89results about How to "Shorten immobility time" patented technology

The invention discloses application of Akkermansia Muciniphila in preparing a drug or health-care product for preventing and treating depression. In the application, in vivo pharmacodynamic research is performed on the effect of the Akkermansia Muciniphila in incidence of the depression and depression resistance; a result shows that abundance of the Akkermansia Muciniphila in an intestinal tract of a patient with the depression is obviously lowered; and a result of an animal experiment shows that abundance of the Akkermansia Muciniphila in an intestinal tract of a mouse with the depression isremarkably lowered. In the application disclosed by the invention, the Akkermansia Muciniphila is transplanted into a model of the mouse with the depression; and tests show that through Akkermansia Muciniphila transplantation, a movement distance of the mouse can be increased, the immobility times of a tail suspension test and a forced swimming test can be shortened, the depression state of the mouse is remarkably relieved, and the Akkermansia Muciniphila shows very good anti-depression curative effect without side effect.

A pharmaceutical composition for the treatment and / or prevention of depression comprising a compound having an antagonistic activity for EP1 receptor which a prostaglandin E2 receptor subtype.EP1 antagonist is useful for the treatment of depression, for example, endogenous depression, reactive depression, weatherability depression, neurological depressed state, the depressed state of brain organic mental disorder.

The invention discloses a pharmaceutical composition for treating and preventing depression and a preparation method of the pharmaceutical composition. The composition consists of radix bupleuri extract, Chinese angelica extract and white atractylodes rhizome extract. According to the pharmacological experiment results, the pharmaceutical composition can be used for obviously reducing dead time in a mouse forced swimming test and a mice hanging test, remarkably increasing chronic temperature and the weight and the sweet water eccentricity of an unpredictable depression model, and has an obvious anti-depression effect which can reach or exceed that of the existing clinical common anti-depression drugs.

The invention discloses a medicine for treating depression, and a preparation method thereof. The medicine is prepared from bupleurum chinense, root of red-rooted salvia, acorus gramineus, thinleaf milkwort rootbark, zedoary, coptis chinensis, dragon bone, oyster, and chlorite schist in a certain weight part proportion; bupleurum chinense, root of red-rooted salvia, acorus gramineus, thinleaf milkwort rootbark, zedoary and coptis chinensis are extracted by a percolation method, dragon bone, oyster, and chlorite schist are extracted by a levigation method, then extracts are mixed, and mixed extracts and auxiliary materials are mixed to be prepared into any common oral formulation. The medicine has the effects of soothing the liver and regulating vital energy, activating blood and dissolving stasis, tranquilizing the mind, reducing phlegm and purging fire and the like, is used for treating liver qi stagnation, vexation and sleeplessness and other symptoms, and is also used for treating depression.

The invention discloses a Chinese herbal composition and extract used for treating depression and a preparation method and an application thereof. The Chinese herbal composition is composed of bupleurum, Chinese angelica, fried white atractylodes rhizome, honey-fried licorice root, mint and dried ginger, thus a formula is simpler. The preparation method of the Chinese herbal composition comprises the steps of weighing the Chinese herbal medicines in proportion, smashing the Chinese herbal medicines, placing the smashed Chinese herbal medicines into a CO2 extraction kettle, controlling parameters such as pressure, temperature, CO2 flow and extraction time and obtaining the extract. Pharmacodynamic test results show that the extract can obviously reduce dead time in a mouse forced swinging test and a mouse tail suspending test, which proves that the extract disclosed by the invention has obvious anti-depression effect, anti-depression activity reaches up to or is higher than those of anti-depression western medicines which are frequently used in clinical application and the traditional anti-depression Chinese herbal medicine compound Xiaoyao powder. And the extract is prepared by adopting an advanced and non-toxic supercritical CO2 extraction process without pollution or solvent residue, thus safety is better, and the extract disclosed by the invention is an ideal anti-depression medicine.

