163results about How to "Promote functional recovery" patented technology

Provided is an artificial heart control device for controlling a blood pump which assists flow of blood in a heart, the artificial heart control device including: a timing detection part which is configured to detect reference timing within a cardiac cycle of the heart; and a blood pump control part which is configured to control a rotational speed of the blood pump, wherein the blood pump control part controls, with reference to the reference timing detected by the timing detection part, the rotational speed of the blood pump such that the rotational speed becomes a rotational speed corresponding to a predetermined control pattern. According to the present invention, it is possible to provide an artificial heart control device, an artificial heart system and an artificial heart control method which can provide a load control optimum for the recovery of functions of a patient's own heart.

The disclosure provides an apparatus and method for assessing brain plasticity by measuring electrical brain biomarkers, for example, with a near real-time analysis of electrical brain biomarkers, where an increase or decrease in at least one biomarker is indicative of a state of brain plasticity in response to a stimulus or treatment. Brain plasticity can be measured with or without an added stimuli, for example, to determine the best time for learning. Also provided is a method for treating a neurological disease or trauma by applying an electrical or drug stimulus to a patient, where the stimulus is increased or decreased depending on the changes of electrical brain biomarker of the patient. This treatment can occur in near real-time, so a course of treatment can be tailored immediately to a patient's needs.

The present invention relates to the field of diagnosis and treatment of neurodegenerative diseases, ischemic events, and central nervous system injury, and provides compositions and methods for alleviation or reduction of the symptoms and signs associated with damaged neuronal tissues whether resulting from tissue trauma, or from chronic or acute degenerative changes. The present invention in particular relates to the discovery that the expression of Annexin II is involved in apoptosis induced by oxidative stress, and that anti-sense Annexin II RNA and Annexin II siRNA protected the cells from this apoptosis. Thus Annexin II inhibitors prevent the damage caused by said ischemic event.

The invention relates to an active intention control-based portable ankle joint rehabilitation robot comprising a leg protection fixing mechanism, a walking-assisting mechanism connected to the leg protection fixing mechanism, a foot plate mechanism arranged on the leg protection fixing mechanism to be connected with the walking-assisting mechanism, and a gait correction mechanism connected to thefoot plate mechanism. A pressure sensor and a microprocessor are integrated on the foot plate mechanism. With a plantar pressure sensing system, a plantar pressure signal of a testee can be processedduring the test and active motion intention of the testee can be captured; the active motion intention is converted into a control instruction and the walking-assisting mechanism can be controlled and ankle dorsal flexure and plantar flexion rehabilitation and normal gait walk can be assisted for the testee; and the gait correction mechanism can be controlled and ankle inward turn and outward turn rehabilitation training can be completed. Reliable foundation is laid for the rehabilitation evaluation system and the training system; and the active intention control-based portable ankle joint rehabilitation robot has high overall control precision and great real-time control capability.

This invention relates to a shear and temperature stable antibody formulations that are more stable than compared to a standard formulation (such as 30 mM citrate, 100 mM NaCl, pH 6.5). The present invention's shear and temperature stable antibody formulations show reduced precipitation when subjected to stress conditions but the standard formulation had aggregated. This result was unpredictable because thermodynamically the two formulations are similar as seen by their DSC (differential scanning calorimeter) profiles.

The present invention discloses a system for the administration of a plasma modified field (PMF) to a subject comprising: (a) a non thermal plasma (NTP) emitting source for emitting a plasma beam; (b) a plasma modified field coupling mechanism (PMFCM) comprising a plasma beam dish having at least one opening for the passage of said plasma beam; said plasma beam dish having a first surface and a second opposite surface; and (c) a controller for controlling said PMFCM. In a main aspect of the invention, said first surface of said plasma beam dish is mounted with: (i) at least one coupling element selected from the group consisting of: (1) at least one ferroelectric element for providing said field; (2) at least one ferromagnetic element for providing said field; (3) at least one piezoelectric element for providing said field; and (4) at least one piezomagnetic element for providing said field; and (ii) at least one reflecting element. In a further main aspect, the PMFCM and said controller are configured to adjust any of said at least one coupling and reflecting element in a predetermined manner thereby providing said PMF for inducing a therapeutic or regenerative or beneficial effect on said subject. The present invention further discloses methods and use of the aforementioned system.

A method for treating neural damage with a composition prepared from roots of bupleurum and scutellaria.

