591 results about "Medical research" patented technology

A medical record is partitioned into personal and medical data portions, and an identification code is concatenated into each portion. The personal data portion is encrypted so a patient's identity cannot be linked to the patient's medical data except by authorized viewers. Each portion of the secure medical record can be transferred over a network as separate files, and stored in a data storage system separately. Access to the entire medical record is thereby provided only to those who know the key for the personal data portion of the medical record. The system and method can be used to help ensure patient confidentiality while allowing patient medical records to be accessed over a network such as the Internet, providing physicians and patients quick access to their medical records. The system and method can be used to create a database of anonymous medical records useful for medical research.

In a system for conducting medical studies a number of medical locations, such as clinics or medical practices, are connected to a central server via a computer network. The system is constructed in modular fashion, and it is automatically determined, with computer support within the system, whether a specific patient is eligible to participate in a medical study of the system, and if so, the sequence of the corresponding medical study is controlled centrally by corresponding modules, automatically and in a study-specific and patient-specific fashion.

Medical apparatus and processes controllably generate medically useful micro or nano bubbles of medically desirable and controllably selectable size, size distribution, homogeneity and concentration (and / or other key bubble parameters) for patient infusion, and / or which may incorporate therapeutic or other agents for patient infusion and / or may be combined with therapeutic or other agents prior to infusion into patients. The bubble generation apparatus and processes controllably permit the adjustment and selection of key bubble parameters through bubble generation actuation and orientation techniques and through selection of bubble fluid compositions in order to facilitate medical research and / or to optimize treatment for imaging, therapy, sonoporation, inertial and non-inertial cavitation, and acoustic activation, among other medical uses. Disposable cartridges containing such bubbles are provided and may include means for patient infusion.

The present invention provides a fundus image classification method and device of retinopathy. The method comprises a step of obtaining the fundus image of an eye detection patient, a step of preprocessing the fundus image and obtaining a corresponding grey fundus image, a step of extracting a preset image characteristic in the grey fundus image, a step of analyzing the preset image characteristic according to the diabetic retinopathy classification model of the fundus image, and obtaining the classification result of the corresponding fundus image, a step of extracting the preset image characteristic in the preprocessed grey fundus image, and carrying out prediction classification on the above preset image characteristic through the diabetic retinopathy classification model established according to a support vector machine and a deep neural network so as to obtain a final classification result. The artificial participation is not needed in the whole process, the workload of doctors is reduced, the high standard requirement of the medical qualification level of the doctor is reduced, the accuracy of classification is improved, and the method and the device have great significance for specific applications and medical research.

A system and method for providing balanced, automated regulation of a patient's physiological condition by monitoring at least one physiological parameter and, optionally, monitoring and controlling additional physiological parameters, is disclosed. The system includes a physiological parameter monitor, an intelligent control device and a multi-channel delivery device for providing controlled intravenous delivery of at least two medications that affect the physiological condition being controlled. Control logic in the intelligent control device is derived by an algorithm based on model predictive control. The control logic includes mathematically modeled systems, empirical data systems or a combination thereof. The system of the present invention is optionally included in a networked system to provide centralized data storage and archival of system information as well as data export and query capabilities that can be used for patient file management, health care facility management and medical research.

A data processing system is provided for determining clinical outcomes of medical data gathered by the system. The system can allow a person to define a medical study and can then administer the medical study and can collect and analyze data from potentially geographically diverse doctors, patients and other people associated with a study. Users enter sets of medical information. The system can analyze the medical data according to any number of clinical algorithms that may be custom defined and edited before and during the study. The system conditionally outputs the clinical outcome to the user. The clinical outcome can be used for treatment of patients participating in the study immediately after the data is input and analyzed. The medical outcomes can indicate such things as performance comparisons, composite outcomes, and risk stratification and assessments for such things as treatments, drugs, illnesses, doctors, patients and physician groups.

Disclosed are living, three-dimensional tissue constructs for in vitro scientific and medical research, arrays thereof, and methods of making said tissues and arrays.

