2771results about How to "Avoid interaction" patented technology

A system (100) and method for immersion lithography is disclosed in which an immersion medium (112) interfaces with a proximal lens (110) that focuses a patterned light beam on a light sensitive material (116), wherein the light sensitive material (116) is covered by a protective film (300) that interfaces with the immersion medium (112).

The present application relates to anti-PD-L1 antibodies or antigen binding fragments thereof, nucleic acid encoding the same, therapeutic compositions thereof, and their use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, such as tumor immunity, for the treatment of and cancer.

Chimeric antibodies specific to human CD4 antigen, DNA encoding, pharmaceutical compositions containing and use thereof as therapeutic agents are taught. These chimeric antibodies contain Old World monkey variable sequences and human constant domain sequences, preferably human gamma 1, gamma 4 or mutated forms thereof. These antibodies possess desirable therapeutic properties including low antigenicity, reduced (or absent) T cell depleting activity, good affinity to human CD4 and enhanced stability (in vivo half-life).

A semiconductor structure is provided that includes a Vt stabilization layer between a gate dielectric and a gate electrode. The Vt stabilization layer is capable of stabilizing the structure's threshold voltage and flatband voltage to a targeted value and comprises a nitrided metal oxide, or a nitrogen-free metal oxide, with the proviso that when the Vt stabilization layer comprises a nitrogen-free metal oxide, at least one of the semiconductor substrate or the gate dielectric includes nitrogen. The present invention also provides a method of fabricating such a structure.

A method of consolidating particulate materials into articles having combinations of properties not available by conventional processes by liquid phase sintering. These particulate materials are comprised of core particles individually coated with layers of a metal compound having a relatively higher fracture toughness than the core, such as WC or TaC. These coated particles include an outer layer comprised a metal, such as Co or Ni. The particles with these coatings are pressed to form an article and the article densified at pressures and temperatures where full density is achieved without the degradation of the material forming the core particle.

A value in a counter on a processor is incremented for occurrences of a monitored event, providing a measured value for the event. The value of the counter register for a first thread is saved responsive to a switch from the first thread to a second thread. The value is saved in an accumulator in system memory. Then, responsive to a switch back to the first thread, the value for the first thread is restored from the accumulator. In this way, a counter may be read, and its value, for the first thread, for example, remains consistent despite any intervening thread switches. Since the counter register may be read directly, in the user state, this provides a faster and more consistent way to update performance counts.

The present disclosure relates to combining tunable antenna matching circuit adjustments and RF power amplifier output power adjustments of a first RF terminal in response to output power adjustment commands received from a second RF terminal. The output power adjustment commands may be part of an output power control loop between the first RF terminal and the second RF terminal to control the output power from the first RF terminal. The first RF terminal may include an RF receiver, an RF power amplifier, and a tunable antenna matching circuit coupled between an output of the RF power amplifier and an antenna. The tunable antenna matching circuit adjustments may be impedance adjustments of the tunable antenna matching circuit and the RF power amplifier output power adjustments may result from adjustments to one or more input signals to the RF power amplifier.

Drug tablets that include a prolonged-release core and an immediate-release layer or shell are prepared with a thin barrier layer of drug-free polymer between the prolonged-release and immediate-release portions of the tablet. The barrier layer is penetrable by gastrointestinal fluid, thereby providing full access of the gastrointestinal fluid to the prolonged-release core, but remains intact during the application of the immediate-release layer, substantially reducing or eliminating any penetration of the immediate-release drug into the prolonged-release portion.

Described herein are nanoparticles that are coated with a bilayer of molecules formed from surface binding molecules and amphiphatic molecules. The bilayer coating self assembles on the nanoparticles from readily available materials / molecules. The modular design of the bilayer coated nanoparticles provides a means for readily and efficiently optimizing the properties of the bilayer coated nanoparticle compositions. Also described herein are uses of such nanoparticles in medicine, laboratory techniques, industrial and commerical applications.

