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68results about How to "Active ingredient clear" patented technology

Dendrobium officinale extract as well as preparation method and application thereof

The invention provides a dendrobium officinale extract. In the extract, the content of dendrobium officinale polysaccharides is 70.0-90.0%, and the content of general flavones is 0.5-1.0%. The dendrobium officinale extract is capable of being used for preparing medicines or health products for preventing and treating embolic cardiovascular and cerebrovascular diseases and renal diabetes. The invention further provides a preparation method of the extract. The preparation method specifically comprises the four steps of organic solvent degreasing, flash extraction after ethanol solution soaking, Sevage reagent deproteinization and active carbon decolouration. The preparation method is capable of protecting the dendrobium officinale effective ingredient not to be thermally broken and furthest effectively extracting the dendrobium officinale polysaccharides and the flavones simultaneously, low in solvent dosage, short in extraction time, and capable of improving product quality and reducing production cost.
Owner:ZHEJIANG JIGONGYUAN PHARMA

Use of hederagenin and its derivatives in preparing antidepressant product

The present invention relates to a novel purpose of hederagenin and a derivative of the hederagenin. An anti-depression test of the hederagenin and the derivative of the hederagenin shows obvious anti-depression activity, wherein, the salt derivative of the hederagenin has stronger anti-depression activity than the hederagenin; the hederagenin has stronger anti-depression activity than hederangenoside; the activities of the hederagenin and a hypericum extract are equivalent; sodium hederagenin has higher activity than the hypericum extract. The present invention has obvious pharmacological effect and stable quality; the raw material of the present invention has abundant source and cheap price and is safe with low toxin; the present invention has simple preparation technology and high yield, which provides novel medicine source for preventing, diagnosing, examining, protecting, remedying and researching on the depression and diseases directly related to the depression, is fit for the industrialization production, is easy for popularizing and applying and has very important value for developing and using Chinese officinal plant resource. Affective mental disorder is listed at top in Chinese disease general burden, and the research and manufacture of the drug for preventing and remedying the depression has obvious social benefit and economic benefit.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY

Antineoplastic usage of sinomenine and its preparation

An antineoplastic action of coculine and the composite medicine containing said coculine and the application of coculine in preparing antineoplastic medicines are disclosed.
Owner:MOLECULAR BIOLOGY +1

Active site composition of isatis roots, as well as preparation method and application thereof

The invention discloses an active site composition of isatis roots, as well as a preparation method and the application thereof. The active site composition of isatis roots is prepared from a general phenylpropanoid part of isatis roots, a total alkaloid part, a total organic acid part and a total polysaccharide part. The active site composition obtained by the invention has high effective component contents and accurate active components. Proved by experimental results, the active site composition of isatis roots has obvious antiviral activity and favorable antibacterial and antipyretic activities. After being combined, the effective components reach favorable synergy, exert the antiviral, antibacterial and antipyretic activities at a plurality of targets spots through multiple paths, can be used for treating a viral disease with the bacterial inflammation of a febrile disease and have a wider clinical application range. Moreover, the invention optimizes and designs the extracting and refining process according to the physicochemical properties of the effective components, the active parts obtained through preparation has high effective component contents, and the preparation method has strong maneuverability and can realize industrialized mass production.
Owner:NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE

Chinese herbal compound effective composite for treating dysmenorrhea and preparation method and application thereof

The invention discloses a Chinese herbal compound effective composite and a preparation method and application thereof. The effective composite is prepared by carrying out precipitation on Chinese herbal compound water decoction consisting of Chinese angelica, szechuan lovage rhizome, rehmannia glutinosa, white paeony root, nutgrass galingale rhizome, costustoot and rhizoma corydalis by ethanol to remove impurities, then using a macroporous absorption resin column, using ethanol to carry out gradient elution and purification and recovering the solvent of eluent. The invention selects the raw materials to compose prescription compatibly according to the theory of traditional Chinese medicine and the pathogenesis of dysmenorrhea. Pharmacological tests show that the Chinese herbal compound effective composite provided by the invention has good anticoagulation, has effect of preventing formation of blood stasis, has clearer ingredients and lower untoward effect, and is expected to be developed into a novel generation of medicine for treating dysmenorrhea.
Owner:NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE

Traditional Chinese medicine for treating insulin resistance of type 2 diabetes

The invention relates to a traditional Chinese medicine for treating insulin resistance of type 2 diabetes, and is used for solving the problem that the safe and efficient drugs for treating insulin resistance of type 2 diabetes are not available at present. The traditional Chinese medicine for treating insulin resistance of type 2 diabetes is prepared from the following components in parts by weight: 10-20 parts of American ginseng, 20-40 parts of coix seed and 10-20 parts of alisma. The traditional Chinese medicine has mild drug property and low toxic and side effect, and is used for treating insulin resistance of type 2 diabetes with the main characteristics, such as deficiency of spleen qi and interior accumulation of dampness and turbid. Compared with the similar traditional Chinese medicines, the traditional Chinese medicine has clear main active ingredients and definite disease treatment effect, and can obviously improve insulin resistance of type 2 diabetes.
Owner:HEILONGJIANG UNIV OF CHINESE MEDICINE

Patrinias cabra aglycon extraction and its preparation method and anti colon cancer application

The invention relates to a medicine treating carcinoma of colon and the method for preparing the same, which in detail is aglycone extract from root of Patrinia scabra Bge and the preparation method. The effective component is iridoid glycosides aglycone, the content is above 40%. The invention also provides the medicine agent and preparation. It is proved by pharmacologia test that the medicine is characterized by safe utilization, function of preventing the weight of tumor in transplanted carcinoma of colon. The extract can be produced into preparations of tablet, capsule, drop pill, granular or oral.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY

Chinese medicine compound effective part with effect of treating arthritis

ActiveCN103405487AEffective parts and active ingredients are clearGood anti-inflammatory effectAntipyreticAnalgesicsDiseaseMyrrh
The invention discloses a Chinese medicine compound effective part with an effect of treating arthritis. The effective part is prepared via the steps as follows: 10-50 parts of frankincense and 10-50 parts of myrrh are abstracted via water or alcohol, impurities are removed via alcohol deposition, and the frankincense and the myrrh are placed on a macropore adsorption resin column, and eluted and purified with alcohol gradient with optimized concentrate. The effective part is refined and prepared via modern analytical apparatuses and pharmacological experiments section and according to Chinese medicine theories, the pathogenesis of rheumatic and rheumatoid arthritis. Shown by the experiment result, the Chinese medicine compound effective part provided by the invention has the good effects of antiphlogosis, pain easing, immunization regulation and the like, can be used for treating rheumatic and rheumatoid arthritis, proliferative arthritis, and inflammation pain diseases, is clear in ingredient, low in clinical dosage and lower in adverse reaction, and possibly can be developed as a new generation of medicine for treating the arthritis.
Owner:南京百草和康医药科技有限公司

Ganoderma spore oil fat emulsion and quality control method and application thereof

The invention discloses ganoderma spore oil fat emulsion and quality control method and application thereof, comprising 2 percent to 25 percent of ganoderma spore oil, 0.5 percent to 10 percent of emulsifier, 0.2 percent to 5 percent of isotonic agent, and the rest of water; the final pH of the fat emulsion is adjusted to be six to nine. By accurately measuring the contents of 1, 2-oleic acid-3-palm acid triglyceride and glycerin trioleate as well as ergosterol in the preparation, the quality control method is used as the method and basis for controlling the product quality. By using a fingerprint, the product quality is controlled from the overall chromatographic feature appearance. The invention has clear product active ingredient and good biological activity, can be used for treating the tumor and enhancing the immune capacity of an organism, improves the survival quality of the radiotherapy and chemotherapy tumor patients and alleviates the drug toxicity after the treatment. The product is especially suitable for artery and intravenous injection; the ganoderma spore oil directly enters the human blood; and the product has the advantages of fast effect, complete absorption, high security, reliable quality and low toxicity.
Owner:GUANGZHOU HANFANG PHARMA

Application of bilobalide as synergist in preparation of drug for preventing cranial nerve injury diseases