The invention provides new application of sea-buckthorn seed oil extracted from sea-buckthorn seeds, i.e., application of the sea-buckthorn seed oil to preparation of a medicament or a health-care food for preventing and / or treating depression, and application of the sea-buckthorn seed oil serving as a raw material to preparation of the medicament or the health-care food for preventing and / or treating the depression. Test results prove that the immobility time in forced swimming tests of mice and tail suspension tests of the mice can be obviously reduced by the sea-buckthorn seed oil and the sea-buckthorn seed oil has an obvious depression suppression effect. The sea-buckthorn seed oil is a natural anti-depression effective substance which has the advantages of easiness and convenience in preparation, obvious effect, safety, reliability and easiness for industrial production. The sea-buckthorn seed oil can be prepared into formulations such as soft capsules, dropping pills and emulsion for anti-depression medicaments or health care foods.

The invention relates to the field of medicine, and in particular relates to an application of ocimene to preparation of an antidepressant. As proved by the results of a mouse chronic unpredictable mild stimulation depression model weight appearance experiment, sucrose preference test, open field test, forced swimming test and the like, the ocimene has remarkable anti-depression activity, and can be applied to preparation of antidepressants.

A Chinese medicine for preventing and treating depression is prepared from 8 Chinese-medicinal materials including white peony root, acanthopanax bark, tribulus fruit, schisandra fruit, etc.

The invention belongs to the field of biotechnology and particularly relates to application of lactobacillus kefiranofaciens ZW3 in the fields of pharmacy and food. The invention provides applicationof lactobacillus kefiranofaciens ZW3 in preparation of medicines and foods for preventing or improving mental problems caused by stress pressure. Viable lactobacillus kefiranofaciens ZW3 serves as aneffective component to prepare dosage forms capable of being accepted in medicines and foods, and mental problems caused by stress pressure can be obviously improved.

The invention discloses application of all-cannabinoid in preparation of drugs for treating depression. The all-cannabinoid is prepared by uniformly mixing, by weight, 0.3-99.7 parts of an industrial hemp seed extract with 99.7-0.3 parts of industrial cannabinoids. The all-cannabinoid has the obvious relieving effect on the symptoms such as secondary learning memory deterioration of the depression and can be used for preparing the drugs for treating various depression symptoms including endogenous depression, reactive depression, latent depression, secondary depression caused by drugs, climacteric or postnatal depression, depression induced by cerebral trauma or stroke, diabetes-complicated depression and depressive neurosis and used for preparing the drugs for treating the symptoms such as secondary learning memory deterioration and anhedonia which are caused by the depression, and the effect of the all-cannabinoid is better than that of cannabidiol. The all-cannabinoid can be prepared into the clinical drugs of various dosage forms through a conventional preparation method and is convenient to use.

The invention discloses an application of trifolirhizin to preparation of medicines for preventing or treating depression. The trifolirhizin is a flavonoid compound extracted from sophora alopecuroides, is safe and non-toxic in sources, has the effect of resisting depression, can be used for preparing antidepressant medicines, does not produce side effects and is safe and efficient. Besides, the invention also provides an antidepressant medicine. The antidepressant medicine comprises the trifolirhizin and a carrier acceptable for medicines.

The invention discloses a traditional Chinese medicine composition with an anti-depression function and a preparation method of the traditional Chinese medicine composition. The preparation method comprises the steps of firstly, carrying out heating reflux extraction after respectively and uniformly mixing coptis chinensis and cinnamomum cassia with water, and obtaining coptis chinensis liquor and cinnamomum cassia liquor; distilling by water vapor to obtain cinnamomum cassia volatile oil; then sequentially carrying out concentration treatment and drying treatment after uniformly mixing the coptis chinensis liquor, the cinnamomum cassia liquor and the cinnamomum cassia volatile oil. Compared with Jiaotai pills prepared through a traditional decoction method, the traditional Chinese medicine composition with the anti-depression function, disclosed by the invention, has the advantages that chemical components are relatively clear and definite, the curative effect is remarkable, the quality is controllable, and the like; the traditional Chinese medicine composition with the anti-depression function, prepared by the preparation method has the characteristics that the pharmacological effect is clear, the effect is achieved rapidly, toxic and side effects are little, the preparation technology is simple, the operation and the popularization are convenient, and a new medicine source is provided for preventing and treating depression and complications thereof, obstacles or symptoms.

The invention relates to a novel medicinal application of a known traditional Chinese medicine composition, and particularly relates to application of a known traditional Chinese medicine composition in preparation of a medicine for preventing and treating depression. Experiments prove that the traditional Chinese medicine composition has a remarkable curative effect on anti-depression, is quick in response and small in toxic and side effect, and is a safe anti-depression medicine. In the prior art, the traditional Chinese medicine composition is developed and prepared into a Sailuotong capsule for treating ischemic cerebrovascular diseases, vascular dementia and senile dementia diseases, while a novel medicinal application is provided to the Sailuotong capsule.

