52results about How to "Good antidepressant activity" patented technology

The invention relates to the novel use of pharmaceutical preparations in the field of pharmacy, more specifically the use of barrenwort flavones and barrenwort glycosides monomers as active components in preparing medicament for preventing and treating suppression. Pharmaceutical test shows that, the barrenwort flavones and barrenwort glycosides monomer can appreciably shorten rat's tail suspension time and forced swimming standby time, reverse the decrease of mouse sucrose consumption caused by CMS, suppress animal brain monoamines oxidation enzyme an and B, thus achieving the purpose of suppression resistance.

An application of helicidum analog in preparing medicines for preventing and treating depression is disclosed. Its chemical structure is also disclosed.

The invention discloses a preparation method of caulis spatholobi extract and an application. The preparation method comprises the following detailed steps of: taking crude caulis-spatholobi powder, adding into a solvent, heating for extraction, and after vacuum concentration to certain concentration, adding an organic solvent for precipitation; and filtering, taking filtrate, performing vacuum concentration, drying and obtaining the caulis spatholobi extract. The preparation method and the application disclosed by the invention have the advantages that the medicine taking resource is rich, the extract preparation method is simple and easy, the material is convenient and easy to obtain, and the preparation method can be used for large-scale preparation of the caulis spatholobi extract; and the cost is low, the pollution is less, the benefit for large-scale production under the conditions of saving energy and reducing emission is achieved and the industrial prospect is very clear. The caulis spatholobi extract can be used for multiple purposes from foods and health-care products to preparation of medicines for special diseases so as to have scientific basis for clinic application in the aspect of preventing or treating depression.

The invention belongs to the technical field of medicine and relates to a pharmaceutical composition with an anti-depression effect. The pharmaceutical composition is prepared from, by weight, 5-100 parts of morinda roots, 5-100 parts of fructus gardenia, 5-100 parts of poria cocos and 1-50 parts of fermented soybeans. The pharmaceutical composition is a refined formula determined with the theory of traditional Chinese medicine as the basis and the modern pharmacological study result as indexes, and can remarkably relieve somatic symptoms such as vigor deficiency, sleep disorder and anorexia of patients while treating mental symptoms such as the amorphous type, hebetude, retardation of thinking and bulesis reduction of depression patients.

The invention discloses an application of an anti-depression compound on the preparation of anti-depression drugs and anti-depression health-care foods. The structure of the anti-depression compound is shown in the formula I. The anti-depression compound serves as the only active ingredient or one of active ingredients of the anti-depression health-care foods. The anti-depression compound is a liquid preparation or a solid preparation or a spray preparation or an aerosol preparation or the like. According to the application of the anti-depression compound on the preparation of the anti-depression drugs and the anti-depression health-care foods, the chemical structure of the anti-depression compound is different from that of any known anti-depression drug, the anti-depression compound has prominent anti-depression activity, obvious toxic and side effects do not occur, marketizing large-scale utilization and popularization are facilitated, and wide application prospects are achieved. (Please see the formula I in the specification.).

The invention relates to a new use of 20(S)-protopanoxadiol derivatives and 20(S)-protopanaxatriol derivatives, and mainly relates to a use in the preparation of medicines for treating or preventing depressive mental diseases. 20(S)-protopanoxadiol and 20(S)-protopanaxatriol are used as raw materials, and undergo oxidative cyclization to prepare dammara-20S-24(R)-epoxy-3beta,12beta,25-triol, dammara-20S-24(S)-epoxy-3beta,12beta,25-triol, dammara-20S-24(S)-epoxy-3beta,6beta,12beta,25-tetrol or dammara-20S-24(R)-epoxy-3beta,6beta,12beta,25-tetrol. Researches of pharmacological experiments show that dammara-20S-24(R / S)-epoxy-3beta,12beta,25-triol and dammara-20S-24(R / S)-epoxy-3beta,6beta,12beta,25-tetrol can obviously shorten the tail immobility time of mice in mouse tail suspension tests of a classic depression model, and can obviously shorten the swimming immobility time of the mice in mouse forced swimming model tests, so dammara-20S-24(R / S)-epoxy-3beta,12beta,25-triol and dammara-20S-24(R / S)-epoxy-3beta,6beta,12beta,25-tetraol have potential development values in the preparation of medicines for treating or preventing depressive mental diseases.

