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Application of gecko or extract thereof in preparation of anti-depression drug

An extract and depression technology, which is applied in the application field of Gecko or its extract in the preparation of antidepressant drugs, can solve the problems of not containing Gecko extract, etc., and achieve low cost, good industrialization prospects, and little pollution Effect

Active Publication Date: 2021-03-16
GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] It can be seen that there are many studies on Gecko at present, but the existing public literature only discloses the use of Gecko in the aspects of nourishing the lungs and kidneys, assisting Yang and replenishing essence, nourishing Qi and calming asthma, anti-tumor, and enhancing immune function; Gecko extract is not used in medicines for the treatment of depression and related diseases caused by it, and the medicine for treating or suppressing depression does not contain gecko extract

Method used

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  • Application of gecko or extract thereof in preparation of anti-depression drug
  • Application of gecko or extract thereof in preparation of anti-depression drug
  • Application of gecko or extract thereof in preparation of anti-depression drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Preparation of Gecko Extract

[0024] Take 1 kg of Gecko, add 6L of ethanol with a volume concentration of 90% and soak for 60 minutes, then heat for reflux extraction for 60 minutes, filter, and collect the filtrate; Collect the filtrate; add 6 L of ethanol with a volume concentration of 90% to the filter residue, continue heating for reflux extraction for 60 minutes, filter, and collect the filtrate; combine the three extracts and concentrate to recover ethanol to form a paste.

Embodiment 2

[0025] Example 2 Preparation of Gecko Extract

[0026] Take 1 kg of gecko, add 4L of ethanol with a volume concentration of 95% and soak for 80 minutes, then heat for reflux extraction for 40 minutes, filter, and collect the filtrate; Collect the filtrate; add 4L of ethanol with a volume concentration of 95% to the filter residue, continue heating for reflux extraction for 40 minutes, filter, and collect the filtrate; combine the three extracts and concentrate to recover ethanol to form a paste.

Embodiment 3

[0027] Example 3 Preparation of Gecko Extract

[0028] Take 1 kg of Gecko, add 8L of ethanol with a volume concentration of 85% and soak for 40 minutes, then heat for reflux extraction for 80 minutes, filter and collect the filtrate; Collect the filtrate; add 8L of ethanol with a volume concentration of 85% to the filter residue, continue heating for reflux extraction for 80 minutes, filter, and collect the filtrate; combine the three extracts and concentrate to recover ethanol to form a paste.

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Abstract

The invention discloses an application of gecko or extract thereof in preparation of an antidepressant drug. The gecko is the dried body obtained by removing internal organs of Gekko gecko Linnaeus, and the gecko extract is ethanol extract of the gecko. An extraction method of the gecko extract comprises the following steps of taking the gecko, adding ethanol, performing soaking for 40-80 minutes,performing heating, carrying out reflux extraction for 40-80 minutes, performing filtration, repeatedly carrying out reflux extraction on filter residues for multiple times, finally combining filtrates obtained by multiple times of extraction, performing concentration, and recovering the ethanol to obtain the gecko extract. It is found for the first time that the gecko or the extract thereof hasobvious anti-depression activity and has the patent medicine potential of preparing a medicinal preparation for preventing or treating depression and related diseases, and the preparation method of the medicinal preparation is simple, low in cost and good in patent medicine economic benefit.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to the application of a gecko or an extract thereof in the preparation of antidepressant drugs. Background technique [0002] Depression is an affective disorder and mental illness characterized by low mood, lack of interest, and sleep disturbance. It has two high and one difficult treatment characteristics (high incidence, high recurrence rate, and difficult cure). At present, the drugs used to treat depression are mainly monoamine oxidase inhibitors, monoamine oxidase reuptake inhibitors, tricyclic drugs, etc. These drugs generally have the disadvantages of slow onset of action, low efficiency, and many adverse reactions. There are records of the use of traditional Chinese medicine to treat depression in the classics of traditional Chinese medicine, and the use of traditional Chinese medicine to treat depression in folk clinical practice is effecti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/583A61P25/24A23L33/00
CPCA61K35/583A61P25/24A23L33/00A23V2002/00A23V2200/322
Inventor 何俊慧李力李冬梅韦洁何飞赵成坚李懿韦冬梅韦桂宁
Owner GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI
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