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634 results about "Oleanolic acid" patented technology
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Oleanolic acid or oleanic acid is a naturally occurring pentacyclic triterpenoid related to betulinic acid. It is widely distributed in food and plants where it exists as a free acid or as an aglycone of triterpenoid saponins.
Antioxidant inflammation modulators: C-17 homologated oleanolic acid derivatives
ActiveUS7943778B2Suppresses demyelinationSuppresses transectionAntibacterial agentsSenses disorderAntioxidantMedicinal chemistry
This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula:wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
Owner:REATA PHARMA INC
Formulations and method for treating baldness
InactiveUS20060067905A1Lower Level RequirementsSlow, prevent, or even reverse hair lossCosmetic preparationsHair removalPersonal careApigenin
The present invention includes 1) a novel formulation for the treatment of hair loss comprising oleanolic acid (a 5α-reductase inhibitor), apigenin (a vasodilator), and biotinyl-GHK (a cell metabolism stimulant), 2) a novel additive for the treatment of hair loss comprising oleanolic acid, apigenin, biotinyl-GHK and a delivery agent, 3) a personal care, cosmetic, and / or dermopharmaceutical composition comprising oleanolic acid, apigenin, biotinyl-GHK, and at least one additional ingredient, and 4) a method for treating hair loss comprising the administration of oleanolic acid, apigenin, and biotinyl-GHK.
Owner:SEDERMA SA
Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17
ActiveUS8124799B2Suppresses demyelinationSuppresses transectionSenses disorderNervous disorderAntioxidantInflammation
This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula:wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
Owner:REATA PHARM HLDG LLC
Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at c-17
ActiveUS20100048892A1Improving glomerular filtration rateImproving creatinine clearanceSenses disorderNervous disorderAntioxidantInflammation
This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula:wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
Owner:REATA PHARM HLDG LLC
Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the c-ring
ActiveUS20100056777A1Suppresses demyelinationSuppresses transectionNervous disorderAntipyreticAntioxidantMedicinal chemistry
This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula:wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
Owner:REATA PHARMA INC
Antioxidant inflammation modulators: c-17 homologated oleanolic acid derivatives
ActiveUS20100041904A1Suppresses demyelinationSuppresses transectionAntibacterial agentsSenses disorderAntioxidantMedicinal chemistry
This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula:wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
Owner:REATA PHARMA INC
Compositions for Regulation of Hair Growth
InactiveUS20080254055A1Reduce frequencyImprove shaving efficiencyBiocideCosmetic preparationsPersonal carePhytic acid
Personal care composition comprising at least one hair growth regulating compound selected from the group consisting of glyceryl dilaurate, apigenin, tetrahydrocurcumin, oleanolic acid, azelaic acid, sulforaphane, canavanine, pyridoxal 5-phosphate, phytic acid, tannic acid, grape seed extract, NG-nitro-L-arginine-methyl ester, benzamidine, sodium butyrate, betulinic acid, polyornithine, polyarginine, fisetin, jasmonates, methyl-jasmonate, cis-jasmone, caffeic acid phenethyl ester, delphinidin, ethyl abietate, esculetin, sorbic acid methyl ester, canaline, N-formyl-methionine, N-formyl-alanine, taurine, palmitoyl carnitine, undecanol, undecylenic acid, rutin, fusidic acid, phenyl pyruvic acid, L-isoleucine, phenyl glycine, silibinin, silymarin, L-ascorbic acid-6-palmitate, N-undecylenoyl-L-phenylalanine, and salts, derivatives and mixtures of any of the foregoing; and a dermatologically-acceptable carrier.
Owner:THE PROCTER & GAMBLE COMPANY
Antioxidant inflammation modulators: novel derivatives of oleanolic acid
InactiveUS20120238767A1Suppresses demyelinationSuppresses transectionNervous disorderSteroidsDiseaseOxidative stress
Disclosed herein are novel oleanolic acid derivatives. Methods of preparing these compounds are also disclosed. The oleanolic acid derivatives of this invention may be used for the treatment and prevention of many diseases, including cancer, neurological disorders, inflammation, and pathologies involving oxidative stress.
