125 results about "Ph changes" patented technology

Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.

Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as interfering species, ischemia, pH changes, temperatures changes, known or unknown sources of mechanical, electrical and / or biochemical noise, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system processes some or the entire data stream continually or intermittently based at least in part on whether the signal artifact event has occurred.

A method and system that provides for minute-to-minute EBC pH monitoring (or for other EBC characteristic monitoring) of a subject that greatly assists in determining the time-course of airway pH changes (or other characteristic changes) in evolving disease processes, and may assist in determining the predictive ability of these tests, as well as determining response to therapy.

One aspect of the present invention relates to a method to control biological fluid flow at a site in a mammal by use of an in situ formed polymer plug. In certain embodiments, the present invention relates to a method to control bleeding following a catheterization procedure, a method to control leakage of cerebral spinal fluid following a lumbar puncture, a method to seal a fistula, or a method to control the flow of serous fluid after a lymphadenectomy. In certain embodiments, the polymer plug is generated in situ by temperature changes, pH changes or ionic interactions. In certain embodiments, the polymer plug comprises at least one optionally purified reverse thermosensitive polymer.

The present invention relates generally to the amphiphilic polyelectrolyte, poly(2-ethylacrylic acid) and covalently bonded lipids to generate Lipo-PEAA. These Lipo-PEAA are then used to make pH-sensitive liposomes which become unstable, permeable or fusogenic with certain pH changes. In addition, this invention generally describes methods for delivering therapeutic compounds and drugs to target cells by administering to a host the pH-sensitive liposomes of the present invention.

A reaction solution to be used for image recording with an ink containing a coloring material in a dissolved or dispersed state in order to achieve a high level of image density with stability, wherein the reaction solution contains a polyvalent metal ion and an organic solvent to destabilize the dissolved or dispersed state of the coloring material in the ink in contact with the ink, has a pH of 2 or higher, and has a buffering action for pH, wherein the buffering action means it can maintain pH variation within the range of 0.5 before and after the addition of 1.0 ml of a 0.1 N aqueous lithium hydroxide solution to 50 ml of the reaction solution.

This invention discloses a surgical prep solution formulation, either film forming or non-film forming, that changes color upon a change in pH to indicate that the solvent has sufficiently evaporated. The major components of this surgical prep solution include: antimicrobial agents, solvents, pH adjusters, color changing pH indicators, and optionally: film forming polymers, dyes and viscosity regulators. The pH of the solution may rise or fall depending on the pH of the original solution as compared with the normal pH range of the acid mantle of the human skin or the normal pH range of a sterilizing solution. As the pH changes, the pH indicator may cause the surgical prep solution to change color. Concurrently, as the fluids evaporate, the pH indicators interact with atmospheric CO2, causing the solution to change color based on the pH of the solution. The solution may also be used as coating for medical devices.

The invention discloses the preparation method and uses of carboxymethyl chitosan and sodium alginate blend microcapsule wherein the method comprises, using water as solvent to blend the water solution of carboxymethyl chitosan and sodium alginate into blending liquid I, dissolving the contained medicament bovine serum albumin into the blended solvent I and mixing homogeneously, obtaining blended liquid II, dispersing the blended liquid II into fluid wax containing emulsifying agent, dropping CaCl2 coagulated liquid into the system, charging 10-30 mL alcohol isopropylicum and hardening to obtain micro-encapsulation, which exhibits sensitive response function to the pH changes.

A method and system that characterizes hydrogen sulfide in petroleum fluid employs a tool that includes a fluid analyzer for performing fluid analysis (including optical density (OD) for measuring carbon dioxide concentration) of a live oil sample, and a storage chamber for an analytical reagent fluidly coupled to a measurement chamber. An emulsion from fluid of the sample and the reagent is produced into the measurement chamber. The reagent changes color due to pH changes arising from chemical reactions between components of the sample and the reagent in the measurement chamber. The tool includes an optical sensor system that measures OD of a water phase of the emulsion at one or more determined wavelengths. The pH of the water phase is derived from such OD measurements. The pH of the water phase and the carbon dioxide concentration in the sample is used to calculate hydrogen sulfide concentration in the sample.

