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Optically similar reference samples and related methods for multivariate calibration models used in optical spectroscopy

Systems and methods for establishing and / or maintaining the prediction capability over time of a multivariate calibration model designed for quantitative optical spectroscopic measurement of attributes or analytes in bodily tissues, bodily fluids or other biological samples, which are particularly useful when the spectral absorbance of the attribute or analyte is small relative to the background. The present invention provides an optically similar reference sample to capture the characteristics of instrument and environmental variation and to reduce the effect of such variation on the measurement capability of the model. The optically similar reference is preferably stable over time and is designed such that its optical properties are sufficiently matched to the sample of interest that instrument and environmental variations are captured in the same manner in both the test sample of interest and the optically similar reference sample. The optically similar reference sample may include one or more physical components which are spectroscopically measured in a manner which closely mimics the spectroscopic measurement of the test sample of interest. Spectral similarity may also be achieved by using alternative components with spectral characteristics similar to the components contained in the test sample of interest.
Owner:RIO GRANDE MEDICAL TECH

Robotic storage buffer system for substrate carrier pods

A storage / buffering system for the stocking and / or buffering of substrate and / or substrate carriers in a process environment includes a 6-axis robot. An end-effector is connected with the robot providing an additional one degree of freedom and a mechanism for grabbing and moving of substrate and / or substrate carriers. The robot is mounted in an inverted orientation to a removable service cart for easy removal of the robot to a service area in the event of breakdown. The robot receives commands from a programmable controller connected to control the robot and configured to direct the arm of the robot through a set of movements. Product is loaded in and out of the system through I / O load ports. Product is stored inside the storage / buffering system on a plurality of storage locations, each with product presence / absence detect sensor. The robot can alternatively be mounted directly to the storage system enclosure structure.
Owner:SEMINET

Instrument for surgically cutting tissue and method of use

An instrument for precisely cutting tissue to controlled dimensions (length, width, depth, and shape) is provided for the removal of tissue specimens from remote sites in the body of a patient, such as from the gastrointestinal tract, urinary tract, or vascular structures, or any tissue surface or soft tissue of the body. The instrument has a housing and a substantially flexible shaft extending from the housing to a distal end. The distal end of the instrument has an open cavity into which tissue is receivable. Suction can be communicated along the shaft to the distal end for distribution across the cavity utilizing a manifold having a grated tissue engaging surface with opening(s) for applying the suction, thereby pulling tissue adjacent to the distal end into the cavity against the tissue engaging surface of the manifold. One or more hollow needles are extendable from the housing through the shaft into the cavity to enable infusion of fluid, such as saline or a hemostatic agent, into the tissue. A blade in the distal end is extendable through the cavity over the manifold and across the opening to cut the tissue held by suction and stabilized by the needles in the cavity. The shape and depth of the tissue removed by the cuts is in accordance with the contour of the tissue engaging surface and the size and shape of the cavity at the distal end. The tissue so removed by the instrument may be for therapeutic intervention and / or represent a tissue specimen for biopsy suitable of diagnostic evaluation. The tissue edges in the patient's body left after cutting with this instrument readily avail themselves to apposition for enhanced healing.
Owner:LSI SOLUTIONS

Clot capture systems and associated methods

A clot capture system for disengaging a clot from a vessel wall and removing the clot from the vessel, comprises a clot capture device for placement on a distal side of a clot. The clot capture device has a retracted delivery configuration and an expanded deployed configuration. The clot removal device has a proximal support frame, and a distal fibre net. The support frame has a retracted delivery configuration and an expanded deployed configuration. The proximal support frame in the expanded configuration defines a proximal inlet mouth for engaging a clot and a net for confining the clot. An elongate member facilitates capture and / or withdrawal of a clot from a vessel.
Owner:NEURAVI

Method and system for adaptive direct volume rendering

An adaptive image volume rendering system first fragments a 3-D dataset into multiple sub-volumes and constructs an octree structure, wherein each sub-volume is associated with one node on the octree. The system then establishes a 2-D image plane and selectively launches a plurality of rays towards the 3-D dataset, each ray adaptively interacting with a subset of the sub-volumes. The ray energy reflected by each sub-volume is estimated using a modified Phong illumination model, constituting a pixel value at the ray origin on the 2-D image plane. Finally, the system interpolates pixel values at a plurality of selected locations and generates a 2-D image of the 3-D dataset.
Owner:FOVIA
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