324results about How to "Reduce oxidative damage" patented technology

The invention provides a method for reducing oxidative damage in a mammal, a removed organ, or a cell in need thereof. The method comprises administering an effective amount of an aromatic cationic peptide. The aromatic cationic peptide has (a) at least one net positive charge; (b) a minimum of three amino acids; (c) a maximum of about twenty amino acids; (d) a relationship between the minimum number of net positive charges (p_m) and the total number of amino acid residues (r) wherein 3p_m is the largest number that is less than or equal to r+1; (e) a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 3a or 2a is the largest number that is less than or equal to p_t+1, except that when a is 1, p_t may also be 1; and (f) at least one tyrosine or tryptophan amino acid.

Methods and compositions for prevention and therapy of cancer are provided. Compositions comprising therapeutically effective amounts of two or more of an extract of Ganoderma lucidum, an extract of Salvia miltiorrhiza and an extract of Scutellaria barbata and optionally a therapeutically effective amount of an extract of Hippophae rhamnoides are provided. Novel synergistic effects of the use of these compounds in combination therapy are disclosed. Embodiments further comprising therapeutically effective amounts of at least one chemotherapeutic agent are also provided.

Disclosed are compositions and corresponding methods of their use that include plant, plant parts, or extracts thereof from Michelia magnifica, Xylosma japonicum, Prunus cerasifera, Nyssa sinensis, Chimonanthus praecox, Sassafras tzumu, Inula helianthus-aquatica, Capparis bodinieri, Passiflora caerulea, Galium aparine, Boehmeria platyphylla, Colquhounia coccinea, Sageretia rugosa, Jasminum stephanense, Antirrhinum majus, Daphniphyllum oldhamii, Cuscuta chinensis, Salix variegate, Osmanthus parvifolius, Euphorbia trigona, Calliandra haematocephala, Excoecaria acerifolia, Dianthus chinensis, Myriophyllum spicatum, Nymphoides peltatum, Prunus salicina, Solanum coagulans, Elaeis guineensis, Rhododendron moulmainense, Spatholobus suberectus, Artabotrys hexapetalus, Hibiscus syriacus, Lonicera calcarata, Hydnocarpus hainanensis, Ilex fragilis, Antidesma venosum, Acacia pennata ssp. Kerrii, Althaea rosea, Millettia velutina, Themeda japonica, Dalbergia hancei, Ipomoea batatas, Photinia glomerate, Hippophae rhamnoides, Azadirachta indica, Karelinia caspica, Bauhinia touranensis, Eriobotrya japonicas, Anaphalis contorta, and/or Cratoxylum prunifolium, or any combination thereof.

The invention relates to whey protein antioxidant peptides, a preparation method thereof and application thereof. In the method, whey protein, which is a cheese by-product, and an enzymatic preparation undergo enzymatic hydrolysis to form a whey protein antioxidant peptide zymolyte, the zymolyte is subjected to static or dynamic primary purification by macroporous absorption and separation and purification by gel filtration chromatography, preparative high-performance liquid chromatography and analytical high-performance liquid chromatography to give pure whey protein antioxidant peptide products, and a polypeptide amino acid sequence is measured. The product has high digestion resistance, heat resistance, acid resistance and alkali resistance, high storage stability, low molecular weightand specific amino acid sequence, and can effectively remove free radicals, stop oxidation reaction and reduce the generation of oxidation damages, so the products have a wide application prospect inthe field of food, medicaments, feed and cosmetics.