Owner:REATA PHARMA INC
Antioxidant inflammation modulators: novel derivatives of oleanolic acid
ActiveUS8071632B2Suppresses demyelinationSuppresses transectionBiocideNervous disorderDiseaseMedicine
Owner:REATA PHARMA INC
Slowly-released compound acidifier for poultry and livestock feed, preparation method thereof and feed
ActiveCN102578387AMatching scienceDefinitelyClimate change adaptationAnimal feeding stuffDiseaseFeed conversion ratio
The invention discloses a slowly-released compound acidifier for poultry and livestock feed, a preparation method thereof and feed containing the same. The compound acidifier comprises the following compositions in part by weight: 30 to 80 parts of complex organic acid, 15 to 50 parts of supplementary materials and 5 to 20 parts of coating agents. The complex organic acid is citric acid, fumaric acid, malic acid, lactic acid, linoleic acid, crataegolic acid, ursolic acid, chlorogenic acid, glycyrrhizic acid and oleanolic acid, and the supplementary materials are silicon dioxide, hydroxypropyl methylcellulose and ethyl cellulose. The acidifier is scientifically proportioned, has strong efficiency and is long-acting and slow-releasing, nutrients in the feed are free from being damaged, the acidifier has good fluidity and is easy to be uniformly mixed with the feed, the digestive absorption of nutrients can be promoted, the conversion rate of the feed can be improved, the productivity of poultry and livestock can be improved, the time for domestic animals for sale can be effectively shortened, the health of gastrointestinal mucosa of the animals can be protected, the immunologic function of the animals can be strengthened, and diseases can be prevented.
Owner:BEIJING DABEINONG ANIMAL HEALTH TECH +1
Triterpene compositions and methods for use thereof
Owner:RES DEVMENT FOUND
Anti-skin damage compositions with complimentary dual mode of action
InactiveUS20090169651A1ConstantMaintenanceBiocideCosmetic preparationsChlorogenic acidAdditive ingredient
Disclosed are skin care compositions exerting a novel complementary dual mode of action in protecting the skin from day-to-day insults. The skin care compositions of the present invention comprise the extract from the liquid endosperm of Cocos nucifera as the principle ingredient along with one or more actives including the fruit rind extracts of Garcinia cambogia, Garcinia indica and Garcinia mangostana, seed coat extract of Tamarindus indicus, Chlorogenic acid extract from the beans of Coffea arabica, seed extracts of Nelumbo species, the leaf extracts of Murraya koenigii and the triterpene pentapeptides of oleanolic acid and ursolic acid. While the extract of Cocos nucifera has been included as a nutritional supplement (a natural cell culture medium) to ensure the maintenance of the viability and constant renewal of the cells of the skin, the other actives have been carefully chosen based on one or more of their effective skin care properties. The compositions of the present invention offer a safe prophylactic / therapeutic management solution to the wide range of pathological states associated with skin insults and the associated psycho-social issues.
Owner:SAMI LABS LTD
Method of treating non-insulin dependent diabetes mellitus and related complications
InactiveUS20050019435A1Block slow down conversionRelieve peripheral symptomBiocideUnknown materialsInsulin dependent diabetesCoptis
A method of treating non-insulin dependent diabetes mellitus comprising the step of providing a composition comprising a predetermined amount of berberine and a predetermined amount of catalpol, wherein said berberine and said catalpol are major active ingredients of said composition. The composition may further comprise a predetermined amount of oleanolic acid as another active ingredient. The berberine is obtained from natural herbs selected from the group of Berberis, Chelidonium, Stephniz, Coptis, Phellodendron, and Ziziphus, the catalpol is obtained from natural herbs selected from the group of Rehmannia, Verbascum, Panulownia, Glubularia and Adonis, and the oleanolic acid is obtained from natural herbs selected from the group of Olea, Swertia, Astrantia, Lonicera and Beta.
Owner:YOUNG JEFFREY
Moisturizing retinol composition
An anti-aging composition is provided that contains high potency retinol along with anti-irritant properties. In particular, an anti-aging composition includes a base, from about 0.001% to 20.0 vol % retinol, at least one anti-irritant agent, at least one antioxidant, at least one anti-inflammatory agent, and a moisturizing complex. In one non-limiting illustration, the anti-aging composition contains about 1.0 vol % retinol, plantago lanceolata, hypericum perforatum leaf extract, phytosphingosine, leontopodium alpinum extract, glycyrriza glabra root extract, sambucus nigra flower extract, nordihydrognaiaretic acid, oleanolic acid, spiraea ulmaria flower extract, evodia rutaecarpa fruit extract, boswellia serrata extract, and additives.
Owner:DERMADOCTOR LLC
Novel oleanolic acid derivatives, and preparation method and application thereof
InactiveCN104861027AOrganic active ingredientsMetabolism disorderChemical synthesisStructural formula
The invention relates to novel oleanolic acid derivatives, and a preparation method and an application thereof. The compounds are modification compounds of 3-site and 28-site substitutes in an oleanolic acid structural formula, are prepared with oleanolic acid as a raw material and by a chemical synthesis method, and can be used for treatment of cancer, diabetes, AIDS, hepatitis B and hepatitis C.