A system and methods for a network for medical research and clinical trials are provided. Methods and systems for setting-up a clinical trial have been disclosed. Methods and system for identifying and qualifying participants in a trial have also been disclosed. Methods and systems for the automatic collection, extraction, distribution and review of data are also provided. Integration of a healthcare transcription platform with a clinical trial system is also disclosed.

The present invention relates to a head restraint kit for use with a medical head device for immobilizing the head of a patient in medical research, diagnosis and operation. The head restraint kit is particularly suitable for use with a head coil for magnetic resonance imaging. The head restraint kit contains a head rest pillow for providing support to the head of a patient, a neck cushion for providing neck support, and one or more wedge cushions for providing further support for the head. The head restraint kit may also contain one or more compact square cushions which can be inserted into a space between the head and the medical head device for additional head support. The head restraint kit may further contain a cloth strap placed over the forehead of a patient for protecting and securing the head against movement.

The invention relates to a structured report template-based medical image knowledge base establishment method and belongs to the field of medical information processing and application. For improving data availability, a multi-modal stored medical image is converted into structured big data, so that data innovation and value addition are realized and accurate data support is provided for medical research. The method comprises the steps of establishing characteristic noumena of the medical image; defining standards of disease syndromes; designing report templates by taking structured data as elements; forming knowledge elements and exchanging information; and establishing learning rules. Through noumenon library establishment, disease syndrome definition, a text report template, an image-text report template and a CDA document, a relationship between a diagnosis conclusion and image presentation is established, so that the retrieval efficiency is high and the accuracy is greatly enhanced; by establishing the learning rules, the knowledge elements are continuously perfected, so that the medical research is assisted and the medical image level of the whole industry is improved; and the method has extremely wide application values.

The invention relates to a clinical medical entity and an attribute extraction method thereof. The method comprises the following three modules: (1) preprocessing; (2) comprehensive expression of information of the sentences; and (3) joint learning of the clinical medical entity and attribute extraction thereof. The joint learning method mainly comprises two modes: (1) a serial joint mode; and (2)a parallel combination mode. The serial combination mode is divided into three sub-modules: (1) identification of'entities / attributes' of clinical medical treatment; (2) extracting an entity-attribute relation of clinical medical treatment; (3) joint learning. The parallel combination mode is that a sequence labeling method is adopted to carry out clinical medical entity and attribute combinationextraction. The method is of great significance to clinical medical aid decision making, clinical medical research and the like.

The invention discloses a method for improving the efficiency of CRISPR mediated homologous recombination. The method includes the steps of: inhibiting the expression of Lig4, DNA-PK and XRCC6 by shRNA so as to inhibit the non-homologous end joining (NHEJ) repair pathway; conducting fusion expression on sgRNA and shRNA at targeting genome specific positions to form shRNA-sgRNA polycistron; and placing the polycistron at the RNA polymerase II or RNA polymerase III promoter downstream. The carrier constructed by the method provided by the invention has a concise structure and is convenient to use, also enhances the homologous recombination efficiency by dozens of times, greatly expands the function and application of the CRISPR carrier, and is a good tool for functional gene and signal pathway research, medical research, and recombinant protein expression.

The invention discloses a method for breeding rmnd5b (required for meiotic nuclear division 5homolog B) gene deletion type zebra fish through gene knockout and belongs to the field of gene knockout. According to the method, construction of a gRNA expression vector and gRNA in-vitro synthesis are performed through design of a CRISPR / Cas9 (clustered regularly interspaced short palindromic repeats / CRISPR-associated 9) gene knockout target site, micro-injection is performed on an embryo of the zebra fish, the effectiveness of the target site is detected, tail cutting identification is performed, TA cloning is performed on a target sequence, plasmids are subjected to Sanger sequencing, an F1 generation of heritable zebra fish mutants is obtained, the same mutant female fish and male fish are picked from mutants of the F1 generation, hybridization is performed, an F2 generation of the zebra fish mutants is obtained, F2 generation homozygote is picked from the F2 generation of the zebra fishmutants, F3 generation pure-line inheritance is performed, and an rmnd5b gene deletion type zebra fish strain is obtained. The method is lower in off-target rate and has good medical research value inresearch of the correlation between rmnd5b gene deletion and development of other organs.