The invention relates to a new use of 20(S)-protopanoxadiol derivatives and 20(S)-protopanaxatriol derivatives, and mainly relates to a use in the preparation of medicines for treating or preventing depressive mental diseases. 20(S)-protopanoxadiol and 20(S)-protopanaxatriol are used as raw materials, and undergo oxidative cyclization to prepare dammara-20S-24(R)-epoxy-3beta,12beta,25-triol, dammara-20S-24(S)-epoxy-3beta,12beta,25-triol, dammara-20S-24(S)-epoxy-3beta,6beta,12beta,25-tetrol or dammara-20S-24(R)-epoxy-3beta,6beta,12beta,25-tetrol. Researches of pharmacological experiments show that dammara-20S-24(R / S)-epoxy-3beta,12beta,25-triol and dammara-20S-24(R / S)-epoxy-3beta,6beta,12beta,25-tetrol can obviously shorten the tail immobility time of mice in mouse tail suspension tests of a classic depression model, and can obviously shorten the swimming immobility time of the mice in mouse forced swimming model tests, so dammara-20S-24(R / S)-epoxy-3beta,12beta,25-triol and dammara-20S-24(R / S)-epoxy-3beta,6beta,12beta,25-tetraol have potential development values in the preparation of medicines for treating or preventing depressive mental diseases.

The invention discloses a medicine composition for treating depression. The medicine composition consists of the following four components: geniposide, naringin, neohesperidin and magnolol; the medicine composition comprises the following components in parts by weight: 5-20 weight parts of geniposide, 5-20 weight parts of naringin, 5-20 weight parts of neohesperidin and 0.5-2 weight parts of magnolol; and preferably, the medicine composition comprises the following components in parts by weight: 10 weight parts of geniposide, 10 weight parts of naringin, 10 weight parts of neohesperidin and 1 weight part of magnolol. The composition disclosed by the invention can be used for preparing medicines for treating depression, and has the advantages of accurate composition, significant medicine effect, safety and reliability.

The invention relates to a rosa roxburghii active extract with an anti-depression effect and application. The active extract is obtained from rosa roxburghii fruits or rosa roxburghii fruit residues by adopting a chemical extraction or membrane separation technology, wherein the chemical extraction technology comprises the following steps of: performing alcohol reflux extraction on freshly squeezed rosa roxburghii fruit residues or rosa roxburghii fruits, filtering, concentrating to remove ethanol, adding water to disperse water-insoluble precipitates, filtering, washing the precipitates by using water and petroleum ether or n-hexane in sequence, removing water-soluble substances and grease, and drying, thereby obtaining the active extract. The active extract contains triterpene and flavone components, and the research finds that the active extract is obvious in anti-depression activity, can be used for preparing anti-depression medicines and auxiliary medicines or serving as a healthy food additive and has high application values and market prospects. The active extract disclosed by the invention has significance for high-value utilization and sustainable development of the rosa roxburghii industry, an intermediate or additive raw material is provided for the anti-depression medicines or health foods, and the preparation method is simple and feasible, low in cost and capable of realizing industrial production.

The invention provides the application of a saffron crocus pigment composition to the preparation of a medicine for treating or improving depressive disorder, and relates to the field of depressive disorder medicines. Through research findings, the saffron crocus pigment composition can obviously antagonize ptosis of upper eyelid of a mouse caused by reserpine, obviously improve the akinesis condition, obviously reduce the tail suspension immobility time and increase sweet water preference coefficient, so that the saffron crocus pigment composition has a good anti-depression effect, can improve various symptoms of the depressive disorder, serves as an anti-depression medicine and provides a new scheme for research and treatment on the depressive disorder.

An extract for preventing and treating depression is extracted from 4 Chinese-medicinal materials including inula flower, hematite, bamboo leaf, etc.

