250 results about "Learning memory" patented technology

The invention generally provides supplements and methods of using the same to improve cognitive functions such as learning, memory, concentration, focus, attention, and mood.

A switch is turned on by a learning control start command from a master control unit, and the positional deviation at respective cycles is read in. Correction data read out from a learning memory is added to the positional deviation, and the result is filtered by band limiting filter and then stored in the learning memory as correction data. The correction data read out from the memory is compensated for phase delay, fall in gain, and the like, by a dynamics compensating element, and is added to the positional deviation and input to a positional control section. When the command pattern for the same shape is completed, and a learning control end command is output, whereupon the switch is turned off and learning control terminates.

In response to a learning control start command from an external apparatus, an input switch for inputting a position deviation to learning control means and an output switch for outputting correction data from the learning control means are turned on, respectively, so that a position deviation is captured for each period. The position deviation is added to correction data fetched from a learning memory, and the result is stored as correction data in the learning memory. On the other hand, a value obtained by compensating the correction data fetched from the learning memory with a dynamic characteristic compensation element is added to the position deviation, and the result is inputted to a position control section. When a learning control end command is issued after the termination of a command pattern for an identical shape, the input switch and output switch are turned off, respectively.

The invention discloses an animal behavior memory test maze device which comprises a main body that is a big box made of a transparent organic glass plate, wherein a center platform is placed in the center of the big box, movable food boxes are respectively placed at four bottom corners of the outer part of the big box, a channel is arranged between each food box and the big box, the inlet of the channel of each food box is provided with an opaque door which can be pushed open, the middle floor in each food box is provided with a small disk; and bags consisting of four pellets are respectively placed on gaps between the floors in the four food boxes and the bottom of the disk. Different patterns of vertical plates and illuminating devices are arranged close to four side surfaces of the outside of the big box, an opaque cover covers outside the big box, the food boxes, the pattern vertical plates and the illuminating devices, and the top end of the cover is provided with a camera. The invention can solve the technical problem of existing limit of a simple experiment observing target in a traditional test for an animal learning memory or cognitive function.

In response to a learning control start- command from an external apparatus, an input switch for inputting a position deviation to learning control means and an output switch for outputting correction data from the learning control means are turned on, respectively, so that a position deviation is captured for each period. The position deviation is added to correction data fetched from a learning memory, and the result is stored as correction data in the learning memory. On the other hand, a value obtained by compensating the correction data fetched from the learning memory with a dynamic characteristic compensation element is added to the position deviation, and the result is inputted to a position control section. When a learning control end command is issued after the termination of a command pattern for an identical shape, the input switch and output switch are turned off, respectively.

A servo controller is provided wherein a switch is turned on by a learning control start command from a master control unit, and positional deviation at respective cycles is read in. Correction data read out from a learning memory is added to the positional deviation, and the result is filtered by a band limiting filter and then stored in the learning memory as correction data. The correction data read out from the memory is compensated for phase delay, fall in gain, and the like, by a dynamics compensating element, and is added to the positional deviation and input to a positional control section. When the command pattern for the same shape is completed, and a learning control end command is output, the switch is turned off and learning control terminates.

The invention discloses a tuckahoe extract which is prepared through ethanol extraction and macroporous absorption resin purification. The tuckahoe extract enriches more effective parts. Moreover, a rat memory disorder model test proves that the tuckahoe extract can improve the learning and memory capacity of a model rat, so that the number of errors of the model rat is reduced and the latent period is prolonged.

The invention provides a method for preparing a 5,6,7,4'-tetrahydroxyflavone compound, which is characterized by comprising the following steps: taking breviscapinun as a raw material, and performing heating reflux reaction between the breviscapinun and alcohol under the catalysis of acid, namely adding 200 to 500 ml of alcohol substance and 1 to 3 ml of 4 to 5 percent acid into 12 to 20 g of the breviscapinun for the heating reflux reaction; and filtering a product, and drying to a constant weight to obtain 5,6,7,4'-tetrahydroxyflavone shown in a formula I. Experiments prove that the 5,6,7,4'-tetrahydroxyflavone shows obvious strengthening effect on acquisition, consolidation and representation of brain memory of a mice model of alzheimer disease, has obvious improving effect on learning memory of the mice model with memory loss caused by anisodine of an M-cholinergic inhibitor, and can obviously improve the recent memory and long-term memory capacities of mice. The experiments also prove that the 5,6,7,4'-tetrahydroxyflavone has the effect of treating arthritis, and also has good treating effects on diabetes mellitus and osteoporosis.

A snuff for preventing and treating senile dementia, improving memory and regulating the permeability of blood brain barrier is prepared from the active component(s) chosen from eugenol, its salt, its isomer and their mixture, and selective natural spice.

