Compound traditional Chinese medicine extractive composite for preventing and curing Alzheimer disease

Abstract

The invention discloses a compound traditional Chinese medicine extractive composite for preventing and / or curing Alzheimer disease, which is composed of total formula flavone extractive and total formula polysaccharide extractive which are extracted from the following traditional Chinese medicine composite. The mass ratio of total formula flavone extractive to total formula polysaccharide extractive is 50-80:200-400; the traditional Chinese medicine composite is composed of the raw materials in parts by mass: 3000-12000 parts of herba epimedii, 3000-120000 parts of seed of Chinese dodder (fried), 3000-12000 parts of barbary wolfberry fruit, 1500-6000 parts of raspberry, 375-1500 parts of Schisandra chinensis (steamed) and 750-3000 parts of plantain seed (stir-heated with salt). Experiments prove that by the rat place navigation and spatial probe test, the total flavone extractive and the total polysaccharide extractive can improve the space learning memory ability of an AD (Alzheimer disease) model rat, shorten escape response latency and detection range, and obviously improve search time of quadrant on which the original platform is arranged in the spatial probe test as well as the percentage of space accounting for total time and space. Thus, the extractive composite can be used for preventing or curing the Alzheimer disease.

Description

technical field [0001] The invention relates to a compound traditional Chinese medicine extract composition for preventing and treating senile dementia. Background technique [0002] With the continuous acceleration of the pace of the world's entry into the aging society, various neurodegenerative senile diseases, such as mild cognitive impairment and Alzheimer's disease, have become important risk factors that threaten the health of human beings in their later years and reduce the quality of life of the elderly. The society and family have brought serious economic burden and heavy mental pressure. Therefore, the development of drugs for improving cognitive dysfunction and treating Alzheimer's disease has become the research focus of medical workers in various countries around the world, and has been highly valued by Chinese and Western medical circles. [0003] The thinking of the Western medical circles to study anti-mild cognitive impairment and senile dementia drugs bas...

AI Technical Summary

Problems solved by technology

[0003] The thinking of the Western medical circles to study anti-mild cognitive impairment and senile dementia drugs based on Alzheimer's disease mainly revolves around four anti-inflammatory (anti-inflammatory, anti-oxidation, anti-cholesterol, anti-β-amyloid protein) and two anti-( Currently, drugs approved by the US Food and Drug Administration for the treatment of Alzheimer's disease (AD) include tacrine, donepezil, rivastigmine, galantamine, and memantine. etc. Although these drugs can improve the symptoms of dementia patients in the short term, they cannot delay the development of the disease, and some of them have strong toxic and side effects on the liver, so they are hardly used at present. Some drugs are expensive and difficult for patients and their families Therefore, there is an urgent need to develop new drugs with good curative effect, few side effects and low price

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