The invention relates to a novel chalcone compound Chalcone-1203, and also relates to a preparation method for the compound, a composition using the compound as an active component and application of the compound in preparation of an antidepressant drug. The novel chalcone compound Chalcone-1203 provided by the invention has substantial anti-depression effect. Results of animal testing in the embodiments show that Chalcone-1203 can substantially reduce immobility time of mice in forced swimming test and tail suspension test of the mice, has fast action and small toxic and side effect (TD50>2000 mg / kg), is suitable for long-term usage and shows valuable antidepressant pharmacological properties. The novel chalcone compound uses widely-available and cheap raw materials, is simple to prepare and can be used for preparation of antidepressant drugs of a variety of dosage forms.

This invention relates to the field of traditional Chinese medicine, particularly to the application of traditional Chinese medicine composition. The invention provides the application of a traditional Chinese medicine composition comprising Sichuan lovage rhizome and tall gastrodia tuber in the traditional Chinese medicine preparation for increasing the content of serotonin, norepinephrine and dopamine in the brain. This invention also provides the application of the traditional Chinese medicine composition comprising Sichuan lovage rhizome and tall gastrodia tuber in the manufacture of a medicament for the treatment and / or prophylaxis of depression. The experimental results of the invention show that the provided composition can significantly reduce the immobility time in the mice forcing swimming and the tail suspension experiment, and increase the amount of serotonin (5-HT), norepinephrine (NE), Dopamine (DA), whose effect is similar to the positive control drug paroxetine, suggesting that the compositions provided by the present invention will play an important role in the treatment or prevention of depression.

The invention discloses a traditional Chinese medicine combined extract with an anti-depression effect as well as a preparation method and application thereof and belongs to the technical field of traditional Chinese medicinal preparations. The traditional Chinese medicine combined extract with the anti-depression effect is prepared from salviae miltiorrhizae, ligusticum wallichii, kudzuvine root and earthworm in certain parts by weight. The traditional Chinese medicine combined extract is scientific in compatibility and reasonable in preparation; experiments show that the traditional Chinese medicine combined extract or traditional Chinese medicine tablets thereof can obviously reduce the dead time of mouse tail suspension and forced swimming of a behavioural despair model, and open-field test results show that the autonomic activity of a mouse is not influenced while the dead time is reduced; and meanwhile, the traditional Chinese medicine combined extract also can obviously resist mouse body temperature decrease caused by reserpine and obviously improve the mouse head shaking frequency induced by 5-hydroxytryptophane, so that the traditional Chinese medicine combined extract has the anti-depression effect, plays a role by changing the monoaminergic level in the brain, and has an application prospect of being developed into an anti-depression drug.

The invention discloses application of licorisoflavan A in preparation of drugs for treating depression. Licorisoflavan A is a flavonoid compound separated from a Chinese herb, namely radix glycyrrhizae; the immobilization time of a mouse forced swimming test and tail suspension test of a chronic unpredictable mild stress depression model can be obviously shortened, it is indicated that licorisoflavan A has an excellent anti-depression effect, and by regulating and controlling AMPA receptors, a BDNF-TrkB passage can be adjusted to achieve the anti-depression effect. Licorisoflavan A can be combined with auxiliary agents, used for preparing the drugs for treating depression and applied with other anti-depression drugs.

The invention relates to the field of biological medicines and aims at providing an application of ginsenoside Rg5 in preparation of an antidepressant drug. The antidepressant drug is single-component ginsenoside Rg5 or comprises the ginsenoside Rg5 and pharmaceutically acceptable auxiliary materials, wherein the application dosage of the antidepressant drug is 10-500mg / kg everyday on the basis of the weight of the ginsenoside Rg5; and the administration mode of the antidepressant drug is oral administration, instillation or injection. The ginsenoside Rg5 has the beneficial effects that the ginsenoside Rg5 is significant in treatment effect on a depressive disorder, small in toxic or side effect, and high in security.

The invention belongs to the field of drugs and health-care foods, and relates to an application of a trepang extract in products for preventing and treating depression. The effective component of the products for preventing and treating depression is the trepang extract. The invention discloses a new purpose of the trepang extract for effectively resisting the depression, and a new field is developed for the clinical application of new medical or health-care functions of trepang. Classical depression resistant animal model test results prove that a trepang enzymolysis extract can obviously shorten the dead time in a mouse forced swimming test, so that the trepang enzymolysis extract has good depression resisting effect, is obvious in the efficacy of preventing, conditioning and treating the depression, is free from adverse effects of conventional depression resistant drugs, as a natural marine resource extract, and has favorable application prospects.