The invention provides a stupid-rat-maze-type intelligence rehabilitation training device, comprising multiple layers of training cages, the multiple layers of training cages are arranged up and down in a laminating way, adjacent training cages are mutually nested and connected and are communicated by virtue of a ladder; a maze is arranged in each training cage, the mazes comprise relaxation mazes, plug board mazes, elevated anxiety mazes and escape hole mazes, and the mazes can be combined and arranged at will. In the invention, natural behavioral expression of conditioned response of a stupid rate to construct a voluntary activity maze learning memory training device, improvement of stupid rat behaviour function expression is promoted by virtue of a learning memory maze training space which is fresh, changeable, interesting, comfortable and ready to activities, spatial learning capability and memory capability are improved, search capability and retelling capability of an animal canbe more accurately and objectively reflected, the stupid-rat-maze-type intelligent rehabilitation training device provided by the invention is beneficial to improvement and evaluation on learning andmemory functions of senile dementia, and rehabilitation process is sped up, thus the stupid-rat-maze-type intelligence rehabilitation training device provided by the invention has great significance.

The present invention relates to a medicine formed from ganglioside and ginkgo leaf extract and its healht-care product and application. The animal experiments and clinical trials show that the medicine and health-care product possess good synergistic action, and can obtain obvious effect for curing and preventing senile dementia, preventing and curing Parkinson's disease, curing and preventing ischemic cerebrovascular disease, and have the functions of delaying senility and raising resistance to fatigue and learning memory.

The invention discloses an application of whey protein peptide in the preparation of medicines, health foods or foods for improving learning memory. Whey protein peptide has the characteristics of easy absorption, fast absorption, low viscosity, good water solubility and the like. The whey protein peptide can promote a laboratory mouse to establish active avoidance of conditioned response, slows down the memory decay speed of passive avoidance of conditioned response, and simultaneously improves the space learning memory capability of the laboratory mouse. The whey protein peptide has the efficacy of improving learning memory and has certain scientific value and economic benefit when applied to the preparation of medicines, health foods or foods for improving learning memory. The invention provides a new approach for improving learning memory by means of diet.

The invention discloses a traditional Chinese medicine formulation for curing senile dementia and a preparation method thereof. The traditional Chinese medicine formulation is made of ginseng, milk veteh, epimedium, fumitory, rhizoma gastrodiae, angelica, radid polygoni multflori preparata, sealwort and grassleaf sweelflag rhizome which are performed by an ethanol extracting technology and a poach technology. The traditional Chinese medicine formulation is ground by the theory of traditional Chinese medicine and adopts a scientific theory and an advanced technology to develop the traditional Chinese medicine formulation with good curative effect and fewer side effects and being used for curing the senile dementia. The experimental research shows that the traditional Chinese medicine formulation can improve the learning memory ability of an AD rat model. Meanwhile, the traditional Chinese medicine formulation can improve the antifatigue and anti-stress ability of an organism and has good curative effect on the kidney empty. In addition, the invention also provides an optimized preparation method suitable for the industrial production.

The invention relates to application of polydatin which is an extract of polygonum cuspidatum. In-vitro researching experiments show that the polydatin has strong protecting effect for pathological injuries caused by rats multiple infarctional cerebral ischemic injuries, can significantly improve learning memory function of dementia model rats, so the polydatin can be used for preparing a product for resisting vascular dementia and a product, particularly a medicine for resisting senile dementia. The modes for using the polydatin include independent use, or combined use with other chemical substances. Dementia is a key disease impacting health of the elderly, particularly, frequency of disease development of the vascular dementia and the senile dementia is significantly increased to seriously threaten health and life of human beings. The invention provides a novel drug source for clinically treating the vascular dementia and the senile dementia, and has important value for developing and utilizing medicinal plant resource in China.

A metal detector (40) used for identifying contaminants in packages (49, 50, 51) introduced into the metal detector by a conveyor. The detector (40) includes coils (1), a search head (2) and an analog to digital converter (3) that generates a reactive signal (13) and a resistive signal (14) in response to the presence of a contaminant in the region of the coils. A high pass filter (4) receives the reactive and resistive signals (13, 14). During a learning mode a sample product is introduced into the metal detector (40) to provide a representative product effect signal which is stored by the reactive learn memory (19) and the resistive learn memory (28). The learn memory values (29, 32) are forwarded to reference processors (20, 35) to provide a reference value which is subtracted from each product signal during a normal production cycle, thereby canceling the product effect caused by each individual package as it passes through the metal detector. The long term product effect is monitored during successive cycles (54, 62) composed of a series of packages undergoing normal inspection by the metal detector (40). A tracking processor (48) averages the product effect signal (57, 58, 59) produced by the individual packages (49, 50, 51) and continuously produces and updates a product effect trend signal (60) to be used by the reference processors as the signal to be subtracted from each product signal.

