of the bellows-shaped section is no greater than 2 mm and the crest-to-valley depth of the bellows-shaped section is 0.01-1 mm; collagen is added to the cylindrical body to produce a composite comprising the cylindrical body and collagen.

Microvessel networks are produced in vitro from tissue-engineered parent vessels sprouting into a supporting matrix, as for example gels, of extracellular matrix proteins. The microvessel systems are integrated into devices that allow for controlled perfusion with fluids. The vessels may include cells from one cell type, for example, endothelial cells, or from combinations of two or more cell types.

A printed stretchable strain sensor comprises a seamless elastomeric body and a strain-sensitive conductive structure embedded in the seamless elastomeric body. The strain-sensitive conductive structure comprises one or more conductive filaments arranged in a continuous pattern. A method of printing a stretchable strain sensor comprises depositing one or more conductive filaments in a predetermined continuous pattern into or onto a support matrix. After the depositing, the support matrix is cured to embed a strain-sensitive conductive structure in a seamless elastomeric body.

The invention relates to a method of cell culture comprising providing a pluripotent ES cell encapsulated within a support matrix to form a support matrix structure, maintaining the encapsulated cell in 3-D culture in maintenance medium, and optionally differentiating the encapsulated cell in 3-D culture in differentiation medium. The invention further relates to screening methods incorporating the use of encapsulated cells.

A method of producing a tissue engineering construct. The method includes providing a population of embryonic stem cells, seeding the embryonic stem cells on a cell support matrix, and exposing the embryonic stem cells to at least one agent selected to promote differentiation of the stem cells along a predetermined cell lineage or into a specific cell type. The step of exposing may be performed before or after the step of seeding.

A cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof. The matrix suitable for preparation of cellular or acellular implants for growth and de novo formation of an articular hyaline-like cartilage. A gel-matrix composite system comprising collagen-based matrix having a narrowly defined porosity capable of inducing hyaline-like cartilage production from chondrocytes in vivo and in vitro.

The present invention relates generally to improved methods for tissue engineering including tissue transplantation, augmentation and regeneration. More particularly, the present invention provides a method for the generation of donor vascularized tissue suitable for use in tissue transplantation, augmentation and / or repair. The present invention further enables the use of a support matrix in the generation of an anatomical construct comprising the donor vascular tissue. The support matrix may be devised such that it has dimensions of a size and shape adapted to simulate those of tissue to be transplanted, augmented and / or repaired. In addition to its use in tissue repair, the methods and support matrix of the present invention may also find application as a means for delivering a desirable gene product to a subject. The method and support matrix of the present invention is conveniently be made available in the form of a kit, for use generally in the field of tissue engineering.

An anode material with lithium-alloying particles contained within a porous support matrix is provided. The porous support matrix preferably has a porosity of between 5 and 80% afforded by porosity channels and expansion accommodation pores, and is electrically conductive. More preferably the support matrix has a porosity of between 10 and 50%. The support matrix is made from an organic polymer, an inorganic ceramic or a hybrid mixture of organic polymer and inorganic ceramic. The organic polymer support matrix and can be made from a rod-coil polymer, a hyperbranched polymer, UV cross-linked polymer, heat cross-linked polymer or combination thereof. An inorganic ceramic support matrix can be made from at least one group IV-VI transition metal compound, with the compound being a nitride, carbide, oxide or combination thereof. The lithium-alloying particles are preferably nanoparticles with a mean linear dimension of between 5 and 500 nanometers, and more preferably have a mean linear dimension of between 5 and 50 nanometers.

Methods, compositions and kits to capture cross-linked protein complexes to a support matrix in a stable, covalent bridge of attachment are provided.

An activated carbon monolith catalyst comprising a finished self-supporting activated carbon monolith having at least one passage therethrough, and comprising a supporting matrix and substantially discontinuous activated carbon particles dispersed throughout the supporting matrix and at least one catalyst precursor on the finished self-supporting activated carbon monolith. A method for making, and a method for use, of such an activated carbon monolith catalyst in catalytic chemical reactions are also disclosed.

