A drain cassette for a
dialysis unit has a fluid channel between venous and arterial connection ports, and a valve may controllably open and close fluid communication between a drain outlet port and the venous connection port or the arterial connection port. A blood circuit
assembly and drain cassette may be removable from the
dialysis unit, e.g., by hand and without the use of tools. A blood circuit
assembly may include a single, unitary member that defines portions of a pair of blood pumps,
control valves, channels to accurately position flexible tubing for an occluder, an air trap support, and / or other portions of the
assembly. A blood circuit assembly engagement device may assist with retaining a blood circuit assembly on the
dialysis unit, and / or with removal of the assembly. An
actuator may operate a
retainer element and an ejector element that interact with the assembly.