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88 results about "Protopanaxatriol" patented technology

Protopanaxatriol (PPT) is an organic compound characterizing a group of ginsenosides. It is a dammarane-type tetracyclic triterpene sapogenins found in ginseng (Panax ginseng) and in notoginseng (Panax pseudoginseng).

Method for preparing protopanoxadiol and protopanaxatriol by using synergistic oxidation and alkaline bydrolysis of oxide and hyperoxide

This invention relates to a method for preparing protopanaxadiol and protopanaxatriol by co-oxidizing with oxygen and peroxide and alkali-hydrolyzing total notoginsenoside. The method comprises: (1) oxidizing and alkali-hydrolyzing Panax ginseng total saponin extract and Gynostemma pentaphyllum total saponin extract by applying cooperative effect of oxygen and peroxide, and alkali-hydrolyzing using alkoxide in situ formed in alcohol at 80-95 swg..C for 8-24 h, where the Panax ginseng total saponin extract and Gynostemma pentaphyllum total saponin extract / alcohol ratio is 30-150 g / L; (2) purifying by column chromatography to obtain protopanaxadiol and protopanaxatriol. The method adopts cooperative effect of oxygen and peroxide, thus can obtain high-purity protopanaxadiol and protopanaxatriol with high yields at low reaction temperatures and short reaction time. This invention provides a simple, convenient and low-cost method for preparing protopanaxadiol and protopanaxatriol in large amounts, which can satisfy the needs of drugs for treating cardiovascular and cerebrovascular diseases and tumor.
Owner:中山以诺生物科技有限公司

Process of preparing 20(S)-ginsenoside Rh1 with streptomycete fermentation of pseudo-ginseng saponin

A Streptomyces fradiae NTGA-344 strain with the preservation number of CGMCC No.2074 and a method for preparing 20(S)-ginsenoside Rh1 (6-O-belta-D-Glucopyranoside-20(S)-Protopanaxatriol by using the strain to ferment and convert panaxatriol saponins in various notoginsenosides in a fermentation cylinder are provided. 1(GA), ISP2, humic acid (HSG culture medium) and asparagines culture medium are selected as the culture media. In the process of fermentation, the inventory rating proportion of various notoginsenosides is 0.1% to 10 % (w/v), the fermentation temperature is 18 to 50 DEG C, the pH value of 0.1% to 35% (w/v) ammonia is dynamically adjusted to be between 2 and 8, the ventilation ratio is 0.1 to 10 (v/v), the stir speed is 10 to 900r/min, the fermentation time is 5h to 200h, and the macroporous absorbent resin is 0.1% to 30% (w/v). The invention provides the streptomyces yunnanensis with stable property, simple nutritional requirement and good growth and a practical and convenient fermentation cylinder fermentation and separation extraction process for large-scale fermentation and conversion of various notoginsenoside and preparation of 20(S)-ginsenoside Rh1. The 20(S)-ginsenoside Rh1 is prepared by the strain and the technology, thereby having low manufacturing cost, less impurity and high product yield.
Owner:KUNMING NOVOGINSENG BIOENG

Application of protopanaxadiol derivative and protopanaxatriol derivative in preparation of drugs

The invention provides an application of a protopanaxadiol derivative and a protopanaxatriol derivative in the preparation of drugs for treating or preventing neurodegenerative diseases. Pharmacological experiment results show that the above derivatives have a stronger anti-oxidation protection effect than 20(S)-protopanaxadiol and 20(S)-protopanaxatriol in H2O2 damage models of PC12 cells and N2a cells. Two vascular dementia models comprising a repeated occlusion rat bilateral vascular carotid cooperation sodium nitroprusside pressure reduction process stimulated dementia model and a bilateral hippocampus injection Abeta1-42 duplicated senile dementia model can improve the rat space exploration and orientation capability.
Owner:SHANGHAI INNOVATIVE RESEARCH CENTER OF TRADITIONAL CHINESE MEDICINE
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