A panel support and wiring system is used as part of a bi-directional solar panel support matrix having lower support joists and upper panel rails. Both the panel clip and wiring arrangements are configured to facilitate rapid deployment and installation of the entire solar panel system, including supports and interfaces with the underlying substrate. A standardized wiring system is one of the factors facilitating rapid installation.

Neo-cartilage constructs suitable for implantation into a joint cartilage lesion in situ and a method for repair and restoration of function of injured, traumatized, aged or diseased cartilage. The construct comprises at least chondrocytes incorporated into a support matrix processed according to the algorithm comprising variable hydrostatic or atmospheric pressure or non-pressure conditions, variable rate of perfusion, variable medium composition, variable temperature, variable cell density and variable time to which the chondrocytes are subjected.

The present invention provides thermal devices, materials and methods for use in transferring heat from heat sources. One embodiment comprises a thermal transfer body that has first and second end portions and includes a thermally anisotropic material that conducts more thermal energy in a longitudinal direction than in a direction transverse thereto, wherein at least one of the first and second end portions includes a projection having a surface area oriented obliquely to the longitudinal direction. Multiple projections may be provided of various geometries, such as pyramids, cones, triangular prismoids and domes. The thermally anisotropic material may include an ensemble of longitudinally thermally conductive fibers, such as carbon fibers derived from precursors such as petroleum or coal pitch, which may be embedded in a support matrix of various materials.

A method for the manufacture of a support matrix exhibiting amino groups I, possibly in acylated form, comprising the step of polymerizing one or more monovinyl monomers (monomer I) with one or more di- tri- or polyvinyl monomers (monomer II). The method is characterized in that that the polymerization is run in the presence of one or more amino-(C0-10)hydrocarbon vinyl aromatic monomers possibly in acylated form (monomer III). The preferred combination of monomers are ethyl vinyl benzene, divinyl benzene and amino styrene. The support matrix comprising a polyvinyl backbone [(-CH2CH2)n] and amino groups or groups derived from said amino groups while retaining the nitrogen of the amino group, each of which groups being attached to said backbone via a link structure containing an arylene group. The matrix is characterized in that each of said groups is directly attached via said nitrogen to said arylene group. Additionally, the use of the support matrix for solid phase synthesis, for instance of an oligo / poly-nucleotide or an oligo / polypeptide.

A phosphor deposition process and apparatus that enables an efficient, consistent, and flexible white light LED light engine by spraying a conformal coating of phosphor matrix onto an array of LEDs to achieve high color uniformity, consistency, and efficiency. A predetermined ratio of one or more phosphor powders are mixed with a support matrix (preferably silicone), the types and amounts of which are calculated to provide a predetermined spectral output. A low-viscosity carrier is introduced into the phosphor matrix to allow for further processing and deposition. The phosphor matrix and carrier mixture is atomized and sprayed in one or more uniform layers onto one or more LED devices. Computerized control, movable stages, and in-process spectral monitoring are incorporated to provide rapid and accurate processing of LED devices.

A tissue engineered construct. The construct includes endothelial cells, muscle cells, and a three-dimensional support matrix on which the endothelial cells and the myoblasts are seeded.

A roof panel support system is supported by at least two structural beams, and includes a support matrix for panels, such as solar panels, that can constitute the roof of a structure. The support matrix includes panel rails that can hold panels installed from beneath the support matrix.

The present invention provides materials and methods that can serve as a prosthetic and / or, for tissue engineer applications, as a supporting matrix in the stabilization of the myocardium.