Owner:上海兰蒂斯生物医药科技有限公司
Glossy privet fruit total triterpenes extract and total phenols extract as well as preparation method thereof
The invention discloses total triterpene extract and total phenol extract extracted from Chinese herbal medicine glossy privet fruit and a preparation method thereof. The total triterpene extract mainly contains oleanolic acid, ursolic acid, acetyl oleanolic acid, indicant compound and other derivatives with acetyl oleanolic acid as the mother nucleus. The total phenol extract mainly contains hydroxyl mandelic, 3, 4-dihydroxy phenylethyl alcohol, salidroside and indicant compound and other derivatives with salidroside as the mother nucleus. The glossy privet fruit total triterpene extract and total phenol extract can be prepared by any method of solvent distillation, solvent extraction, deposition, macroporous resin absorption, supercritical fluid extraction, column chromatography and liquid-liquid countercurrent distribution chromatography, or any combination of these methods. The total percentage of various triterpenoids of the prepared glossy privet fruit total triterpene extract is 5 to 100 percent (w / w); wherein, the content of oleanolic acid and ursolic acid accounts for 5 to 100 percent (w / w) of the total triterpene. The total percentage of various phenols of the prepared glossy privet fruit total phenol extract is 5 to 100 percent (w / w); wherein, the content of salidroside accounts for 5 to 100 percent (w / w) of the total phenol.
Owner:石任兵
Inhibitors and Enhancers of Uridine Diphosphate-Glucuronosyltransferase 2B (UGT2B)
ActiveUS20090074708A1Increase heightReduced activityBiocideHydroxy compound active ingredientsPolyethylene glycolEriodictyol
A UGT2B inhibitor capable of increasing the bio-availability of a drug, is a compound in a free base or a pharmaceutically acceptable salt form that is selected from the group consisting of: capillarisin, isorhamnetin, β-naphthoflavone, α-naphthoflavone, hesperetin, terpineol, (+)-limonene, β-myrcene, swertiamarin, eriodictyol, cineole, apigenin, baicalin, ursolic acid, isovitexin, lauryl alcohol, puerarin, trans-cinnamaldehyde, 3-phenylpropyl acetate, isoliquritigenin, paeoniflorin, gallic acid, genistein, glycyrrhizin, protocatechuic acid, ethyl myristate, umbelliferone, PEG (Polyethylene glycol) 400, PEG 2000, PEG 4000, Tween 20, Tween 60, Tween 80, BRIJ® 58, BRIJ® 76, Pluronic® F68, Pluronic® F127, and a combination thereof. A UGT2B enhancer capable of enhancing a clearance rate of morphine-like analgesic agents, is a compound in a free base or a pharmaceutically acceptable salt form that is selected from the group consisting of: nordihydroguaiaretic acid, wogonin, trans-cinnamic acid, baicalein, quercetin, daidzein, oleanolic acid, homoorientin, hesperetin, narigin, neohesperidin, (+)-epicatechin, hesperidin, liquiritin, eriodictyol, formononetin, quercitrin, genkwanin, kaempferol, isoquercitrin, (+)-catechin, naringenin, daidzin, (−)-epicatechin, luteolin-7-glucoside, ergosterol, rutin, luteolin, ethyl myristate, apigenin, 3-phenylpropyl acetate, umbelliferone, glycyrrhizin, protocatechuic acid, poncirin, isovitexin, 6-gingerol, cineole, genistein, trans-cinnamaldehyde, and a combination thereof.
Owner:NAT DEFENSE MEDICAL CENT
Oleanolic acid triterpene with A ring and C ring both containing multiple oxygen-containing substituents and use thereof
The invention provides an oleanolic acid triterpenoid, whose A ring and C ring contain multiple oxygen substituents, represented as formula (1). The inventive compound can inhibit the growth activity of tumor cell, thereby being applied in the preparation of anti-tumor drug and can inhibit mice ear swelling caused by dimethylbenzene, thereby being applied in the preparation of anti-inflammatory agent. The formula (1) is represented as above.
Owner:ZHEJIANG UNIV
Oregano and mint Anti-inflammatory compositions and methods
InactiveUS20120135094A1Facilitates frameworkReduce painFood ingredient as antioxidantBiocideAdditive ingredientLiquid chromatography mass spectroscopy
The present invention relates to bioactivity-guided isolation and identification of bioactive compounds from oregano and mint plants, in particular, rosmarinic acid, oleanolic acid and ursolic acid, and use of these compounds or combinations thereof as anti-inflammatory agents for the treatment of conditions related to pain and inflammation and / or as ingredients of dietary supplements. The invention also relates to optimization of the methods for qualitative and quantitative analysis of the bioactive compounds in oregano and mint plants. In particular, this invention introduces an LC / MS (SIM mode) method to achieve co-quantitation of the three organic acids using a unique tandem column system. In addition, the invention also relates to the methods for recovering various water-soluble polyphenols and triterpenes from aromatic plants.
