Product
Patsnap Eureka
For R&D, Patsnap Eureka makes reading and utilizing patents & technical documents easy.
Patsnap Eureka AIR
Designed for self-driven R&D workflows. Generate viable solutions, solve complex R&D challenges, empower your innovation with AI.
Patsnap Eureka Materials
Designed for material experts only. Revolutionize your material R&D, from search, analyze, to developing new materials.
Feature
TechResearch
Generate reliable direction feasibility study reports for your R&D in just a few steps.
TechSeek
Discover and master advanced knowledge NOW. Basics, ideas, possibilities, all at once.
TechMind
As an expert in R&D Theories, TechMind can generates customized viable solutions instantly.
TechRisk
Analyze your overall solution with one click, know your potential R&D risks in advance.
TechMonitor
Get weekly tech updates, stay abreast of the latest tech innovations and key insights.
Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
43 results about "Trans stilbene" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
Hybrid metal organic scintillator materials system and particle detector
ActiveUS7985868B1Minimized quenching effectMinimize quenching effectPolycrystalline material growthOrganic chemistryOctahedronZinc nitrate
We describe the preparation and characterization of two zinc hybrid luminescent structures based on the flexible and emissive linker molecule, trans-(4-R,4′-R′) stilbene, where R and R′ are mono- or poly-coordinating groups, which retain their luminescence within these solid materials. For example, reaction of trans-4,4′-stilbenedicarboxylic acid and zinc nitrate in the solvent dimethylformamide (DMF) yielded a dense 2-D network featuring zinc in both octahedral and tetrahedral coordination environments connected by trans-stilbene links. Similar reaction in diethylformamide (DEF) at higher temperatures resulted in a porous, 3-D framework structure consisting of two interpenetrating cubic lattices, each featuring basic to zinc carboxylate vertices joined by trans-stilbene, analogous to the isoreticular MOF (IRMOF) series. We demonstrate that the optical properties of both embodiments correlate directly with the local ligand environments observed in the crystal structures. We further demonstrate that these materials produce high luminescent response to proton radiation and high radiation tolerance relative to prior scintillators. These features can be used to create sophisticated scintillating detection sensors.
Owner:SANDIA NAT LAB
Topical pharmaceutical compositions
ActiveUS10195160B2Reduce stimulationExtension of timeAntimycoticsHydroxy compound active ingredientsAntioxidantOil phase
Owner:DERMAVANT SCI GMBH
Novel method of use
The present invention relates to a novel method of treatment of acne in a human patient in need thereof, comprising administering topically to said patient an effective amount of the compound 3,5-Dihydroxy-4-isopropyl-trans-stilbene (Compound 1) or a pharmaceutically acceptable salt thereof.
Owner:DERMAVANT SCI GMBH
Therapeutic agents for skin diseases and conditions
ActiveUS20160287531A1Reduce the possibilityQuick fixHydroxy compound active ingredientsEther/acetal active ingredientsDiseaseTherapeutic effect
The present invention relates to method(s) of treating a subject afflicted with a skin disease or condition, the method comprising administering to the subject or patient in need a composition comprising a therapeutically effective amount of a substituted cis or trans-stilbene or a stilbene hybrid. A method of treating or reducing the likelihood of a skin disease or condition in a patient is an additional embodiment of the present invention. Preferred pharmaceutical compositions of the invention include nanoemulsions comprising a therapeutically effective amount of a substituted cis or trans-stilbene or stilbene hybrid and at least one antibiotic.
Owner:STC UNM
Topical pharmaceutical compositions
ActiveUS20180064656A1Improving residency timeEliminate side effectsHydroxy compound active ingredientsAerosol deliveryAntioxidantOil phase
The present invention relates to topical pharmaceutical emulsion compositions comprising a therapeutically effective amount of 3,5-Dihydroxy-4-isopropyl-trans-stilbene or a pharmaceutically acceptable salt thereof, an oil phase, a water phase, a surfactant, and an antioxidant, and wherein the emulsion composition is homogeneous and / or the active is solubilized in the oil phase. The invention also relates to methods of treating a dermatological condition or disorder in a patient by administering the present compositions to the skin of the patient.
Owner:DERMAVANT SCI GMBH
(E)-3,5-dimethox-4'-hydroxy diphenyl ethylene synthesis method
InactiveCN1876613AImprove economySimple reaction stepsOrganic chemistryOrganic compound preparationAcetic acidDecarboxylation
The invention discloses the synthesis of pterostilbene. The method comprises the following steps: using p-hydroxyphenyl acetic acid and veratraldehyde as raw material, carryingout Perkin reaction, getting (Z)-2(4-acetoxylation phenyl)-3-(3, 5- dimethoxy benzoic) acroleic acid, deacetylation, decarboxylation, and getting pterostilbene. The invention has the advantages of cheap raw material, simple technology, easy operation and high productivity. The invention has the advantages of low cost, good economy benefit and environment protection.