Performance events are counted for a computing system. This includes designating a first processor counter as a low-order counter for counting a certain performance event encountered by the processor and associating with the first counter a second counter as a high-order counter. The first counter is incremented responsive to detecting the performance event for a first processing thread. Responsive to a second thread, an accumulator in system memory for the first thread and first and second counters is updated. Responsive to the first thread becoming active, values of the first and second counters are loaded from the accumulator. Responsive to a user call to read and return a combined value, a first instance of the second counter is read, then the first counter is read and a second instance of the second counter is read before returning the combined value.

An improved method of treating immune cell mediated systemic diseases, particularly T and B cell mediated diseases, is provided by increasing the systemic exposure, or bioavailibility, of a therapeutic protein. Such therapeutic protein is selected from the group consisting of a monoclonal antibody, a soluble receptor and a soluble ligand which binds to an antigen expressed on the surface of an immunce cell.

Personal menu generator method, system, and autonomous mobile device will assist users in the selection of the most affordable and beneficial subset of food items to order at food serving establishments by composing and presenting to each guest an individualized subset of menu items and recommended portion sizes out of the larger set of available food items usually listed on the menus of food serving establishments; the presented individualized subset of food items is selected based on one or more of a multitude of criteria, such as the remaining daily balances of each user's macronutrient and micronutrient budgets, each available food item price, ingredients and energy and nutrient contents, the names, doses, and timing of medications and dietary supplements taken by each individual, favorite and restricted foods and ingredients, monetary spending limit for food, and healthcare provider recommendations.

A system and method for graphing data for a web application. A developer associates a graph component with a web page. In response to a web browser accessing the web page, the web server executes the graph component. The graph component generates information useable to display a graph in the web browser and generates scripting code which enables the user to interact with the graph in various ways. In response to the user interacting with the graph, the scripting code asynchronously communicates with the graph component on the web server to receive information for updating the graph displayed in the web browser.

Disclosed herein are in vitro assays for the identification of interactions between proteins or other molecules, the identification of transcriptional activator proteins, and the detection of compounds that inhibit protein / protein or protein / compound interactions. Also disclosed herein are in vitro assays for the selection of interacting proteins and transcriptional activator proteins out of libraries.

Methods and devices are provided for absorber layers formed on foil substrate. In one embodiment, a method of manufacturing photovoltaic devices may be comprised of providing a substrate comprising of at least one electrically conductive aluminum foil substrate, at least one electrically conductive diffusion barrier layer, and at least one electrically conductive electrode layer above the diffusion barrier layer. The diffusion barrier layer may prevent chemical interaction between the aluminum foil substrate and the electrode layer. An absorber layer may be formed on the substrate. In one embodiment, the absorber layer may be a non-silicon absorber layer. In another embodiment, the absorber layer may be an amorphous silicon (doped or undoped) absorber layer. Optionally, the absorber layer may be based on organic and / or inorganic materials.

The present invention relates to a method for preparing a peptide having a stable, internally constrained alpha-helical, beta-sheet / beta-turn, 310-helical, or pi-helical region and a method of stabilizing an alpha-helical, beta-sheet / beta-turn, 310-helical, or pi-helical region within a peptide structure. The resulting peptides and methods of using them are also disclosed.

The present invention concerns an appliance, a process and a computer program product for the processing of unstructured or semi-structured digital data in a file system. In order to create an appliance, a process and a computer program product which allow simple, reliable, high-performance and purpose oriented management of every manner of digital, stored, unstructured data, it is proposed that, when accessing data, logical access be carried out jointly with physical access and, when doing so, a particularly transparent, common access mechanism be implemented for both types of access.

An electronic device with a touchscreen display is provided comprising an active touchscreen region and a virtual bezel area, the active touchscreen region functioning to process a first set of touch-based inputs from a user of the electronic device according to a first mode of operation, and the virtual bezel area functioning to process a second set of touch-based inputs from a user of the electronic device according to a second mode of operation.