The invention discloses a new application of sodium hydrosulfide for promoting germination of wheat seeds under the stress of heavy metals, namely, the application is that the sodium hydrosulfide is taken as a sprout-promoting agent of germination in the soil polluted by heavy metals of Al<3+>, Cd<2+>, Cr<3+>, Cr<6+>, Pb<2+>, Hg<2> and the like. The invention can effectively improve the germinability of the wheat seeds under the stress of heavy metals, and induces the seeds to germinate fast and regularly. Research proves that the sodium hydrosulfide of the hydrogen sulfide donor is adopted to preprocess the wheat seeds, which can remarkably induce the activity expression of hydrolytic enzyme of amylase, protease, lipase and the like, in the seeds, enhances the oxygenolysis of storage matter, relieves the oxidative damage caused by the stress of the heavy metals in the seeds and maintains the lower membrane lipid overoxidation level in the seeds and the seedlings, thus being beneficial to the normal growth of embryo and radicle. The invention solves the key problem of restoring the production of the wheat in the areas polluted by heavy metals, has simple operation; the needed reagent is single and is easy to be obtained.

The present invention discloses a cigarette containing Chinese herbal medicine additives and a making method. The cigarette uses salvia, peony peel, balloonflower, rhubarb and Thunberg fritillary bulb as raw materials, which are purified through different extraction solvents and methods according to the different characteristics of the Chinese herbal medicines. Then, the Chinese herbal medicines are prepared with essences and flavors according to proportions and are added in cut tobaccos. And a cigarette is made. The formula and the making method of the present invention are unique, which can obviously reduce the content of free radicals in cigarette smoke and decrease and release the damages on the myocardial ischemia and the hypoxia caused by smoking.

The present invention aims at providing one kind of natural plant-originated antisenility skin care factor for cosmetics preparation. Bamboo leaf general flavone has the beautifying effect of resisting free radical, resisting oxidation, resisting radiation, resisting bacteria, bacteriostasis, promoting proliferation of skin cells, preventing skin from oxidation damage, reducing melanin synthesis and delaying skin senility; and it has special scent,no irritation to skin and no allergic reaction. It may be applied in various cosmetics, such as nourishing agent, sun block skin care agent, anti-wrinkle whitening agent, face cleaning cream, shampoo, bathing cream, etc.

The invention relates to novel application of melatonin in resistance to waterlogging stress of plants. A product which takes melatonin as an effective component is applied to a plant subjected to waterlogging stress to remarkably enhance the ability of the plant for eliminating ROS, alleviate oxidative damages on the plant caused by waterlogging stress and remarkably improve the ability of the plant for resisting the waterlogging stress, so that the yield and quality drop caused by waterlogging is reduced.

The invention discloses a method for encapsulated osteoblasts to support and regulate the in-vitro amplification of cord blood hematopoieticstem/progenitorcells (He) in the hypoxia condition, belonging to the fields of biotechnology and tissue TSPCS engineering. The method is characterized in that the human osteoblasts are embedded by gelatin-alginate-chitosan (GAC) microcapsule as matrix feeder cells and co-cultured with the cord blood HSPCs in the 5% hypoxia environment to obtain the HSPCs. The invention adopts GAC microcapsule to separate the human osteoblasts from the cord blood HSPCs to avoid the cell contamination and immunological rejection. Furthermore, the pore passages of the microcapsule are capable of causing hemopoietic growth factors secreted by the osteoblasts in the microcapsule to expand to the habitat of the HSPCs and play a role of stimulating the amplification of the hematopoietic stem/progenitor cells. Moreover, the material of the microcapsule has the slow release function to the expansion of the growth factors to increase the concentration gradient of the growth factors on the surface of the microcapsule, which is helpful for the long-term function of the growth factor. In addition, the microencapsulated osteoblasts form the 3D environment, which not only causes the culture system to contain more osteoblasts, but also causes the culture system to have bigger HSPCs-OBs action area compared with the co-culture pattern of the osteoblasts cultured by adherence. Besides, in the 5% hypoxia environment, the co-culture system is capable of better simulating the hematopoietic microenvironment iche of human bone marrow the osteoblasts have significant effects on the characteristic maintenance and number amplification of stem cells of the HSPCs.

