4361 results about "Collagenan" patented technology

The present disclosed subject matter relates to methods and compositions for restoring a diseased or damaged tooth such that infection is inhibited or eliminated and pulp regeneration is facilitated. The disclosed subject matter also includes a composition comprising a physiologically acceptable matrix seeded with pulp cells. The matrix can be capable of being injected into the pulp chamber of a tooth. In some embodiments, the matrix of a composition includes a hydrogel (e.g., collagen, chitosan, alginate, MATRIGEL™, gelatin, JELL-O®, fibrin), a mesh (e.g., polylactide-coglycolide (PLGA) mesh, polylactide (PLA) mesh, or polyglycolide (PGA) mesh, a cross-linked fiber mesh, a nanofiber mesh, a mesh fabric, biodegradable polymer mesh), a microsphere (biodegradable polymer microsphere, a hydrogel microsphere), or a combination of any of the foregoing. In yet other embodiments, the matrix includes a nanofiber, an artificial three-dimensional scaffold material, or a synthetic three-dimensional scaffold material.

Methods, systems, and devices to treat a region of skin; the treatment may be used to stimulate the production of collagen or destroy adipose tissue. The region of skin is exposed to a uniform energy application or series of applications. The region of skin may be exposed to positive and negative pressures. Therapeutic substances may be applied to the region of skin.

A wound dressing is provided comprising a wound treatment composition (1) including at least one absorbent or adsorbent compound contained within a sheath having an operatively inner and an operatively outer wall (5, and 6 respectively). The wound dressing is characterized in that the surface of the operatively inner wall that is to contact a wound in use is a substantially smooth continuous surface, conveniently of a plastic inner wall, selected for easy release from a wound. The inner wall is perforated (7) to enable exudate or slough to pass therethrough. The invention also provides a wound treatment composition characterized in that it comprises, in combination, an adsorbent material, preferably silica, for adsorbing moisture on or around a wound; and, a collagen, conveniently gelatin.

A treatment for subcutaneous fat and/or cellulite includes delivering a beam of radiation to a subcutaneous fat region disposed relative to a dermal interface in a target region of skin. The beam of radiation affects at least one fat cell in the subcutaneous fat region without causing substantial unwanted injury to the epidermal region and causes thermal injury to a dermal region to induce collagen formation to strengthen the target region of skin in a target region of skin. The treatment can include cooling an epidermal region of the target region of skin.

The invention provides a composition for promoting regeneration of tissue which has degenerated in a subject as a result of a disease or disorder and a method of using the composition is provided. The composition comprises a biodegradable acellular matrix, and passaged autologous fibroblasts substantially free of immunogenic proteins, e.g., culture medium serum-derived proteins, integrated within the matrix. Also provided is an injectable composition comprising an acellular filler material (e.g., any type of collagen) and passaged autologous fibroblasts substantially free of immunogenic proteins, e.g., culture medium serum-derived proteins, for correcting defects in skin, such as wrinkles or scars, and for augmenting tissue in the subject, particularly facial tissue.

An N-acyl anthranilic acid derivative represented by general formula (1) or a salt thereof is useful for prevention or treatment of diseases associated with excessive production of collagen. (In the formula, R¹ represents a carboxyl group or the like; R² represents a hydrogen atom or the like; R³ represents an optionally substituted aryl group or the like; X¹ represents a carbonyl group; X² represents a bonding hand; X³ represents a bonding hand; X⁴ represents a bonding hand or the like; and A represents an optionally substituted phenyl group or the like.)

The invention provides a collagen facial mask and a preparation method thereof. The method comprises the following steps of: stirring 1 to 20 mass percent of aqueous solution of collagen and 0.1 to 2 mass percent of aqueous solution of a modifier at the temperature of between 20 and 60 DEG C for reacting for 15 to 45 minutes to obtain stock solution; adding a plasticizer, a functional additive and an antimicrobial growth promoter into the stock solution, and continuing to stir at the temperature of between 20 and 60 DEG C for 30 to 60 minutes to obtain mixed solution; and pouring the mixed solution into a die for forming, and drying at the temperature of between 30 and 60 DEG C for 3 to 10 hours to obtain the collagen facial mask. The prepared collagen facial mask is mainly formed by macromolecular substances extracted from natural animals and plants, safe and effective and does not have toxic or side effect, has the high heat stability, toughness, ductility and adhesion, and can be in fit with skin well and achieve the effects of preserving moisture doubly, softening cutin skin, resisting winkle, whitening the skin, restoring the skin and the like under the assistance of the functional additive; rejected materials of the facial mask are degradable, and do not cause environmental pollution; and the collagen facial mask can be widely applied in the field of daily cosmetics and has the excellent market application prospect.

Methods and devices for applying high intensity focused ultrasound to modulate collagen in animal tissue (such as to disrupt collagen fibrils in a mammal, such as a human), particularly to enhance the aesthetic appearance of skin, and/or to otherwise improve skin conditions.

A fiber reinforced basic collagen scaffold with neutralization capacity for delivery of protein based bioactives that have higher solubilities under acidic condition than at neutral pH.

The invention provides fish skin collagen based composite sponge and a preparation method thereof. The fish skin collagen based composite sponge is prepared by the steps of: based on fish skin collagen and chitosan as raw materials, freeze-drying, carrying out cross-linking, and carrying out secondary freeze drying. The composite sponge prepared by the invention can improve the disadvantages that the previous sponge is easy to degrade and the like, is simple in preparation process, is cheap and easy to obtain, and overcomes some defects of the existing collagen sponge. The fish skin collagen based composite sponge prepared by the invention has a specific three-screws structure of an I type collagen protein; a microstructure is a double-faced porous net-shaped sheet layer; and the fish skin collagen based composite sponge has good hygroscopicity, improves the degradability of the collagen sponge, is simple in preparation process and is cheap and easy to obtain, so that the fish skin collagen based composite sponge is a better biomedical material.

A moldable, bioresorbable, biocompatible, non-allergenic crosslinked collagen derivative dressing for the prevention of post extraction alveolar osteitis (dry socket) pain is disclosed along with methods for use of the gel. The dressing is placed at the time of surgery acting as a bone covering obtundant and physiologic scaffolding for the conduction of normal alveolar bone healing sequence of fibroblast ingrowth, blood vessel formation, and reossification of the extraction site defect. In one form, the dressing is a flowable, moldable, biocompatible, bioresorbable dressing prepared by reacting (i) a collagen derivative, such as gelatin or atelocollagen, and (ii) a non-cytotoxic crosslinking agent.