A method and apparatus for information repository workflows to transfer information between a first domain (e.g., healthcare sites) and a second domain (e.g., medical research facilities). Large quantities of medical information may be directly transferred to an information repository or indirectly transferred to the repository through the use of pointers. The information is cleansed and normalized prior to storage in a production database within the repository. The cleansing process is conducted while ensuring integrity of the production database is maintained and while continuing to receive additional information transfers. Errors encountered during processing are logged and reported.

The invention provides a deep learning-based cell detection counting method and system. The method comprises the steps of scanning a pathological section, and converting entity section information into a digital pathological image; performing real situation marking on cells or cell nuclei in the digital pathological image, recording mark information, and constructing a data set based on the digital pathological image and the mark information; dividing the data set into a training set and a test set; inputting the training set to a deep convolutional neural network-long-short-term memory network for performing training; and inputting the test set to the trained deep convolutional neural network-long-short-term memory network, and outputting a counting result. According to the method and thesystem, the robustness and accuracy of cell detection counting can be remarkably improved; the digital pathological image is subjected to quantitative analysis with a high-flux processing rate; and reliable data analysis support is provided for pathological image-based medical research.

A method and computer program manages medical research study information and laboratory test result information. The program generates an interactive user interface with elements for setting up a study (702), managing study member information (704), managing patient information (706), receiving and displaying comments (708), and configuring data to be stored in a database associated with the research study (710). The program also receives medical event information from a user and laboratory test result information from a laboratory information system (20d), and generates a chart (934) that correlates the test results and the medical events. The program also receives a normal range pertaining to a test result from the laboratory information system (20d) and provides a normal range indicator (952) for the test result.

The invention relates to a medical information processing method and device. According to a human organ tissue structure defined by a clinical medical term standard, a framework of a hierarchical tree topology structured language file format is built; a standard organ tissue node, a clinical vocabulary node and a corresponding logical relationship node and an attribute node are established in the framework; patients' medical information stored in a medical information system is collected and then converted into structured information; the converted structured information is classified to put into an attribute node under a corresponding hierarchical organ tissue node, so that integrated storage and expression of digital information of various types of patients are enabled to be realized. According to the invention, the information processing method and the information processing device can be integrated with various medical application platform systems to provide comprehensive medical information of a patient, and can be used as an indexer to be applied into various retrieval systems and can be applied into the medical research and teaching fields; utilization efficiency of patients' medical information can be increased and the use value chain of the medical information can be prolonged; the establishment and popularization of individual medical health information file can be promoted.

The present invention discloses a health data detection bracelet for old people. The health data detection bracelet comprises heart rate detection, fall detection and GPS positioning. By using the bracelet, a user can call for help from families and hospitals through a network cloud end server. Fall detection is added compared with a conventional health bracelet so as to prevent severe injuries easily caused by falls of the old people. Community hospitals are added as a third party, diseases of unhealthy old people can be timely intervened and treated, thereby greatly shortening treatment response time and raising treatment initiatives. Through cloud storage of health data, related medical researches and individualized health service customization based on big data become convenient. With addition of a WeChat public platform of a hand-held terminal and a mobile phone app, the families can timely learn about health conditions of the old people in the family whenever and wherever possible. And with further addition of an energy-saving display, the service life of the health data detection bracelet for old people is prolonged.

The invention relates to natural anti-acne cream. The formula of the natural anti-acne cream mainly comprises 0.5-10wt% of salicylic acid, 0.05-50wt% of witch hazel extract, 0.05-90wt% of aloe extract, 0.05-20wt% of allantoin, 0.05-20wt% of penetration enhancer and the balance of water. China noted medical research institution Zhongshan School of Medicine, Guangzhou Sun Yat-sen University (national-level authoritative cosmetic testing institution recognized by the Ministry of Health) is authorized to carry out strict human body safe test and human body efficacy test on the product. Human bodyskin patch test results of 30 subjects show that all the subjects are negative, namely the product has no stimulus action on human body skin; successive four-week clinical anti-acne efficacy testing results of 20 acne patients show that the patients with obviously improved various indexes of acne appearance account for 30%, and the patients with completely improved various indexes of acne appearance account for 20%, and the total effective rate reaches 95%; all the subjects have no any side or discomfortable responses; and the clinical test results show that the product is very effective and safe.