Owner:GUANGZHOU INST OF GEOCHEMISTRY - CHINESE ACAD OF SCI
Topical pharmaceutical compositions
ActiveUS20160338973A1Improving residency timeReduce stimulationAntimycoticsHydroxy compound active ingredientsAntioxidantOil phase
The present invention relates to topical pharmaceutical emulsion compositions comprising a therapeutically effective amount of 3,5-Dihydroxy-4-isopropyl-trans-stilbene or a pharmaceutically acceptable salt thereof, an oil phase, a water phase, a surfactant, and an antioxidant, and wherein the emulsion composition is homogeneous and / or the active is solubilized in the oil phase. The invention also relates to methods of treating a dermatological condition or disorder in a patient by administering the present compositions to the skin of the patient.
Owner:DERMAVANT SCI GMBH
Substituted stilbenes and their reactions
InactiveUS7220784B2High activityHigh yieldBiocideHalogenated hydrocarbon active ingredientsAlkoxy groupDouble bond
The present invention relates to stilbene and quinone compounds related to combretastatin A-4 and their use as anticancer compounds and prodrugs. The compounds include those with an alkyl group on the double bond of cis or trans-stilbenes, compounds with one or more (and preferably 2 or 3) alkyl group substituents on the stilbene A ring, compounds with an alkoxy group other than methoxy at position 3, 4, and / or 5 of the stilbene A ring, compounds (or prodrugs) in which BOC amino acid esters are formed with the phenolic hydroxyl at the 3-position of the B ring and compounds (or prodrugs) based on a benzoquinone B ring. The present invention further relates to the photochemical reactions of stilbene compounds, either the above compounds disclosed for the first time herein or compounds based on prior art stilbenes. These reactions include the photochemical release of an active form of the compound from a prodrug conjugate and the photochemical isomerisation of the compounds, especially from a trans to cis form of compounds. The reactions can be used alone or in combination to convert inactive or comparatively less active forms of the compounds to more active forms, thereby allowing the compounds to be selectively targeted, e.g. activating them at the site of a tumour.
Owner:UNIVERSITY OF SALFORD
Molecular probes for detecting lipid composition
A method of detecting myelin in a subject includes administering to the subject a molecular probe that includes a fluorescent trans stilbene derivative and detecting the amount or distribution of the molecular probe in a tissue of interest of the subject.
Owner:CASE WESTERN RESERVE UNIV
Molecular probes for imaging of myelin
ActiveUS20110189090A1Organic chemistryRadioactive preparation carriersMolecular probeStilbene derivative
Owner:CASE WESTERN RESERVE UNIV
Nitrogenatd trans-stilbene analogs, method for the obtention and medical applications thereof
This invention is related to new nitrogenated trans-stilbene analog compounds, more specifically, imine, pyrrol and Indole derivatives, with procedures for the preparation and use thereof as pharmaceutical compositions for the treatment and / or chemoprevention of those mammalian diseases such as cancer, fibrosclerosis and acute / chronic inflammation, graft-versus-host reaction, ischemic-reperfusion tissue injury in stroke and heart attack, neurodegeneration, and during organ transplantation, whose pathogenic and pathophysiological mechanisms depend on or are significantly contributed by undesirable oxidative stress, angiogenic and proliferative responses.
Owner:DOMINION PHARMAKINE +1
Method for synthesizing trans-stilbene compound under assistance of microwave
InactiveCN104447228AShort reaction timeEasy post-processingOrganic compound preparationOrganic chemistry methodsBenzeneMicrowave
The invention discloses a method for synthesizing a trans-stilbene compound under the assistance of microwave. The method comprises the following steps of dropwise adding titanium tetrachloride into a mixture of zinc powder and an organic solvent under the ice bath condition, adding a benzaldehyde compound (a formula 2 shown in the specification) into the reaction system after dropwise adding of titanium tetrachloride, stirring for 1 hour at room temperate, and carrying out refluxing reaction on the reaction system in a microwave reactor to generate the trans-stilbene compound (a formula 1 shown in the specification). The method provided by the invention has the advantages of short reaction time, convenience in after-treatment and high yield. According to the method, catalysis by a precious metal and strict anhydrous operation are omitted, and thus the method is easy and convenient to operate and facilitates large-scale production.