A microfibrous matrix with embedded supporting particulates / fibers and chemically reactive materials is provided as a filtration system for the removal of contaminants and other harmful agents from liquid and gaseous streams. Such filter may be used for example to protect the intolerant anodes and cathodes of fuel cells from damaging H2S while simultaneously aiding the selective conversion of CO to CO2 in fuel streams predominated by hydrogen. In general, the reactive materials utilized as well as the supporting matrix of fibers may be broadly selected to remove specific contaminants at specific reaction conditions inherent to the application. Such materials may include chemically reactive materials as high surface area carbons, zeolites, silicas, aluminas, inorganic metal oxides, polymer resins, ZnO, ZnO / Carbon, Pt / γ-Al2O3, PtCo / γ-Al2O3, ZnO / SiO2 and various other catalysts, sorbents or reactants. In an alternative embodiment, entrapped sorbents and other reactants may be used to provide a highly efficient gas and / or liquid separation and purification methodology for gas masks, building filtration systems, and / or as polishing media located downstream of traditional packed bed filtration systems so as to achieve the high volume loading / capacity of the packed bed along with the overall contacting efficiency of the outlet polishing layer.

This invention relates to a fuel cell system comprising a fuel cell stack, external circuit electrical leads coupled to the fuel cell electrodes, and a thermal enclosure assembly enclosing the stack. The stack includes a plurality of inner tubular solid oxide fuel cells, the inside of the inner fuel cells being fluidly couplable to a first reactant source, and a porous support matrix embedding the inner fuel cells and being fluidly couplable to a second reactant source such that a second reactant is flowable through the matrix and to the outer surface of the embedded fuel cells. The stack may also include an outer tubular solid oxide fuel cell surrounding the matrix and the inner fuel cells such that the second reactant is flowable through the matrix and to an inside surface of the outer fuel cell and wherein the outer surface of the outer fuel cell is fluidly couplable to a first reactant source.

Neo-cartilage constructs suitable for implantation into a joint cartilage lesion in situ and a method for repair and restoration of function of injured, traumatized, aged or diseased cartilage. The construct comprises at least chondrocytes incorporated into a support matrix processed according to the algorithm comprising variable hydrostatic or atmospheric pressure or non-pressure conditions, variable rate of perfusion, variable medium composition, variable temperature, variable cell density and variable time to which the chondrocytes are subjected.

Disclosed is an elevated support matrix for a shoe, which may either form a sole, heel, or sole and heel combination. The matrix is formed of metal, or other high-tensile materials. To minimize the weight of the matrix, but still maintain the structural integrity of the matrix and properly support the wearer's foot, passageways are created in the matrix. The passageways result in void space and lattice, which have corresponding volumes. The increased volume of void space correlates with an overall weight reduction. A support matrix is thus provided that takes advantage of higher-tensile materials to create a reduced weight structurally maintained support matrix. Methods of manufacturing the matrix are also disclosed.

A process for the production of paraffin sections of biological tissue, especially for molecular pathology studies is disclosed. In the process, the tissue sample is simultaneously fixed, dehydrated and cleared in a first step, subsequently dehydrated and cleared in a second step and infiltrated with an inert specimen matrix in a third step. The specimen can then be further embedded in a casting supporting matrix according to the standard procedures followed by any local pathology or research laboratory. A kit and a processing station for automating paraffin embedding of a tissue sample suitable for histopathological and molecular analysis is also described. A bio-indicator system is described for measuring the degree of crosslinking. A tissue sample holding means or a vial which includes a tissue sample holding means provided with a data logging device capable of registering and transmitting data regarding the sample and conditions where the sample was processed is also disclosed.

A product for absorption purposes includes a water insoluble support matrix wherein the support matrix is substituted with a hydrophobic entity which in turn is connected to a positively charged entity, a method for its manufacture, use thereof and applications of the product. The product for absorption purposes includes a first support matrix connected to a hydrophobic entity and a second support matrix connected to a positively charged entity, a method for its manufacture, use thereof and applications of the product. The product for absorption purposes includes a support matrix wherein the support matrix is substituted with a hydrophobic entity and a positively charged entity, a method for its manufacture, use thereof and applications of the product.

Packaging for heatable food portions comprises an ovenable tray including a plurality of serving containers connected by a detachable support matrix. In one embodiment, the support matrix is attached to the serving containers by hot melt glue which melts during baking or heating to automatically release the support matrix from the serving containers. Pre-filled trays are shipped with display covers fitted to the serving containers, such that the covers may be placed on the individual serving containers after the food portions are baked and the serving containers are separated from the support matrix to provide individually packaged, freshly baked food portions for display.