46results about How to "Negligible loss" patented technology

Antibody binding assays and radiolabeling kits are disclosed for radiolabeling and testing therapeutic antibodies in the commercial setting. In particular, the kits are designed for making and evaluating radiolabeled anti-CD20 conjugates to be used for the treatment and imaging of B cell lymphoma tumors. All kit reagents are sterile and are designed to achieve a high level of antibody radiolabeling and product stability with results which are highly reproducible.

A hybrid clamshell system encapsulates two of the six sides of an electronic circuit board to provide a high heat density solution and environmental protection. The clamshell enclosures seal to both sides of the PCB and contain fluid shut-off couplings. A two-phase cooling system directs a coolant via a supply path located in the sidewall of the enclosure to one or more cooling modules and collects the coolant via a return path within the enclosure. With the addition of an inject / eject mechanism attached to the clamshell, the fully assembled blade can be “fluid hot-swapped” in and out of the chassis with negligible loss of coolant. The interrelation of the clamshell module and it's implementation in an exemplary system are detailed herein.

A frame comprising four angles each angle having two legs, each leg connected to a a leg of a neighboring angle wherein locations of attachment of the legs are adjustable so as to accommodate a range of sizes of boards for a surface mount manufacturing process. One leg of each angle has a tongue and the other leg has a groove so that tongue of one leg slideably engages the groove of the leg of a neighboring angle to enable adjustment in size of the frame opening. The board is supported on a shoulder around the frame opening with the surface of the board opposite the supporting shoulder surface coplanar with the plane surface of the frame. A flat spring loaded rotatable finger on the plan surface in one corner of the board urges the board toward the opposite corner of the frame.

An apparatus and a method for active reduction of the noise emission from a jet engine having an air inlet, a gas outlet and an engine arranged between the air inlet and the gas outlet. A first acoustic transducer is arranged in the air inlet upstream of the engine and / or in the gas outlet downstream of the engine in order to convert sound waves into first signals that are a measure of the frequency, amplitude and phase of the sound waves. An electronic control unit converts the first signals into second signals. A second acoustic transducer is centrally arranged in the air inlet upstream of the engine and / or in the gas outlet downstream of the engine in order to convert the second signals into compensation sound waves whose frequency, amplitude and phase are such that the sound waves and the compensation sound waves at least partially cancel one another out.

The present invention may relate to Aeroponic Systems and their individual elements. More particularly to automated systems capable of monitoring and adjusting some if not all of the light, nutrient, water quality and environmental factors required for the propagation and sustained growth of all types of plants. It may also describe methods to support the plants during propagation from seeds and for growth and harvesting. It may describe various methodologies for reducing space requirements and for increasing plant density without detriment to the growth cycles.

The preservation of live viral vaccines is disclosed. These liquid formulations comprise a live virus and a preservative, namely chlorobutanol. The preserved, live virus formulations of the present invention are (1) suitable for a vaccine or gene therapy product with a multi-dose image; (2) compatible with parenteral administration; and (3) are stable for extended periods of time with negligible loss of activity.

The invention is to an optionally piloted aircraft that can takeoff and land conventionally or vertically, and can convert between the two. The aircraft is immune to one or more engine failures during vertical flight through multiple engines and the use of a virtual nozzle. Aerodynamic controls are similarly redundant. Hovering flight is enabled with a novel stabilization system. Long range efficient cruise is achieved by turning off some engines in flight and sealing them into an aerodynamic fairing to achieve low drag. The resulting aircraft is capable of CTOL and VTOL, and is capable of converting between the two modes while in the air or on the ground. The aircraft can also be easily taxied on the ground in the conventional manner. Automatic controls considerably reduce the amount of training a pilot needs to fly and land the aircraft in either VTOL or CTOL mode.

