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A kind of traditional Chinese medicine extract with antidepressant effect and application thereof

A technology of extracts, drugs, applied in the field of medicine

Active Publication Date: 2018-01-30
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no relevant report about the use of Pseudomonas and its extracts for antidepressant

Method used

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  • A kind of traditional Chinese medicine extract with antidepressant effect and application thereof
  • A kind of traditional Chinese medicine extract with antidepressant effect and application thereof
  • A kind of traditional Chinese medicine extract with antidepressant effect and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: the preparation of False Betel Extract

[0035] After pulverizing the stems and leaves of Pseudomonas chinensis, put them into the extraction tank, heat them with 80% ethanol for 3 times, each time the amount of solvent is about 10 times the amount of crude drug, each extraction time is 2 hours, combine the extracts and concentrate to dryness , and further dried to obtain the total extract of False Betel, that is, the False Betel extract of the present invention.

[0036] After dissolving the total extract of Pseudomonas in water, extract with equal volumes of petroleum ether, dichloromethane, ethyl acetate, and n-butanol for 3 to 5 times, according to the order of the polarity of the solvents used from small to large (The order of polarity from small to large is: petroleum ether, dichloromethane, ethyl acetate, n-butanol) for extraction. The ethyl acetate fraction of the extract of the betel, the petroleum ether fraction of the extract of the betel, the ...

Embodiment 2

[0037] Example 2: Antidepressant Pharmacodynamics Experiment of False Betel Extract

[0038] 2.1 Experimental materials

[0039] ICR mice, male, weighing 18-22 g, were provided by Shanghai Slack Experimental Animal Co., Ltd., license number: SCXK (Shanghai) 2012-0002. Drink water and eat freely, room temperature (25±2)℃, 12h circadian rhythm. Positive control drug fluoxetine hydrochloride dispersible tablets (Eli Lilly Suzhou Pharmaceutical Co., Ltd., batch number: 2842A, specification: 20 mg). Electronic balance (AL104), Mettler-Toledo Instrument (Shanghai) Co., Ltd., rotary evaporator (RE-52C), Shanghai Qingpu Huxi Instrument Factory.

[0040] 2.2 Experimental grouping and administration

[0041] 2.2.1 Experimental grouping and administration of the total extract of Konjac

[0042] Mice are randomly divided into groups according to body weight, and every group of 10 is divided into blank control group (given same volume of distilled water); positive drug fluoxetine hydro...

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Abstract

The present invention relates to a total extract and active parts of Pseudomonas aeruginosa, its preparation method and its application in preparing medicines or foods for preventing or treating depression. The advantages of the present invention are: the pseudokonjac extract of the present invention and its ethyl acetate extracted parts have significant antidepressant activity and can be used to prepare antidepressant drugs or food; the medication is safe and has no central excitatory or inhibitory effects; the present invention finds high-efficiency and low-efficiency drugs. Drugs that are toxic to treat depression provide a new source for the search for new antidepressant drugs.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the antidepressant effect of the betel extract and its application in medicine or food for the prevention or treatment of depression. Background technique [0002] Depression is a common mental illness that seriously endangers people's physical and mental health. It can be caused by a variety of reasons, with significant and persistent depression as the main clinical feature, mainly depression, loss of interest, pessimism and disappointment, accompanied by symptoms such as psychomotor agitation or hysteresis, low self-evaluation, loss of appetite, and insomnia , In severe cases, suicidal thoughts and behaviors may appear. Statistics show that the lifetime prevalence of depression is 6% to 9%, and about 13% to 20% of the population will be affected by it in a certain period of life. In addition to the severe emotional and social costs of suffering from depression, the economic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/67A61P25/24A23L33/00A61K135/00A61K127/00
Inventor 韩婷秦路平李清瞿发林张巧艳辛海量郑承剑蒋益萍
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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