The invention discloses a composite premixed feed for reducing heavy metal residue in animal products as well as a preparation method and application thereof. The composite premixed feed comprises the following components in percentage by weight: 40%-88% of inorganic absorbent, 0.6%-9% of organic absorbent, 5%-25% of inorganic absorbent, 5%-30% of super-micro smashing tea powder, 0.0002%-0.015% of Se and 0.2%-10% of vitamin C. The composite premixed feed provided by the invention is added to livestock and poultry (pig, chicken and duck) compound feed, can be used for releasing the oxidation damage and other toxicity brought by heavy metal, and reducing the residue of multiple heavy metals in the animal products effectively, and has the characteristics of rich raw materials, moderate cost as well as safety and no toxicity, and is simple and convenient to prepare. The feed provided by the invention fills the blank of feed products obtained through heavy metal reduction control in the market.

The invention relates to the technical field of biology, and particularly provides an application of noninvasive ultrasonic processing of cells to preparation of exosomes, the exosomes and a preparation method and application of the exosomes. The preparation method of the exosomes provided by the invention adopts noninvasive ultrasonic processing for the cells, the cells are certainly stimulated,the expression richness of microRNA in the cell exosomes is adjusted and controlled, and/or the expression of brain-derived neurotrophy factors is potentially increased, and/or the elimination of protein from the brain is promoted, and/or the oxidation damage of hazardous substances to brain tissue is alleviated. The method is applicable to all of the cells, is good in universality and simple to operate. The exosomes are high in yield, and can obtain target exosomes within a short time. In addition, through the method, simultaneous increment of the expression richness of microRNA in the exosomes can be realized, the exosomes being high in microRNA expression changes but not the exosomes being changed in single microRNA can be obtained.

The present invention relates to an animal multi-component foodstuff which enables the animal to optimise the macronutrient content of its diet. The invention also relates to food components for use in such a foodstuff, and to use of the multi-component foodstuff in animal health benefits. The present invention relates to an animal multi-component foodstuff comprising two or more compartmentalised food compositions, of which at least two compositions differ in their content of at least two of fat, protein or carbohydrate.

The invention provides an adult regulatory T cell in-vitro amplification culture medium and an application method thereof. The adult regulatory T cell in-vitro amplification culture medium comprises transform growth factor-beta (1-4 ng/ml), bone morphogenesis protein 4 (8-12 ng/ml), recombinant human interleukin-2 (300-500U/ml), rapamycin (80-100nM/ml), al-trans vitamin A acid (1-4 uM/mL), 4-hydroxyethylpiperazinoethylsulfonic acid (20-30mM/ml), L-glutamine (2mM/ml), 2-mercaptoethanol (40-50uM/ml), 5% human AB type serum, CD3CD28 magnetic bead, penicillin (50U/ml) and streptomycin (50ug/ml). When being used for performing amplification culture and induced differentiation on regulatory T cells, the culture medium can shorten the amplification and differentiation time of the regulatory T cells, and can obtain the high-purity Foxp3CD4+CD25+CD127-regulatory T cells. Therefore, the regulatory T cells can be used in the aspect of clinical treatment of anti-transplantation immunity rejection, autoimmune disease, allergic disease and the like to perform a novel clinical cell therapy.

The invention provides an application of a metal derivative containing chlorophyll and hydrolyzate thereof as a plant growth regulator. The metal derivative containing chlorophyll and hydrolyzate thereof is selected from chlorophyll metal chelate, a chlorophyllin metal chelate and a monomeric metal chelate obtained by separating a chlorophyllin mixture. The chlorophyll is a green pigment extracted from a natural plant raw material and provided with a phaeophytin mother ring structure. The chlorophyllin is a mixture of multiple dihydroporphin components obtained by hydrolyzing the chlorophyll.The monomeric chlorophyllin component is selected from dihydroporphin-e4, dihydroporphin-e6 or phaeophorbide a monomethyl ester. Metal ions comprise bivalent or trivalent transition metal manganese, iron, copper or zinc ions in an oxidation state. The plant growth regulator provided by the invention has the advantages of safety, non-toxicity, low residue, strong activity, good effect, stable product property, controllable and reliable quality and easiness in promotion and application; the chlorophyll content of the plant can be increased, the root growth is promoted, the germination ratio is increased, the stress resistance is enhanced and the yield is also increased.