The invention provides a ratio-type pH fluorescence probe for water-soluble locating lysosome as well as a preparation method, an application and a test method of the ratio-type pH fluorescence probe. The chemical structural formula of the ratio-type pH fluorescence probe is shown in the specification. The probe can detect changes of strength of fluorescence with two emission wavelengths simultaneously, external influences are eliminated through self-calibration, the detection accuracy is high, the speed of response to pH changes is high, and the probe has excellent water solubility and has very good anti-interference capacity in the existence of various metal ions. The fluorescence strength changes remarkably in the pH range from 5.8 to 6.8, and the probe is suitable for pH detection under a weak acidic condition. Experiments prove that the probe can selectively dye lysosome in cells, the light stability in the cells is good, and the probe is non-toxic to the cells and can be used for pH detection of live cells. The probe has very important application value in cell imaging and detection of changes of the pH value in lysosome.

Disclosed are a phosphate-binding polymer having a true specific gravity of 1.18-1.24, tablets that solely consist of the particles of a phosphate-binding polymer having an average particle size of no more than 400 μm, with at least 90% being occupied by particles no larger than 500 μm, and having a true specific gravity of 1.18-1.24 and a water content of 1-14%, or tablets that contain both the particles and crystalline cellulose and / or low substituted hydroxypropyl cellulose, and a process for producing such tablets. The phosphate-binding polymer can be formulated as tablets either alone or in combination with specified additives. Whichever the case, the tablets have satisfactory hardness, contain the active ingredient in high proportion, have high phosphate-binding capability and exhibit rapid disintegrability in an acidic to neutral region while having little sensitivity to the strength of agitation. The tablets are excellent pharmaceutical preparations that undergo reduced variations in bioavailability in spite of movements within the digestive tracts and pH changes.

The invention provides ion-selective sensors capable of selectively measuring ions, e.g., Na+, K+, Cl−, etc., in the cytosol of a single living cell. The sensor comprises one or more quantum dots or a fluorescent dye, a pH-sensitive dye, and optionally an ion-selective component such as an ionophore. These elements may, for example, be disposed in a polymer matrix. The polymer matrix comprises an internalizing moiety which enables the sensor to localize within the cytosol of a cell. The internalizing moiety comprises a small molecule or peptide such as an amine, antepennepedia, mastoparan, or melittin that react under acidic conditions to release a sensor from the confines of a endosome. Once in the cytosol the sensors may detect ionic analytes by selective ion extraction by the polymer, thereby inducing a pH change within the sensor which in turn changes the absorbance of the pH-sensitive dye. The change of absorbance may in turn attenuate the intensity of detectable emissions, e.g., fluorescence, from the quantum dot or dye by directly absorbing its fluorescence emission.

The invention discloses application of a PEI modified carbon dot-FITC compound as a rate fluorescent pH probe and a Cu2+ fluorescent probe. Cherry tomatoes are used as raw materials, carbon dots with fluorescence insensitive to pH changes are prepared through hydro-thermal synthesis, then CDs are modified with PEI, amidogen on PEI react with isothiocyanic acid radicals on FITC molecules, and the compound is formed. The responsivity of fluorescence of FITC in the compound to the pH changes is high, and a rate probe based on CDs and FITC fluorescence is used for pH detection; amidogen on PEI and Cu2+ are subjected to coordination, so that the fluorescence intensity of CDs and FITC is reduced along with increase of the concentration of Cu2+ in a solution, and Cu2+ detection is achieved. According to the constructed fluorescent probe, selected materials are novel, the advantages of being high in sensitivity, good in selectivity, easy to operate, wide in linear range, low in detecting limit and the like are achieved, and the constructed fluorescent probe can be used for efficient detection of the pH and Cu2+ in the aqueous solution and a biological sample.

The invention provides a polyurethane block copolymer, which comprises a block A shown as a formula (I) and or a formula (III) and a block B shown as a formula (II). Since the polyurethane block copolymer simultaneously contains a tertiary amine group and a 1, 2-dithioheterocyclic ring, the polyurethane block copolymer has good pH (potential of hydrogen) sensitivity, good reduction sensitivity and unique amphipathic characteristic, the pH sensitive interval is between 5.5 and 7.0, and responses can be quickly made to both physiologically related pH changes and oxidation-reduction environment changes. The invention additionally provides a preparation method of the polyurethane block copolymer, wherein the preparation method of the polyurethane block copolymer is simple, feasible and easy to control. The invention additionally provides a preparation method of polyurethane block copolymer nano hydrogel. Since the molecular chain of the polyurethane block copolymer contains the 1, 2-dithioheterocyclic ring, inter molecular chain linkage can happen to obtain nano hydrogel. The nano hydrogel has the advantages that the self-assembling form can be changed with pH and oxidation-reduction environment, the stability is high and the medical application prospect is good.

