92 results about "Diagnostic evaluation" patented technology

The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia / reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and / or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease. Moreover, the present invention provides methods for the diagnostic monitoring of patients undergoing clinical evaluation for the treatment of cardiovascular disease, and for monitoring the efficacy of compounds in clinical trials. Additionally, the present invention describes methods for the diagnostic evaluation and prognosis of various cardiovascular diseases, and for the identification of subjects exhibiting a predisposition to such conditions.

The present invention relates to methods for the diagnosis, evaluation, and treatment of mood disorders, particularly bipolar disorder. In particular, patient test samples are analyzed for the presence and amount of members of a panel of biallelic markers comprising one or more specific markers for bipolar treatment and one or more non-specific markers for bipolar treatment. A variety of markers are disclosed for assembling a panel of markers for such diagnosis and evaluation. Algorithms for determining proper treatment are disclosed. A diagnostic kit for a panel of said markers is disclosed. In various aspects, the invention provides methods for the early detection and differentiation of mood disorders or bipolar treatment. Methods for screening therapeutic compounds for mood disorders are disclosed. The invention (1) gives methods providing rapid, sensitive and specific assays that can greatly increase the number of patients that can receive beneficial treatment and therapy, thereby reducing the costs associated with incorrect diagnosis, and (2) provides methods for improved therapies.

The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders. For example, genes which are differentially expressed within and among T helper (TH) cells and TH cell subpopulations, which include, but are not limited to TH0, TH1 and TH2 cell subpopulations are identified. Genes are also identified via the ability of their gene products to interact with gene products involved in the differentiation, maintenance and effector function of such TH cells and TH cell subpopulations. The genes identified can be used diagnostically or as targets for therapeutic intervention. In this regard, the present invention provides methods for the identification and therapeutic use of compounds as treatments of immune disorders, especially TH cell subpopulation-related disorders. Additionally, methods are provided for the diagnostic evaluation and prognosis of TH cell subpopulation-related disorders, for the identification of subjects exhibiting a predisposition to such conditions, for monitoring patients undergoing clinical evaluation for the treatment of such disorders, and for monitoring the efficacy of compounds used in clinical trials.

An instrument for precisely cutting tissue to controlled dimensions (length, width, depth, and shape) is provided for the removal of tissue specimens from remote sites in the body of a patient, such as from the gastrointestinal tract, urinary tract, or vascular structures, or any tissue surface or soft tissue of the body. The instrument has a housing and a substantially flexible shaft extending from the housing to a distal end. The distal end of the instrument has an open cavity into which tissue is receivable. Suction can be communicated along the shaft to the distal end for distribution across the cavity utilizing a manifold having a grated tissue engaging surface with opening(s) for applying the suction, thereby pulling tissue adjacent to the distal end into the cavity against the tissue engaging surface of the manifold. One or more hollow needles are extendable from the housing through the shaft into the cavity to enable infusion of fluid, such as saline or a hemostatic agent, into the tissue. A blade in the distal end is extendable through the cavity over the manifold and across the opening to cut the tissue held by suction and stabilized by the needles in the cavity. The shape and depth of the tissue removed by the cuts is in accordance with the contour of the tissue engaging surface and the size and shape of the cavity at the distal end. The tissue so removed by the instrument may be for therapeutic intervention and / or represent a tissue specimen for biopsy suitable of diagnostic evaluation. The tissue edges in the patient's body left after cutting with this instrument readily avail themselves to apposition for enhanced healing.

The inventive subject matter as a whole is an improved transceiver apparatus and system for diagnostic evaluations of living subject, human or animal; and is particularly effective as a clinical tool for the spectroscopic scanning or magnetic resonance imaging of humans suspected of being afflicted with a particular disease, disorder, or pathology. The improved transceiver apparatus is used as an essential component in a computer controlled system suitable for magnetic resonance imaging (“MRI”), or nuclear magnetic resonance spectroscopy (“MRS”), and / or nuclear magnetic resonance spectroscopic imaging (“MRSI”); and the present improvement of these electromagnetic signaling systems will provide far more accurate and precise visual images and accumulated data for the clinician or surgeon, as well as serve as a basis upon which to make a diagnosis and decide upon a mode of therapeutic treatment for that individual.

