124results about How to "Effectively lead to differentiation" patented technology

An apparatus and a method for processing checks and other negotiable instruments efficiently captures MICR data required for electronic payment and an image of the check or negotiable instrument enabling the amount, payee, and other information printed or written on the check face to be clearly read. The image reading unit 11 of the check processing apparatus 110 scans and outputs a gray scale image of the check. A threshold value determination unit 12 sets a threshold value for digitizing the image data based on the density level frequency distribution of primary gray scale image data obtained by the image data reading unit scanning a first scanning area T. This first scanning area contains part of a printed text area 127 where text is printed on the negotiable instrument and part of the background 49 of the negotiable instrument. A digital image processor 20 digitizes and converts secondary gray scale image data to digital image data based on the threshold value set by the threshold value determination unit 12. The secondary gray scale image data is generated by the image reading unit 11 scanning a predefined second scanning area of the negotiable instrument.

The present invention provides compositions and methods for the production of differentiated mammalian cells. More particularly, the present invention provides cellular differentiation methods employing culturing the cells on a feeder layer or under feeder-free conditions in cell culture and further contacting the cells with an inhibitor of the PI3-kinase pathway and a member of the TGFb family for the generation of differentiated mammalian cells from pluripotent mammalian stem cells. Preferably, the differentiated cell is selected from the group consisting of a mesendodermal cell, a mesodermal cell, and an endodermal cell.

Provided herein are methods for the in vitro maintenance, expansion, culture, and / or differentiation of pluripotent cells, such as human embryonic stem cells (hESC) or induced pluripotent cells (iPSC), into hematopoietic precursor cells or endothelial cells. The pluripotent cells may be maintained and differentiated under defined conditions; thus, the use of mouse feeder cells or serum is not required in certain embodiments for the differentiation of the pluripotent cells into hematopoietic precursor cells or endothelial cells. The resulting hematopoietic precursor cells may be further differentiated into various myeloid or lymphoid lineages.

The present invention provides a clinically applicable method of inducing differentiation of embryonic stem cells, particularly a method of inducing differentiation of embryonic stem cells into forebrain neurons. More specifically, the present invention provides a method of inducing differentiation of embryonic stem cells, comprising culturing the embryonic stem cells as a floating aggregate in a serum-free medium, particularly a method of inducing differentiation of the embryonic stem cells into nervous system cells such as forebrain neurons and cerebellar neurons and sensory organ cells; a floating aggregate of embryonic stem cells obtained by culturing the embryonic stem cells as a floating aggregate in a serum-free medium; and cells derived from a floating aggregate of embryonic stem cells, particularly nervous system cells such as forebrain neurons and cerebellar neuron, sensory organ cells such as retinal precursor cells, and the like.

The invention discloses a method that identifies whether a channel is LOS or NLOS in a mobile communication system. After coherent accumulation and non-coherent accumulation have been made by the system, first the method takes power difference between the direct path and the non-direct path in a same power delay profile to identify a channel; and then the result is further determined by {overscore (τ)} / σ difference of a LOS channel and a NLOS channel (where {overscore (τ )}and σ is the mean delay and the RMS delay spread of a multipath power profile, respectively). A channel is determined as a LOS channel, if the power ratio of the Maximum Path to the Local Maximum Path is greater than a threshold K, and simultaneously the arrival time difference between the First Path and said Maximum Path is less than a time interval T; otherwise it is a NLOS channel. The method is easier to implement and compatible with the present mobile communication system.

A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells. The method comprises ex-vivo providing the stem cells with conditions for cell proliferation and with at least one copper chelator in an amount and for a time period for permitting the stem cells to proliferate and, at the same time, for reducing a capacity of the stem cells to differentiate

A computer-implemented method, apparatus, and article of manufacture for security validation of a user input in a computer network application. The method includes: providing a subset of security rules of a server-side protection means to a pre-validation component deployed at a client side, so as to enable security validation of a user input on the client side by the pre-validation component; validating the user input based on at least one of the security rules; determining, in response to detecting a user input violation and that a violated security rule has not been provided to the pre-validation component, the user as a first class of users; determining, in response to detecting the user input violation and that the violated security rule has been provided to the pre-validation component, the user as a second class of users; and performing different security protection actions to the first and second class of users.

A cell population cultured ex-vivo in a culture medium under conditions permitting cells of the cell population to proliferate and, at the same time, reducing a capacity of the cells in utilizing cooper, the cells are hence expanded yet not further differentiated as compared to ex-vivo seeded cells from which the cell population developed.

Bit lines in SRAM array are multi-divided, so that a segment read circuit is connected to local bit line, which circuit serves as amplifying transistor of an amplifier with load device of a block read circuit. Thus the amplified voltage is latched by a current mirror which serves as another amplifier in the block read circuit, such that one data is latched early but another data is latched later because the amplifier changes its output quickly or slowly depending on the local bit line voltage. In this manner, time-domain sensing scheme is introduced to differentiate fast data and slow data, where the locking signal is generated by a read enable signal or a reference signal based on fast data. Particularly, memory cell includes bottom gate transistor as a pull-up device to reduce area. Additionally, alternatives are described, such as stacked memory cell structure and CAM application.

For realizing high speed flash memory, bit line is multi-divided for reducing parasitic capacitance, so that local bit line is quickly discharged when reading a memory cell and multi-stage sense amps are used, wherein the multi-stage sense amps are composed of a first dynamic circuit serving as a local sense amp connecting to the local bit line through a read transistor, a second dynamic circuit serving as a segment sense amp for reading the local sense amp, and a tri-state inverter serving as an amplify circuit of a global sense amp for reading the segment sense amp. When reading data, a cell current difference is converted to a time difference for differentiating low threshold data and high threshold data by the multi-stage sense amps. And a buffered data path is connected to the global sense amp for achieving fast data transfer. Additionally, alternative circuits and memory cell structures are described.

Provided is a method for inducing mesoderm, comprising a step of bringing pluripotent stem cells into contact with bone morphogenetic protein 4 (BMP4) or CHIR for at least 3 days.