The invention discloses a compound traditional Chinese medicine extractive composite for preventing and / or curing Alzheimer disease, which is composed of total formula flavone extractive and total formula polysaccharide extractive which are extracted from the following traditional Chinese medicine composite. The mass ratio of total formula flavone extractive to total formula polysaccharide extractive is 50-80:200-400; the traditional Chinese medicine composite is composed of the raw materials in parts by mass: 3000-12000 parts of herba epimedii, 3000-120000 parts of seed of Chinese dodder (fried), 3000-12000 parts of barbary wolfberry fruit, 1500-6000 parts of raspberry, 375-1500 parts of Schisandra chinensis (steamed) and 750-3000 parts of plantain seed (stir-heated with salt). Experiments prove that by the rat place navigation and spatial probe test, the total flavone extractive and the total polysaccharide extractive can improve the space learning memory ability of an AD (Alzheimer disease) model rat, shorten escape response latency and detection range, and obviously improve search time of quadrant on which the original platform is arranged in the spatial probe test as well as the percentage of space accounting for total time and space. Thus, the extractive composite can be used for preventing or curing the Alzheimer disease.

The invention provides a salicylic acid compound and a medicinal composition of a pharmaceutically acceptable salt thereof. The compound can be added into a pharmaceutically permissible excipient to prepare various pharmaceutically acceptable medicinal preparations. Research proves that the compound disclosed by the invention has a protection effect on in-vitro cultured nerve cell damage induced by hydrogen peroxide, the learning and memory capabilities and the neuron-pathologic change of patients with senile dementia and vascular dementia can be dose-dependently improved, and the compound can be used for effectively treating and / or preventing the neurodegenerative related disease.

The invention provides a traditional Chinese medicine composition for improving memory and mild cognitive impairment. The traditional Chinese medicine composition comprises 40-80 parts of thinleaf milkwort root-bark, 40-80 parts of grass leaf sweetflag rhizome, 40-80 parts of ginseng, 80-120 parts of tall gastrodia tuber, 80-120 parts of papermulberry fruit, 80-120 parts of ginkgo leaves and 0.01-3 parts of borneol. The traditional Chinese medicine composition can achieve the effects of obviously increasing the number density and surface density of synapse of the molecular layer of mouse hippocampal CA1, obviously enhancing the SOD activities of central cerebral cortex and hippocampus, reducing the content of lipofuscin of the neuron, obviously improving the learning and memory impairment of spontaneous senile dementia model mice, obviously enhancing the activity and fiber density of NOS1 of the central cerebral cortex and hippocampus and obviously up-regulating the contents of SS, AVP and ACTH of the cerebral cortex and hippocampus, especially the content of SS. The traditional Chinese medicine composition can achieve the effect of obviously improving the clinical symptoms of memory and cognitive impairment and has definite curative effects and great application prospects.

The invention discloses a drug for treating depression. The drug is prepared by evenly mixing 0.3-99.7 parts by weight of industrial hemp seed extract and 99.7-0.3 parts by weight of industrial cannabinoid. It is proved through experiments that the drug can significantly shorten the tail suspension immobilization time of mice of a behavioral despair depression model and significantly shorten immobility time of forced swimming, has an obvious anti-depressant effect on a mouse depression model caused by reserpine and can significantly increase the frequency of spontaneous activities of the mice, and the effects are all superior to those of cannabidiol. The drug can be used for preparing drugs for treating various depression symptoms including endogenous depression, reactive depression, masked depression, secondary depression caused by drugs, climacteric or postnatal depression, depression caused by cerebral trauma or cerebral apoplexy, diabetes combined depression and depressive neurosis and used for preparing drugs for treating symptoms such as secondary learning memory decline and anhedonia caused by depression.

The present invention relates to a kind of fused transduction peptide-humanized choline acetylase protein and nucleic acid molecule connecting the nucleotide sequence of the said fusion protein. The present invention also relates to expression vector containing said nucleotide molecule. The present invention also relates to the use of the fusion protein in preparing medicine for treating neurodegeneration disease, preventing Alzheimer's disease, promoting learning memory function and promoting intelligence growth. The medicine composition containing the said fusion protein may be applied through injection, sublingual taking, aspiration, etc.

The invention discloses a drug combination used for improving cognitive function dysfunctions and treating senile dementia using ginseng, white paeony root and ginkgo leaves as raw materials. The invention also discloses the preparation method of the drug combination. The experiment confirms that the invention combination can significantly improve learning and memory ability of ageing rats dysmnesia caused by scopolamine, and meanwhile can increase acetylcholine content in the hippocampus of the subjective rats.

