262 results about "Amphiphile" patented technology

The present invention is directed to an oral composition containing a gel network phase comprising: (i) one or more fatty amphiphiles, (ii) one or more surfactants, and (iii) one or more solvents; and an oral carrier phase. In certain embodiments, the gel network is used to structure the oral composition. The present invention is also directed to a method of forming an oral composition containing a gel network.

Described herein are nanoparticles that are coated with a bilayer of molecules formed from surface binding molecules and amphiphatic molecules. The bilayer coating self assembles on the nanoparticles from readily available materials/molecules. The modular design of the bilayer coated nanoparticles provides a means for readily and efficiently optimizing the properties of the bilayer coated nanoparticle compositions. Also described herein are uses of such nanoparticles in medicine, laboratory techniques, industrial and commerical applications.

The compositions of the present invention relate to personal cleansing compositions having from about 4% to about 50%, by weight, of a surfactant selected from the group consisting of an anionic, cationic, nonionic, amphoteric, and zwitterionic surfactants and mixtures thereof; from about 0.05% to about 10% by weight of a dispersed, water insoluble solid particles or solid, temperature stable particles; from about 0.025% to about 5% by weight of an organic, non crosslinked, cationic homopolymer or copolymer having a cationic charge density of from about 2 meq/gm to about 10 meq/gm and an average molecular weight of from about 1,000 to about 5,000,000; from about 0.1% to about 10%, by weight, of a phase separation initiator selected from the group consisting of electrolytes, amphiphiles and mixtures thereof; and from about 50% to about 95%, by weight, of water.

The present invention relates to the use of self-assembling peptide amphiphiles to prevent tumor formation by transplanted stem cells. The present invention further relates to the use of self-assembling peptide amphiphiles to treat cancers.

A method for preparing amphoteric liposomes loaded with polyanionic active agent as cargo, characterised by admixing an aqueous solution of said polyanionic active agent and an alcoholic solution of one or more amphiphiles and buffering said admixture to an acidic pH, said one or more amphiphiles being susceptible of forming amphoteric liposomes at said acidic pH, thereby to form such amphoteric liposomes in suspension encapsulating said active agent under conditions such that said liposomes form aggregates, and thereafter treating said suspension to dissociate said aggregates. Also disclosed are nucleic acid loaded amphoteric liposomes produced in accordance with the method, wherein said nucleic acids are oligonucleotides and said liposomes are multilamellar.

The invention relates to compositions and methods for drug delivery suitable for promoting the transmucosal absorption of drugs, especially drugs with poor intrinsic bioavailability, such as peptides, proteins, vaccines, and nucleic acids. The delivery system of this invention preferably comprises fatty acid esters and their hydrophilic derivatives that associate with water and other polar solvents to form reverse micelles tha are physically stabilized in the presence of gastrointestinal fluid, water, and other hydrophilic solvents. Such stable reverse micelles are formed by suitable mixtures of polymeric or non-polymeric compounds with amphiphiles. Micelles made using these methods undergo phase transformation more slowly resulting in delayed drug release profiles and sustained absorption. When administered as a pharmaceutical to mucosal surfaces following oral ingestion or intranasal administration, therapeutic molecules principally solubilized in the aqueous phase are protected from digestion by mucosal enzymes and other mucosal degradative processes and are taken up by absorptive cell mechanisms and reach appropriate body compartments. The reverse micelle compositions may comprise mono-, di-glycerides and/or their transesterifed products containing C6-C12 fatty acids chains, wherein the transester groups consist of hydrohilic moieties.

The Dissolvable Solid Structure as described herein can be in the form of a fibrous structure comprising: (a) a polymeric structurant; (b) a high melting point fatty compound such as a fatty amphiphile, and (c) a cationic surfactant. The polymeric structurant has a weight average molecular weight of from about 10,000 to about 6,000,000 g/mol, and the components of the fibrous material form a homogenous material when molten. When water is added to the dissolvable solid structure at a ratio of about 5:1 a lamellar structure is formed.

