The invention discloses a
polygonum multiflorum extract with excellent water
solubility and a preparation method thereof. The preparation method comprises following steps: 1)
polygonum multiflorum, which is taken as a
raw material, is grinded and is subjected to
reflux extraction with
ethanol so as to obtain an extracting solution, the extracting solution is condensed and
ethanol is recycled so as to obtain a concentrated solution, wherein the concentration of
ethanol is 45-55%; 2) a compound
enzyme is added into the concentrated solution, the mixture is subjected to
enzymatic hydrolysis for 3 to 5h at a temperature of 40 to 50 DEG C, the compound
enzyme is killed after
enzymatic hydrolysis, the mixture is centrifuged, and the supernatant is collected, wherein the weight of the compound
enzyme is 0.2 to 0.3% of the weight of the
raw material; 3) the supernatant is filtered with a
ceramic membrane of 0.4 to 0.5 microns, and the filtrate is collected; 4) the filtrate is eluted by using a
macroporous resin column, wherein firstly the
macroporous resin column is eluted with water until the
effluent is clear, and then is eluted by ethanol with a concentration of 60 to 70%, the eluate is condensed and dried, and the
polygonum multiflorum extract with excellent water
solubility is obtained. The content of
stilbene glucoside in the polygonum multiflorum extract is 5 to 60%. The preparation method is capable of reducing the content of
anthraquinone compounds and increasing the extraction efficiency of
stilbene glucoside.