The present invention discloses application of bilobalide as a synergist in preparation of a drug or a heath product for preventing cranial nerve injury diseases. An inventor discovers that compounds of bilobalides, particularly bilobalide, bilobalide extracts, and hydroxyl derivatives of bilobalides, particularly glucoside derivatives, ester derivatives and ether derivatives can well promote drug molecules with a treating or health care function on cranial nerve injury diseases to enter brain tissues, wherein the drug molecules comprise ginsenoside, stibene glucoside, resveratrol, levodopa, edaravone, vinpocetine, nicergoline, citicoline, oxiracetam and the like; under the conditions of not increasing drug concentration in blood, the concentration of bilobalide can be increased to a large extent in the brain tissues, so that the efficacy of the drug can be improved, and side effects and adverse reactions of the drug can be reduced.
Owner:GUANGDONG PHARMA UNIV

Chinese wampee fruit extract and application thereof in preparation of medicine for preventing and treating alzheimer disease

The invention relates to a Chinese wampee fruit extract and application thereof in preparation of a medicine for preventing and treating an alzheimer disease. The prepared Chinese wampee fruit extract disclosed by the invention can be applied to the medicine for preventing and treating the alzheimer disease as a new method for preventing and treating the alzheimer disease. The medicine disclosed by the invention has the effects of resisting oxidation, inhibiting generation of Abeta, reducing activation of astrocyte cells, and protecting nerve cells, so that the cognitive disorder caused by the disease can be effectively relieved; and the Chinese wampee fruit extract has a relatively good effect on prevention and treatment of the alzheimer disease.
Owner:GUANGDONG MEDICAL UNIV

Use of bufadienolide compound in preparing medicines for treating oral mucosal malignant tumors

The invention discloses a use of a bufadienolide compound in preparing medicines for treating oral mucosal malignant tumors. Anti-cancer experiments of human tongue squamous cancer cells are carried out in vitro through a bufadienolide extract and monomeric compounds, namely gamabufalin, arenobufagin, telocinobufagin, bufotaline, cinobufagin, desacetylcinobufotalin, heloniogenin, resibufogenin, and cinobufotalin, and experimental results show that the bufadienolide compound has strong inhibition effect on tongue squamous cancer cells and compared with the bufadienolide extract and eight monomeric compounds, namely gamabufalin, arenobufagin, telocinobufagin, bufotaline, desacetylcinobufotalin, heloniogenin, resibufogenin, and cinobufotalin, cinobufagin has a stronger anti-tumor cell activity. The bufadienolide compound provided by the invention has clear components, controllable quality, strong anti-tumor activity and little adverse reaction and is expected to be developed into a novel anti oral mucosal malignant tumor medicine.
Owner:NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE

Food for resisting and recovering from drunkenness

InactiveCN102106544AActive ingredient clearStabilizes anti-drunkness and hangover effectFood preparationVitamin CSide effect
The invention discloses food for resisting and recovering from drunkenness, which comprises the following components based on the intake every day: 2 to 10 milligrams of octacosanol, 20 to 100 milligrams of vitamin E, 0.5 to 3 grams of konjac powder, and 100 to 500 milligrams of vitamin C. Known natural extracts with definite active ingredients and stable content are used as main raw materials in the food, so the food has stable effect of resisting and recovering from drunkenness and can eliminate the drunken symptoms of excessive drinking persons such as dizziness, intestine and stomach discomfort, liver discomfort and thirst, and normal body conditions of the excessive drinking persons are recovered in short time. The raw materials of the formula are edible safe materials, and any chemical additive is not contained, so the food is safe to use and has no toxic or side effect.
Owner:SOUTHWEST UNIV

Maca extract with sexual dysfunction improving function and preparation method and application thereof

The invention relates to a maca extract with sexual dysfunction improving function and a preparation method and application thereof. The maca extract is an effective part which is extracted from maca, and mainly consists of maca amide active ingredients, such as N-benzyl linenamide, N-benzyl linoleamide, and N-benzyl hexadecanamide. In the maca extract of effective part, the content of maca amide is 30% to 100%. The invention also provides a preparation method of the maca extract, an active ingredient content measuring method and application. The maca extract has the advantages that the function of improving sexual dysfunction, improving fertility and resisting fatigue is good, and the effect is better than the effect of the maca raw material. The preparation method of the maca extract has the advantages that the preparation method is normal and standard, the technology is simple, and the industrialized production is easy; the content of effective component in maca extract is higher, and the medicine effect is clear.
Owner:YUNNAN INST OF MATERIA MEDICA