The invention discloses application of catalpol in the preparation of an antidepressant medicine. The catalpol can be used as the antidepressant medicine for preventing and treating depression. A mouse forced swimming test (FST), a mouse tail suspension test (TST) and a rat chronic unpredictable mild stress (CUMS) test prove that the catalpol has an obvious antidepressant effect, the antidepressant activity of the catalpol reaches or exceeds that of the anti-depression western medicine fluoxetine commonly used in the clinic, and the catalpol can be used for preparing the medicine for preventing and treating depression.

The invention discloses application of patchouli alcohol to preparation of antidepressive medicine. The first research finds that the patchouli alcohol can effectively increase the parallel moving lattice number and the number of up-right times in a depression model rat open field experiment; the sweet water preference value in a depression model rat sweet water consumption experiment is increased; the motionless time in a depression model rat forced swimming experiment is reduced; an obvious anti-depression effect is achieved; the anti-depression effect is superior to that of fluoxetine; verygood development values are realized; the patchouli alcohol is a pure natural monomeric compound; very good large-area popularization and application prospects are realized in the anti-depression aspect.

The invention relates to the technical field of traditional Chinese medicine, and in particular, relates to an application of a traditional Chinese medicine composition in preparation of antidepressant drugs. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 5-15 parts of fructus aurantii, 4-8 parts of white atractylodes rhizome, 4-8 parts of rhizoma pinellinae praeparata, 5-15 parts of rhizoma coptidis, 3-7 parts of codonopsis pilosula, 2-6 parts of liquorice, 2-6 parts of poria cocos, 4-12 parts of cortex magnoliae officinalis, 2-6parts of malt, and 2-6 parts of dry ginger. Experiments show that the traditional Chinese medicine composition can improve the cell survival rate of a corticosterone-induced PC12 nerve cell injury model, restore the mitochondrial membrane potential, inhibit the expression of apoptotic genes and / or promote apoptosis and inhibit the gene expression; the traditional Chinese medicine composition significantly reduces the tail suspension immobility time and forced swimming immobility time of mice, and increases the serum 5-hydroxytryptamine content; the depressive behavior of the mice is improved obviously, and the results show that the composition has remarkable curative effect on depression.

The invention provides a pharmaceutical composition for treating depression and a preparation method and application thereof. The pharmaceutical composition comprises the active pharmaceutical ingredients, by weight, 80-150 parts of rhizoma cyperi, 80-150 parts of cardamom, 80-150 parts of mint, 80-120 parts of fennel, 60-100 parts of radix bupleuri, 30-80 parts of selfheal, 80-120 parts of humifuse euphorbia herb, 120-200 parts of liquorice, 100-150 parts of Chinese date, 50-100 parts of spina date seed, 30-50 parts of cortex albiziae and 60-100 parts of myrobalan. A rat chronic mild unpredictable stress model, a rat olfactory bulb excision model, a mouse behavior despiring model and a 5-hydroxytryptophan induced mouse head shaking behavior model prove that the pharmaceutical compositionhas an anti-depression effect, in addition, the pharmaceutical composition can be prepared into tablets, pills, granules, syrups and capsules through a conventional method, and the preparation methodis simple, safe, economical and effective.

The present invention discloses total flavone extract with the anti-depression effect and a preparation method and application thereof. The total flavone extract is prepared by the following preparation method of adding an extraction solvent into cuscuta chinensis lam. powder, performing heating reflux extraction, combining filtrate, and performing concentration to obtain extractum; and sequentially adding the extractum into a polyamide column and a macroporous resin column for chromatography, and concentrating obtained eluent to obtain the total flavone extract of cuscuta chinensis lam.. Theprepared total flavone extract is high in purity, experimental results show that total flavone of the cuscuta chinensis lam. can obviously shorten dead time of CUMS mice TST and FST and does not affect autonomic activities of the mice, and it is indicated that the total flavone extract of the cuscuta chinensis lam. has the relatively strong anti-depression effect and no central excitation or inhibition effect. Moreover, the total flavone of the cuscuta chinensis lam. can activate a TXNIP / NLRP3 inflammasome signal path, and it is proved that the total flavone of the cuscuta chinensis lam. exerts the anti-depression effect by adjusting the TXNIP / NLRP3 inflammasome signal path.