The present invention provides a method an apparatus for adaptively refining the sampling within an IP network performance monitoring and diagnosis framework. This ability to adaptively adjust the resolution of the sampling can enable variable accuracy and detail in the related IP network analysis. The sampling resolution can be defined as, for example, the load on the network in terms of the rate of packet transmission, the statistical variance thereof and the complexity of the sampling procedure. Each sampling and analysis procedure determines one or more network parameters referred to as critical indicators. Decisions for subsequent samplings and actions are made based on the determination of these critical indicators. As such various evaluation activity levels are defined by conditions that can be checked for and detected within the context of that activity level. A feedback / feedforward process can be used to enhance the resolution of subsequent samplings, for example movement to a more detailed activity level, if the need is required. In addition, the present invention can support activities such as automated remediation wherein problems in a given IP network path that are identified during the sampling and diagnostic evaluation thereof are subsequently resolved by making changes in the path. The present invention can automate and enhance the monitoring, diagnosis and remediation processes, thereby reducing human involvement until human intervention may be required. In addition, the automatic functionality inherent within the present invention can enable the sampling to be scalable and responsive to changes in IP network conditions as they arise.

The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders. For example, genes which are differentially expressed within and among T helper (TH) cells and TH cell subpopulations, which include, but are not limited to TH0, TH1 and TH2 cell subpopulations are identified. Genes are also identified via the ability of their gene products to interact with gene products involved in the differentiation, maintenance and effector function of such TH cells and TH cell subpopulations. The genes identified can be used diagnostically or as targets for therapeutic intervention. In this regard, the present invention provides methods for the identification and therapeutic use of compounds as treatments of immune disorders, especially TH cell subpopulation-related disorders. Additionally, methods are provided for the diagnostic evaluation and prognosis of TH cell subpopulation-related disorders, for the identification of subjects exhibiting a predisposition to such conditions, for monitoring patients undergoing clinical evaluation for the treatment of such disorders, and for monitoring the efficacy of compounds used in clinical trials.

The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders. For example, genes which are differentially expressed within and among T helper (TH) cells and TH cell subpopulations, which include, but are not limited to TH0, TH1 and TH2 cell subpopulations are identified. Genes are also identified via the ability of their gene products to interact with gene products involved in the differentiation, maintenance and effector function of such TH cells and TH cell subpopulations. The genes identified can be used diagnostically or as targets for therapeutic intervention. In this regard, the present invention provides methods for the identification and therapeutic use of compounds as treatments of immune disorders, especially TH cell subpopulation-related disorders. Additionally, methods are provided for the diagnostic evaluation and prognosis of TH cell subpopulation-related disorders, for the identification of subjects exhibiting a predisposition to such conditions, for monitoring patients undergoing clinical evaluation for the treatment of such disorders, and for monitoring the efficacy of compounds used in clinical trials.

A device for obtaining dental measurements to determine a patient's occlusal vertical dimension and centric relation position where these dental measurements are used to make dentures for the patient; and for obtaining dental measurements for balancing a patient's dentures and methods for making these dental measurements with the device. The device comprises a contact plate, a post, a ball nut, and a striking plate, where the combination of the contact plate being attached to the central lingual surface of the lower base plate, the ball nut being swivelably attached in a tapered opening in the contact plate, the post being adjustably secured to the ball nut; and the striking plate being attached to the central lingual surface of the upper base plate, are received in the mouth of the patient such that they cooperate with each other to obtain dental measurements including, but not limited to, occlusal vertical dimension, centric relation position, or measurements for balancing a patient's dentures.

Methods and apparatus are disclosed for non-invasive bone evaluation based on a broadband ultrasonic transducer emitting a train of ultrasonic wave packets of multiple carrier frequencies ranging from about 50 kHz to about 2 MHz. Receiving broadband ultrasonic transducer accepts broadband ultrasonic signal propagated through the bone. Computer processing means provide for data analysis and feature extraction allowing diagnostic evaluation of the bone, including comparing the features of the received signal to a database of known bone conditions.