Chinese traditional medicine composition for relieving side effects of hormones

InactiveCN1733244AReduce hormone side effectsDoes not interfere with the positive effect of hormone immunosuppressionDrug compositionsPlant ingredientsSide effectAnemarrhena asphodeloides
The invention discloses a Chinese traditional medicine composition for relieving side effects of hormones, wherein the composition comprises barren wort flavones extract, anemarrhena rhizome saponins extract and glycyrrhetinic acid. The invention also discloses the process for preparing medicament for reducing side effect of hormones.
Owner:SHANGHAI CENT OF RES & DEV OF NEW DRUGS

Antineoplastic traditional Chinese medicine preparation and preparation method thereof

InactiveCN101342179ASolve the problem of poor solubilitySolve the problem of not being easily soluble in waterOrganic active ingredientsPharmaceutical non-active ingredientsChemical synthesisNatural product
An anti-tumor Chinese medicine product comprises medicine, reagent, food and drink and is characterized in that the effective component of the Chinese medicine product is a betulic acid liposome containing betulic acid. The entrapment rate of the betulic acid liposome reaches over 90 percent and particle diameter is 100 to 1000 nanometers. Firstly, the betulic acid plastid is obtained by membrane process; and then the single betulic acid liposome or the betulic acid liposome as well as other chemical substances comprising a pharmaceutically acceptable carrier, the food, a natural product, synthetic chemicals or medicine composition for human are made into the medicine, the food or the drink by general process.
Owner:中国人民解放军第四五四医院 +1

Rhizoma cyperi four-drug decoction transdermal patch and preparation method thereof

The invention discloses a rhizoma cyperi four-drug decoction transdermal patch and a preparation method of the rhizoma cyperi four-drug decoction transdermal patch. The patch comprises a heating bag, a back lining layer fixed on the heating bag, a medicine-containing base material layer fixed on the back lining layer and an anti-sticking layer covering the medicine-containing base material layer, wherein the medicine-containing base material layer comprises 30-70 parts of hydrogel base material, 10-50 parts of rhizoma cyperi four-drug decoction extracting part and 10-40 parts of a transdermal accelerant. The transdermal patch disclosed by the invention has scientific and reasonable component proportions and great medicine loading amount; and an organic solvent does not need to be added in a preparation process so that the patch has no skin irritation and sensitization. An experiment result shows that the transdermal patch has the very good effect of treating primary dysmenorrheal; the biological utilization rate is high; the transdermal patch can be continuously released at a constant speed and is good for keeping a stable blood medicine concentration; the pesticide effect time is long; and a preparation process of the patch has strong operability and can realize industrial production.
Owner:NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE

Medicine composition and application thereof in preparation of medicines for treating depression

The invention discloses a medicine composition for treating depression. The medicine composition consists of the following four components: geniposide, naringin, neohesperidin and magnolol; the medicine composition comprises the following components in parts by weight: 5-20 weight parts of geniposide, 5-20 weight parts of naringin, 5-20 weight parts of neohesperidin and 0.5-2 weight parts of magnolol; and preferably, the medicine composition comprises the following components in parts by weight: 10 weight parts of geniposide, 10 weight parts of naringin, 10 weight parts of neohesperidin and 1 weight part of magnolol. The composition disclosed by the invention can be used for preparing medicines for treating depression, and has the advantages of accurate composition, significant medicine effect, safety and reliability.
Owner:CHINA PHARM UNIV

Combinaton of medication for treating depression and preparation method

A composite medicine for treating depression is prepared from pachyman (3.5-14 g) and ginger oil (0.2-3.5g) through proportioning, including ginger oil by beta-cyclodextrin, and mixing. Its advantages are sure curative effect and high safety.
Owner:NANJING UNIV

Myrrh target area for treatment of gynecological tumor and preparation method and application thereof

