Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
Hiro

544 results about "Cell metabolism" patented technology

Polymer formulations containing perfluorinated compounds for the engineering of cells and tissues for transplantation that improves cell metabolism and survival, and methods for making same

InactiveUS6630154B1High viscosityMedium viscosity alginatesPowder deliveryBiocideCross-linkInorganic salts
Disclosed and claimed are: a composition including at least one glycosaminoglycan, e.g., CIS, at least one perfluorinated substance and at least one alginate, e.g., sodium alginate, wherein:the at least one glycosaminoglycan and / or the perfluorinated substance and / or the alginate are cross-linked or polymerized, e.g., the alginate is cross-linked or polymerized, for instance by addition of an inorganic salt, such as a calcium salt; orthe at least one glycosaminoglycan, the perfluorinated substance and the alginate are covalently bound, e.g., by means of a coupling reaction involving a linker molecule such as DVS; orthe at least one glycosaminoglycan and / or the perfluorinated substance and / or the alginate are cross-linked or polymerized, e.g., the alginate is cross-linked or polymerized, for instance by addition of an inorganic salt, such as a calcium salt, and the at least one glycosaminoglycan and the alginate are covalently bound, e.g., by means of a coupling reaction involving a linker molecule such as DVS, and the covalent binding can have been performed prior to cross-linking or polymerizing or vice versa; and,gels comprising the composition; mixtures of such gels or of at least one such gel and at least one such composition; and,methods for making and using such compositions and gels, including products therefrom such as "paints", sprays, matrices, beads, microcapsules.
Owner:BIOMM +1

Anti-aging cream

ActiveUS20080057088A1Reviving radianceRestore abilityBiocideCosmetic preparationsCellular metabolismAntioxidant
A skin care composition is useful for augmenting cellular metabolism in skin cells and thereby enhancing the regulation of intracellular signaling. The composition comprises a primer for skin cell mitochondrial function, such as a Krebs cycle intermediate, a precursor of a Krebs cycle intermediate, salts or esters thereof, or combinations thereof. The composition may also include antioxidants for free radical regulation and a pharmaceutically acceptable topical vehicle, such as an emollient base for skin health. A method for stimulating the mitochondrial activity of skin cells comprises administering to the skin of a person in need thereof a composition as described herein.
Owner:BLASS JOHN P

Negative correlation between IRP-2 and Transferrin receptor expression as a diagnostic of Alzheimer's disease

A method of diagnosing Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) is disclosed which was identified by the fact that an increased level of iron regulating protein-2 (IRP-2) was identified in Alzheimer's patients. Further, diseases of increased cellular metabolism such as cancer showed high levels of both IRP-2 and transferrin receptor. This suggests that, in diseases of increased cellular metabolism, both aspects of iron accumulation are highly expressed, while in Alzheimer's disease only IRP-2 is highly expressed. From these results, a non-invasive test for Alzheimer's disease may be produced using patient samples containing peripheral blood cells and identifying the level of expression of IRP-2 and Transferrin receptor. Those patients which: 1. over-express IRP-2 as compared with normal controls, and 2. have comparable levels of Transferrin receptor expression to normal controls, can be identified as having or prone to AD and MCI. Further, it can be envisioned that this may be used for further diagnosis and staging of cancers of the blood.
Owner:LOMA LINDA UNIV MEDICAL CENT

Artificial flexible-posture preserved ornamental plant and processing method thereof

The invention discloses an artificial flexible-posture preserved ornamental plant and a processing method thereof. The artificial flexible-posture preserved ornamental plant is prepared from a naturally grown living herbaceous plant or woody plant which is harvested, kept natural posture, subjected to disinfection, fresh-keeping and coloring treatment, and then used as an ikebana material. The processing method comprises that: after pretreated, a living flowering plant material is soaked by a flexible-posture plant treating agent prepared from carbohydrate, a nourishment regulator, an antioxidant, a humectant, a preservative, edible pigment and water in a soaking container at an environmental temperature of between 15 and 22 DEG C and a relative humidity of between 70 and 80 percent untilleaves on the top of the plant are evenly dyed; and the soaked plant is aired, dried, graded and shaped into the artificial flexible-posture preserved flower material. The method utilizes the naturalmechanism of cell metabolism of flower plants, performs cellular fluid displacement and cell enclosing treatment through the flexible-posture plant treating agent, and makes the plants keep natural postures, texture and flexibleness, not influenced by spacial environment, and preserved as long as 1 to 2 years. The artificial flexible-posture preserved ornamental plant taken as a bonsai flower material does not need water dressing or daily maintenance, has stronger enjoyment property than a dry flower, and prolongs the fresh-keeping time by hundreds of times than fresh cutting plants and flowers.
Owner:云南绿荫园艺有限公司 +1