The invention discloses a multifunctional hand rehabilitation training rectification device; a finger training four-link mechanism is provided, and comprises a plurality of support poles, a slide block and a column, wherein the slide block is arranged on the column, and driven by a power mechanism to move up and down; each support pole comprises an upper support rod and a lower support rod; the end of each upper support rod is hinged to the top of the column; one end of each the lower support rod is hinged to the middle portion of the upper support rod, and the other end is hinged to the slide block; the top of the column is a palm support portion, and provided with a palm fixing ring; the middle of each upper support rod is provided with a finger fixing ring. The multifunctional hand rehabilitation training rectification device is simple in structure, friendly in price, excellent in performance, can conveniently allow a patient to carry out hand rehabilitation rectification, and the hand function of the patient can be restored for certain level after using the multifunctional hand rehabilitation training rectification device for a period.

The invention discloses a citicoline sodium glucose injecta and a preparation process thereof. The citicoline sodium glucose injecta mainly contains the active ingredients: citicoline sodium, isotonic agent glucose, a stabilizer, a pH regulator and water for injection, wherein the stabilizer is selected from one or two of malic acid, sale compounds thereof and sulfite compounds; the pH regulator is one or more of sodium hydroxide, hydrochloric acid, malic acid and apple sodium; the weight ratio of the active ingredients of the Citicoline sodium to the isotonic agent glucose is 1:(20-100), theweight ratio of the active ingredients of the citicoline sodium to the stabilizer is 1:(0.02-2), and the stabilizer is added to solve the problem of unstable heating and excessive related substances of the injecta in the production and storage process and improve the quality stability and the safe validation of medicaments.

The invention belongs to the biotechnical field and in particular to tissue engineering skin containing appendage and a preparation method thereof. The preparation method comprises the following steps: performing transfection of a urine cell to induce to generate a multifunctional stem cell; continuously inducing the multifunctional stem cell to generate a mesenchymal stem cell; differentiating the mesenchymal stem cell to form an epidermis cell, a fibroblast and a hair follicle cell; and constructing tissue engineering double-layered skin containing the appendage with a biological stent material amniotic membrane. The seed cell of the tissue engineering skin prepared by the preparation method is the urine cell which is convenient to obtain and short in cultivation period. The hair follicle structure which is contains facilitates union of a wound, and the tissue engineering skin containing the appendage provided by the invention lays a foundation for follow-up development of the tissue engineering skin containing the appendage.

The present invention discloses a compound burn oil for treating burn, scald and skin infection. The invention is a medicine oil preparation for external use which is an active ingredient extracted from solution; the solution is formed by six Chinese traditional medicines, that is, giant knotweed, sanguisorba, lithospermum, rhubarb, red paeonia and borneol which are dissolved in menstruum seed fat according to certain proportion. The oil has remarkable effects of having strong anti-inflammation, analgesic, convergence, bacteriostasis, rot removing and flesh growing, protecting wound surface, promoting healing efficacy, in particular the wound surface of fallen skin, reducing body fluid effusion after taking medicine, alleviating pain of the wound surface, having anti-pressure of the wound surface, small pain of patients, using no antibiotics in treating deep II, III degree burn with no infection, no skin-grafting and no scar after healing. The compound burn oil for treating burn basically solves difficult problems of pain, infection and scar forming of burn and scald on current clinic. The medicine is convenient in transportation, storage and operation and low in treatment cost.

The present invention provides compositions and methods for alleviation or reduction of the symptoms and signs associated with damaged neuronal tissues whether resulting from tissue trauma, or from chronic or acute degenerative changes. In particular, some embodiments of the present invention provide one or more pharmaceutical compositions comprising as an active ingredient a BMP2A inhibitor further comprising a pharmaceutically acceptable diluent or carrier. An additional embodiment provides a method for reducing damage to the central nervous system in a patient who has suffered an injury to the central nervous system, comprising administering to the patient a pharmaceutical composition in a dosage sufficient to reduce the damage. Yet another embodiment provides of the use of a BMP2A inhibitor for the preparation of a medicament for promoting or enhancing recovery in a patient who has suffered an injury to the central nervous system. Preferable inhibitors according to some embodiments of the invention are siRNA molecules and neutralizing antibodies. An additional embodiment provides a method for identifying a chemical compound that modulates apoptosis. Further, a process for diagnosing a neurodegenerative disease or an ischemic event in a subject is provided. The preferred methods, materials, and examples that will now be described are illustrative only and are not intended to be limiting; materials and methods similar or equivalent to those described herein can be used in practice or testing of the invention. Other features and advantages of the invention will be apparent from the following detailed description, and from the claims.