Method and system are disclosed for coupling energy from at least on energy source, e.g. UV light source, ultrasonic transducer, or combination thereof, to a target site, e.g. hazardous bacteria, through a streaming liquid, e.g. water. The bacteria toward which energy is to be coupled could be present in the water stream itself and / or on a surface toward which the water stream is to be launched at the end of its flow. Accordingly, in-line aseptic filling is provided, which can fill and simultaneously disinfect a container. According to another embodiment where the water is used for washing, in-line aseptic washing device is provided. A variety of other embodiments is disclosed as well.

A multi-mode RF amplifier is disclosed having high and low output power modes and two power paths. A first RF amplifier delivers power to both paths. When the multi-mode RF amplifier is biased into the high power, HP, mode, substantial power is delivered via both (first and second) paths. While in the low power, LP, mode, an RF switch is turned off, creating a high input impedance, open circuit for the first path, and effectively isolating the two paths. Therefore, power is delivered by the first RF amplifier to the second path only. The impedance presented to the output of the first RF amplifier is equal to the input impedance of the second path which may be optimally set for maximizing power added efficiency or output power in LP mode. Note that, in a preferred embodiment, even in the HP mode more power is delivered to the second power path than to the first power path.

An adaptive signal processing system utilizes a pseudo-median cascaded canceller to compute a set of complex adaptive weights and generate a filtered output signal. The system includes a plurality of building blocks arranged in a Gram-Schmidt cascaded canceller-type configuration for sequentially decorrelating input signals from each other to thereby yield a single filtered output signal. Each building block includes a local main input channel which receives a local main input signal, a local auxiliary input channel which receives a local auxiliary input signal, and a local output channel which sends a local filtered output signal. Each building block generates a complex adaptive weight which is the sample median value of the real and imaginary parts of the ratio of local main input weight training data to local auxiliary input weight training data, and each building block generates a local output signal utilizing the complex adaptive weight. The effect of non-Gaussian noise contamination on the convergence MOE of the system is negligible. In addition, when desired signal components are included in weight training data they cause little loss of noise cancellation.

The present invention is a method for identifying unknown parameters in a system having a set of governing equations describing its behavior that cannot be put into regression form with the unknown parameters linearly represented. In this method, the vector of unknown parameters is segmented into a plurality of groups where each individual group of unknown parameters may be isolated linearly by manipulation of said equations. Multiple concurrent and independent recursive least squares identification of each said group run, treating other unknown parameters appearing in their regression equation as if they were known perfectly, with said values provided by recursive least squares estimation from the other groups, thereby enabling the use of fast, compact, efficient linear algorithms to solve problems that would otherwise require nonlinear solution approaches. This invention is presented with application to identification of mass and thruster properties for a thruster-controlled spacecraft.

A sinewave inverter for converting unstable DC voltage from a variable source such as batteries, fuel cells, wind mills and the like into a distortionless sinusoidal AC voltage of constant amplitude and constant frequency is provided. This pure sinewave inverter with line and load regulated voltage is obtained by using a combination of a hyperbolic frequency modulator with a sinusoidal pulsewidth modulator in the inverter circuit.

The invention relates to a spray drying system and a method for its operation that provides a composition of dry. or essentially solvent free, particles from a solution of an agent. The system comprises a generally vertical tube reactor arranged for counter-current removal of solvent from a process flow fed with aerosol droplets of solution descending from the top said reactor with an ascending gas flow. The reactor includes a perforated process tube for transportation of the process flow from the outlet of an aerosol generating device to a dry particle collecting device. A membrane sleeve essentially surrounds the peripheral area of said process tube and separates the descending process stream from the ascending gas stream. Vaporized solvent is transported from the process stream to the ascending gas stream. A reactor housing is sealingly covering said process tube and membrane sleeve and is provided with means for introducing and / or removing the process fluids.

