3222results about How to "High retention rate" patented technology

A surgical stapling apparatus includes a housing and an end effector secured to the housing. The housing supports a knife assembly including a knife. The end effector has first and second jaw members. One or both of the first and second jaw members define a knife channel. The first jaw member defines fastener slots and the second jaw member defines fastener pockets. One or more of the knife channel, the fastener slots, and the fastener pockets includes lateral recesses. Fasteners are disposed in the fastener slots and formed by the fastener pockets. One or more surgical buttresses have a body that overlies one or both of the fastener slots and the fastener pockets. Portions of the body of the one or more surgical buttresses are disposed within the lateral recesses to secure the one or more surgical buttresses to one or both of the first jaw member and the second jaw member.

A surgical stapling apparatus includes a housing and an end effector secured to the housing. The housing supports a knife assembly including a knife. The end effector has first and second jaw members. One or both of the first and second jaw members define a knife channel. The first jaw member defines fastener slots and the second jaw member defines fastener pockets. One or more of the knife channel, the fastener slots, and the fastener pockets includes lateral recesses. Fasteners are disposed in the fastener slots and formed by the fastener pockets. One or more surgical buttresses have a body that overlies one or both of the fastener slots and the fastener pockets. Portions of the body of the one or more surgical buttresses are disposed within the lateral recesses to secure the one or more surgical buttresses to one or both of the first jaw member and the second jaw member.

A method displaying information for viewing by a user characterised by the steps of: peripherally displaying primary information (5) on a first focal plane (3), and displaying secondary information (6) on at least a second focal plane (2) to said primary information (5), wherein said secondary information (6) exhibits at least one characteristic capable of augmenting the effect of the primary information (5) on the viewer.

A polymeric, surgical clip having first and second curved legs with each having a pair of opposing side surfaces joined at their proximal ends by a flexible hinge section and movable from an open position to a closed position for clamping a vessel between curved opposing inner surfaces. The first leg terminates at its distal end in a female locking member, and the second leg member terminates in a male locking member complimentary to the female locking member such that when the first and second leg members are moved from an open position to a closed position about the hinge section the male member is lockingly engaged in the female locking member. The clip has at least one cutting guide extending outward from and disposed along at least a portion of the length of at least one of the side surfaces of at least one of the first and second legs. The cutting guide aids in cutting the ligated tissue a safe distance from the clip such that a tissue cuff is formed.

The present invention provides systems and methods for extending media retention. Methods are provided in which a set of aging preferences are obtained. Data elements of a data set stored on storage media are evaluated against the aging preferences to determine whether each of the data elements satisfy the aging preferences. Each of the data elements that is determined to satisfy the aging preferences is aged. Aging can include freeing a portion of storage media, previously used to store a data element, for other storage usage.

A polymeric, surgical clip having first and second curved legs joined at their proximal ends by a flexible hinge section and movable from an open position to a closed position for clamping a vessel between curved opposing inner surfaces. The first leg terminates at its distal end in a female locking member comprising a resilient inwardly turned hook having a recess in the mouth of the hook, and the second leg member terminates in a male locking member complimentary to the female locking member and comprising a detent such that when the first and second leg members are moved from an open position to a closed position about the hinge section the hook member will deflect about the distal end of the second leg member thereby engulfing the male locking member in the mouth of the hook and matingly engaging the detent in the recess thereof, thus securely locking the clip in the closed position. The locking feature provides greater closure security to the clip when clamping large diameter or uncompressible tissue.

An apparatus and system for delivering a lipophilic agent associated with a medical device including: a medical device, a first lipophilic agent capable of penetrating a body lumen, wherein the transfer coefficients of the first lipophilic agent is by an amount that is statistically significant of at least approximately 5,000, wherein the first lipophilic agent is associated with the medical device, wherein the first lipophilic agent / medical device is placed adjacent to said body lumen, and wherein a therapeutically effective amount of the first lipophilic agent is delivered to a desired area within a subject. Furthermore, the invention relates to a method for improving patency in a subject involving placement of a medical device in a body lumen for treating and / or preventing adjacent diseases or maintaining patency of the body lumen.

An apparatus and system for delivering a lipophilic agent associated with a medical device including: a medical device, a first lipophilic agent capable of penetrating a body lumen, wherein the transfer coefficients of the first lipophilic agent is by an amount that is statistically significant of at least approximately 5,000, wherein the first lipophilic agent is associated with the medical device, wherein the first lipophilic agent / medical device is placed adjacent to said body lumen, and wherein a therapeutically effective amount of the first lipophilic agent is delivered to a desired area within a subject. Furthermore, the invention relates to a method for improving patency in a subject involving placement of a medical device in a body lumen for treating and / or preventing adjacent diseases or maintaining patency of the body lumen.