Disclosed is a method of preparing inorganic particles using a hydrothermal synthesis device, including introducing a precursor liquid or slurry stream including a reaction precursor for preparation of an inorganic material into a hydrothermal synthesis reactor, introducing a supercritical liquid stream including water into the hydrothermal synthesis reactor, preparing an inorganic slurry by hydrothermal reaction in the hydrothermal synthesis reactor and discharging the inorganic slurry therefrom, and filtering the discharged inorganic slurry, wherein the precursor liquid or slurry stream includes an NH3 source at a high temperature of the supercritical liquid stream and thus clogging of the stream in the hydrothermal synthesis reactor is inhibited by pH changes in the hydrothermal reaction.

The invention discloses metallic surface anti-corrosion paint. The metallic surface anti-corrosion paint is prepared from, by weight, 60-80 parts of epoxy acrylate resin, 10-15 parts of butylated amino resin, 5-8 parts of fluorocarbon resin, 2-5 parts of methyl isobutyl ketone, 2-4 parts of cobaltous oxide, 1-2 parts of zinc phosphate, 1-2 parts of aluminum triphosphate, 5-10 parts of polymer nanometer microparticles wrapped by benzotriazole, 2-4 parts of polyacrylic ester, 1-2 parts of xylene, 2-5 parts of triethylene tetramine and 40-60 parts of industrial water. The adopted method comprises the steps that polymer nanometer materials are used for wrapping a corrosion inhibitor, and then the corrosion inhibitor is mixed into a coating. The carriers can prevent unnecessary losses of the corrosion inhibitor and prevent the corrosion inhibitor from directly damaging the coating, and certain environment stimulus responsiveness such as mechanical damage, pH changes and illumination is achieved.

A device and system that allows an inverted microscope with a movable x-y stage to also function as a time-resolved plate reader. The device, which is sized to fit into the condenser holder of an inverted microscope, not only provides plate-reading function at very low cost compared to that of purchasing a plate reader, but it also allows the correlation of plate reader measurements with images of a specimen. The device and system is also able to measure other parameters associated with cell metabolism, such as pH changes.

The invention discloses a composite electrode for electro-kinetic remediation of heavy metal contaminated soil, an electro-kinetic remediating device and an electro-kinetic remediation method, and belongs to the technical field of remediation of heavy metal contaminated soil. The composite electrode disclosed by the invention is formed by a reticularly-coated composite material composed of conducting mediums; the composite material comprises modified sepiolite and modified chitosan; the composite material for the composite electrode disclosed by the invention is relatively large in surface area and is capable of adsorbing heavy metal ions coming from migration, so that in-site removal of heavy metal pollutants is realized, and cathode liquor needs not to be pumped out and treated subsequently after electro-kinetic remediation is ended. The electro-kinetic remediation method disclosed by the invention is capable of reducing pH changes near the cathode of the soil and preventing OH- generated by the cathode from entering the soil, so precipitation of heavy metal ions in the soil is avoided. By monitoring the pH near the anode and the cathode, the electric conductivity and concentration changes of heavy metal ions in real time, the electro-kinetic remediation method and the electro-kinetic remediating device disclosed by the invention have the advantages of being persistent, high in efficiency, simple and convenient in replacement and capable of remarkably shortening the remediation period and lowering the remediation cost.

The invention discloses a benzothiazole lysosome-targeted pH fluorescent probe and preparation and application thereof. A preparation method of the probe comprises the steps that quinoline-4-formaldehyde, 2-methyl-benzothiazole and trimethylchlorosilane (TMSCl, serving as a catalyst) are dissolved into dimethylformamide according to the mole ratio of 1:1:10 in a sealed tube, the solution is heated to 100 DEG C, a reaction is conducted for 16 hours, and precipitates are filtered out; the precipitates are dissolved with dichloromethane, the pH value is regulated to be 8.0 with a NaCO3 solution, extraction is conducted with dichloromethane, drying and recrystallizing are conducted, and the pure product is obtained. The probe has the large Stokes displacement (110 nm) and has the high sensitivity and selectivity on H<+> changes. The pKa value is 3.52, and the pH linear range is 3.0-3.8. A laser co-focus experiment shows that the probe can be positioned to a lysosome in a targeted mode and makes a response for pH changes of the lysosome in a weak acid environment. In addition, the probe can detect pH changes in escherichia coli in a highly acidic environment (the pH value is smaller than 4) in a highly sensitive mode.

