2513results about How to "Good sustained release effect" patented technology

The invention discloses a preparation method of a core-shell structured synthetic polymer-natural polymer composite fiber, and the method comprises the steps of: (1) selecting one or several of synthetic polymers to dissolve in a solvent, and conducting stirring until complete dissolution; (2) selecting a natural polymer to dissolve in a solvent, or adding a spinning assistant, and carrying out stirring until complete dissolution; and (3) taking the solution prepared in step (1) as an outer tube spinning solution, adopting the solution prepared in step (2) as an inner tube spinning solution, injecting them into the inner tube and the outer tube of a coaxial spinneret, and performing coaxial electrospinning at room temperature. The core-shell structured nano-fiber prepared by the invention selects the synthetic polymer as the shell layer, and can inhibit water molecules from penetrating the natural polymer as the core layer. The natural polymer as the core layer can more effectively encapsulate active substances to avoid inactivation of the active substances in the presence of an organic solvent, so that the core-shell structured composite fiber can play a good drug sustained release role in the drug carrier field, and an integral activity can be maintained.

The present invention relates to sustained-release pharmaceutical compositions for ionic pharmaceutically active substances containing ionic compounds having opposite charges to those of ionic prostanoic acid derivatives and increasing hydrophobicity of the active substances. More specifically, the invention relates to sustained-release pharmaceutical compositions comprising the ionic prostanoic acid derivatives and the ionic compounds having opposite charges to those of the prostanoic acid derivatives and increasing hydrophobicity of these derivatives that contain hydrophobic groups in the molecule thereof.The pharmaceutical composition of the invention can exhibit excellent sustained release effect of the ionic prostanoic acid derivatives, irrespective of water solubility possessed by the ionic prostanoic acid derivatives.

The invention discloses a biochar base soil modifier and a preparation method thereof. The biochar base soil modifier comprises the following components in percentage by weight: 95.5-98.5% of biomass carbon black and 1.5-4.5% of probiotics agent. Agricultural waste serves as a biomass raw material to carry out low-temperature carbonization to form the porous biomass carbon black; beneficial microorganism is enlarged and cultivated and is fermented into probiotics liquid; after mixing, solid and liquid separation, flash evaporation and drying are carried out to obtain the probiotics agent; the beneficial microorganism is selected from one or more of paenibacillus polymyxa, trichoderma strains, nitrogen-fixing bacteria, rhizobium, phosphate solubilizing bacteria, potassium bacteria, cellulose decomposition bacteria, antibiotic generation bacteria and photosynthetic bacteria. The biochar base soil modifier disclosed by the invention adopts the microporous biomass carbon which has strong adsorption capability and good light absorption and temperature-increasing effect. The probiotics agent has a high survival rate and can be stored for a long time at the normal temperature, the fertilizer synergy action is obvious, and the soil borne disease can be effectively prevented and cured.

A PLG copolymer material, termed a PLG(p) copolymer material, adapted for use in a controlled release formulation for a bioactive material is provided, wherein the formulation exhibits a reduced “initial burst” effect when introduced into the tissue of a patient in need thereof. A method of preparation of the PLG copolymer material is also provided, as are methods of use.

The invention relates to a fermented alga liquid fertilizer synergist and a production method and an application thereof. The fertilizer synergist is a fermented alga liquid fertilizer synergist obtained by performing microbial fermentation on natural alga serving as a raw material, preparing an alga extracting solution through procedures such as alkali extraction, filter pressing and the like, and adding chelated state trace elements into a liquid. Due to the adoption of the fermented alga liquid fertilizer synergist disclosed by the invention, the soil urease activity can be suppressed remarkably, slow release of a fertilizer is enhanced, and the crop yield can be increased remarkably; trace elements such as boron, zinc, manganese and the like which are generally lacked in soil in China can be replenished; root growth of crops can be facilitated, root activity is increased, and the capabilities of crops of absorbing phosphorus, potassium and medium and trace elements are increased; and the fermented alga liquid fertilizer synergist has the characteristics of reduction in nutrient loss, avoidance of secondary pollution, reduction in the production cost of a synergic fertilizer, wide raw material source, convenience for adding in fertilizer production and the like, and has a wide application prospect in the production of the synergic fertilizer.

The invention relates to a preparation method of a slow-release pesticide. The method comprises the steps of: adsorbing a pesticidal active compound into a porous material; using a pore channel sealing material to seal the pore channels of a porous carrier; conducting further processing so as to obtain a suspending agent, powder, a granule, a tablet and other products of different preparation forms. The pesticidal active compound can be a pesticide, a bactericide, a herbicide or a plant-growth regulator. The preparation method of a slow-release pesticide in the invention can be used to prepare slow-release powder, slow-release granules, slow-release tablets, slow-release suspending agents and other products of different preparation forms so as to meet different demands of agricultural production, and can control the release of pesticidal active components into a surrounding environment at a predetermined speed or a low speed within a predetermined time. One-time application of a slow release pesticide prepared in the invention can control diseases, pests and weeds of a whole growth period (or a certain period). Thus, the slow-release performance of pesticides can be substantially enhanced, the release time can be prolonged, and long-time stable release of slow release pesticides can be maintained.