The invention relates to a medicine scientific research data management system and a method thereof. The system includes a database, a data table management module, a data table recording module and a file export module. The method includes steps as follows: the data table management operation, the data table record operation, an Excel file setting and exporting operation, a Word file templet management operation and a Word file export operation. Using the system and the method can realize function that cooperates researcher recording, storing, amending and exporting clinic data conveniently, furthermore, processing medicine statistic. Using the system and the method has convenient rapid realization course, stable reliable working performance, can generate recording interface directly and increase researching and working efficiency of medicine researcher greatly, can quicken recording speed, the program control SQL inquire single refurbishing amount is 50 pieces per time, time for exporting 998 data is 67.23 seconds and the exporting time is infinitude, which has wide application range and takes great convenient to medicine research work.

A method and system of supplying rodents, such as mice, to medical researchers pre-installs and / or embeds physiologic sensors onto or within the rodents prior to selling the modified rodents to the researchers. The specialty skills, such as small animal surgical and anesthesia skills and sensor placement and testing, are centralized in one organization rather than being spread about a collection of researchers. The subjects with preinstalled, pre-tested hardware, are sold to the researcher as needed. Communication hardware and software will be supplied for the user to convert their desktop computer into a wireless monitoring station. Additionally an external pulse oximeter for small rodents, such as mice, provides measurements on a hand or foot of the rodent with a sensor configured to avoid shunting around the rodent appendage, and configured for high heart rates (200-900 beats per minutes) of the subjects.

A system and method for recruiting participants for medical research over an extended computer network is disclosed. The system and method comprise an enhanced services server built on the same architecture as a plurality of Electronic Health Record (EHR) systems, an input device configured to receive search criteria corresponding to clinical criteria that a patient must satisfy to qualify to participate in the medical research, search functionality configured to search the patient data captured by each of the plurality of EHR systems based on the search criteria, an output device configured to output data for a plurality of qualifying patients identified by the search functionality as satisfying the search criteria, and messaging functionality configured to send an electronic message via a network connection to one or more healthcare provider sites at which patient data for at least one of the plurality of qualifying patients was captured, wherein, upon receiving authorization in response to the request, the researcher can access the patient-identifying information associated with the patient data for the at least one of the plurality of qualifying patients identified with the output data and use it to recruit that patient for medical research.

The invention relates to a novel measurement method and the device thereof, which combines the time-resolved self-fluorescence lifetime imaging technology and a laser scanning confocal ophthalmoscopeand realizes the early diagnosis of the ocular fundus diseases by obtaining and analyzing the self-fluorescence intensity and the service life information of the ocular fundus. The light which is emitted by a pulse laser is sent to the scanning head of the laser scanning confocal ophthalmoscope to excite the ocular fundus inner-source flgorgen, and the fluorescence which is emitted from the ocularfundus is collected by a time-correlated single photon counter or a high-repetition-rate synchronous scanning camera, so as to realize the service life measurement and the imaging of the self-fluorescence. As the service life of the self-fluorescence of the ocular fundus is very sensitive to the micro-environment and the cell metabolism state of flgorgen molecule and is not affected by the difference of the intensity of the flgorgen of the ocular fundus, the measurement of the fluorescence service life provides a brand new route for the detection of ocular fundus diseases and the obtainment of the function information of ocular fundus. The invention can become the solution and the basis of the early diagnosis of various ocular fundus diseases, which plays an important role in pathogeny research, clinical diagnosis, staging and typing, prognosis judgement, real-time observation and the analysis of the development of ocular fundus diseases, therefore the invention can be widely appliedin the field of medical research and clinical medical diagnosis.