The invention discloses nerve regeneration biogum and a preparation method and an application thereof. The nerve regeneration biogum is prepared from fibrinogen, NaCl, hemopexin and 12 neurotrophic factors, wherein the fibrinogen, the hemopexin and the NaCl form a base support matrix. The biogum disclosed by the invention can promote regeneration and intramedullary extension of a nerve cell, and can increase the contact frequency of damaged nerve cynapse and normal nerve synapse by verification of an in-vitro cell test and an animal test. A plurality of neurotrophic factors in the biogum have important roles in regeneration and extension of the nerve cell, building of synaptic connection and forming of a blood vessel, can be further used for clinically repairing spinal nerve trauma and treating patients with spinal cord injury. The nerve regeneration biogum can be gradually applied to other central nervous system diseases, such as injury of brain tissue, optic nerve injury and the like.

The invention discloses a health-care food with effects of improving eyesight and reinforcing intelligence, and belongs to the technical field of health-care foods. The health-care food comprises the following raw materials in parts by weight: 100-600 parts of a needle mushroom extract, 150-500 parts of a Europe blueberry extract, 80-260 parts of a ginkgo leaf extract, 100-400 parts of soyabean lecithin, 50-200 parts of taurine, 80-400 parts of DHA, 0.5-5 parts of VB1, 0.5-5 parts of VB2, 5-20 parts of VB3, 0.25-0.8 part of VA and 5-80 parts of VE. The raw materials are organically combined, so that various different effect components are fused into a product, and the components are matched and coordinated; nutrition is complemented and organisms are conditioned in a systematical and comprehensive manner; and the health-care effects of realizing two functions of improving the memory and relieving the eyesight fatigue are achieved.

The invention discloses a multifunctional rehabilitation training device. The multifunctional rehabilitation training device comprises a bed and an air compressor, and is further provided with a handand waist exercising mechanism, a lifting mechanism, a leg bending and stretching exercising mechanism, a control circuit, a switching power supply, a power switch and a detecting circuit, the hand and waist exercising mechanism comprises guiding rods, electromagnets, sliding plates, resistance springs, guiding wheels, lifting rings, connecting steel wire ropes, a movable supporting table, a ballscrew single linear rail sliding table and electric pushing rod equipment, the electric pushing rod equipment comprises an electric pushing rod body, a connecting guiding shell, a needle-type air cylinder and an upper piston rod, the leg bending and stretching exercising mechanism comprises motor speed reducing equipment, an active gear, a sector gear, an intermediate gear, movable plates, movablefoot sleeves, tension springs, a connecting guiding shell and a needle type air cylinder, the lifting mechanism is an electric pushing rod, and the control circuit, the switching power supply, the power switch and the detecting circuit are installed inside an element box and connected with the waist exercising mechanism, the lifting mechanism and the leg bending and stretching exercising mechanism through wires.

The present invention relates to an ostrich oil and Chinese Tibetan medicine ointment for effectively using wound, burn and scald and its preparation method. Said invention includes the following components: 81g of dried rhizome of paris polyphylla, 81g of rubia root, 81g of Chinese angelica root, 100g of sanguisorba root, 150g of flavescent sophora root, 85g of rhubarb, 100g of phellodendron bark, 90g of giant knotweed rhizome and ostrich oil, the weight ratio of ostrich oil and above-mentioned all the Chinese Tibetan medicines extract is 2.5:1. Its preparation method includes the following steps: dissolving ostrich oil at 80deg.C, progressively adding the Chinese Tibetan medicines extract broken to 120 meshes into the dissolved ostrich oil according to the mixing ratio of 2.5:1, then adding small quantity of paraffin wax, quickly stirring them, uniformly mixing them, disinfecting and filling so as to obtain the invented finished product.

The invention discloses a facial palsy rectify patch and a treatment method. The rectify patch consists of medicines and the patches for bearing the medicines. The medicines are made of master medicines and auxiliary medicines. The master medicines comprise the medicines as follows: radix astragali, cassia twig, gambir plant, red peony, salvia miltiorrhiza, szechuan lovage rhizome, kudzuvine root, great burdock achene, earthworm, weeping forsythiae capsule, baical skullcap root, honeysuckle flower, medcinal evodia fruit, zedoary root, turmeric, divaricate saposhnikovia root, magnetite, Bungarus multicinctus, Chinese sage herb, simpleleaf shrub chastetree fruit and paris polyphylla; while the auxiliary medicines comprise one milliliter of laurocapam with a concentration of one percent. The invention can make full use of the Chinese medicine effect and has quick medical effect and obvious efficacy; the medicine is stuck at the joints, channels and collaterals on the surface corresponding to the human body viscera so as to exert a certain positive excitation, so that the nerves can change during the process of energy conversion and information coding; the invention also can activate, enhance, decrease or deactivate some enzymes inside the cell, thereby promoting the body own solution and the recovery ability through the nerves and the internal secretion so as to cure diseases and eliminate symptoms.