Owner:RUTGERS THE STATE UNIV
Composition to retard the onset of symptoms of alzheimer's disease
A composition and a method for using the composition to delay the onset of the symptoms of Alzheimer's disease in humans, comprising curcumin, piperine, oleic acid, oleanolic acid, ursolic acid, galantamine, and huperzine A, among other compounds. Curcumin is an antioxidant, while galantamine and huperzine A inhibit the activity of acetylcholinesterase in the brain. Piperine and oleic acid increase the bioavailability and gastrointestinal absorption of curcumin, galantamine, huperzine A, and other nutrients.
Owner:CONSEAL INT
Oleanolic acid couple derivatives and their pharmaceutical use
The invention discloses an oleanolic acid couple, which is a nitric oxide donator type OLA derivative coupled by dissimilar NO donators with hepatic disease treating medicament oleanolic acid (OLA) through binding groups with ester bonds or amido bonds, wherein the suppressor cell apoptosis action of some of the compounds is stronger than that of the NCX-10000 that are undergone US stage I clinical research, thus may possibly be used for the treatment of hepatitis and cirrhosis.
Owner:CHINA PHARM UNIV
Method of separating and purifying ursolic acid and oleanolic acid
InactiveCN101016328AGood chemical stabilityReduce difficultySugar derivativesSteroidsSlagUrsolic acid
The invention discloses an extracting method of urson and oleanolic acid from bitter leaves, which comprises the following steps: adopting bitter leaves from Hainan as raw material; extracting through pure water; filtering; refluxing filter slag to extract through alcohol; adopting inorganic film filtering method to remove macromolecular impurity in the extract; hyperfiltering; condensing the penetration liquid through nanofiltering; adsorbing and eluting through macromolecular resin chromatographic column; condensing eluent to crystallize; obtaining rough product of total triterpenic acid; washing the rough product; dissolving in the alcohol; alkalining; acidifying; washing again; recrystallizing; obtaining the total triterpenic acid; dissolving the total triterpenic acid in the carbinol to boil; filtering; condensing filtrate; evolving; obtaining the monomer product of oleanolic acid; washing the sediment; dissolving the crystal through alcohol; obtaining the monomer product of urson; hyperfiltering and clarifying filtrate of bitter leaves; nanofiltering; condensing; adsorbing through polyamide resin selectively; eluting; condensing the eluent; obtaining the monomer of tea polyphenol with certain purity.
Owner:JIANGSU JIUWU HITECH
Pharmaceutical composition and method for preventing or treating hepatitis c
A pharmaceutical composition for preventing or treating hepatitis C is provided, including oleanolic acid derivatives as an active ingredient and a pharmaceutically acceptable carrier. A method for preventing or treating hepatitis C in a subject in need thereof is also provided by administering the subject the pharmaceutical composition given above.
Owner:IND TECH RES INST
Method of protecting plants from bacterial and fungal diseases
Improved methods and compositions for protecting plants or seeds from plant diseases are provided. The compositions comprise (and preferably consist essentially of) saponin, such as triterpene type saponins extracted from quinoa or quillaja. Compositions according to the invention may comprise (or consist essentially of) a quantity of a sapogenin compound, preferably a sapogenins selected from the group consisting of oleanolic acid, hederagenin, phytolaccinic acid, and quillaic acid. The methods comprise contacting the portion of the plant (e.g., foliage, shoot, etc.) to be treated with a disease-inhibiting or protective amount of the composition. The compositions can also be used to treat plant seeds or tubers prior to planting thereof, as well as soil adjacent a growing plant. The inventive compositions are particularly useful for the treatment, control and / or prevention of bacterial diseases. The saponins of the invention can be applied as liquids or dry particulates, and are especially suited for the treatment of tomato and potato plants and their respective seeds.