An embodiment provides a method for determining the alkalinity of an aqueous sample using an alkalinity sensor, including: monitoring the pH of an aqueous sample using a pH sensor in a sample cell, the pH sensor including a pH sensor electrode made of boron-doped diamond; generating hydronium ions, using a hydronium generator, in the aqueous sample in the sample cell, the hydronium generator including a hydronium-generating electrode; changing the pH of the aqueous sample by causing the hydronium generator to generate an amount of hydronium ions in the aqueous sample; quantifying and converting a current or charge to the number of hydronium ions produced to an end point of the electrochemical titration, the end point correlating to the alkalinity of a sample; and analyzing the alkalinity of the aqueous sample based on the generated amount of hydronium ions and the resulting change in pH monitored by the pH sensor.

The invention provides an aggregation-inducing luminescent lysosomal probe independent of acidic pH, a preparation method and an application thereof. The preparation method comprises the steps of: halogen-substituted phenylvinyl derivative A and heterocyclic derivative B to Buchwald - Hartwig coupling reaction to form the crude product, remove the solvent in the crude product, add ethanol and acetone to dissolve the crude product, filter, the filtrate is dried, and then purified by silica gel column chromatography with chloroform and methanol as eluent, ie An aggregation-inducing luminescent lysosomal probe that does not depend on acidic pH is obtained. The bioprobe of the present invention has a property that does not depend on an acidic pH change, and is responsive to environmental viscosity. Its mechanism of action in lysosome imaging is viscosity-induced intramolecular motion limitation, which has better photostability and is not affected by microenvironmental acidity than traditional PET mechanism of action.

The invention discloses a pH fluorescent sensing film which comprises a film base material and is characterized in that fluorescent dyes of CPIPA (Chloro Phenyl Imino Propenyl Aniline) and fluorandiol 10-GN are uniformly mixed together, and the two fluorescent dyes are fixed on the surface of the film base material by virtue of a chemical embedding method. On the basis of the pH fluorescent sensing film, the invention also discloses a method for detecting pH two-dimensional dynamic distribution of basic sediment, wherein the pH fluorescent sensing film is put into the sediment, spectral information of the two dyes is obtained by virtue of an imaging device under the illumination of exciting light, and distributional characteristics of the pH of the sediment are obtained by virtue of R and B passage fluorescent ratio quantification. According to the sensing film disclosed by the invention, the CPIPA and the fluorandiol 10-GN which has a reference effect and a brightening effect are mixed together to form a fluorescent indicator, and the sensing film has high detection sensitivity and high spatial resolution and is sensitive to respond pH changes. The method adopts a plate electrode technology to realize real-time and in-situ acquisition of pH two-dimensional and dynamic distribution information of the basic sediment by reducing optical interference by virtue of fluorescent ratio quantification.

A novel method for producing a natural cheese is described. The present method utilizes a combination of heating, mechanical processing and pH changes to produce a natural cheese.

The invention provides a preparation method of a silver nanocluster. The prepared silver nanocluster has high purity and high fluorescence intensity, and is uniform and good in reproducibility. The preparation method is simple, feasible and fast. Raw materials are wide in source and low in price, the preparation process is free of pollution, and the preparation method can be used for large-scale industrialized production. The prepared silver nanocluster is sensitive to the pH value, the fluorescence intensity is enhanced along with the increase of pH, and it is shown that the silver nanocluster can be used as a fluorescence switch to indicate pH changes in a system.

The invention discloses an application of detecting the pH of a benzothiazole derivative in the extremely acidic environment. The structural formula of the benzothiazole derivative is shown in the specification. A probe has the good selectivity and high sensitivity for H+ on the strongly acidic condition, has the obvious ratio fluorescence emission characteristic and has the advantages of having the large Stocks displacement and the like. The probe can be used for detecting the pH changes of escherichia coli in the extremely acidic environment, and can also be used for detecting pH changes in the extremely acidic environment.