The invention relates to a composition for dispelling the effects of alcohol and protecting the liver. The composition comprises the following raw materials in parts by weight: 15-20 parts of extracts from pueraria, 15-20 parts of flower of kudzuvine extracts, 8-12 parts of turnjujube extracts and 45-55 parts of dandelion extracts. Proved by the in-vitro ADH (alcohol dehydrogenase) activity test and the ORAC (oxygen radical absorption capacity) test, the composition provided by the invention has the capability of improving the activity of the ADH timely and effectively, and can accelerate the alcohol metabolism, meanwhile can efficiently remove free radicals, can reduce the oxidative damage caused by alcohol, can prevent undesirable effects of drunkness, dizzy giddy, alcoholic liver injury and the like which are caused by heavy drinking one time and long-time drinking, can be prepared into food and healthcare food which can dispel the effects of alcohol and protect the liver, and can act as auxiliary products and the like for dispelling the effects of alcohol instantly and protecting the liver.

The present invention features therapeutic and prophylactic compositions comprising xanthohumol and/or xanthohumol/cyclodextrin complexes and methods of using such compositions for treating a skin condition, disease, or disorder.

The invention belongs to the field of nanomaterials and medical engineering and relates to antioxidant Ce-doped CQDs (carbon quantum dots) as well as a preparation method and an application thereof. Glycine is taken as a surface passivator, citric acid is taken as a carbon source material, cerium nitrate provides a cerium element, residues and water are removed through dialysis and freeze drying with a one-step hydrothermal carbonization method, and the Ce-doped CQDs are obtained. The prepared Ce-doped CQDs have excellent characteristics of a higher fluorescence property, better antioxidant effects and good biocompatibility and the like, are successfully applied to antioxidant experiments of in-vitro live cells and have broad application prospects in the field of biomedicine. The providedpreparation method has the characteristics of being simple in process, low in cost and prone to mass production.

The invention discloses a medicament for relieving alcoholism and protecting liver and preparation method thereof, which is prepared by extracts of fruit of Japanses raisintree, radices puerarire and shizandra berry. The steps are as follows: A. fruit of Japanses raisintree, radices puerarire and shizandra berry are respectively crashed; B. reflux extraction is carried out by ethanol; C. filtering is carried out while hot; D. reflux extraction is carried out by ethanol; E. filtering is carried out while hot; F. the extracting solution is merged to carry out rotatory evaporation till no alcohol taste so that dry extracts of fruit of Japanses raisintree, radices puerarire and shizandra berry are respectively obtained; G. ethanol is recovered; H. the three extracts are dried, displaced in a drier and cooled till room temperature so that dry extracts of fruit of Japanses raisintree, radices puerarire and shizandra berry are respectively obtained; I. the dry extracts of fruit of Japanses raisintree, radices puerarire and shizandra berry are mixed. The method in the invention is simple and rapid, has high extraction yield and innocuous solvent and is applied to industrial production. The recipe clears heat and promotes diuresis, removes blood stasis and removes poisonous substance, cures liver and stomach diseases, has the functions of inhibiting absorption of alcohol, promoting evacuation of alcohol, and preventing liver oxidation damage due to alcohol, can strengthen human resistance to alcohol and reduce damage of alcohol for liver.

The invention discloses a window blocking material used for a high silicon alloy smelting electric furnace, and relates to the field of chemical materials. The window blocking material comprises, by weight percent, 10 to 30% of a solid-state inorganic binder, 40 to 60% of a carbon material and 10 to 30% of a liquid-state organic binding agent. The window blocking material can effectively avoid the pollution to the high silicon alloy, it is ensured that the redox reaction of anhydrous steam and the carbon material causes the furnace window carbon brick erosion, and in the use process, the furnace window is repaired, so that the furnace window carbon brick damage speed is effectively reduced; the maintaining period of the furnace window is prolonged to 28 to 42 days, and the furnace window repair cost is reduced; the furnace window replacing frequency is reduced, the coil base yield and the product quality are improved, and the economic benefit is improved; and the window blocking material can be used in cooperation with a high silicon alloy smelting electric furnace window opening and blocking machine, the automation level is improved, operation is easy, and labor force and time are reduced.

