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Neural restoration promoting tube as well as preparation method and application thereof

A nerve repair and nerve technology, applied in the fields of bioengineering and biomedicine, can solve problems such as poor recovery of organ function, achieve good clinical application prospects, facilitate wound recovery, avoid subsequent compression and cause inflammation

Active Publication Date: 2016-08-24
SINOPHARM A THINK PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, if the nerve is sutured directly, the recovery of the function of the organs innervated by the nerve after the operation is not very good.

Method used

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  • Neural restoration promoting tube as well as preparation method and application thereof
  • Neural restoration promoting tube as well as preparation method and application thereof
  • Neural restoration promoting tube as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1. Preparation and use of the nerve-promoting tube of the present invention

[0043] Since the diameter of the sciatic nerve in rats is generally 1.5 mm, we printed a nerve tube mold with an inner diameter of 1.5 mm, a diameter of 4 mm, and a length of 15 mm with polycaprolactone through a 3D printer. Dissolve 50mg of gelatin in 1mL of deionized water (60°C), then quickly mix with 10mg of EDC.HCL and add to the mold. After reacting in a refrigerator at -20°C for 12 hours, the formed nerve-promoting repair tube was taken out. Place the neuroprosthetic tube in deionized water to remove excess EDC.HCL. Place the nerve-promoting repair tube at -20°C to crystallize the water in it, and then freeze-dry the nerve tube in a lyophilizer for 3 days to remove the water therein. The freeze-dried nerve-promoting repair tube is firstly compressed and then expanded through a mold, so that the diameter increases from 37% of the original inner diameter to 133% of the origin...

Embodiment 2

[0045] Embodiment 2. In vivo effect test of the nerve-promoting tube of the present invention

[0046] Animal experiments: We selected adult rats (body weight 200-250 g) to evaluate the performance of nerve repair in the shape memory neuroprosthetic tube. We divided the rats into 4 groups for functional evaluation, group A was the sham operation group, group B was the negative control group, and group C was the neuroprosthetic tube. Rats were anesthetized by intraperitoneal injection of chloral hydrate (0.5 ml / 100 g). The hair on the right hind body of the rat was removed, a 1 mm wound parallel to the femur was cut at the sciatic nerve, and the biceps femoris was separated to expose the sciatic nerve. At a distance of 5mm from the bifurcation nerve, the sham operation group did not cut the nerve, the group B cut the nerve and sutured it, and the group C cut the nerve bag shape memory to promote nerve repair tube. Functional recovery of the sciatic nerve with a shape-memory n...

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Abstract

The invention relates to the field of bioengineering and particularly relates to a neural restoration promoting tube as well as a preparation method and application thereof. In order to overcome the problem of unsatisfactory neural functional recovery of current direct nerve suture operation, the invention provides a neural restoration promoting tube with a shape memory function. The neural restoration tube is prepared and formed by injecting a gelatin solution into a neural restoration tube mould; and the neural tube mould can be a neural restoration tube mould prepared by 3D printing. The neural restoration promoting tube has a shape memory function; and after being implanted into a body, the tube can recover to the original shape under the effect of water and automatically extends along the axial direction of nerves so as to better wrap and cover the periphery of the injured nerves and provide a stable microenvironment for the nerve growth. Moreover, the wounds of the nerves separated by operation can be greatly reduced, the wound recovery is facilitated, the functional recovery of the nerves is promoted, and the clinical application prospect is perfect.

Description

technical field [0001] The invention relates to the fields of bioengineering and biomedicine, in particular to a tube for promoting nerve repair and its preparation method and application. Background technique [0002] At present, various traumas such as compression, stretching, tearing, cutting and other reasons cause partial or complete damage to the nervous system, which leads to loss of function and other neurological diseases. For damaged nerves, the neuronal axons of the nerve can regenerate under the right circumstances. With the development of neurosurgery, especially microneurosurgery, the repair and regeneration of nerve injury has become possible. The current research and clinical application of nerve repair techniques mainly include: direct suture, nerve transplantation (autograft or allograft) and repair through nerve-promoting tubes. Direct anastomosis is only limited to shorter nerve cuts (less than 5mm), otherwise there will be anastomotic tension, which is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/22A61L27/58A61L27/50
CPCA61L27/222A61L27/50A61L27/58A61L2400/16A61L2430/32C08L89/06
Inventor 苟马玲魏于全陶杰张久盟苟智元
Owner SINOPHARM A THINK PHARMA
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