1586 results about "Experimental animal" patented technology

The invention discloses a visual cognitive behavioral learning automatic training system of big and small mice. The visual cognitive behavioral learning automatic training system of the big and small mice comprises a training box, a main control unit, a video monitor, a microcontroller, a reward unit, a punishment unit, and a visual clue display unit. The microcontroller is connected with the main control unit through a universal serial bus (USB) interface in a communication mode. The training box is a structure that an opening is formed in the upper portion of the training box. The video monitor is arranged on the upper portion of the training box. The reward unit is composed of a food plate which is arranged on the lower portion of the training box, an infrared induction switch which is arranged on one side of the training box, and a water supply pipe which is arranged above the food plate and controlled by an electric control valve. The punishment unit is composed of a sweep frequency ultrasonic speaker which is arranged on the upper portion of the training box. The visual clue display unit comprises a capacitance-type touch screen and a display screen. The capacitance-type touch screen is arranged inside a frame. The lower frame of the frame is hinged with the side wall of the training box. The upper frame of the frame is connected with the side wall of the training box through a tension spring. The display screen is arranged at a rear position of the capacitance-type touch screen. The visual cognitive behavioral learning automatic training system of the big and small mice has the advantages that a visual cognitive behavioral learning automatic training to experimental animals is achieved.

An animal memory training system with a closed rotary maze comprises a maze device and a stimulating device. A rotary wheel (6) driven by a motor (4) is provided on the bottom of the case (1) of the maze device. The motor (4) is set in a central column, and its output shaft is tightly connected with the rotary wheel (6) along the central column shaft direction, thus the rotary wheel (6) is driven by the motor (4) to rotate around said central column. A number of pulleys (12) are set on the lower periphery of the frame of the case (1) to support said rotary wheel (6), and a sieve-like supporting net (5) is arranged above the rotary wheel (6). The stimulating device includes an automatic manipulator stimulating device and a remote control stimulating device. Compared with the existing maze model, the rotary drive action of the training system's rotary wheel is moderate, and is more coincident with the movement actual of animals' normal physiological behavior. Further, the stimulating device can respectively realize the rewards and punishments for the experimental animals, and has the characteristics of accurate positioning, timely stimulation, complete stimulation variety, no ravage and convenient operation. The training system has overtaken the existing shortcomings of unilateral dominance in the detection of the present maze training systems, such as Y-maze and T-maze detection.

The invention relates to a reconstructed ovum of an albinism model pig and a construction method thereof, and a construction method of the model pig. According to the construction method of the reconstructed ovum, tyrosinase is knocked out to obtain the reconstructed ovum of the albinism model pig. The combination of a CRISPP / Cas9 gene knock-out technique and a somatic nucleus transplantation technique proves that the method for constructing the gene modified pig has high feasibility. The obtained TYR gene knock-out pig has the typical characteristics of albinism, can provide a reliable animal model for researching human albinism, can be applied to toxicity and anaphylaxis detection and many other aspects, and is hopeful to become a standardized experimental animal for albinism-like mice.

The present invention is directed to non-pathogenic, oncolytic, recombinant polioviruses for the treatment of various forms of malignant tumors. The recombinant polioviruses of the invention are those in which the internal ribosomal entry site (IRES) of the wild type poliovirus was exchanged with the IRES of other picornaviruses, and optionally P1, P3 or the 3'NTR thereof was exchanged with that of poliovirus Sabin type. More particularly, the present invention is directed to the administration of the non-pathogenic, oncolytic, recombinant poliovirus to the tumor directly, intrathecally or intravenously to cause tumor necrosis. The method of the present invention is particularly useful for the treatment of malignant tumors in various organs, such as: breast, colon, bronchial passage, epithelial lining of the gastrointestinal, upper respiratory and genito-urinary tracts, liver, prostate and the brain. Astounding remissions in experimental animals have been demonstrated for the treatment of malignant glioblastoma multiforme, an almost universally fatal neoplasm of the central nervous system.

The present invention discloses an experimental animal low-pressure cabin for plateau medicine research, and a pressure control method based on the experimental animal low-pressure cabin, and belongs to the technical field of medical scientific research instrument equipment. The experimental animal low-pressure cabin comprises a work cabinet and an electrical cabinet arranged on the bottom portion of the work cabinet, wherein the work cabinet adopts the full transparent design so as to easily meet the illumination requirements of the experimental animals and make the laboratory personnel easily perform real time observation on the experimental animals, a gas inlet pipe extending into the work cabinet and a gas discharge pipe extending into the work cabinet are arranged inside the electrical cabin, the gas inlet pipe and the gas discharge pipe are respectively provided with an electrically controlled proportional valve and a diaphragm vacuum pump, an electrical program control system is further arranged inside the electrical cabinet, and a PLC controller adjusts the dynamic balance between the gas complementing amount and the gas exhaust amount by controlling the opening degree of the electrically controlled proportional valve and the opening of the diaphragm vacuum pump so as to make the altitude fluctuation be maintained at a certain level. According to the present invention, the air pressure control way used by the control method of the present invention is unique, the fluctuation range is small, the accuracy is high, and the number of the gas exchange can be ensured.

A breeding cage for experimental animals is composed of a box body and a cover body covered with the box body. A side of the cover body is disposed with an air intake valve and an air vent valve. A partition is disposed in the cover body to allow an inside of the cover body to define a drainage channel. Fresh air enters from the air intake valve and is then downwardly introduced into the box body through the drainage channel and pushes air originally within the box body to exhaust it away from the air vent valve to allow air within the box body to perform circulation.