Method and device for fundus oculi affection early diagnosis using time discrimination autofluorescence lifetime imaging

The invention relates to a novel measurement method and the device thereof, which combines the time-resolved self-fluorescence lifetime imaging technology and a laser scanning confocal ophthalmoscopeand realizes the early diagnosis of the ocular fundus diseases by obtaining and analyzing the self-fluorescence intensity and the service life information of the ocular fundus. The light which is emitted by a pulse laser is sent to the scanning head of the laser scanning confocal ophthalmoscope to excite the ocular fundus inner-source flgorgen, and the fluorescence which is emitted from the ocularfundus is collected by a time-correlated single photon counter or a high-repetition-rate synchronous scanning camera, so as to realize the service life measurement and the imaging of the self-fluorescence. As the service life of the self-fluorescence of the ocular fundus is very sensitive to the micro-environment and the cell metabolism state of flgorgen molecule and is not affected by the difference of the intensity of the flgorgen of the ocular fundus, the measurement of the fluorescence service life provides a brand new route for the detection of ocular fundus diseases and the obtainment of the function information of ocular fundus. The invention can become the solution and the basis of the early diagnosis of various ocular fundus diseases, which plays an important role in pathogeny research, clinical diagnosis, staging and typing, prognosis judgement, real-time observation and the analysis of the development of ocular fundus diseases, therefore the invention can be widely appliedin the field of medical research and clinical medical diagnosis.
Owner:SHENZHEN UNIV

Scaffold for skin tissue engineering and a method of synthesizing thereof

The embodiments herein disclose a method of fabricating composite scaffolds for skin tissue regeneration. The methacrylated hyaluronic acid (HAMA) and methacrylated gelatin (GelMA) are synthesized. The poly (glycerol sebacate)-poly(ε-caprolactone) (PGS-PCL) microfibrous scaffolds are synthesized. The hydrogel is synthesized. The composite scaffold comprising hydrogel and poly (glycerol sebacate)-poly(ε-caprolactone) (PGS-PCL) microfibrous scaffolds is fabricated. A plurality of physico-chemical characteristics of the composite scaffold comprising hydrogel and poly (glycerol sebacate)-poly(ε-caprolactone) (PGS-PCL) microfibrous scaffolds are analysed. The physico-chemical characteristics comprises mechanical properties, swelling ratio and enzymatic degradation and scanning electron microscope imaging. The fibroblast cells are encapsulated within the composite scaffold comprising hydrogel and poly (glycerol sebacate)-poly(ε-caprolactone) (PGS-PCL) microfibrous scaffolds and hydrogels. The fibroblast cells are seeded on composite scaffold and PGS-PCL scaffold. The fibroblast cell viability, fibroblast cell attachment, fibroblast cell spreading, fibroblast cell proliferation and fibroblast cell metabolism are analysed in composite scaffolds, PGS-PCL scaffolds and hydrogels.
Owner:ESLAMI MARYAM +2

Microbial feed additive capable of accelerating lactation and improving milk product quality and preparation method

The invention relates to a microbial feed additive for promoting lactation and improving the quality of dairy products and a production method thereof, and is characterized in that raw materials of lactobacillus plantarum, streptococcus lacticus, lactobacillus casei, saccharomyces cereviseae, nutritive medium, sterile water, etc., are first treated with anaerobic fermentation; fermentation liquor are then mixed after centrifugation and blended with nutrition carriers evenly to be placed in a closed fermentation chamber for anaerobic fermentation and finally crushed into power after dried so as to obtain the finished products. The invention comprises a great deal of effective microorganisms, antioxidants of coenzyme, SOD and vitamins, etc., and physiological metabolins of amino acid and active peptides, etc. which can have effects of nutrifying and repairing cell and improving cell metabolism after entering the body of a cow so as to form sound ecological environment in the cow body, promote transformation and absorption of nutrient matters and immunity of the organism and even prevent garget of the cow and improve the ability of anti-heat stress and the quality of dairy products while improving the milk yield of cows.
Owner:SHANGHAI CHUANGBO ECOLOGICAL ENG

Fluorochrome for cytolysosome positioning and preparation method and application thereof

The invention discloses fluorochrome for cytolysosome positioning and a preparation method and application thereof. The preparation method of the fluorochrome compound includes the steps that a benzophenone derivative containing methyl substituents is reacted under the catalysis of Zn/TiC14, an obtained product and N-bromosuccinimide are subjected to a bromination reaction, then a product is reacted with morpholine, and the tetraphenyl ethylene derivative stain containing morpholine groups is obtained. The preparation method is easy to implement, raw materials are easy to get, and reaction conditions are mild. The obtained fluorochrome contains tetraphenyl ethylene fluorescence groups capable of gathering the activity of inducing fluorescence emission and can be used for performing specific staining on all kinds of cytolysosome. The fluorochrome has the advantages of being small in cytotoxicity, stable in cell metabolism resistance, good in photobleaching resisting effect and the like and hardly affects normal physiological activities of cells, and a new method is provided for observing the morphologic changes of cytolysosome for a long time. The fluorochrome can be widely applied to monitoring the morphology of cytolysosome, observing the apoptosis process and the like.
Owner:CENT SOUTH UNIV

