199 results about "Repetitive Sequences" patented technology

A battery assembly utilizing a compact and robust bus bar configuration is provided. The batteries within the assembly are divided into groups, where the batteries within each battery group are connected in parallel and the groups are connected in series. The batteries are interconnected using a repetitive sequence of non-overlapping, alternating polarity bus bars. The bus bars, which are integrated into a battery assembly upper tray member, are devoid of contact fingers and positioned such that there is a single bus bar located adjacent to either side of each battery group.

An industrial system including a machine for processing or producing a product. The machine includes at least one actuator providing a repetitive sequence of movements of a machine part, and a regulator controlling the movements of the actuator in response to a reference value. An industrial robot is adapted to tend the machine. The robot includes a drive unit and a robot controller adapted to generate control signals to the drive unit based on a control program including movement instructions for the robot. The robot controller is adapted to generate the reference value to the regulator based on a control program including movement instructions for the machine part. The regulator may also be an integrated part of the robot controller.

Disclosed are new methods comprising the use of in situ hybridization to detect abnormal nucleic acid sequence copy numbers in one or more genomes wherein repetitive sequences that bind to multiple loci in a reference chromosome spread are either substantially removed and / or their hybridization signals suppressed. The invention termed Comparative Genomic Hybridization (CGH) provides for methods of determining the relative number of copies of nucleic acid sequences in one or more subject genomes or portions thereof (for example, a tumor cell) as a function of the location of those sequences in a reference genome (for example, a normal human genome). The intensity(ies) of the signals from each labeled subject nucleic acid and / or the differences in the ratios between different signals from the labeled subject nucleic acid sequences are compared to determine the relative copy numbers of the nucleic acid sequences in the one or more subject genomes as a function of position along the reference chromosome spread. Amplifications, duplications and / or deletions in the subject genome(s) can be detected. Also provided is a method of determining the absolute copy numbers of substantially all RNA or DNA sequences in subject cell(s) or cell population(s).

A new mechanism of therapeutic action of electromagnetic fields, based upon systemic effect, applies selected EMF signals to cause efficacious therapeutic effects at sites distant from the point of application. The method of generating specific EMF waveshape and application of this exogeneous signal for therapeutic purposes allows the benefit to be achieved via the systemic effect. The EMF signals take the form of a repetitive sequence of semi sinewaves, resulting in a pulsating waveform occurring at a frequency in the range of from about 50 to about 300 pulses per second. Bridge rectification is applied to a sinusoidal signal, and a resultant therapy signal takes the form of a repetitive sequence of semi sinewaves of up to about 300 pps with a periodically recurring DC component. The shape of alternating pulses in the resultant therapy signal is modified under computer control to achieve therapeutic effects. Flux densities in the range of several hundred Gauss up to several thousand Gauss are generated. The treatment with the resultant therapy signal may be applied to an arm or leg of a therapy recipient for a sufficient length of time to cause the recipient's entire blood volume to be exposed to the therapeutic field such that this can initiate effects in cells, tissues, and organs distant from the point of application

The current invention provides for methods and medicaments that apply oligonucleotide molecules complementary only to a repetitive sequence in a human gene transcript, for the manufacture of a medicament for the diagnosis, treatment or prevention of a cis-element repeat instability associated genetic disorders in humans. The invention hence provides a method of treatment for cis-element repeat instability associated genetic disorders. The invention also pertains to modified oligonucleotides which can be applied in method of the invention to prevent the accumulation and / or translation of repeat expanded transcripts in cells.

The invention relates generally to the field of identification of DNA sequences, genes or chromosomes. Methods and composition to obtain Unique Sequence DNA probes are provided. Composition comprises of any double stranded DNA containing Unique Sequences from which the repetitive sequences are eliminated according to the method described in this invention. The invention also relates to the preservation of cells that have been identified after immunomagnetic selection and fluorescent labeling in order to further interrogate the cells of interest. Furthermore the invention relates to genetic analysis of cells that have been identified after immunomagnetic selection and fluorescent labeling.

The present invention is generally directed to powerful and flexible methods and systems for consensus sequence determination from replicate biomolecule sequence data. It is an object of the present invention to improve the accuracy of consensus biomolecule sequence determination from replicate sequence data by providing methods for assimilating replicate sequence into a final consensus sequence more accurately than any one-pass sequence analysis system.

Apparatus for use in making a device by forming repetitive sequences of coatings on a flexible substrate including defining a path for the flexible substrate; the flexible substrate being disposed about at least a portion of the path; a first deposition source for depositing material located around the path periphery and in cooperative relationship with the surface of the disposed flexible substrate; actuable means effective when actuated for moving the flexible substrate around at least more than one revolution around the path; and actuating the actuable means and the first deposition source so that at least two separate material coatings are provided on the substrate by the deposition source.

The invention relates to a method for acquisition of an oligonucleotide probe. The method comprises the following steps: downloading genomic sequence of crop species from a public database, filtering and finding out tandem repeat sequences, screening preliminarily found repetitive sequences, comparing residual tandem repeat sequence and known probe sequence, removing already used probe sequence, comparing residual screened tandem repeat sequences, carrying out probe design and synthesizing and verifying the designed probe sequence so as to obtain effective oligonucleotide sequence. According to the invention, cost is low and efficiency is high. The probe can be used for non-degenerated fluorescence in situ hybridization (ND-FISH) analysis of crop chromosome, determination of distribution of tandem repeat sequences represented by the probe on chromosome, understanding of the structure characteristics of chromosome and establishment of specific landmark of chromosome. Thus, specific chromosome or chromosome region of crops is identified, and the developed new oligonucleotide probe has specificity of chromosome or chromosome region.

A marker structure on a substrate includes line elements and trench elements, the line elements and trench elements each having a length in a first direction and being arranged in an alternating repetitive sequence in a second direction perpendicular to the first direction, the alternating repetitive sequence having a sequence length, the marker structure having at least one pitch value, the at least one pitch value being the sum of a line width of one line element and a trench width of one trench element. A width of the line elements varies over the sequence length of the marker structure between a minimum line width value and a maximum line width value, while a width of the trench elements likewise varies over the sequence length of the marker structure between a minimum trench width value and a maximum trench width value. A duty cycle of a pair of a line element and an adjacent trench element is substantially constant over the sequence length of the marker structure. Thus, the pitch value varies from a minimum pitch value to a maximum pitch value over the sequence length.

Disclosed are new methods comprising the use of in situ hybridization to detect abnormal nucleic acid sequence copy numbers in one or more genomes wherein repetitive sequences that bind to multiple loci in a reference chromosome spread are either substantially removed and / or their hybridization signals suppressed. The invention termed Comparative Genomic Hybridization (CGH) provides for methods of determining the relative number of copies of nucleic acid sequences in one or more subject genomes or portions thereof (for example, a tumor cell) as a function of the location of those sequences in a reference genome (for example, a normal human genome). The intensity(ies) of the signals from each labeled subject nucleic acid and / or the differences in the ratios between different signals from the labeled subject nucleic acid sequences are compared to determine the relative copy numbers of the nucleic acid sequences in the one or more subject genomes as a function of position along the reference chromosome spread. Amplifications, duplications and / or deletions in the subject genome(s) can be detected. Also provided is a method of determining the absolute copy numbers of substantially all RNA or DNA sequences in subject cell(s) or cell population(s).