An integrated, fully automated video production system provides a video director with total control over all of the video production devices used to produce and broadcast a show. Such devices include, but are not limited to, cameras, robotic pan / tilt heads, video tape players and recorders (VTRs), video servers and virtual recorders, character generators, still stores, digital video disk players (DVDs), audio mixers, digital video effects (DVE), video switchers, and teleprompting systems. The video production system provides an automation capability that allows the video director to pre-produce a show, review the show in advance of “air time,” and then, with a touch of a button, produce the live show. In one embodiment, the invention provides a video production system having a processing unit in communication with one or more of the video production devices. The processing unit also records the show or elements from the show following its production. The show or elements can be recalled for subsequent broadcasts. An Internet interface supports live or on-demand requests for content from the video production. In an embodiment, an online user selects specific. elements and reorganizes the elements to personalize a broadcast. The processing unit receives and executes the online request to continuously stream or download the content to the user. In an embodiment, various supporting features enhance and extend the content of the video production, such as real time polling, hyperlinks to related web sites, video captions, and the like.

A coaxial cable connector generally includes a connector body, a nut rotatably coupled to the connector body, a post disposed in the connector body and a biasing element acting between the post and the nut. The nut has an internal thread for engagement with an external thread of a mating connector. The internal thread of the nut and the external thread of the mating connector can be mismatched, wherein an interference fit is created therebetween upon connection of the nut to the mating connector. Also, the post can have a forward flanged base portion disposed within the axial length of the internally threaded surface of the nut, which, together with the biasing element, provides a constant force between the post and the nut.

A vessel filter comprising a first region and a second region wherein the filter is movable between a collapsed position for delivery to the vessel and an expanded position for placement within the vessel. A first region has a filter portion having a converging region to direct particles toward the center of the filter and the second region is flared in the expanded position to have a transverse dimension increasing toward a second end portion opposite the first end portion. The second region includes a vessel engaging portion at the second end portion. The first region includes a plurality of spaced apart elongated struts with adjacent struts being joined.

A user-retainable monitoring system is disclosed. At least a pair of sensors is provided in association with a support member. The support member is preferably of a type that may be worn by or at least temporarily implanted in a patient. Possible sensor types include temperature sensors and impedance sensors. Temperature sensors may be used to detect a temperature differential between areas of tissue indicative of pathology. Impedance sensors are used to detect subcutaneous fluid detection. The support member may take the form of a bandage, drain or other structure. Monitor structures as described may have stand-alone utility or be connected to a processor or data recorder to enable various functions.

Compositions and methods are provided for preparing a metal substrate having a uniform textured surface with a plurality of indentations with a diameter in the nanometer and micrometer range. The textured surface is produced by exposing the substrate to an etching fluid comprising a hydrohalic acid and a mixture of a hydrohalic acid and an oxyacid, a chloride containing compound, and an oxidant. The etching solution can be used at ambient temperature. This textured surface enhances adherence of coatings or cells onto the textured surface, improves the retention of proteins on the surface, and encourages bone in-growth.

Apparatus and methods facilitate customizable and extensible performance monitoring of a computer network. One method accepts a composite score definition in terms of N system variables, wherein N≧2; determines N raw data values, each raw data value corresponding to one of the N system variables; computes the composite score in accordance with the definition using the N raw data values as inputs; and outputs the composite score. The composite score definition is preferably in the form of a markup language, such as XML. The composite score definition preferably comprises, for each of the N system variables, a mapping and a weight. Preferably the composite score is displayed in at least one graphic form, such as a dial gauge, a bar indicator or a number, on a hypertext page. The hypertext page preferably contains one or more links to hypertext pages containing information regarding the scores and / or raw data values from which the composite score is derived. Another method accepts a mapping by which a raw data value associated with a corresponding system variable is mapped to a score, determines a raw data value corresponding to the system variable, converts the raw data value to a score in accordance with the mapping; and produces an output based on the score. One apparatus comprises a composite score definition, a data collector, a calculation logic and an output. The data collector collects a raw data value corresponding to one of the N system variables. The calculation logic is connected to the data collector and calculates the composite score in accordance with the definition using the N raw data values as inputs. The composite score is conveyed by way of the output. Preferably, the data collector comprises a database in which at least some of the raw data values are stored and a communication module by which at least some of the raw data values are transported, preferably according to the SNMP and / or the ICMP protocols. Another apparatus comprises a mapping, a data collector, a converter and an output. A raw data value associated with a corresponding system variable is mapped to a score, according to the mapping.

The present inventors succeeded in discovering specific amino acid mutations in the variable region, framework region, and constant region of TOCILIZUMAB, and this enables to reduce immunogenicity risk and the heterogeneity originated from disulfide bonds in the hinge region, as well as to improve antigen binding activity, pharmacokinetics, stability under acidic conditions, and stability in high concentration preparations.

The present invention provides an improved vascular occlusion device having improved flexibility and retention of the type fabricated from braided tubular metal fabric having an expanded preset configuration and an elongated collapsed reduced diameter configuration for delivery through a catheter to a treatment site and shaped to create an occlusion of an abnormal opening in a body organ or vessel, the woven metal fabric having a memory property whereby the medical device tends to return to said expanded preset configuration when unconstrained. The device further including at least one disk portion adjacent a body cylindrical portion formed from the fabric and having a transition diameter between the disk and cylindrical portion, significantly smaller than the diameter of the disk and the diameter of the cylindrical portion.