174results about How to "Low effective concentration" patented technology

The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders. For example, genes which are differentially expressed within and among T helper (TH) cells and TH cell subpopulations, which include, but are not limited to TH0, TH1 and TH2 cell subpopulations are identified. Genes are also identified via the ability of their gene products to interact with gene products involved in the differentiation, maintenance and effector function of such TH cells and TH cell subpopulations. The genes identified can be used diagnostically or as targets for therapeutic intervention. In this regard, the present invention provides methods for the identification and therapeutic use of compounds as treatments of immune disorders, especially TH cell subpopulation-related disorders. Additionally, methods are provided for the diagnostic evaluation and prognosis of TH cell subpopulation-related disorders, for the identification of subjects exhibiting a predisposition to such conditions, for monitoring patients undergoing clinical evaluation for the treatment of such disorders, and for monitoring the efficacy of compounds used in clinical trials.

Antimycotic compositions comprising a rhamnolipid component and related methods of use.

The present invention relates to systems, methods and kits for low-level detection of nucleic acids, detecting at least two different viral sequences in a single reaction vessel, and increasing the dynamic range of detection of a viral target nucleic acid in a sample. The present invention also relates to T-structure invasive cleavage assays, as well as T-structure related target dependent non-target amplification methods and compositions. The present invention further relates to methods, compositions, devices and systems for consistent nucleic acid dispensing onto surfaces.

The present invention relates to a kind of inorganic mesoporous antiseptic material carrying nano ZnO or Ag particle and its preparation process. The preparation process includes dissolving mesoporous material and inorganic metal salt in volatile solvent via stirring; setting in the air to volatilize solvent; and direct roasting or high temperature roasting under nitrogen protection to decompose and crystallize metal salt to obtain the required mesoporous antiseptic material powder. The mesoporous antiseptic material has ordered tunnel structure, great specific surface area and pore volume, small nano ZnO or Ag particle with narrow size distribution, high sterilizing effect and other features.

Disclosed are specific binding agents, such as fully human antibodies, that bind to angiopoietin 1 and / or angiopoietin-2. Also disclosed are heavy chain fragments, light chain fragments, and CDRs of the antibodies, as well as methods of making and using the antibodies.

A well treatment fluid and method uses an organic peroxide. An activator embodiment can lower an effective concentration of the peroxide to break the fluid. A weight ratio of activator:organic peroxide can be at least about 1:20 in one well treatment fluid embodiment. A peroxyester breaker embodiment can be used in a well treatment fluid and method. A breaker delay agent embodiment can control the polymer break window in a well treatment fluid and method using an organic peroxide. A breaker package embodiment used in a well treatment fluid and method can include an organic peroxide and an amine breaker delay agent having the formula RR1NR2 wherein R, R1 and R2 are independently selected from hydrogen, alkyl, hydroxyalkyl, and combinations thereof.

The invention discloses a disinfectant special for an inspection instrument in the inspection department and a preparation method of the disinfectant. The disinfectant is prepared mainly by the following steps of crushing pawpaw, fructus aurantii immaturus, schisandra chinensis, pericarpium citri reticulatae, smoked plum, chinese holly, pomegranate bark, exocarpium, eucalyptus robusta smith, dogwood, folium eriobotryae, selfheal, myrobalan, corn silk, ligusticum wallichii, glossy privet fruits and pericarpium citri reticulatae viride, soaking, heating and reflowing, wherein an auxiliary material is a filter liquor which is prepared by heating poinsettia, radix angelicae, hemp fimble stem-fibre, subprostrate sophora and fungus-infected rice spike with ethanol and extracting, wherein an additive of polyhexamethylene guanidine is added. The disinfectant is faintly acid, and the environmental acidity can be changed, so that most bacteria which grow best within a PH range of 6.0 to 8.0, have the strongest enzymatic activity and strongly grow and breed cannot exist, and the bacterial growth is effectively inhibited; the disinfectant is easily dissolved in water, and the disinfectant is easily washed out without residues after being used; the disinfectant has the advantages of being small in corrosivity, good in stability and simple in preparation process, can be widely applied to disinfecting the inspection instrument in the inspection department and is suitable for mass production.