The invention relates to a vegetable soup preparation, which comprises the following materials in part by weight: 4-5 parts of green vegetables, 2.5-3.5 parts of carrots, 2.5-3.5 parts of Chinese black mushrooms, 0.5-1.5 parts of chive, 5.5 parts of eggs, 0.3 part of vegetable extract, 0.4 part of chicken essence, 0.95 part of table salt, 0.25 part of hydrolyzed vegetable proteins, 0.1 part of mushroom extract, 0.1 part of ginger, 0.936 part of glucose, 0.936 part of corn starch, 0.9 part of maltodextrin, 0.02 part of pepper and 0.03 part of perilla herb oil. The vegetable soup preparation provided by the invention contains rich dietary fibers and minerals, not only can intestinal peristalsis be promoted, but also diseases can be prevented. Since the perilla herb oil is rich in alpha-linolenic acid, the vegetable soup preparation contributes to the reduction of blood fat, the reduction of blood pressure, anticoagulation, thrombolysis, the improvement of heart and brain blood vessels, the reduction of total cholesterol concentration, the prevention of cardiovascular diseases, the suppression of the occurrence myocardial infarction and cerebral infarction, the prevention and the suppression of the formation of tumors, the prevention of senile dementia, the restoration of eyesight and the improvement of learning memory. The vegetable soup preparation provided by the invention has the advantages that the nutrients are balanced, the color, fragrance and taste are good, and not only can the nutrients required by human bodies be provided, but also a certain curative effect is taken.

There is discloses a transgenic mouse over-expressing a potassium channel BEC1, which can be used as an effective tool for screening a substance for antidementia or a substance to improve learning and memory.Also disclosed are an in vivo screening method of a substance for antidementia or a substance to improve learning and memory, which uses the learning and memory abilities of said mouse as the index, and an in vivo screening of a substance for antianxiety, which uses acceleration of anxiety as the index.In addition, there is disclosed a method for producing a pharmaceutical composition for antidementia, learning and memory improvement use or antianxiety, using a substance capable of inhibiting the learning and memory potassium channel activity as the active ingredient which can be obtained by the aforementioned screening method of the present invention.

This invention discloses the uses of IL-22 in the treatment and prevention of a nerve damage disease or a neurodegenerative disease. In particular, the invention discloses the uses of IL-22 or IL-22 dimers as follows: (i) can protect neurons to recover the functions of injured neurons after ischemic nerve damage in animals in vivo, thus enabling effective treatment of nerve damage diseases, (ii) can significantly inhibit the loss of dopaminergic neurons in substantia nigra in PD model animal, enhance the functions of dopaminergic neurons, significantly reduce neuronal apoptosis in hippocampus, improve learning and memory capacity of AD model rats, and effectively prevent neuronal loss, thereby enabling more effective treatment of neurodegenerative diseases.

The invention belongs to the technical field of medicine, in particular to medicine for preventing and treating depression, and a preparation method and purposes thereof. The medicine for preventing depression contains polygonum multiflorum or extract thereof; the polygonum multiflorum is steamed polygonum or / and polygonum prepared from black beans or / and polygonum prepared from wine, and the extract of the polygonum multiflorum is the acetone extract of the polygonum multiflorum; the medicine for preventing depression is used to prevent and treat endogenous depression, reactive depression, masked depression, secondary depression caused by drugs, menopausal or post-natal depression, depression induced by cerebral trauma or cerebrovascular disorder, depressive neurosis and other depression and secondary learning and memory declination, lack of pleasure and other symptoms and the like caused by depression, and has the advantages of the good effect and little toxin.

The invention discloses an animal learning memory individualized evaluating method based on a water maze. The animal individualized evaluating method is used for determining cognition abnormity by analyzing data of the time (incubation period) from water entering to platform boarding of multiple batches of mice / rats with a Morris water maze experiment as a tool and normal animals and cognition abnormal animals as the objects. Compared with a traditional method emphasizing comparison among groups of samples, the method has the advantages that the overgeneralization means of the pure 'average value + / - standard deviation' form in the traditional method is abandoned, and model animals are separated according to the cognition difference and studied one by one; by means of the method, the animal cognition level difference can be more objectively reflected, and the state is closer to the real state of animals; the method is easy to operate and feasible, and the reliability and scientificity of the method are ensured through repeated experiments of multiple batches of animals and the confirmatory experiments of models.

The invention relates to the field of biotechnology, and in particular to application of dental pulp mesenchymal stem cells in treatment of Alzheimer disease. According to the invention, through experimental research, it is found for the first time that transplantation of dental pulp mesenchymal stem cells can inhibit chronic inflammation of the brain, improve learning and memory capacity and movement capacity to a certain extent, reduce number of microglia in each region of the hippocampus, and effectively treat Alzheimer disease.