A process for preparing the size and shape controllable ampholytic metal oxides and their metallic nanotubes features that based on the principle that under existance of excessive alkali the ampholytic metal hydroxide can become coordinate anions, under the action of surfactant as "soft template", the ampholytic metal oxide and its metallic nanotubes can be prepared by direct hydrothermal reaction or redox reaction (for example, ZnO, CuO, Al2O3, PbO2, SnO2 and relative metals). Its advantages are simple process, controllable sizes of nanotube, uniform wall thickness, and high output.

Water-soluble fluorescent particles are formed in a simple process. A mixture comprising a solvent, water, a fluorescent polymer dissolved in the solvent, and an amphiphilic molecule is provided. The fluorescent polymer comprises a hydrophobic segment. The amphiphilic molecule comprises hydrophilic and hydrophobic segments. The solvent is removed from the mixture to allow the fluorescent polymer and the amphiphilic molecule to entangle in the presence of water, thus forming the water-soluble fluorescent particles. In the formed particles, the hydrophilic segments of the amphiphilic molecule are entangled with one another, and the hydrophobic segments of the fluorescent polymer and amphiphilic molecule are entangled with one another. The amphiphilic molecule encapsulates the fluorescent polymer and at least some of the hydrophilic segments are exposed to render the particle soluble in water.

A shampoo composition comprising: a) from about 5% to about 50% of one or more detersive surfactants, by weight of said shampoo composition; b) a dispersed solid crystalline gel network phase comprising: i) a first component comprising at least about 0.05% of one or more fatty acids by weight of said shampoo composition; ii) a second component comprising at least about 0.05% of one or more additional fatty amphiphiles by weight of said shampoo composition; iii) water; and c) at least about 20% of an aqueous carrier, by weight of said shampoo composition; wherein said first component is combined with said second component in the ratio of 10:1 to about 1:5 to form said solid crystalline gel network phase.

The present invention relates to a non-amphiphile-based water-in-water emulsion composition. The non-amphiphile-based water-in-water emulsion composition includes a water-soluble polymer, a non-amphiphilic lyotropic mesogen encapsulated by the water-soluble polymer; and water. In one embodiment, the non-amphiphilic lyotropic mesogen includes, without limitation, a lyotropic chromonic liquid crystal, and more specifically disodium cromoglycate (DSCG). In another embodiment, the water-soluble polymer can include, without limitation, a polyacrylamide, a polyol, a polyvinylpyrrolidone, a polysaccharide, or a water-soluble fluoride-bearing polymer. The present invention also relates to a porous hydrogel made with the use of the non-amphiphile-based water-in-water emulsion. The present invention further relates to using the emulsion and hydrogel for various applications.

The present disclosure provides an antimicrobial composition including a polycationic amphiphile compound, and the method of making and the method of using such a compound or composition. The compound having the formula (I) or (II) R₁, R₂, R₃, R₄, R₅, R₆, R₁₀, or R₁₁ is H or a C_1-12 alkyl unsubstituted or optionally substituted with a functional group such as —OH, —OR′, —NH₂, —NHR′, —NR′₂, —N—C(O)R′, —N—C(O)CR′═CR′, —SH, —SR′, —O—C(O)R′, —C(O)R′, —CF₃, —OCF₃, halogen, benzyl, o-vinylbenzyl, m-vinylbenzyl, p-vinylbenzyl, phenyl, allyl, and substituted allyl. R₇, R₈ or R₉ is a C_1-12 alkyl unsubstituted or optionally substituted with a functional group such as —OH, —OR′, —NH₂, —NHR′, —NR′₂, —SH, —SR′, —O—C(O)R′, —C(O)R′, —CF₃, and —OCF₃. R′ is H or a C_1-4 alkyl. X or Y is a halogen, m and n are integers in the range from 1 to 25.