The invention belongs to the field of Chinese traditional medicines and relates to a new use of 8-0-4' lignan in preparing an anti-complement medicine. The compound 8-0-4' lignan is extracted from a Chinese medicinal herb eucommia bark, and in vitro experiments prove that the compound 8-0-4' lignan can inhibit cell hemolysis caused by the activations of classical and alternative pathways of a complement system, and has obvious inhibitory action on the activation of the classical and alternative pathways of the complement system; and the results of pharmacological tests prove that the compound 8-0-4' lignan has obvious anti-complement effect and low effective concentration. The compound 8-0-4' lignan of the invention can be further taken as an active ingredient for preparing a novel anti-complement medicine.

The invention relates to a skin antibacterial agent and a preparation method thereof. The skin antibacterial agent comprises components such as ginkgo leaf juice, white chrysanthemum juice, eggplant root juice, kudzuvine root juice, mugwort leaf juice, portulaca oleracea juice, fistular onion stalk juice, distilled water and the like. The preparation method for the skin antibacterial agent comprises the following steps of: mixing the ginkgo leaf juice, the white chrysanthemum juice, the eggplant root juice, the kudzuvine root juice, the mugwort leaf juice, the portulaca oleracea juice, the fistular onion stalk juice and the distilled water, stirring uniformly, heating for 6 to 8 hours at the temperature of 65 to 70 DEG C, adding an auxiliary raw material into the mixed solution to ensure that the mixed solution is subjected to catalytic reaction, and thus obtaining the skin antibacterial agent, wherein a biological monitor in a catalytic reaction device is used for automatically tracking and testing in the process of the catalytic reaction. The invention has the advantages that: the skin antibacterial agent has wide sterilization spectrum, is low in effective concentration, quick in response and stable in performance, greatly improves healing degree of wounds and relieves pain of patients in the process of changing and applying medicines; and in addition, the preparation method for the skin antibacterial agent is simple and convenient to operate.

The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders, and also for the treatment of mast cell-related processes and disorders, ischemic disorders and injuries, including ischemic renal disorders and injuries. For example, genes which are differentially expressed within and among T helper (TH) cells and TH cell subpopulations, which include, but are not limited to TH0, TH1 and TH2 cell subpopulations are identified. Genes are also identified via the ability of their gene products to interact with gene products involved in the differentiation, maintenance and effector function of such TH cells and TH cell subpopulations. The genes identified can be used diagnostically or as targets for therapeutic intervention. In this regard, the present invention provides methods for the identification and therapeutic use of compounds as treatments of immune disorders, especially TH cell subpopulation-related disorders. Additionally, methods are provided for the diagnostic evaluation and prognosis of TH cell subpopulation-related disorders, for the identification of subjects exhibiting a predisposition to such conditions, for monitoring patients undergoing clinical evaluation for the treatment of such disorders, and for monitoring the efficacy of compounds used in clinical trials. Methods are also provided for the treatment of symptoms associated with mast cell-related processes or disorders and ischemic disorders and injuries using the genes, gene products and antibodies of the invention.

The invention discloses a rice heavy metal absorption blocking agent and a use method thereof. The blocking agent includes one or more effective components of alpha-ketoglutarate, glycerol and oxaloacetic acid. The aim of preventing heavy metal from being absorbed and transferred to rice can be achieved through leaf surface spraying in the rice tillering period, heading period and / or postulation period. The contents of lead, cadmium and other heavy metal polluting rice in rice fields can be remarkably reduced, and rice produced in rice fields slightly or intermediately polluted by heavy metal meets the food safety standard. The effective spraying concentration of the blocking agent is low, the blocking agent can be sprayed after being mixed with pesticides for preventing and treating rice diseases and pests, and cost is low.