A rapid method of microwave-assisted formalin fixation of tissue that is described as: (a) a two-step process; (b) applicable to large (>5 mm thick) and small (<5 mm thick) tissues; (c) exposure of fresh tissue (i.e. a surgical biopsy) in a formalin solution to continuous microwave irradiation; (d) formalin circulated and cooled to maintain a constant temperature; (e) microwave-assisted formalin fixation performed at a temperature between 4° C. and 40° C.; (f) a temperature probe used to monitor fixative temperature in the cavity (g) after processing via microwave-assisted formalin fixation, the tissue can be processed by microwave methods or in an automatic tissue processor into paraffin for diagnostic evaluation. The two step process consists of a first low power microwave run followed by a second high power microwave run. An alternate embodiment of the present invention employing a one step MW oven process using other selected fixatives (glyoxal, glyoxal based and other aldehyde fixatives, alcohol, acetone, etc.)

A portable apparatus which allows a user to perform self-diagnostic evaluation of nerve sensory latency between a pair of epidermal locations proximal to nerve conduction paths. The device provides a simple and low-cost self-diagnostic apparatus which may be used for the detection and ongoing monitoring of sensory latency, such as sensory latency which is the result of carpal tunnel syndrome. The apparatus is powered by a single battery which provides power to all circuitry of the apparatus. Upon power activation, the device generates a series of high voltage stimulus pulses at an electrode in epidermal contact with the user / operator. The nerve response voltage is detected by a second electrode located along nerve pathway and the time delay between stimulus and response is displayed and periodically updated as each new response is detected.

In various embodiments, the present disclosure describes methods and systems for detecting microbes in a sample. The methods are generally applicable to quantifying the number of target bacteria in a sample counted from a detection region of a flow cytometer histogram. The detection methods can be employed in the presence of other microorganisms and other non-target microbe components to selectively quantify the amount of a target microbe. The methods are advantageous over those presently existing for testing of foodstuffs and diagnostic evaluation in their speed, accuracy and ease of use. Various swab collection devices and kits useful for practicing the present disclosure are also described herein.

The present invention relates to methods and compositions for the treatment of body weight disorders, including, but not limited to, obesity. Specifically, the present invention identifies and describes genes which are differentially expressed in body weight disorder states, relative to their expression in normal, or non-body weight disorder states, and / or in response to manipulations relevant to appetite and / or weight regulation. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in body weight disorders and / or appetite and / or body weight regulation. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of body weight disorders. Additionally, the present invention describes methods for the diagnostic evaluation and prognosis of various body weight disorders, and for the identification of subjects exhibiting a predisposition to such conditions.

An adaptive optics microperimetry, infrared beacon emits infrared light to the pupil of the subject, the Hartmann wavefront sensor measures the wavefront aberration of the human eye carried by the reflected light of the fundus, and the computer calculates the control voltage based on the measured aberration , driving the wavefront corrector to correct the aberration of the human eye. After the aberration correction is completed, the fixed optotype for fixing the line of sight of the examinee and the optical stimulation optotype for providing optical stimulation to the fundus of the examinee are displayed at a plurality of predetermined positions on the stimulus optotype display device. The pupil camera uses the infrared light emitted by the infrared light source in front of the eye to capture the subject's human eye pupil image and calculate the pupil diameter. The computer controls the change of the optical stimulus visual target according to the change of the subject's pupil diameter, and measures the subject's field of vision. The invention has high reliability, reduces the stimulus redundancy caused by the aberration of the human eye in the visual field test, is beneficial to discover early micro-perspective defects, and provides a powerful tool for the evaluation of the micro-perspective defects of the human eye and the diagnosis of related diseases.

A system and method for remote servicing of an in-field product at a customer site. The remote servicing system includes a portable service interface, typically a laptop computer, which is utilized to connect a remote servicing on-line center with the in-field produce, such as a medical image scanner. The portable service interface includes software not resident with the in-field product to permit such servicing functions as diagnostic evaluations of the in-field product, as well as downloading configuration files, original source files, protocols and other software from the on-line center through the portable service interface at the customer site. The field engineer or other operator is able to provide service functions to in-field products that are not networked or are not readily networked with the on-line center and that do not have the on-line center connecting software resident on the portable service interface.