The invention relates to a new use of inducing wheat seeds to resist salt and bud through hydrogen sulfide donor sodium hydrosulfide, in particular to application of using hydrogen sulfide donor sodium hydrosulfide to improve the germination rate of wheat seeds under salt stress. The application can remarkably improve the germination situation of the wheat seeds under salt stress and promote the seeds to germinate fast and tidily. Research shows that the pretreatment of taking sodium hydrosulfide as hydrogen sulfide (H2S) can remarkably improve the activity of amylase, lipase, protease and other hydrolases in the wheat seeds, relieve the oxidative damage of the seeds because of the salt stress, maintain ionic relative balance in the internal microenvironment of the wheat seeds and promote the growth of germs and radicle. The application is single in reagent, easy to get the reagent and simple to operate, and provides a method with important reference value for solving the problem of sowing wheat on widely distributed alkaline land and salinized farmland.

The invention relates to a cosmetic composition in the technical field of daily chemical products, in particular to an anti-blue-light cosmetic composition and a preparation method thereof. The composition is mainly prepared from, by mass, 0.1-8 parts of a citrus extract, 0.1-4 parts of a lespedeza capitata leaf/stem extract, 0.1-4 parts of cerium oxide, 0.1-8 parts of a buddleja officinalis extract, 0.1-10 parts of a hedychium coronarium root extract and 0.1-8 parts of a rutin compound. The anti-blue-light cosmetic composition can brighten the skin, reduce the oxidative damage to the skin caused by blue light, increase the survival quantity of epidermal keratinocytes under the UV radiation, maintain the integrity of the skin function, reduce the chronic mild inflammation of light aging, and provide a skin protection effect by reducing free radicals produced by the induced oxidative stress, so that the generation amount of active oxygen ROS declines to improve local microcirculation and play a vasoconstriction role, thereby controlling the fatigue signs caused by direct blue light irradiation, keeping the skin in balance of circadian rhythms, and keeping the skin in a health status.

The invention relates to blueberry and lutein ester bicolor composite tablets and a preparation method thereof, and belongs to the technical field of health-care products. The blueberry and lutein ester bicolor composite tablets comprise the following raw materials in percentage by weight of 40-80% of a glycitols sweetening agent, 3-10% of blueberry powder, 1-5% of black Chinese wolfberry fruit powder, 3-10% of lutein esters, 0.6-2% of zeaxanthin, 1-2.5% of a sour agent, 0-1% of essence and 0.5-8% of a demoulding agent. According to the blueberry and lutein ester bicolor composite tablets provided by the invention, the taste of the lutein esters can be improved, the eating desire and interest are increased, and the blueberry and lutein ester bicolor composite tablets have excellent efficacy of resisting oxidation, improving immunity and the like. Besides, the invention provides the preparation method of the blueberry and lutein ester bicolor composite tablets.

The invention discloses an antioxidant feed additive. The antioxidant feed additive is composed of, by weight parts, 5-25 parts of vitamin E, 1.5-2.5 parts of vitamin C, 15-40 parts of alpha-lipoic acid and 32.5-78.5 parts of corn starch. The invention also discloses application of the antioxidant feed additive. The antioxidant feed additive can be widely applied to feedstuff and is added into livestock feedstuff at a proportion of 0.2%, thereby improving the organic antioxidant capacity and reducing oxidative stress and oxidative damage during a livestock breeding process, and further guaranteeing viability and completeness of cells and facilitating organic health maintenance of animals and high yield.