Apparatus and process for removing and / or converting contaminants in water-miscible organic solvent mixtures by surface interaction effects to forms less objectionable with lesser metabolic impacts for humans. The process both changes distillation entrapped contaminant compounds in-situ and effects removal of the compounds and their reaction products. In what follows, water-miscible-organic-solvent and water mixtures can be substituted for alcohols. The alcohol to be treated is placed in a ventilated vessel leaving room for head space. Contaminant free air or a specific organic-contaminant-free gas is injected into or otherwise placed in contact with the alcohol. A vacuum is pulled within the vessel, which draws the gas through the alcohol into the head space creating gas bubbles. Energy within a specified range of frequencies is imparted to the fluid causing cavitation and reaction. Wetting, solvent polarity characteristics and pressure are fixed or varied dynamically during processing, and inert or reactive gases are added. Reacted and unreacted contaminants enter the bubble cavities and are swept from solution.

This is simple and efficient rotary machine that can be implemented as compressor, pump, motor and mainly as internal combustion engine. The engine comprises a housing, a rotor(s) with a radial blade(s), a chamber(s) swept by the blade(s), an intersecting planar valve(s) with slot, and a combustion chamber. Blades and slots have matching shapes that allow the traversal of the blades through the slots with negligible loss of air / gases. After traversing the slot, the blade aspires air into one side of the chamber while compresses air on the other side. Fuel is injected in the compressed stream in its way to the combustion chamber, where it is ignited. In a double-rotor implementation, combustion gases are then introduced in the second rotor chamber, just after its blade has traversed the corresponding slot. One side of this blade is pushed by the expansion while the other expels gases from the previous stroke.

The invention addresses the area utilization and capital efficiency of systems for converting solar energy into electricity. A solid-state solar system includes photovoltaic and thermoelectric or thermionic cells. The system can be implemented in various configurations and by a solar insolation flux collection and concentration method to improve the area utilization and solar-to-electricity conversion efficiency. A thermal expansion matched multilayer board is also used to withstand ultra high concentration of solar insolation flux.

Compositions comprising nanosized objects (i.e., nanoparticles) in which at least one observable marker, such as a radioisotope or fluorophore, is incorporated within the nanosized object. The nanosized objects include, for example, metal or semi-metal oxide (e.g., silica), quantum dot, noble metal, magnetic metal oxide, organic polymer, metal salt, and core-shell nanoparticles, wherein the label is incorporated within the nanoparticle or selectively in a metal oxide shell of a core-shell nanoparticle. Methods of preparing the volume-labeled nanoparticles are also described.

This is simple and efficient rotary machine that can be implemented as compressor, pump, motor and mainly as internal combustion engine. The engine comprises a housing, a rotor(s) with a radial blade(s), a chamber(s) swept by the blade(s), an intersecting planar valve(s) with slot, and a combustion chamber. Blades and slots have matching shapes that allow the traversal of the blades through the slots with negligible loss of air / gases. After traversing the slot, the blade aspires air into one side of the chamber while compresses air on the other side. Fuel is injected in the compressed stream in its way to the combustion chamber, where it is ignited. In a double-rotor implementation, combustion gases are then introduced in the second rotor chamber, just after its blade has traversed the corresponding slot. One side of this blade is pushed by the expansion while the other expels gases from the previous stroke.

The invention relates to a spray drying system and a method for its operation that provides a composition of dry. or essentially solvent free, particles from a solution of an agent. The system comprises a generally vertical tube reactor arranged for counter-current removal of solvent from a process flow fed with aerosol droplets of solution descending from the top said reactor with an ascending gas flow. The reactor includes a perforated process tube for transportation of the process flow from the outlet of an aerosol generating device to a dry particle collecting device. A membrane sleeve essentially surrounds the peripheral area of said process tube and separates the descending process stream from the ascending gas stream. Vaporized solvent is transported from the process stream to the ascending gas stream. A reactor housing is sealingly covering said process tube and membrane sleeve and is provided with means for introducing and / or removing the process fluids.