Carboxyl substituted resveratrol analog compound and its preparation method
InactiveCN1807391AEnhance anti-tumorImprove protectionPreparation from nitrilesAntineoplastic agentsHydrogenBenzaldehyde
The resveratrol compound with carboxyl substituent has general formula as following, wherein, R acts for hydrogen, hydroxyl or nitryl. The opposite preparation method comprises: using Perkin reaction to the 3, 5-dimethoxylphenylacetic acid with opposite p-substituting R-benzaldehyde; removing the methoxy protection to obtain the product as the derivative of 1, 2-toluylene. This invention is similar to the resveratrol as 3, 4', 5-trihydroxy -trans-stilbene, and has wide application for antitumor and cardiovascular protection.
Owner:JIANGSU INST OF NUCLEAR MEDICINE
Method of use
Owner:DERMAVANT SCI GMBH
Orally bioavailable stilbenoids- compositions and therapeutic applications thereof
InactiveUS20100204340A1Enhanced ability to preventInhibit lipogenesisBiocideOrganic chemistryAdipogenesisCosmeceuticals
A novel, bioavailable and safe stilbenoid 3,5-dimethoxy-3,4′-dihydroxystilbene represented by STR#1 with an unexpected enhanced ability to prevent the accumulation of lipids accompanying the terminal differentiation of adipocytes, thereby inhibiting adipogenesis, and nutraceutical and cosmeceutical compositions comprising 3,5-dimethoxy-3,4′-dihydroxystilbene useful for anti-obesity and anti-cellulite therapy, are disclosed. Further the enhanced SIRT-1 activation ability of 3,5-dimethoxy-3,4′-dihydroxystilbene represented by STR#1 and 2,3′,5′,6-tetrahydroxy-trans-stilbene represented by STR#II are disclosed. The enhancement of SIRT-1 polypeptide activity of the said compounds is unexpectedly much higher than resveratrol or its natural analog pterostilbene. Sirtuin modulating compositions comprising an orally bioavailable SIRT-1 enhancing compounds (i) 3,5-dimethoxy-3,4′-dihydroxystilbene represented by STR#I and (ii) 2,3′,5′,6-tetrahydroxy-trans-stilbene represented by STR#II are also disclosed. An additional embodiment, also discloses the enhanced anti-Propionibacterium acnes activity of 3,5-dimethoxy-3,4′-dihydroxystilbenes represented by STR#I and compositions thereof.
Owner:SAMI LABS LTD
Substituted cis- and trans-stilbenes as therapeutic agents
ActiveUS8980954B2Reduce activationReduce the possibilityBiocideNervous disorderTherapeutic effectRisk stroke
The present invention relates to method(s) of treating a subject afflicted with cancer or a precancerous condition, an inflammatory disease or condition, and / or stroke or other ischemic disease or condition, the method comprising administering to the subject or patient in need a composition comprising a therapeutically effective amount of a substituted cis or trans-stilbene.
Owner:STC UNM
Light-operated fluorescent switch based on coordination polymer as well as preparation method and application of light-operated fluorescent switch
InactiveCN107880276ASimple processMild reaction conditionsRecord information storageLuminescent compositionsPolymer scienceFluorescence
The invention discloses a light-operated fluorescent switch based on a coordination polymer as well as a preparation method and an application of the light-operated fluorescent switch. The light-operated fluorescent switch is a coordination polymer 1--[zinc(1,4-benzene diacetoxyl)(4,4'-di(4-pyridyl)-trans-stilbene)]n or a coordination polymer 2--[zinc(1,4-benzene diacetoxyl)(1,2,3,4'-tetra(4-phenyl-4'-pyridyl)cyclobutane)0.5]n. 4,4'-di(4-pyridyl)-trans-stilbene molecules and 1,2,3,4'-tetra(4-phenyl-4'-pyridyl)cyclobutane molecules in the coordination polymer can be freely switched under radiation of light with different wavelengths, and the coordination polymer has remarkable difference in fluorescence-emission intensity before and after conversion. Therefore, the coordination polymer is atypical light-operated fluorescent switch and can be applied to the field of light information storage as a rewritable optical recording material.
Owner:HUAIBEI NORMAL UNIVERSITY
Compositions comprising blockers of L-DOPA renal cell transfer for treatment of Parkinson's disease
A pharmaceutical composition for the treatment of Parkinson's disease comprises L-DOPA and at least one compound capable of blocking the L-DOPA renal cell outward transfer pathway; said blocking compound being chose from (a) a flavonoid phenyl benzopyran derivative; (b) a trans-stilbene derivative; or (c) phloretin [3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone]. The composition may also comprise an inhibitor of the enzyme amino acid decarboxylase (AADC), such a carbidopa or benserazide, and / or an inhibitor of the enzyme catechol-O-methyl transferase (COMT), such as entacapone or tolcapone. The composition is preferably administered in soli form and the L-DOPA may be administered simultaneously or sequentially with the L-DOPA renal cell outward transfer blocking compound.