The invention discloses a compound preparation capable of resisting depression, and a preparation method thereof. The compound preparation consists of the following raw materials: hypericum perforatumherba, paeoniae alba radix, fructus gardenia, flos albiziae and moutan cortex. The raw materials are weighted according to a ratio, extracts are independently obtained, and the extracts are mixed toprepare the compound preparation. The compound preparation prepared by the preparation method has the advantages of being simple in preparation, safe, small in toxic and side effect, free from dependence and the like, and can effectively alleviate depressive emotions.

The invention discloses a medicine composition for treating depression. The medicine composition consists of the following four components: geniposide, naringin, neohesperidin and magnolol; the medicine composition comprises the following components in parts by weight: 5-20 weight parts of geniposide, 5-20 weight parts of naringin, 5-20 weight parts of neohesperidin and 0.5-2 weight parts of magnolol; and preferably, the medicine composition comprises the following components in parts by weight: 10 weight parts of geniposide, 10 weight parts of naringin, 10 weight parts of neohesperidin and 1 weight part of magnolol. The composition disclosed by the invention can be used for preparing medicines for treating depression, and has the advantages of accurate composition, significant medicine effect, safety and reliability.

The invention discloses rubus parvifolius fractional polysaccharide, a preparation method and an application of the rubus parvifolius fractional polysaccharide in depression resistance. The inventionprovides the fractionated polysaccharide which is extracted and separated from the rubus parvifolius leaves and has the alcohol solubility of 40%-50%, the polysaccharide content is (95.3+ / -2.7)%, andthe purity is high; it is found that the rubus parvifolius fractional polysaccharide can remarkably shorten the tail suspension immobility time and the swimming immobility time in a mouse tail suspension test and a mouse forced swimming test, plays a role similar to that of a positive drug, and has obvious anti-depression activity. The rubus parvifolius polysaccharide provided by the invention isa natural active polysaccharide and has no toxic or side effect.

A composite medicine for treating depression is prepared from pachyman (3.5-14 g) and ginger oil (0.2-3.5g) through proportioning, including ginger oil by beta-cyclodextrin, and mixing. Its advantages are sure curative effect and high safety.

The present invention provides compounds with antidepressant activity and a preparation method thereof. The molecular formula of the compound is C13H17NO2Cl, the molecular weight is 252.5, the meltingpoint is 207 DEG C, and the structural formula is shown in the specification. The preparation method comprises the following steps: adding 3-methyl-4-nitrobenzoic acid and thionyl chloride into a first reaction container, stirring, dissolving and uniformly mixing the mixture, and condensing and refluxing the mixture at the temperature of 80 + / -3 DEG C to obtain acyl chloride A1; dropwise adding the acyl chloride A1, cooled to 0 DEG C, into a second reaction container to obtain an intermediate product A2; dissolving A2 in DMF, and adding the solution into a third reaction container to obtain an intermediate product A3; adding the obtained intermediate product A3 into a fourth reaction container to obtain a crude product, and treating the crude product in a chromatographic column to obtainan intermediate product A4; and adding the obtained intermediate product A4 into a sixth reaction container to obtain a powdery solid A5, which is the compound with the antidepressant activity.

The invention belongs to the field of medical treatment, and particularly relates to a morpholine benzamide compound and application thereof, the morpholine benzamide compound has a compound structureshown as a formula (A), and the compound can be applied to antidepressant drug treatment.

The invention discloses xanthone compounds and their use in depression resistance. The xanthone compounds are compounds shown in the structural formula (I) or their pharmaceutically acceptable salts. An experiment proves that the xanthone compounds have good depression-resistant activity and a part of the xanthone compounds have depression-resistant activity superior to that of venlafaxine. Therefore, the xanthone compounds and their pharmaceutically acceptable salts can be used for preparation of depression-resistant drugs.