The invention relates to biodegradable fluorouracil(Fu) polyester drug-bearing manoparticles with a coating material of polylactic acid, polylactic acid-glycolic acid, polylactic acid-polyethylene glycol block copolymer or polylactic acid-glycolic acid-polyethylene glycol block copolymer and the producing method including: firstly, fully dissolving the copolymer in the dichloromethane, under the ultrasonic shock, injecting the fluorouracil NaOH solution in the dichloromethane solution, dispersing uniformly, forming W / O primary latex, and beating up the primary latex and injecting into the fluorouracil saturated water solution containing 5 wt% of polyvinylalcohol (PVA), and storing in the refrigeratory after freeze-dry. The drug-bearing manoparticle has a drug content which is 10-25% of the microparticle mass, and has a smooth surface, an even diameter distribution, a remarkable slow release function and not adhesive. The micropartical size is 100-1000nm.

The invention provides composite antibacterial powder and a preparation method thereof. The composite antibacterial powder contains nano silver, zinc and nonmetallic minerals such as nano calcium carbonate or nano hydrotalcite, nano titanium oxide and nano bentonite and the like serving as carriers, wherein the content of the silver is 10 to 20 mass percent, and the content of the zinc is 20 to 40 mass percent. The composite antibacterial powder has high bactericidal factor content, is more convenient in compatibility and application, and saves the cost; the particle diameter of the bactericidal factors is nano-scale, so that the bactericidal capability is stronger; the composite antibacterial powder has illumination resistance, does not change color, and has high temperature resistance, good slow-release property and long-acting property; and the preparation method is simple in process, time-saving, labor-saving and high in production efficiency. The composite antibacterial powder serving as an antibacterial agent can be widely applied to various building materials, glass, coating (containing powdery coating), wood, paper and products thereof, plastics, plastic cement, daily ceramic, chemical materials, various home appliances, daily chemical products, textiles and the like.

The invention discloses a preparation method of a double-layer wrapped essence micro-capsule, belonging to the technical field of preparation of essence micro-capsules. The preparation method disclosed by the invention comprises the following steps: (1), carrying out micro-capsule embedding on essence for the first time through complex coacervation; (2), solidifying and separating the micro-capsule; and (3), carrying out embedding on the obtained essence micro-capsule for the second time through the spray drying method, and finally, obtaining the double-layer wrapped micro-capsule. According to the invention, first-time complex coacervation embedding on essence is carried out by selecting whey protein and Arabic gum having low cost and good embedding effect as the wall materials; the mixed solution of Arabic gum, maltodextrin, glucose and soy protein is adopted as the spray wall material for the second-time embedding; and finally, the powdery essence micro-capsule is obtained. The preparation method disclosed by the invention has the advantages of realizing industrial production, and being low in cost, steady in physical and chemical property and the like.

The invention discloses a biomass charcoal based probiotic preparation, which is composed of biomass carbon black and concentrated probiotic preparation based on a weight ratio of (8.85-9.15): (0.85-1.15). The preparation is prepared by using agricultural wastes as biomass raw materials, conducting low-temperature carbonization to form porous biomass carbon black; conducting amplification culture to beneficial microorganism, and fermenting to produce probiotic solution; mixing above materials and separating solid from liquid; and drying by flash evaporation to obtain concentrated probiotic preparation, wherein the beneficial microorganism is one or more of paenibacillus polymyxa, trichoderma, nitrogen-fixing bacteria, rhizobium, phosphate dissolving bacteria, potassium dissolving bacteria, cellulose decomposition bacteria, antibiotic producing bacteria, and photosynthetic bacteria. In addition, the invention also discloses a preparation method for the biomass charcoal based probiotic preparation. The biomass charcoal based probiotic preparation provided by the invention uses microporous biomass charcoal, which has very strong absorption capacity and very good light absorption and warming effect. The probiotic preparation is high in survival rate of live bacteria, can be preserved for a long time at normal temperature and has evident synegistic effect for fertilizer.

The invention discloses a special saline and alkaline land organic / inorganic compounded fertilizer as well as a preparation method and application thereof. The compounded fertilizer comprises raw materials, namely a mixture 1 and a mixture 2, wherein the weight ratio of the mixture 1 to the mixture 2 is (1.5-3.5):1; the mixture 1 comprises composite charcoal, a biological organic fertilizer, humicacid substances, furfural residues, an improvement preparation and inorganic nutrients which are mixed according to a certain ratio; the mixture 2 comprises a biological organic fertilizer, humic acid substances, furfural residues and water retention aids which are mixed according to a certain ratio. By adopting the product disclosed by the invention, soil structures can be improved, soil porosity can be improved, soil bulk density can be reduced, contents of organic matters in soil can be increased, the cation exchange amount of the soil can be increased, and the pH value of the soil and thetotal amount of water soluble salts in the soil can be reduced. In addition, the fertilizer has functions of slowly releasing acid substances and nutrients, is capable of activating soil, reducing immobilization of soil upon nutrients and increasing the utilization rate of the nutrients, is capable of continuously and stably improving soil, is free of adverse influence upon environments and plants, and is ecological and environmentally friendly.