A method and apparatus for increasing the size of small particles for a condensation particle counter, in which method a particle containing aerosol flow is divided into a sample flow and a sheath flow. The sheath flow is filtered, saturated with vapor and formed to a vortex flow in a saturator which vortex-flow continues in a condenser. The sample flow is introduced to the centre of the vortex flow of the saturated sheath flow in the condenser for causing the vapor in the saturated sheath flow to condense on the particles in the sample flow thus increasing the size of the particles.

The present invention is directed to improved systems and components for coupling separations technology with MALDI-TOF mass spectroscopy. Specifically, this invention provides new apparatus configurations and methods for interfacing liquid-phase separations with MALDI mass spectrometry. The present invention exploits and expands the use of the collimated hole structure (CHS) sample plate as an integral component of the interface.

An integrated camera, ambient light detection, and rain sensor assembly suitable for installation behind a windshield of a driver operated vehicle or an automated vehicle includes an imager-device. The imager-device is formed of an array of pixels configured to define a central-portion and a periphery-portion of the imager-device. Each pixel of the array of pixels includes a plurality of sub-pixels. Each pixel in the central-portion is equipped with a red / visible / visible / visible filter (RVVV filter) arranged such that each pixel in the central-portion includes a red sub-pixel and three visible-light sub-pixels. Each pixel in the periphery-portion is equipped with a red / green / blue / near-infrared filter (RGBN filter) arranged such that each pixel in the periphery-portion includes a red sub-pixel, a green sub-pixel, a blue sub-pixel, and a near-infrared sub-pixel.

A weight measurement device has a housing that includes a base, a platform located above the base and on which a subject is placed or stands, and a chamber defined by the base and the platform. At least one load cell is contained in the chamber and is supported by the base. A load transmission member is located between the platform and the load cell. A bracket is fixed to the base. An elastic deformation part is located around the load transmission member and connected to the bracket and to the load transmission member. The elastic deformation part has an elasticity that is greater than that of the load transmission member, and allows the load transmission member to change in position with respect to the bracket when force is transmitted from the platform via the load transmission member to the load cell.

Apparatus and process for removing and / or converting contaminants in water-miscible organic solvent mixtures by surface interaction effects to forms less objectionable with lesser metabolic impacts for humans. The process both changes distillation entrapped contaminant compounds in-situ and effects removal of the compounds and their reaction products. In what follows, water-miscible-organic-solvent and water mixtures can be substituted for alcohols. The alcohol to be treated is placed in a ventilated vessel leaving room for head space. Contaminant free air or a specific organic-contaminant-free gas is injected into or otherwise placed in contact with the alcohol. A vacuum is pulled within the vessel, which draws the gas through the alcohol into the head space creating gas bubbles. Energy within a specified range of frequencies is imparted to the fluid causing cavitation and reaction. Wetting, solvent polarity characteristics and pressure are fixed or varied dynamically during processing, and inert or reactive gases are added. Reacted and unreacted contaminants enter the bubble cavities and are swept from solution.

A method of monitoring a sequence of documents passing along a transport path is described. The method including: operating a radiation transmitter with a control signal at a first, working, level to cause radiation at a first intensity to impinge on one side of a document as it passes an inspection position in the transport path; receiving at a radiation receiver, radiation from the transmitter that has passed through the document, the radiation receiver generating an output signal with a level related to the intensity of the received radiation; and monitoring the output signal to detect the presence and / or a characteristic of the document. A calibration process is carried out between successive documents, the calibration process including: operating the radiation transmitter with a control signal at a second, calibration, level to cause radiation at a second intensity less than the first intensity to be transmitted towards the receiver, and adjusting the level of the resultant output signal from the receiver to a predetermined value.

The invention relates to the method of manufacturing of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin by condensation of 7-ethyl-10-hydroxycamptothecin with 1-chlorocarbonyl-4-piperidinopiperidine hydrochloride in a polar aprotic solvent in the presence of 4-dimethylaminopyridine.