The invention discloses an application of gecko or extract thereof in preparation of an antidepressant drug. The gecko is the dried body obtained by removing internal organs of Gekko gecko Linnaeus, and the gecko extract is ethanol extract of the gecko. An extraction method of the gecko extract comprises the following steps of taking the gecko, adding ethanol, performing soaking for 40-80 minutes,performing heating, carrying out reflux extraction for 40-80 minutes, performing filtration, repeatedly carrying out reflux extraction on filter residues for multiple times, finally combining filtrates obtained by multiple times of extraction, performing concentration, and recovering the ethanol to obtain the gecko extract. It is found for the first time that the gecko or the extract thereof hasobvious anti-depression activity and has the patent medicine potential of preparing a medicinal preparation for preventing or treating depression and related diseases, and the preparation method of the medicinal preparation is simple, low in cost and good in patent medicine economic benefit.

The invention discloses a traditional Chinese medicine extract with an anti-depression effect and application thereof. 300 to 600 parts of ginseng root, 200 to 400 parts of thinleaf milkwort root, 200 to 400 parts of grassleaf sweelflag rhizome and 300 to 600 parts of Indian bread as active pharmaceutical ingredients are added with water and extracted, and extract is taken out and concentrated, so that concentrate is obtained; the concentrate is purified by a macroporous resin column, water is first used for removing impurities, ethanol of optimal volume is then adopted for elution, so that eluent is obtained, and the traditional Chinese medicine extract is obtained by concentration. Demonstrated by a mouse tail suspension and swimming depression model and PC12 cell and C6 cell models, the traditional Chinese medicine extract provided by the invention has an effect of obviously improving depressive emotion, inhibiting neurotransmitter degradation and promoting neurotrophic factor expression, the therapeutic effect is reliable, safety is high, adverse reaction is low, and the traditional Chinese medicine extract can be used for preparing anti-depression drugs.

Belonging to the technical field of traditional Chinese medicines and natural drugs, the invention specifically relates to a Chinese medicinal composition, a preparation method and application thereof. The Chinese medicinal composition is characterized by being prepared from the following Chinese herbal medicines by weight: 10-40 parts of poria, 10-40 parts of pinellia ternata, 10-40 parts of radix bupleuri, 10-40 parts of Fructus aurantii Immaturus, 10-40 parts of Radix Paeoniae Alba, 10-40 parts of Magnolia officinalis, 6-24 parts of licorice, 10-40 parts of gardenia, and 10-40 parts of perilla leaf. The Chinese medicinal composition provided by the invention can be prepared into clinically suitable oral preparations according to traditional Chinese medicine conventional preparation methods. The Chinese medicinal composition significantly shortens the immobility time of mouse tail suspension and forced swimming, significantly increases the hand shaking time of mice given 5-hydroxytryptophan, has a significant antagonistic effect on mouse blepharoptosis and hypothermia caused by reserpine, and significantly antagonizes mouse body temperature decline caused by high dose apomorphine. According to the invention, research results show that the Chinese medicinal composition has a significant anti-mouse experimental depression effect.

The invention discloses an application of semiliquidambar cathayensis or an extract thereof in preparation of an antidepressant drug, the semiliquidambar cathayensis is a dry root of Semiliquidambar cathayen.sis Chang, the extract of semiliquidambar cathayensis is an aqueous extract of semiliquidambar cathayensis or an organic solvent extract of semiliquidambar cathayensis. The extraction method of the extract is as follows: taking the semiliquidambar cathayensis, adding a solvent for soaking treatment, heating for extraction, combining liquid medicines extracted for multiple times and concentrating to obtain the extract. It is found for the first time that semiliquidambar cathayensis or the extract of semiliquidambar cathayensis has the obvious anti-depression activity and has the patentmedicine potential for preparing medicine preparations for preventing or treating depression and related diseases, the preparation method of the medicine preparations is simple, the cost is low, and the patent medicine economic benefits are good.