A modelocked linear fiber laser cavity with enhanced pulse-width control includes concatenated sections of both polarization-maintaining and non-polarization-maintaining fibers. Apodized fiber Bragg gratings and integrated fiber polarizers are included in the cavity to assist in linearly polarizing the output of the cavity. Very short pulses with a large optical bandwidth are obtained by matching the dispersion value of the fiber Bragg grating to the inverse of the dispersion of the intra-cavity fiber.

A method of forming a CMOS structure, and the device produced therefrom, having improved threshold voltage and flatband voltage stability. The inventive method includes the steps of providing a semiconductor substrate having an nFET region and a pFET region; forming a dielectric stack atop the semiconductor substrate comprising an insulating interlayer atop a high k dielectric; removing the insulating interlayer from the nFET region without removing the insulating interlayer from the pFET region; and providing at least one gate stack in the pFET region and at least one gate stack in the nFET region. The insulating interlayer can be AlN or AlOxNy. The high k dielectric can be HfO2, hafnium silicate or hafnium silicon oxynitride. The insulating interlayer can be removed from the nFET region by a wet etch including a HCl / H2O2 peroxide solution.

An all-fiber combiner device is described for combining multiple high power inputs, such as high power laser inputs. The device includes a first tapered fiber section made from fibers that allow for efficient size reduction of the optical signals. The output of the first tapered fiber section may then be coupled to a multimode output fiber for delivery of the combined power beam. Alternately, the first tapered section can be coupled to a second, multimode, tapered section, which provides further size reduction of the core for splicing into a final output fiber, while adding cladding to the main fiber.

A device for the reduction of aerodynamic drag and for improved performance and stability of ground vehicles by reducing the mass and velocity of the flow passing under a vehicle is described. The device is particularly suited for a tractor-trailer truck system that includes a motorized lead vehicle pulling one or more non-motorized vehicles. The device is designed to control the flow from entering the undercarriage region from the side of a trailer of a tractor-trailer truck system.

Disclosed is an isomer, enantiomer, diastereoisomer or tautomer of a compound represented by Formula I: or a salt thereof, in which R1, R2, R100, R200, A, A1, B, B1, BG, n, Q and Q1 are substituents described. Also disclosed is the use of compounds of Formula 1 to treat proliferative disorders.

A device for the reduction of aerodynamic drag and for improved performance and stability of ground vehicles by reducing the mass and velocity of the flow passing under a vehicle is described. The device is particularly suited for a tractor-trailer truck system that includes a motorized lead vehicle pulling one or more non-motorized vehicles. The device is designed to control the flow from entering the undercarriage region from the side of a trailer of a tractor-trailer truck system.

Methods of diagnosing and prognosticating the development of human cancers, such as breast cancer, colon cancer, and pancreatic cancer, are provided. The diagnostic and prognostic methods include the detection and / or quantifying of the amount of expression of JAB1 in human cells, particularly in relation to the amount of p27 or c-Jun. In addition, methods for reducing the expression of JAB1 protein in cells and inhibiting its interaction with p27 or c-Jun, for example, are provided.

The embodiment of the invention provides a network slice selection method, device and network architecture, and the technical problem that a network slice cannot be flexibly selected in the prior artis solved. The method includes the steps of using a slice selection control function to acquire one or more items of a slice selection strategy, user subscription information, network slice selectionassistance parameters and the user context; the slice selection control function determining network slice selection information according to the one or more items of the slice selection strategy, user subscription information, network slice selection assistance parameters and the user context, sending the determined network slice selection information to the slice routing function, so as to enable the slicing routing function to execute signaling or data routing (signaling is 5G control signaling), and the data is sent by a user, such as internet surfing data, internet of things data and thelike ). The technical problem that a network slice cannot be flexibly selected in the prior art can be solved.