Owner:波特拉和康潘希亚股份有限公司
Solid phase micro-extraction method of unsaturated compounds
ActiveCN109030677AReduce distractionsEasy to separateComponent separationHplc dadSolid-phase microextraction
Owner:FUZHOU UNIV
New trans-stilbene-type antitumor agent
The present invention provides a novel trans-stilbene antineoplastic agent, the structure of which is represented by the general formula I, II or III, which has significant inhibitory effect on various cancer cell lines. Its pharmaceutically acceptable salts, derivatives, tautomers or solvates thereof, and combinations of the above compounds are used in the prevention or treatment of tumors and other tumor-related diseases.
Owner:NORTHEAST FORESTRY UNIVERSITY
Method for controlling polygonum multiflorum extra-heterogeneous hepatotoxicity
PendingCN112305211AMicrobiological testing/measurementMaterial analysis by optical meansStatistical analysisPharmaceutical drug
The invention discloses a method for controlling polygonum multiflorum extra-heterogeneous hepatotoxicity. The method comprises the following steps: determining dosage of emodin-8-O-glucoside; preparing an emodin-8-O-glucoside solution; giving the emodin-8-O-glucoside solution to a rat through intragastric administration, and collecting plasma and liver specimens; performing index detection; usingSPSS software for statistical analysis. The invention further provides application of the emodin-8-O-glucoside in preparation of a medicine which does not cause the special liver injury and application of the emodin-8-O-glucoside and the trans-stilbene glucoside in evaluation of the special liver injury. The invention also provides a safe content limit of emodin-8-O-glucoside so as to control theliver injury risk of polygonum multiflorum.
Owner:北京圆融科技有限公司
Active substance for treating diabetes, preparation method thereof and medicine
InactiveCN105362282ALower blood sugar levelsOrganic active ingredientsSugar derivativesGlycoside formationHigh fat
The invention belongs to the technical field of medicine and particularly relates to an active substance for treating diabetes, particularly type-2 diabetes, a preparation method thereof and medicine. The active substance is PM extract stilbeneglycoside and more preferably a mixture of cis diphenylethylene glycosides and trans diphenylethylene glycosides. In a type-2 diabetes mouse model induced by high fat, PM extract containing cis-SG and trans-SG represents remarkable blood sugar lowering capacity.
Owner:HUANGGANG NORMAL UNIV
Polyester stilbene composition
InactiveUS20070037958A1Improve the heating effectThin material handlingCyclohexanedimethanolCopolyester
A copolyester composition comprising units of residues of a) about 1-40 mole % of trans 3,3′, trans 4,4′ stilbene dicarboxylic acid and the combination thereof, b) about 99-60 mole % of cis,trans, and the combination thereof of 1,4 cyclohexane dicarboxylic acid, and c) about 50-100 mole % of cis, trans, and the combination thereof of 1,4-cyclohexane dimethanol. The resulting copolyester may be characterized by its clarity, as well as enhanced heat performance due to the presence of the stilbene moiety.
Owner:SABIC GLOBAL TECH BV
Preparation method of polygonum multiflorum cis and trans-stilbene glycoside reference substances
ActiveCN105061524AIncrease polarityHigh puritySugar derivativesSugar derivatives preparationEthyl acetateMonomer
The present invention discloses a preparation method of polygonum multiflorum cis and trans-stilbene glycoside reference substances. The method comprises the steps of: (1) drying and crushing a polygonum multiflorum medicinal material, adding an ethanol solution for extraction, filtering the extract, and concentrating the filtrate to a state without alcohol taste, so as to obtain a concentrated solution; (2) adding petroleum ether to the concentrated solution for extraction, adjusting the pH value of a water phase after extraction to 9-11, adding ethyl acetate for extraction, concentrating the ethyl acetate phase to obtain an extract; (3) separating and purifying the extract by a semi-preparative high performance liquid chromatography, wherein the chromatographic conditions are as below: a chromatographic column of Shim-pack PREP-ODS column, a mobile phase of acetonitrile-water, volume ratio of 25:75, and detection wavelength of 320 nm; collecting chromatographic peaks, detecting purity and merging the same fractions, so as to isolate cis-stilbene and trans-stilbene glycoside reference substances. The high purity trans-stilbene glycoside monomer and cis-stilbene glycoside monomer prepared by the invention provide pure substances for physiological activity tests.