The invention discloses an antidepressant compound preparation and a preparation method thereof, which is composed of the following raw materials: Hypericum perforatum, Radix Paeoniae Alba, Gardenia, Albizia Julibrissin and Cortex Moutan. Raw materials are weighed in proportion to obtain extracts respectively, and mixed to form a compound preparation. The compound preparation prepared by the present invention has the advantages of simple preparation, safety, less toxic and side effects, no dependence, etc., and can effectively relieve depression.

The invention provides a compound with anti-depression activity and a preparation method and application of the compound, and relates to the technical field of medicine and chemical engineering. The structural formula is as shown in the specification. The structure of the compound is different from that of an existing morpholine compound; and the compound has a bran-new molecular structure and also has good anti-depression activity.

The invention relates to a new protopine alkaloid and a preparing method and application thereof, and belongs to the technical field of phytochemistry. The molecular formula of the new protopine alkaloid is C31H34N2O6, and the new protopine alkaloid is a new compound separated and extracted from active parts of rhizoma corydalis decumbentis; meanwhile, the new compound of the new protopine alkaloid has significant anti-depression activity, and an important theoretical foundation and an experiment basis are laid for China to develop anti-depression drugs with independent intellectual property from the rhizoma corydalis decumbentis.

A single chiral compound with antidepressant activity and a preparation method and application thereof are related to the technical field of pharmaceutical chemicals. The single chiral compound has a following structural formula. The structure of the compound is different from that of an existing antidepressant compound, and the compound has a novel molecular structure and has good antidepressant activity.

The invention discloses a total flavonoid extract with antidepressant effect and a preparation method and application thereof. The total flavonoid extract is prepared according to the following preparation method: adding an extraction solvent to dodder seed powder, heating and refluxing for extraction, combining filtrates, and concentrating to obtain The extract; the extract is added to the polyamide column and the macroporous resin column respectively for chromatography, and the obtained eluate is concentrated to obtain the total flavonoid extract of Dodder. The total flavonoids extract prepared by the invention has high purity, and the experimental results show that the total flavonoids of Dodder can obviously shorten the immobility time of TST and FST of CUMS mice without affecting their autonomous activities, indicating that the total flavonoids of Dodder has strong anti-inflammatory properties. Depressive effect and no central excitatory or inhibitory effect. Moreover, total flavonoids from Dodder can activate the TXNIP / NLRP3 inflammasome signaling pathway, which proves that total flavonoids from Dodder can exert antidepressant effect by regulating the TXNIP / NLRP3 inflammasome pathway.

The invention discloses xanthone compounds and their use in depression resistance. The xanthone compounds are compounds shown in the structural formula (I) or their pharmaceutically acceptable salts. An experiment proves that the xanthone compounds have good depression-resistant activity and a part of the xanthone compounds have depression-resistant activity superior to that of venlafaxine. Therefore, the xanthone compounds and their pharmaceutically acceptable salts can be used for preparation of depression-resistant drugs.

The present invention discloses a method of extracting and refining extract from medicinal plant Piper laetispicum, the extract thus obtained, and the application of the extract in medicine and food additive for preventing and treating depression, anxiety neurosis and other psychogenic diseases and other fields.

The invention relates to the technical field of compounds, in particular to an anti-depression active substance BHC-one as well as preparation and application thereof. The quinoline-chalcone derivative BHC-one compound can obviously inhibit the immobility time of mice, an inhibition rate reaches 76.4%, and the quinoline-chalcone derivative BHC-one compound shows good anti-depression activity; the quinoline-chalcone derivative BHC-one compound is prepared from common raw materials and reagents such as acetylacetone, citric acid, 1,4-dioxane and the like, and the common raw materials and reagents are easy to obtain; the reagents used in the scheme can be environment-friendly and pollution-free after being slightly treated, and have small harm to the environment; and the preparation method is high in yield and low in impurity content.