The present application discloses solid compositions for the oral administration of dyes, and diagnostic use thereof. Preferably, such diagnostic use is aimed at the diagnostic evaluation of the gastrointestinal tract.

The invention provides a method for monitoring the operation conditions of power primary equipment. The method comprises the steps of signal acquisition, analysis and transfer, diagnosis and estimation and the like. The invention also provides a monitoring device matched with the method. An operating power grid is monitored in real time by use of a non-contact vibration spectrum monitoring and infrared detection mode, the characteristic curve data is generated for the vibration and temperature parameters of the primary equipment, and a complete expert system is established by use of the fuzzy mathematics theory and artificial neural network. The abnormality prediction diagnosis detecting the abnormal sign at the preliminary service stage of the equipment and the aging diagnosis of the equipment performance changing year by year are realized. Whether the equipment fails or whether overhauling is needed is determined through the self-learning self-diagnosis fuzzy theory. Whether the equipment fails is analyzed and the fault type is diagnosed through the vibration spectrum monitoring and infrared detection technology in combination with an intelligent diagnosis system, thereby effectively improving the operation efficiency of the primary equipment and pushing forward the further development of intelligent power grid.

Pluggable transceiver modules with additional functions and circuitry contained within the module. In a first embodiment, additional circuitry is added to determine bit error rates at the point of the module itself. This allows a much better diagnostic evaluation of location of problem. In an alternate embodiment, various logic is placed in the module. In a first alternate embodiment encryption / decryption units are placed in the converter module so that encryption and decryption operations on the serial bitstream do not need to be performed in a switch. Existing switches can be used but the interconnecting links can still be encrypted. A second alternate embodiment includes compression / decompression units placed in the module to allow effective higher throughput on the selected links.

The invention discloses a diagnostic evaluation method considering disturbing influence for a satellite sensor fault. The diagnostic evaluation method comprises the following steps: aiming at a satellite sensor system influenced by interference factors such as noise and modeling nondeterminacy, respectively taking vector distance similarity and vector direction similarity as evaluation indexes to realize the detection and isolability quantitative evaluation of the sensor fault through deploying conditions of mathematical description, system model and a satellite sensor of a fault mode. The diagnostic evaluation method provided by the invention can bring the fault diagnosis of the satellite sensor forward to a design stage on the condition of not depending on any fault diagnosis algorithm, and guide the optimal configuration of the satellite sensor.

A system for diagnostically evaluating the health of tissue within the fundus of an eye includes a fs laser source, an adaptive optical assembly, an imaging unit, and a computer. The adaptive optical assembly focuses a laser beam to a focal point in the fundus of the eye, and scans the fundus tissue according to a predetermined scanning pattern. Illumination of anisotropic tissue within the fundus, such as the photoreceptors and the Henle-fiber layer, induces a Second Harmonic Generation (SHG) response. Red photons, with a wavelength (λ) of about 880 nm, are converted to blue photons, with a wavelength of λ / 2, through the process of photon conversion. An imaging unit senses the blue photon return light, and uses the return light to generate an image of the fundus. The computer processes the image, and compares it to a template of healthy tissue to evaluate the health of the imaged tissue.

The present application discloses solid compositions for the oral administration of dyes, and diagnostic use thereof. Preferably, such diagnostic use is aimed at the diagnostic evaluation of the gastrointestinal tract.

The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders. For example, genes which are differentially expressed within and among T helper (TH) cells and TH cell subpopulations, which include, but are not limited to TH0, TH1 and TH2 cell subpopulations are identified. Genes are also identified via the ability of their gene products to interact with gene products involved in the differentiation, maintenance and effector function of such TH cells and TH cell subpopulations. The genes identified can be used diagnostically or as targets for therapeutic intervention. In this regard, the present invention provides methods for the identification and therapeutic use of compounds as treatments of immune disorders, especially TH cell subpopulation-related disorders. Additionally, methods are provided for the diagnostic evaluation and prognosis of TH cell subpopulation-related disorders, for the identification of subjects exhibiting a predisposition to such conditions, for monitoring patients undergoing clinical evaluation for the treatment of such disorders, and for monitoring the efficacy of compounds used in clinical trials.