Owner:NORTHERN QUINOA CORP
Process for separating and purifying special component specnuezhenide of glossy privet fruit
The invention relates to a process for separating and purifying a special component specnuezhenide of glossy privet fruit, which is a dry ripe fruit of Ligustum lucidum Ait recorded in the books of Chinese Pharmacopoeia in all ages. The current Chinese Pharmacopoeias shows that the component under the item of the traditional Chinese medicament glossy privet fruit is oleanolic acid after identifying the film and measuring the content, and the component is contained in different medical materials, so it is not special. Through research, the specnuezhenide belongs to secoiridoid glycoside compounds, and is the special component of the glossy privet fruit, so the specnuezhenide can be used as an important index for controlling the quality of the glossy privet fruit. The special component has been recorded under the item of the traditional Chinese medicament glossy privet fruit in Chinese Pharmacopoeias 2010 Edition, and is about to be issued and implemented as the content of Chinese Pharmacopoeia. The process for separating and purifying the specnuezhenide is invented by researchers of Institute of Chinese Materia Medica, China Academy of Chinese Academy of Sciences, and is prepared by ethanol extraction, macroporous absorbent resin separation, and reverse silica gel column purification.
Owner:INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
Oleanolic acid liposome preparation, freeze dried powder injecta thereof and its preparation
InactiveCN1923178AReduce lossesGood biocompatibilityOrganic active ingredientsDigestive systemSide effectCholesterol
The invention relates to the liposome with oleanolic acid, relative freeze dried. Wherein, the liposome comprises oleanolic acid, phosphatide, cholesterol and surface activator, while their ratios are 1:10-80:0-20:0-50; the freeze dried is formed by oleanolic acid agent, dextran, monosaccharide, diose and / or polysaccharide, while their amounts are based on the mass of phosphatide, that one deal of phosphatide takes 0.2-5.0 deals of them; when the oleanolic acid is made into liposome, it can be inactively targeted into liver, to improve the drug density and reduce side effect; the drug will be slowly released in human body, to prolong the effective time; and its package rate is higher than 75%, particle diameter is 100-800cm.
Owner:HENAN UNIVERSITY
Comprehensive extraction technology of rosmarinic acid, ursolic acid, oleanolic acid and carnosic acid
InactiveCN104447334ASimple processEasy to operateOrganic compound preparationSteroidsAlcoholUrsolic acid
The invention discloses a comprehensive extraction technology of rosmarinic acid, ursolic acid, oleanolic acid and carnosic acid. The comprehensive extraction technology comprises the steps of (1) preprocessing raw materials; (2) performing reflux alcohol-extraction; (3) carrying out primary separation; (4) separating out rosmarinic acid; (5) separating out ursolic acid; (6) separating out oleanolic acid. According to the comprehensive extraction technology, the process is simple, the operation is convenient, industrial production can be easily carried out, and meanwhile, the purpose of synchronously extracting rosmarinic acid of rosemary, ursolic acid, oleanolic acid and carnosic acid is achieved, and the active ingredients of rosemary can be extracted to the maximum; the rosmarinic acid, ursolic acid, oleanolic acid and carnosic acid respectively have the purity exceeding 30%, 25%, 20% and 25%.
Owner:付大亮
Oleanoyl peptide composition and a method of treating skin aging
ActiveUS20110091398A1Increase skin thicknessReduce hyperpigmentationBiocideCosmetic preparationsWrinkle skinPremature ageing
The present invention relates to a composition containing peptide of SEQ ID No. 1 linked to oleanolic acid and a method of treating skin aging. The composition effectively reduces signs of ageing due to oxidation, collagen insufficiency and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin, fine expression lines, reduced skin thickness, hyperpigmentation, under eye dark circles, and premature ageing.
Owner:SAMI LABS LTD
Pentacyclic triterpenoid cyclodextrin clathrate compound proliposome and preparation method thereof
ActiveCN102871848ALess irritatingEasy to useCosmetic preparationsBody powdersCholesterolBetulonic acid
Owner:西安雅芝生物科技有限公司
Recombinant saccharymyces cerevisiae for producing ginsengenins as well as construction method and application of same
The invention discloses a recombinant saccharymyces cerevisiae for producing ginsengenins as well as a construction method and an application of the same. The recombinant saccharymyces cerevisiae capable of producing three ginsengenins of oleanolic acid, protopanoxadiol and protopanaxatriol simultaneously is Saccharymyces cerevisiae GY-1, with a collection number of CGMCC No. 7725 in the China General Microbiological Culture Collection Centre. The saccharymyces cerevisiae GY-1 is capable of producing three ginsengenins of oleanolic acid, protopanoxadiol and protopanaxatriol simultaneously, wherein the yields achieve 21.4 mg / L in fermentation broth, 17.2 mg / L in fermentation broth and 15.9 mg / L in fermentation broth respectively, the proportions of which in the total ginsengenin content are 39.3%, 31.5% and 29.2% respectively.
Owner:TIANJIN INST OF IND BIOTECH CHINESE ACADEMY OF SCI
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