A medical data management system in which medical data can be shared by a patient, a medical staff, and a researcher on a communication network. The system can store medical data necessary for a user for a necessary period, disclose medical information to the patient, performing effective remote diagnosis, and provide medical data to a medical study. In medical data management systems (1-1, 1-2, 1-3), a member having an ID and log-in authentication means registers, reads, and processes medical data. The systems include a management file for recording an access right and new authentication means or an access right assigning function to another member by an access right holding member as the means for allowing access right additional recording. Storage and discarding of medical data and a cost paying person are decided according to the management file and the information is disclosed to a patient, remote diagnosis is performed, and medical data is used for research.

A method and computer program manages medical research study information and laboratory test result information. The program generates an interactive user interface with elements for setting up a study (702), managing study member information (704), managing patient information (706), receiving and displaying comments (708), and configuring data to be stored in a database associated with the research study (710). The program also receives medical event information from a user and laboratory test result information from a laboratory information system (20d), and generates a chart (934) that correlates the test results and the medical events. The program also receives a normal range pertaining to a test result from the laboratory information system (20d) and provides a normal range indicator (952) for the test result.

The invention discloses a digital tool applicable to medical research, clinical consultation, condition monitoring, health assessment, academy teaching and individual somesthesia, wherein the digital tool mainly comprises a three-dimensional human body model processing module, a three-dimensional human body physiological function simulation module, a three-dimensional pathological data storage module, a pathological data search and analysis module, a human body pathological data acquisition system, a warning system, a timeline node data storage and calling module, a four-dimensional data confluence analysis module, a multimedia server, image output equipment and the like. The system can be used by over multiple operating systems; the data such as skin, muscles, bones, organs, tissues, systems and acupoints of a human body are input into the system by the virtual digital technology; and the detailed construction of a human body is analyzed, studied and learned by the user in a 360-degree omnidirectional manner through the human-machine interaction technology.

A system and method for enrolling patients in a medical study, includes: a database component operative to maintain a medical practice database component and their corresponding plurality of specialities and a clinical studies database component and their corresponding plurality of medical studies. The system further includes a communications component to alert the medical practices of the medical studies and observe changes to the database components. The system also includes a processor programmed to update the database components, periodically match compatible medical specialties with the medical studies, and generate reports of the matched medical practices in the medical practice database. The system also includes a fee database component which the processor uses to calculate a fee for conducting the study.

This invention proposes a feature based data structure for computer manikin that is constructed from the scanned data of common 3D body scanners. The scanned data is first segmented into six parts and then encoded into range images. Feature recognition algorithms are developed and coded into computer algorithms. The software system can automatically recognize the important human feature points and feature curves. The computer manikin is constructed based on the interpolation between the feature curves. The manikin has geodetic latitudinal and longitudinal curves that pass through the geometric feature points of human body. The geodetic coordination contains all the important features that can be extracted as needed for apparel or ergonomic design, medical researches, and movie amusement industry.

The invention relates to a digital tool applicable to medical research, clinic consultation, teaching in schools and personal somatosensory, in particular to a system for digital analysis of human body and pathology. The system mainly comprises a three-dimension human body model processor module, a pathology document storage module, a pathology data search and analysis module, a multimedia server, video output equipment (such as projectors, displays or touch screens) and the like. A windows Chinese operating system or an android operating system is taken as a main running platform of the system, data of skin, muscles, tissues, organs, bones, acupoints and the like of the human body are recorded into the system by means of a virtual digital technique, and accordingly, a user can do analysis, research and study on detailed structure of the human body comprehensively at 360 degrees through a human-computer interaction technique; as various pathology data of different portions of the human body are recorded into the system, the user can do comparison visually and finally realize study, research and judgment and analysis of pathology.

The present invention is directed to community based health managed health kiosk and research database systems, and more particularly to facilitating large-scale health screening of individuals and aggregation of the resulting data for medical research purposes. The disclosed research database can be combined with community based managed health kiosk systems to allow medical researchers to access searchable, sortable, and non-personally identifiable health information obtained from on-going health screening of kiosk users distributed throughout the world.