The invention discloses TAT-LBD-PEP
fusion protein and application of the TAT-LBD-PEP
fusion protein in treatment of
central nervous system lesion. The TAT-LBD-PEP
fusion protein is combined with
myelin inhibiting factors MAG, Nogo-66 and OMgp, accordingly the
axon regenerative capacity is promoted through
antagonism PirB effect, and the TAT-LBD-PEP fusion
protein has the advantages of being high transduction efficiency and easily transmitting a blood-spinal barrier and a
blood brain barrier, can transduce targeting to a hurt region and has the enrichment effect on an
ischemic region. The problems that additional harm of nervous tissues is caused by the
protein injection in a micro-injection mode or other injection
modes and
macromolecule cannot transmit the blood-spinal barrier and the
blood brain barrier are solved, and the shortcoming that corresponding biological concentration cannot be met is overcome, and the targeting is transduced to the
ischemic region through a
ligand binding domain (LBD). The TAT-LBD-PEP fusion
protein can be prepared in large-scale mode, is low in cost and high in activity, and is used for treatment of various brain and
spinal cord injury including cerebral
ischemia hypoxia, cerebral hemorrhage,
cerebral trauma,
spinal cord injury and the like and promoting regeneration of nervous tissues and neural
functional recovery.