The invention discloses a myrrh target area for treatment of gynecological tumors and a preparation method and application thereof. The preparation method comprises the following steps: extracting with alcohol for myrrh and other solvents through supercritical fluid extraction, impregnation or reflux extraction to obtain alcohol extract; concentrating, suspending the concentrate with water, extracting with ether, petroleum ether, n-hexane or other low-polar solvents to obtain low-polar solvents extract; and concentrating, thereby obtaining the myrrh target area with 0-5 weight percent of diterpene and 0-30 weight percent of diterpenoid resin acid components. The invention combines the modern extraction and separation and the pharmacological activity screening to determine the optimal target area, the active ingredients of the prepared target area are clearer, the contents of the active ingredients are high and the results of in vitro anti-tumor experiments show that the myrrh target area provided by the invention has the function of inhibiting and killing multiple kinds of gynecological tumors with low dosage, and is expected to be developed as the novel traditional Chinese medicine with significant treatment effect and fewer low adverse reactions.
Owner:NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE

Transdermal patch for preventing and treating lumbar disc herniation and preparation method thereof

The invention discloses a transdermal patch for preventing and treating lumbar disc herniation and a preparation method thereof. The transdermal patch includes a back lining layer, a drug-containing substrate layer fixed on the back lining layer and an anti-sticking layer covering the drug-containing substrate layer. The drug-containing substrate layer includes 15-45 parts of a hydrogel substrate, 15-45 parts of a volatile oil part, 30-90 parts of an ethanol refined extract and 8-24 parts of a transdermal penetration enhancer. The traditional Chinese medicines of the transdermal patch are matched scientifically and reasonably and the transdermal patch has a large carrying capacity. A test result proves that the hydrogel transdermal patch has significant effects of inflammation resistance, blood activation and pain relieving, has an excellent effect of treating the lumbar disc herniation, has a long-action slow-releasing effect of slowly releasing active drug components durably, is convenient to use, and is free of stimulation and allergy on skin.
Owner:HEILONGJIANG UNIV OF CHINESE MEDICINE

Preparation for anti-tumor compound medicine active ingredients

The invention provides preparation for anti-tumor compound medicine active ingredients. The compound comprises the following medicines: sculellaria barbata, Chinese lobelia, oldenlandia diffusa and windpipe trachea. The preparation for compound medicine active ingredients comprises the following steps: first, all the medicinal materials of the compound are crushed; second, extraction is carried out with medicinal ethanol for 3 times, filtration is carried out and the extraction solutions are mixed, ethanol is recycled and a dry extract is obtained; third, the dry exact is subjected to ultrasonic dissolution with water, a suspension is obtained, extraction is carried out for 3-5 times by utilization of isopyknic ethyl acetate, the extraction solutions are mixed, heating decolouring is carried out with active carbon, ethyl acetate is recycled and a solid is obtained; fourth, the solid is dissolved through squeezing with petroleum ether, filtration is carried out, insoluble substances are obtained, namely the active ingredients are obtained. The anti-tumor effects are stable, the active components are clear, the quality is controllable, the technology is simple, the preparation method is suitable for industrial production and the officinal prospect is wide.
Owner:CHIFCON DRUG DISCOVERY SUZHOU

Effervescent tablets and preparing method and application thereof

ActiveCN110150528AClear efficacyRelatively high content of ingredientsFood thermal treatmentPill deliveryBULK ACTIVE INGREDIENTBran
The invention discloses effervescent tablets and a preparing method and application thereof. The effervescent tablets comprise active components and auxiliary materials, wherein the active componentscomprise, by mass, 5-30 parts of an extract 1, 10-30 parts of an extract 2, 10-20 parts of an extract 3, 5-20 parts of an extract 4 and 15 parts of an extract 5. The extract 1 is prepared from 30 or 35 parts of fruits of actinidia arguta, 20-40 parts of abelmoschus esculentus and 10-40 parts of Chinese yam; the extract 2 is prepared from 30 or 40 parts of mulberry fruits, 20-50 parts of black currants and 10-40 parts of blueberries; the extract 3 is prepared from 5 parts of radix codcnopsitis pilosulas, 5-10 parts of rhizome chuanxiong, 20-30 parts of herba taraxaci, 20-30 parts of roasted malt, 5-10 parts of fructus evodiae and 10-30 parts of fructus ziziphi jujubae. The extract 4 is prepared from black rice bran; the extract 5 is prepared from honey. The effervescent tablets are appliedto preparing products with the function of alleviating and restoring gastric ulcers, at least one activity function of resisting oxidation, resisting fatigue, resisting tumors and reducing blood sugarand the effect of protecting the liver.
Owner:广东海亿健康科技有限公司
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