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Application of autophagy inducer serving as microtubule stabilizing drug to promotion of nerve regeneration

An inducer and stable technology, which can be used in the field of autophagy inducer as a microtubule stabilizing drug to promote nerve regeneration, which can solve the problems of lack of conclusion in the central nervous system.

Active Publication Date: 2018-03-09
CENT FOR EXCELLENCE IN BRAIN SCI & INTELLIGENCE TECH CHINESE ACAD OF SCI
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  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, whether the regulation of autophagy level can promote the axon regeneration of adult mammalian central nervous system is still inconclusive.

Method used

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  • Application of autophagy inducer serving as microtubule stabilizing drug to promotion of nerve regeneration
  • Application of autophagy inducer serving as microtubule stabilizing drug to promotion of nerve regeneration
  • Application of autophagy inducer serving as microtubule stabilizing drug to promotion of nerve regeneration

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Embodiment Construction

[0024] Inducing autophagy to study the role of autophagy in axon regeneration after axon injury is a straightforward approach, but most compounds that induce autophagy have uncontrollable side effects. In the present invention, we mainly use a polypeptide Tat-beclin1 that can specifically enhance autophagy in vivo and in vitro to induce autophagy. We found in rat cortical neurons cultured in vitro that increased autophagy can stabilize microtubules by degrading a neuron-specific microtubule destabilizing protein (SCG10) and promote the growth of neuronal neurites. In addition, in a mouse model of spinal cord injury, local administration of Tat-beclin1 treatment can significantly reduce the retraction of axons after spinal cord injury, promote axon regeneration and recovery of motor function in mice. The present invention discovers that autophagy can stabilize the key function of neuron microtubules, and proposes an autophagy inducer represented by Tat-beclin1 as a potential th...

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Abstract

The invention provides application of an autophagy inducer serving as a microtubule stabilizing drug to the promotion of nerve regeneration. Specifically, the invention provides a method for promotingthe enation of in vitro culture central neuron and weakening the inhibiting effect on enation by myelin, or stabilizing microtubules central nervous damaged nerve cells, or reducing retracement or formation of retracement vesicles after a central nerve axon is damaged, or promoting axon regeneration after central nervous is damaged, and the method comprises the step of ensuring that an ex vivo nerve cell is in contact with the autophagy inducer, so as to induce autophagy. The invention further provides application of the autophagy inducer to drug preparation. By adopting the method, axon retracement can be obviously reduced after medulla spinalis is damaged, and axon regeneration and the recovery of a movement function can be promoted.

Description

technical field [0001] The invention relates to the use of an autophagy inducer as a microtubule stabilizing drug to promote nerve regeneration. Background technique [0002] The central nervous system is composed of the brain and spinal cord and is the most important part of the human nervous system. The spinal cord is the pathway of connections between the peripheral nerves and the brain. Spinal cord injury refers to damage to the spinal cord due to trauma (e.g. fall, car accident), disease or degeneration (e.g. cancer, inflammation), etc. According to World Health Organization estimates, the annual global incidence rate is 40 to 80 cases per million people, and it shows a trend of increasing year by year. The axon trunk in the spinal cord is difficult to regenerate after being damaged, which leads to serious dysfunction of the limbs below the damaged segment, a series of complications and high mortality, which brings serious physical and mental harm to the patient himse...

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Application Information

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IPC IPC(8): C12N5/0793C12Q1/02A61K38/16A61K45/06A61P25/28
CPCA61K38/16A61K45/06G01N33/502G01N33/5058C12N5/0619C12N2501/065C12N2501/998C12N2501/999C12N2501/727C12N2501/734A61K2300/00
Inventor 罗振革何苗
Owner CENT FOR EXCELLENCE IN BRAIN SCI & INTELLIGENCE TECH CHINESE ACAD OF SCI
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