A stable topical
alcohol-free
aerosol foam containing one or more
keratolytic agents is provided. The foam-forming formulation is an
emulsion which contains an HFA
propellant and one or more
keratolytic agents. The
emulsion has an
oil phase and an aqueous, i.e. water-containing, phase. The
active agent(s) may be present in either phase of the
emulsion or dispersed in the emulsion. The
oil phase may consist at least in part of the HFA
propellant. Either or both of the
oil phase and the aqueous phase may contain one or more surfactants, emulsifiers, emulsion stabilizers, buffers, and / or other excipients. The foam is stable on the
skin, for example, for at least 5 minutes at body temperature, preferably at least 20 minutes at body temperature, and disappears into the
skin upon
rubbing or after prolonged standing. In one embodiment, the formulation contains an HFA
propellant which does not contain additional co-solvents or co-propellants. The formulations demonstrate
reduced intensity of the
odor and / or color associated with the
keratolytic agent(s) as compared to conventional formulations containing keratolytic agents.