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Medicine composition and application thereof in preparation of medicines for treating depression

A composition and technology for depression, which is applied in the field of natural plant active ingredient composition, can solve the problems of large adverse reactions of antidepressant chemical drugs and insufficient curative effect of finished drugs, and achieve obvious antidepressant activity, significant drug effect and low toxicity Effect

Inactive Publication Date: 2015-05-20
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to solve the problem that the current antidepressant chemical drugs have relatively large adverse reactions and the curative effect of antidepressant Chinese patent medicines is not significant enough. The prepared composition and its application in the preparation of medicines for treating depression

Method used

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  • Medicine composition and application thereof in preparation of medicines for treating depression
  • Medicine composition and application thereof in preparation of medicines for treating depression
  • Medicine composition and application thereof in preparation of medicines for treating depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 The effect of the pharmaceutical composition on the behavior of the behavioral despair model mice and the monoamine neurotransmitters in the brain:

[0017] Animals: Kunming male mice, weighing 25±2g, were divided into random groups, 10 mice in each group.

[0018] Preparation of the pharmaceutical composition for gavage: take these 4 kinds of commercially available Chinese medicine ingredients (the purity of which is all required to be 95% or above), and mix them according to 10 parts by weight of geniposide, 10 parts by weight of naringin, and 10 parts by weight of neohesperidin. Parts by weight, 1 part by weight of magnolol, which can be obtained by dispersing it in 1% sodium carboxymethylcellulose solution.

[0019] Separately take appropriate amounts of geniposide, naringin, neohesperidin and magnolol, respectively dissolve or disperse them in 1% sodium carboxymethylcellulose solution to obtain solutions for intragastric administration of each component. ...

Embodiment 2

[0031] The drug effect contrast test of embodiment 2 pharmaceutical composition and Naolejing

[0032]Naolejing is a variety recorded in the 2005 edition of the Chinese Pharmacopoeia for the treatment of depression, and its curative effect is definite. Its main ingredients are licorice extract, jujube and wheat; its function and indications are to nourish the heart and calm the nerves, and it is used for mental depression, insomnia, and irritability caused by mental disorders. In order to compare the drug effect difference between the pharmaceutical composition of the present invention and Naolejing, the following test was carried out.

[0033] Animals: Kunming male mice, weighing 25±2g, were divided into random groups, 10 mice in each group.

[0034] Preparation of the pharmaceutical composition for gavage: take these 4 kinds of commercially available Chinese medicine ingredients (the purity of which is all required to be 95% or above), and mix them according to 10 parts by ...

Embodiment 3

[0042] The acute toxicity test (maximum tolerance dose test) of embodiment 3 pharmaceutical composition to mice

[0043] Animals: 20 Kunming mice, half male and half male, weighing 18±2g.

[0044] Preparation of the pharmaceutical composition for gavage: take these 4 kinds of commercially available Chinese medicine ingredients (the purity of which is all required to be 95% or above), and mix them according to 10 parts by weight of geniposide, 10 parts by weight of naringin, and 10 parts by weight of neohesperidin. Parts by weight, 1 part by weight of magnolol, which can be obtained by dispersing it in 1% sodium carboxymethylcellulose solution.

[0045] The comparative drug is amitriptyline hydrochloride tablet, which is obtained after being ground and dispersed in 1% sodium carboxymethylcellulose solution.

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PUM

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Abstract

The invention discloses a medicine composition for treating depression. The medicine composition consists of the following four components: geniposide, naringin, neohesperidin and magnolol; the medicine composition comprises the following components in parts by weight: 5-20 weight parts of geniposide, 5-20 weight parts of naringin, 5-20 weight parts of neohesperidin and 0.5-2 weight parts of magnolol; and preferably, the medicine composition comprises the following components in parts by weight: 10 weight parts of geniposide, 10 weight parts of naringin, 10 weight parts of neohesperidin and 1 weight part of magnolol. The composition disclosed by the invention can be used for preparing medicines for treating depression, and has the advantages of accurate composition, significant medicine effect, safety and reliability.

Description

1. Technical field: [0001] The present invention relates to the composition of natural plant active ingredients and its medicinal application, in particular to preparing the composition of geniposide, naringin, neohesperidin and magnolol into a medicine for treating depression. 2. Background technology: [0002] Depression is an affective or mood disorder. The basic clinical manifestation is a significant and persistent low mood, showing a state of no desire, boredom, helplessness, hopelessness, and no pleasure. In severe cases, suicidal thoughts appear. In addition to pathological emotional or mood changes, depression also has cognitive function changes and other neurological symptoms, such as inattention, impaired learning and memory, slow thinking, self-blame, guilt, and even delusions. In addition, appetite, sleep disturbance, autonomic nervous dysfunction, and idiopathic pain are also common accompanying symptoms. Depression is a common mental illness with a lifetime p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P25/24A61K31/05
Inventor 冯芳叶小敏李茜茜
Owner CHINA PHARM UNIV
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