The present invention provides a
system and a method for the production of microparticles and nanoparticles of materials that can be dissolved. The
system and method of the present invention provide quicker freezing times, which in turn produces a more uniform distribution of particle sizes, smaller particles, particles with increased
porosity and a more intimate mixing of the particle components. The
system and method of the present invention also produce particles with greater surface area than conventional methods. One form of the present invention provides a method for the preparation of particles. An effective ingredient is mixed with water, one or more solvents, or a combination thereof, and the resulting mixture is sprayed through an insulating
nozzle located at or below the level of a cryogenic liquid. The spray generates frozen particles.