Owner:SHANDONG ANALYSIS & TEST CENT
Light-catalyzed synthesis method of trans-stilbene compound
ActiveCN106588582AMild reaction conditionsGood choiceOrganic chemistryOrganic compound preparationPhotocatalytic reactionSynthesis methods
The invention relates to a light-catalyzed synthesis method of a trans-stilbene compound. Substituted iodobenzene and a substituted styrene compound perform light-catalyzed reaction in a DMF solution in the presence of a catalytic system, the reaction process is monitored by TLC, reaction liquid is subjected to separation and purification to obtain the substituted stilbene compound after the reaction is completed. By the adoption of the technology, a common dye serves as a visible-light-induced photocatalyst for catalyzed synthesis of the trans-stilbene compound according to the novel method, and the method has the advantages that reaction conditions are mild, the photocatalyst is cheap and easy to obtain, the selectivity is good, the yield is high and the like and is suitable for industrial production and application.
Owner:ZHEJIANG UNIV OF TECH
Substituted stilbenes and their reactions
Owner:UNIV UTRECHT UU HLDG
A zirconium-based metal-organic framework material, its preparation and its application in the treatment of nitrofuran antibiotics
ActiveCN113121842BSave raw materialsRaw materials are easy to getOther chemical processesWater contaminantsMetal-organic frameworkDicarboxylic acid
The invention belongs to the technical field of metal-organic framework materials, and in particular relates to the preparation of a zirconium-based metal-organic framework material and its application to the detection and adsorption of nitrofuran antibiotics in water. The present invention is based on trans-4,4'-stilbene dicarboxylic acid and zirconium chloride to synthesize a dual-functional UiO series metal-organic framework—Zr-fcu-sti, which simultaneously detects and adsorbs antibiotics, and can achieve low detection limits. Highly selective fluorescence detection and rapid, high-capacity adsorption removal of nitrofuran antibiotics from water.
Owner:NORTH CHINA ELECTRIC POWER UNIV (BAODING)
Preparation method of trans-stilbene compound
ActiveCN108658718AEfficient responseSimple post-processingHydrocarbon by hydrogenationAsymmetric synthesesSynthesis methodsDiphenylacetylene
The invention relates to a synthesis method of a trans-stilbene compound. In an atmosphere of nitrogen or inert gas and an organic solvent, diphenylacetylene serves as a reaction substrate, and the trans-stilbene compound is obtained through chemically selective reduction of the carbon-carbon triple bond in a diphenylacetylene structure by using elemental selenium and alkali. The raw material diphenylacetylene is easy to synthesize; the elemental selenium is cheap and easily available. The synthesis method of the trans-stilbene compound provided by the invention has the advantages of wide range of reaction substrate, high functional group tolerance, simple reaction conditions and high product yield and purity, provides good synthesis route and means for the trans-stilbene compounds, and has great application potential and research value.
Owner:WENZHOU UNIVERSITY
Synthetic method for beta-bromo ether compound
InactiveCN110156577AControl spawn rateMild reaction conditionsEther separation/purificationOrganic compound preparationAlkali metal halideIndene
The invention discloses a synthetic method for a beta-bromo ether compound. The method comprises the following steps: respectively with indene and trans-stilbene as raw materials, adding methanol, alkali metal halide and bromate-intercalated zinc-aluminum hydrotalcite into the indene and the trans-stilbene, carrying out uniform mixing, carrying out a reaction under stirring for 1 to 6 hours at 25to 50 DEG C and a normal pressure under the action of inorganic acid, allowing a TLC tracking reaction to be completed so as to obtain a reaction mixed solution, and carrying out post-treatment so asto respectively obtain 2-bromo-1-methoxyindan and 1,2-diphenyl-1-bromo-2-methoxyethane. The synthetic method provided by the invention is safer and more environmentally-friendly by using the bromate-intercalated zinc-aluminum hydrotalcite and the alkali metal bromide, has mild reaction conditions, short reaction time and good yield, is simple and convenient in operation, can control the generationspeed of a halogen source by changing reaction conditions, and has strong controllability.
Owner:ZHEJIANG UNIV OF TECH
Molecular probes for imaging of myelin
ActiveUS9987379B2Organic chemistryRadioactive preparation carriersMolecular probeStilbene derivative
Owner:CASE WESTERN RESERVE UNIV
Who we serve
- R&D Engineer
- R&D Manager
- IP Professional
Why Patsnap Eureka
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com