2758results about How to "Avoid interaction" patented technology

The present application relates to anti-PD-L1 antibodies or antigen binding fragments thereof, nucleic acid encoding the same, therapeutic compositions thereof, and their use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, such as tumor immunity, for the treatment of and cancer.

A semiconductor structure is provided that includes a V_t stabilization layer between a gate dielectric and a gate electrode. The V_t stabilization layer is capable of stabilizing the structure's threshold voltage and flatband voltage to a targeted value and comprises a nitrided metal oxide, or a nitrogen-free metal oxide, with the proviso that when the V_t stabilization layer comprises a nitrogen-free metal oxide, at least one of the semiconductor substrate or the gate dielectric includes nitrogen. The present invention also provides a method of fabricating such a structure.

The present disclosure relates to combining tunable antenna matching circuit adjustments and RF power amplifier output power adjustments of a first RF terminal in response to output power adjustment commands received from a second RF terminal. The output power adjustment commands may be part of an output power control loop between the first RF terminal and the second RF terminal to control the output power from the first RF terminal. The first RF terminal may include an RF receiver, an RF power amplifier, and a tunable antenna matching circuit coupled between an output of the RF power amplifier and an antenna. The tunable antenna matching circuit adjustments may be impedance adjustments of the tunable antenna matching circuit and the RF power amplifier output power adjustments may result from adjustments to one or more input signals to the RF power amplifier.

Drug tablets that include a prolonged-release core and an immediate-release layer or shell are prepared with a thin barrier layer of drug-free polymer between the prolonged-release and immediate-release portions of the tablet. The barrier layer is penetrable by gastrointestinal fluid, thereby providing full access of the gastrointestinal fluid to the prolonged-release core, but remains intact during the application of the immediate-release layer, substantially reducing or eliminating any penetration of the immediate-release drug into the prolonged-release portion.

Described herein are nanoparticles that are coated with a bilayer of molecules formed from surface binding molecules and amphiphatic molecules. The bilayer coating self assembles on the nanoparticles from readily available materials/molecules. The modular design of the bilayer coated nanoparticles provides a means for readily and efficiently optimizing the properties of the bilayer coated nanoparticle compositions. Also described herein are uses of such nanoparticles in medicine, laboratory techniques, industrial and commerical applications.

An improved method of treating immune cell mediated systemic diseases, particularly T and B cell mediated diseases, is provided by increasing the systemic exposure, or bioavailibility, of a therapeutic protein. Such therapeutic protein is selected from the group consisting of a monoclonal antibody, a soluble receptor and a soluble ligand which binds to an antigen expressed on the surface of an immunce cell.

Personal menu generator method, system, and autonomous mobile device will assist users in the selection of the most affordable and beneficial subset of food items to order at food serving establishments by composing and presenting to each guest an individualized subset of menu items and recommended portion sizes out of the larger set of available food items usually listed on the menus of food serving establishments; the presented individualized subset of food items is selected based on one or more of a multitude of criteria, such as the remaining daily balances of each user's macronutrient and micronutrient budgets, each available food item price, ingredients and energy and nutrient contents, the names, doses, and timing of medications and dietary supplements taken by each individual, favorite and restricted foods and ingredients, monetary spending limit for food, and healthcare provider recommendations.

A system and method for graphing data for a web application. A developer associates a graph component with a web page. In response to a web browser accessing the web page, the web server executes the graph component. The graph component generates information useable to display a graph in the web browser and generates scripting code which enables the user to interact with the graph in various ways. In response to the user interacting with the graph, the scripting code asynchronously communicates with the graph component on the web server to receive information for updating the graph displayed in the web browser.

Disclosed herein are in vitro assays for the identification of interactions between proteins or other molecules, the identification of transcriptional activator proteins, and the detection of compounds that inhibit protein/protein or protein/compound interactions. Also disclosed herein are in vitro assays for the selection of interacting proteins and transcriptional activator proteins out of libraries.

Methods and devices are provided for absorber layers formed on foil substrate. In one embodiment, a method of manufacturing photovoltaic devices may be comprised of providing a substrate comprising of at least one electrically conductive aluminum foil substrate, at least one electrically conductive diffusion barrier layer, and at least one electrically conductive electrode layer above the diffusion barrier layer. The diffusion barrier layer may prevent chemical interaction between the aluminum foil substrate and the electrode layer. An absorber layer may be formed on the substrate. In one embodiment, the absorber layer may be a non-silicon absorber layer. In another embodiment, the absorber layer may be an amorphous silicon (doped or undoped) absorber layer. Optionally, the absorber layer may be based on organic and/or inorganic materials.

The present invention relates to a method for preparing a peptide having a stable, internally constrained alpha-helical, beta-sheet/beta-turn, 3₁₀-helical, or pi-helical region and a method of stabilizing an alpha-helical, beta-sheet/beta-turn, 3₁₀-helical, or pi-helical region within a peptide structure. The resulting peptides and methods of using them are also disclosed.

The present invention concerns an appliance, a process and a computer program product for the processing of unstructured or semi-structured digital data in a file system. In order to create an appliance, a process and a computer program product which allow simple, reliable, high-performance and purpose oriented management of every manner of digital, stored, unstructured data, it is proposed that, when accessing data, logical access be carried out jointly with physical access and, when doing so, a particularly transparent, common access mechanism be implemented for both types of access.

A modelocked linear fiber laser cavity with enhanced pulse-width control includes concatenated sections of both polarization-maintaining and non-polarization-maintaining fibers. Apodized fiber Bragg gratings and integrated fiber polarizers are included in the cavity to assist in linearly polarizing the output of the cavity. Very short pulses with a large optical bandwidth are obtained by matching the dispersion value of the fiber Bragg grating to the inverse of the dispersion of the intra-cavity fiber.

An all-fiber combiner device is described for combining multiple high power inputs, such as high power laser inputs. The device includes a first tapered fiber section made from fibers that allow for efficient size reduction of the optical signals. The output of the first tapered fiber section may then be coupled to a multimode output fiber for delivery of the combined power beam. Alternately, the first tapered section can be coupled to a second, multimode, tapered section, which provides further size reduction of the core for splicing into a final output fiber, while adding cladding to the main fiber.

A prosthetic heart valve includes a hydrogel material in its sewing cuff. The hydrogel material may be accompanied by an anticoagulant. If the hydrogel (and/or any included anticoagulant) might react with a packaging solution in which the valve is stored after inclusion of the hydrogel (and any anticoagulant), the hydrogel (and any anticoagulant) may be included in a protective but deliberately frangible pouch in the sewing cuff. After the valve is out of the packaging solution, the pouch can be broken to render the hydrogel (and any coagulant) effective following implantation of the valve in a patient.

The embodiment of the invention provides a network slice selection method, device and network architecture, and the technical problem that a network slice cannot be flexibly selected in the prior artis solved. The method includes the steps of using a slice selection control function to acquire one or more items of a slice selection strategy, user subscription information, network slice selectionassistance parameters and the user context; the slice selection control function determining network slice selection information according to the one or more items of the slice selection strategy, user subscription information, network slice selection assistance parameters and the user context, sending the determined network slice selection information to the slice routing function, so as to enable the slicing routing function to execute signaling or data routing (signaling is 5G control signaling), and the data is sent by a user, such as internet surfing data, internet of things data and thelike ). The technical problem that a network slice cannot be flexibly selected in the prior art can be solved.