The present invention is related to benzothiophen-2-carbonylguanidine derivatives, a preparation method thereof, and pharmaceutical compositions containing the same. The derivatives have potent inhibitory effect on the sodium / hydrogen exchanger NHE-I, improve the functional recovery of ischemia / reperfusion-induced heart injury in isolated ischemic heart models, and significantly reduce the myocardiac infarct size in in vivo ischemic animal models, thereby showing excellent cardioprotective effects. Also, the derivatives are protective of both neuronal cells and the brain as proven by their protective effects on neuronal cells from necrosis and apoptosis and by their ability to significantly reduce cerebral infarct sizes in in vivo ischemic brain models. The derivatives can be effectively used for the prevention and treatment of ischemic heart diseases such as myocardiac infarction, arrhythmia, angina pectoris and the like, and cerebrovascular diseases such as cerebral stroke and be used as cardioprotective agents to the patients undergoing reperfusion therapy including chemicals such as thrombolytic agents, or surgery such as coronary artery bypass and percutaneous transluminal coronary angioplasty.

The present invention discloses a system for the administration of a plasma modified field (PMF) to a subject comprising: (a) a non thermal plasma (NTP) emitting source for emitting a plasma beam; (b) a plasma modified field coupling mechanism (PMFCM) comprising a plasma beam dish having at least one opening for the passage of said plasma beam; said plasma beam dish having a first surface and a second opposite surface; and (c) a controller for controlling said PMFCM. In a main aspect of the invention, said first surface of said plasma beam dish is mounted with: (i) at least one coupling element selected from the group consisting of: (1) at least one ferroelectric element for providing said field; (2) at least one ferromagnetic element for providing said field; (3) at least one piezoelectric element for providing said field; and (4) at least one piezomagnetic element for providing said field; and (ii) at least one reflecting element. In a further main aspect, the PMFCM and said controller are configured to adjust any of said at least one coupling and reflecting element in a predetermined manner thereby providing said PMF for inducing a therapeutic or regenerative or beneficial effect on said subject. The present invention further discloses methods and use of the aforementioned system.

The invention discloses a preparation method and an application of human umbilical cord mesenchymal stem cells. The preparation method includes the steps of: performing asepsis treatment to umbilical cord of a full-term caesarean delivered healthy fetus, mechanically cutting the umbilical cord, digesting the umbilical cord through collagenase and performing separation cultivation. In about the third generation, cell shape becomes flat and broad and the cells grow well. The method can culture the cells till the 15th generation, wherein cell division phase is reduced and cytoplasm is loose, there are vacuoles in the cells, and cell aging and proliferation are significantly slowed, so that the third-generation cells have high activity and can be applied in subsequent researching and treatment. The human umbilical cord mesenchymal stem cells are used in therapy of cerebral injury, and improve function recovery after the cerebral injury.

The invention relates to a neurological training potential development rehabilitation training series device which comprises a pulley weight-reducing system device, a framework support device, a sling fixing device, a weight-reducing device and a base, wherein the pulley weight-reducing system device is fixedly mounted on the framework support device, one end is connected with the weight-reducing device, and the other end is connected with the sling fixing device which is worn on a human body; and the base is connected with the bottom part of the framework support device and fixed. The training device can provide the functions of weight reduction and safety protection, create the critical state without danger under the application of the guiding technique of the six-step method of the neurological training rehabilitation method and be conductive to a special series training device for human potential development, thereby recovering the lost motion function of a central nervous system after injuries.

The invention relates to the field of bioengineering and particularly relates to a neural restoration promoting tube as well as a preparation method and application thereof. In order to overcome the problem of unsatisfactory neural functional recovery of current direct nerve suture operation, the invention provides a neural restoration promoting tube with a shape memory function. The neural restoration tube is prepared and formed by injecting a gelatin solution into a neural restoration tube mould; and the neural tube mould can be a neural restoration tube mould prepared by 3D printing. The neural restoration promoting tube has a shape memory function; and after being implanted into a body, the tube can recover to the original shape under the effect of water and automatically extends along the axial direction of nerves so as to better wrap and cover the periphery of the injured nerves and provide a stable microenvironment for the nerve growth. Moreover, the wounds of the nerves separated by operation can be greatly reduced, the wound recovery is facilitated, the functional recovery of the nerves is promoted, and the clinical application prospect is perfect.