The invention is an evaporation waveguide monitoring, diagnosing and evaluating method and device, characterized in that the device is composed of temperature-humidity sensor, electromagnetic wind direction-speed sensor, GPS receiver, air pressure sensor, compass converter, data collector, LCD, communication interface, Flash memory, AC power supply, and multi-channel serial communication and calculation display unit and the method includes the steps: real-time measuring hydro-meteorological parameters and diagnosing the evaporation waveguide height and the vertical distribution of atmosphere correction refraction indexes; calculating the cut-off frequency and cut-off wavelength of a radar, and integrated with the input radar parameters and target parameters, calculating the transmission losses and maximum detection distance of the radar electromagnetic wave to draw a distribution diagram of detection probability of the radar; evaluating if the distribution diagram has over-the-horizon ability. Its advantages: simplifying the measuring method; continuously and real-timely measuring the hydro-meteorological parameters; and the accuracies of evaporation waveguide engine value diagnosis and radar detection evaluation reach above 95%.

The invention relates to an urban traffic signal control running diagnostic system, and refers to the technical field of traffic signal control and traffic simulation. The urban traffic signal control running diagnostic system aims to provide comprehensive, subjective and quantitative diagnostic evaluation for the existing signal control system. The diagnostic system is mainly composed of a lower computer and an upper computer, wherein the lower computer is a diagnostic machine; the diagnostic system is connected with a road side signal machine, the other traffic flow detector or a computer, so as to read the traffic flow detection data and signal timing dial data in real time under the reality or hardware-in-loop simulation environment, and also perform the local storage, upload server, and other operation; the upper computer mainly includes a server end and a client end, wherein the server end can store the data sent by the diagnostic machine, and the client end can load corresponding data from the server end as well as a local memory card, so as to calculate the change trend of the diagnostic index within a certain time section and provide a report for improvement suggestions; thus the urban traffic signal control running diagnostic system can provide an intuitional and visible diagnostic effect for managers.

The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia / reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and / or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease. Moreover, the present invention provides methods for the diagnostic monitoring of patients undergoing clinical evaluation for the treatment of cardiovascular disease, and for monitoring the efficacy of compounds in clinical trials. Additionally, the present invention describes methods for the diagnostic evaluation and prognosis of various cardiovascular diseases, and for the identification of subjects exhibiting a predisposition to such conditions.

The present invention relates to methods and compositions for the treatment of body weight disorders, including, but not limited to, obesity. Specifically, the present invention identifies and describes genes which are differentially expressed in body weight disorder states, relative to their expression in normal, or non-body weight disorder states, and / or in response to manipulations relevant to appetite and / or weight regulation. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in body weight disorders and / or appetite and / or body weight regulation. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of body weight disorders. Additionally, the present invention describes methods for the diagnostic evaluation and prognosis of various body weight disorders, and for the identification of subjects exhibiting a predisposition to such conditions.

An instrument for precisely cutting tissue to controlled dimensions (length, width, depth, and shape) is provided for the removal of tissue specimens from remote sites in the body of a patient, such as from the gastrointestinal tract, urinary tract, or vascular structures, or any tissue surface or soft tissue of the body. The instrument has a housing and a substantially flexible shaft extending from the housing to a distal end. The distal end of the instrument has an open cavity into which tissue is receivable. Suction can be communicated along the shaft to the distal end for distribution across the cavity utilizing a manifold having a grated tissue engaging surface with opening(s) for applying the suction, thereby pulling tissue adjacent to the distal end into the cavity against the tissue engaging surface of the manifold. One or more hollow needles are extendable from the housing through the shaft into the cavity to enable infusion of fluid, such as saline or a hemostatic agent, into the tissue. A blade in the distal end is extendable through the cavity over the manifold and across the opening to cut the tissue held by suction and stabilized by the needles in the cavity. The shape and depth of the tissue removed by the cuts is in accordance with the contour of the tissue engaging surface and the size and shape of the cavity at the distal end. The tissue so removed by the instrument may be for therapeutic intervention and / or represent a tissue specimen for biopsy suitable of diagnostic evaluation. The tissue edges in the patient's body left after cutting with this instrument readily avail themselves to apposition for enhanced healing.