49results about How to "Excessive delivery" patented technology

The present invention relates generally to efficient delivery of viral vectors to cells of the CNS, particularly useful in the treatment of neurodegenerative disorders and motor neuron diseases. The invention involves selecting a first population and a second population of synaptically connected neurons, wherein a therapeutic polypeptide is to be expressed in said second population of neurons; and administering rAAV virions comprising a therapeutic gene to said first subpopulation of neurons of said subject such that the rAAV virions are transported across a synapse between synaptically connected neurons. In another aspect the present invention also comprises the use of rAAV virions carrying a transgene in the preparation of a medicament for the treatment of a disease in a subject, wherein a first population and a second population of synaptically connected neurons are selected and a therapeutic polypeptide is to be expressed in said second population of neurons; and a medicament comprising recombinant adeno-associated virus (rAAV) virions is delivered to said first population of neurons of the subject, wherein said virions comprise a nucleic acid sequence that is expressible in transduced cells to provide a therapeutic effect in the subject, and wherein said rAAV virions are capable of transducing a synaptically connected neurons.

A method and apparatus for controlled feeding of an infant provides a safer and less expensive apparatus for the enteral feeding of a neonatal infant, as well as a mechanism for minimizing separation of fluid for any enteral feeding patient. The apparatus allows for dispensing the feeding solution from conventional baby bottles or breast pump reservoirs, or other convenient reservoirs in combination with a peristaltic pump. The feeding system helps reduce the risk for contaminating the feeding solution by minimizing the handling of the feeding solution. By utilizing a pump which is less expensive than current neonatal feeding pumps, the feeding system is more cost effective in all environments and more suitable for home use.

A novel method and system is provided for dynamically selecting, assembling and inserting content into streaming media. The system and method allow for the selection of the content to be inserted into a streaming media program to be performed after the manifest, or equivalent, defining the streaming media program has been provided to a rendering device and to allow the selection of multiple pieces of content to fill a defined insertion point duration, provided only that the total duration of the selected pieces of content equal the duration of the defined insertion point. Selected pieces of content to be inserted are assembled by the system and method into an assembled emulated single piece of content which removes the need for discontinuity indicators, or equivalents, to be placed in the manifest between the selected pieces of content.

An impact and/or vibration absorbent material and protective articles making use of said material. An impact and/or vibration absorbent material of the present invention has at least two material layers. The individual layers of the impact and/or vibration absorbent material may be of the same material, or of different materials. Each material layer preferably contains a number of holes. The holes in one layer are located and arranged to be offset from the holes in an adjacent layer. The combination of inherent material properties and the inclusion and arrangement of holes renders such a material highly impact and/or vibration absorbent. Through use of a protective article of the present invention, the effects of impact and/or vibration forces on a user of the protective article can be minimized.

The embodiments relate to the wireless communication field, and a data transmission control method and a data transmission device are provided. The method includes: receiving from a sender and buffering data in a buffer, and then forwarding the buffered data to a receiver; receiving an acknowledgement (ACK) returned by the receiver, where the ACK indicates that the data is received; adding or reducing the ACK returned by the receiver according to a volume of data unsent in the buffer; and sending the processed ACK to the sender. The data sending rate of the sender is controlled by the processed ACK. This makes the data transmission be reliable and highly efficient.

An impact and/or vibration absorbent material and articles, particularly a protective glove, making use of said material. An impact and/or vibration absorbent material of the present invention has at least two material layers. The individual layers of the impact and/or vibration absorbent material may be of the same material, or of different materials. Each material layer preferably contains a number of holes. The holes in one layer are located and arranged to be offset from the holes in an adjacent layer. The combination of inherent material properties and the inclusion and arrangement of holes renders such a material highly impact and/or vibration absorbent. When used in an impacting article, deflection of portions of one material layer into the holes in an adjacent material layer at impact further provides an enhanced transfer of impact force to an impacted object.

A method and apparatus for treating skin disorders includes a source of pulsed near black body electromagnetic energy and a means of delivering this energy to a treatment site. A means for cooling the treatment site is described. The number of pulses and intensity of the energy can be varied. Optical filters are used to limit the spectrum of energy emitted and the filters are cooled to allow high-energy operation. The size of the treatment spot is controlled by a series of apertures.

A method of treating brain injury involving intrathecally administering a composite powder comprising superparamagentic nanoparticle and a therapeutic agent compound, and then magnetically transporting the composite into an injured brain.

A mixture or blend of Coffee and Tea into a new beverage comprised of blended quantities of dry ground Coffees and Teas into a single product. Herbal teas may also be added to blends to deliver flavor, health benefits, and in some mixtures help blend the Coffees and Teas. When the mixture is brewed or infused with hot water, the acids and oils extracted interact in a new way. The Coffee acids and oils in fluid, enter the Tea and any Herbal materials, and changes the extraction at that point. The Tea acids and oils in fluid enter the Coffee and any herbal materials, and the Coffee extraction is changed at that point. As all the extracted fluids mix and interact, a third change, a blending, and TeaCafe' is created. This process may take place in a teabag or pod, cup or container, or in a coffee or tea brewing machine material chamber and receptacle, hot water pot, or teapot.

Ice for use in a beverage, wherein the ice comprises a core, an active zone, an external surface, and caffeine. The ice particle has a depth from each point of the external surface extending perpendicularly inwards. It also has a total particle mass. The caffeine in the ice particle has a total caffeine mass, and the ice particle has an ice caffeine concentration equal to the total caffeine mass divided by the total particle mass. The active zone includes at least 40% of the total caffeine mass and local caffeine concentrations of at least 150% of the ice caffeine concentration. At least 67% of the total caffeine mass is contained within a caffeine depth in millimeters from the external surface no greater than 1.06 times the cube root of the total particle mass in grams. The core has local caffeine concentrations of less than 150% of the ice caffeine concentration.

The invention relates to compositions comprising acyl derivatives of 2'-deoxyribonucleosides. The invention also relates to methods of treating or preventing radiation, mutagen and sunlight-induced biological damage, and methods for improving wound healing and tissue repair, comprising administering the compositions of the present invention to an animal.

The present invention relates generally to improved methods for tissue engineering including tissue transplantation, augmentation and regeneration. More particularly, the present invention provides a method for the generation of donor vascularized tissue suitable for use in tissue transplantation, augmentation and/or repair. The present invention further enables the use of a support matrix in the generation of an anatomical construct comprising the donor vascular tissue. The support matrix may be devised such that it has dimensions of a size and shape adapted to simulate those of tissue to be transplanted, augmented and/or repaired. In addition to its use in tissue repair, the methods and support matrix of the present invention may also find application as a means for delivering a desirable gene product to a subject. The method and support matrix of the present invention is conveniently be made available in the form of a kit, for use generally in the field of tissue engineering.