Model and Methods for Identifying Points of Action in Electrically Active Cells

The invention provides a model for generating predicted action potentials of an electrically active cell. The disclosed model includes three operatively coupled submodels. A first submodel contains Hodgkin-Huxley elements generating action potentials based on electrical equivalent circuits. A second submodel is based on reaction kinetics of cell metabolism and is operatively coupled with the first submodel. A third submodel is based on Boolean dynamics representing signaling and associated cellular processes and is operatively coupled with the first and second submodels. The invention includes storing a library of calculated action potentials and associated cellular parameters generated by the model, applying a stimulus to the electrically active cell in vitro so that the cell generates an action potential; and comparing the cell-generated action potential with those stored in the library, wherein a match is predictive of the cellular point of action of the applied stimulus according to the parameters stored.
Owner:UNIV OF CENT FLORIDA RES FOUND INC

Wearable physiotherapy device with functions of emotion and sleep adjustment and skin care

The invention discloses a wearable physiotherapy device with functions of emotion and sleep adjustment and skin care. The wearable physiotherapy device comprises a transverse beam and two side beams,and the two ends of the transverse beam are connected with the two side beams through corner connecting parts; the transverse beam is provided with an air fresher chamber, the tail ends of the two side beams are provided with hanging lugs and micro audio playing modules respectively, and the two corner connecting parts are provided with upper covers and light-emitting panels; the upper covers, thelight-emitting panels and the corner connecting parts define a light-emitting part mounting space, and the light-emitting part mounting space is internally provided with an LED light set, a first-stage light reflecting panel and a second-stage light reflecting panel. According to the wearable physiotherapy device, the personalized sleep adjustment can be achieved by utilizing sound, light rays and odor, and therefore the life quality of a user is significantly improved; the light rays adopted for phototherapy can be set to have specific wave bands, so that the device has the function of promoting blood circulation and cell metabolism and proliferation to achieve the effect of skin care and beautifying; meanwhile, through the combination of the emotion adjustment function of the phototherapy, the product has higher use value.
Owner:苏州美瑞康医疗科技有限公司

Method for preparing three-dimensional cell scaffold for in-vitro toxicological evaluation of tobacco products and method for cell culture by use of three-dimensional cell scaffold

ActiveCN107674141AEvaluation results are objectiveThe evaluation result is trueEpidermal cells/skin cellsArtificial cell constructsIn vitro toxicology3D cell culture
A method for preparing a three-dimensional cell scaffold for in-vitro toxicological evaluation of tobacco products is characterized in that an interconnected and porous material provided with a polymer is obtained through high-internal-phase emulsion polymerization in a cell culture dish, the material has large holes of the size of cells for in-vitro toxicological evaluation of tobacco products, the holes are communicated with one another, thereby facilitating input of oxygen and nutrients required for cell growth and output of cell metabolism waste, and the material surface is modified, so that the material has good cell affinity. Compared with existing panel type monolayer cell culture methods commonly adopted for toxicological evaluation, the method has the advantages that cells can realize three-dimensional growth on the scaffold and have more closer three-dimensional shape and biochemical and functional properties as compared with that originally in vivo. Therefore, when the cellscultured by use of the three-dimensional cell scaffold are used for in-vitro toxicological evaluation of the tobacco products, the evaluation result is more objective and real. The cell scaffold is prepared in the culture dish and is more convenient for following experiments.
Owner:ZHENGZHOU TOBACCO RES INST OF CNTC

Moisturizing cosmetic composition and application thereof

The invention discloses a moisturizing cosmetic composition and application thereof. The moisturizing cosmetic composition comprises barley seed extract, almond extract, aloe extract C14-22 alcohol / C12-20 alkyl glucoside, glyceryl stearate / PEG-100 stearate, cetearyl alcohol, squalane, polydimethylsiloxane, caprylic / capric triglyceride, avocado tree fruit grease and sodium hyaluronate. Natural plants are matched according to a specific proportion, and various functional ingredients are mutually coordinated and synergistic, so that the moisturizing cosmetic composition can effectively promote cell metabolism, soften cuticle, moisten skin, inhibit tryosinase, brighten skin color and nourish nutrition, has comprehensive nursing effect and has more remarkable moisturizing effect especially.
Owner:聚吉减肥塑形科学技术研究院(广州)有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products