The invention discloses multifunctional rehabilitation physical therapy equipment. The equipment comprises a base and a control panel, the base comprises a monitoring device, a supporting assembly, anupper limb rehabilitation training mechanism, a lower limb rehabilitation training mechanism and an upper limb strength training mechanism, the monitoring device is connected with the control panel,and the upper limb rehabilitation training mechanism comprises an upper limb shell, a first driving motor and a rehabilitation training handle; the lower limb rehabilitation training mechanism comprises a lower limb shell, a second driving motor and a rehabilitation training pedal, the supporting assembly comprises a supporting base, a first supporting column and a second supporting column, the first supporting column is arranged at the front end, and the second supporting column is arranged at the rear end; a seat with an adjustable height is arranged at the upper end of the second supportingcolumn, and a backrest of the seat is provided with an abdomen massage arm, a neck massage arm and a head massage arm. The equipment is simple in structure and convenient to operate, the upper limbsand lower limbs can be simultaneously subjected to rehabilitation training, recovery of the limb function is accelerated, the abdomen, neck and head can also be massaged, the safety factor is high, and the occupation space is small.

The invention discloses a muscle tendon repair net, which comprises a muscle tendon repair net body. The muscle tendon repair net body is a net woven by using lines. Extension lines are arranged at the end parts of the muscle tendon repair net body. The invention additionally provides a using method of the muscle tendon repair net. The using method comprises the following steps of: 1) butting ends of a first broken muscle tendon and a second broken muscle tendon and using the muscle tendon repair net to cover the first broken muscle tendon and the second broken muscle tendon which are butted together; 2) suturing the end part of the muscle tendon repair net on the first broken muscle tendon in a circle along the outer circumference of the muscle tendon; 3) suturing the end part of the muscle tendon repair net on the second broken muscle tendon in a circle along the outer circumference of the muscle tendon; and 4) suturing the part of the muscle tendon repair net corresponding to the joint part of the first broken muscle tendon and the second broken muscle tendon in a circle along the outer circumference of the muscle tendon. The muscle tendon repair net and the using method thereof provided by the invention have the advantages that the healing of the muscle tendon is facilitated, the functional training of the muscle tendon can be advanced after the broken muscle tendons are sutured, the muscle tendon is prevented from being adhered because the muscle tendon is fixed for a long term after a surgery, the release through two stages of surgeries is avoided and the functional rehabilitation of a wounded limb is promoted.

The invention discloses an installation method of a distal radius external fixation support. On the precondition of keeping the structure of an original external fixation support unchanged, the unbalanced stress in the prior art is changed and the long-term stability of traction and reduction is kept by changing a screw implanting position, replacing a schanze screw of the external fixation support by virtue of a universal kirschner wire and penetrating through the 2nd, 3rd, 4th and 5th metacarpal bases from the 2nd metacarpal base; therefore the external fixation support has the advantages of being convenient to use, and being capable of reducing pin track infection and the difficulty of skin nursing, adjusting fracture displacement towards an ulnar side easily, avoiding iatrogenic injury, being easy to be accepted by patients and being conducive to function recovery.

The invention provides an artificial laparoscopic surgery spatial device composed of a conveyor and a bag body. The conveyor is composed of an outer sleeve, a handle, an operating rod, an elastic body, a soft belt and a soft belt pull ring. The bag body comprises a bag barrel and an operating opening. Isolated surgery operating space can be created in the abdominal cavity of a patient, and the situation that in the smashing process after tumors are excised, free myoma cells contaminate the abdominal cavity, and therefore tumor transplanting is caused is avoided.

The present invention provides a method of treating neural injury, e.g., spinal cord injury (SCI), or enhancing recovery from the neural injury with silymarin or silybin.

The present invention provides a method for treating brain injury or stroke in a subject in need thereof, comprising implanting a microdialysis probe into the injury or insult core of the subject and perfusing the probe with an oncotic agent dissolved in a physiologically acceptable buffer, wherein the microdialysis probe comprises a dialysis membrane with a molecular weight cutoff less than the molecular weight of the oncotic agent.