4751 results about "Propylene oxide" patented technology

A solid unit oral pharmaceutical dosage form of amorphous nelfinavir mesylate is provided comprising amorphous nelfinavir mesylate in an amount of from about 400 mg to about 700 mg calculated as nelfinavir base, and a pharmaceutically acceptable water soluble, non-ionic synthetic block copolymer of ethylene oxide and propylene oxide, the copolymer having a melting point of at least about 45° C. and an HLB value at 25° C. of from about 18 to about 29, wherein the copolymer is present from about 40% to about 65% by weight of the nelfinavir mesylate. A hot melt granulation process for making the dosage form is provided.

The present invention generally relates to reducing the mucoadhesive properties of a particle. In some embodiments, the particle is coated with and / or associated with a (poly(ethylene glycol))-(poly(propylene oxide))-(poly(ethylene glycol)) triblock copolymer. Methods for preparing inventive particles using a poly(ethylene glycol)-vitamin E conjugate as a surfactant are also provided. In some embodiments, methods are provided comprising administering to a subject a composition of particles of the present invention. Such particles with reduced mucoadhesive properties are useful in delivering agents to mucosal tissues such as oral, ophthalmic, gastrointestinal, nasal, respiratory, and genital mucosal tissues.

Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide) -poly(propylene oxide)-poly(ethylene oxide) polymer. Such polymeric blends provide for both high oxygen solubility and aqueous analyte solubility.

3,4-Dihydroxyphenyl-L-alanine (DOPA) is an unusual amino acid found in mussel adhesive proteins (MAPs) that form tenacious bonds to various substrates under water. DOPA is believed to be responsible for the adhesive characteristics of MAPs. This invention relates to a route for the conjugation of DOPA moieties to various polymeric systems, including but not limited to poly(ethylene glycol) or poly(alkylene oxide) systems such as poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) block copolymers.

The invention discloses a method to synthesize propylene oxide, which is characterized in that alcohol with low content of carbon, propylene and oxydol(mol ratio 1-15:0.5-5:1) are put into a reactor which is fed with catalyzer; the propylene and the oxydol react and produce propylene oxide, and the condition for the reaction includes: temperature 30-90 DEG C, pressure 0.5-4.5MPa, ph value of the solution 5,0-8.0, and airspeed of the solution 0.1-7h-1; wherein the temperature and ph value of the solution in the whole process are adjusted according to the conversion rate of the oxydol, and once the conversion rate of the oxydol drops to 88.5%, the ph value and the temperature of the solution are increased. The method is simple in process, mild in condition, the conversion rate of the oxydol is high and the propylene oxide is of selectivity; meanwhile, the life of the catalyzer is prolonged to over 1200h through the adjustment of the ph value and the temperature of the solution.

The present invention generally relates to reducing the mucoadhesive properties of a particle. In some embodiments, the particle is coated with and / or associated with a (poly(ethylene glycol))-(poly(propylene oxide))-(poly(ethylene glycol)) triblock copolymer. Methods for preparing inventive particles using a poly(ethylene glycol)-vitamin E conjugate as a surfactant are also provided. In some embodiments, methods are provided comprising administering to a subject a composition of particles of the present invention. Such particles with reduced mucoadhesive properties are useful in delivering agents to mucosal tissues such as oral, ophthalmic, gastrointestinal, nasal, respiratory, and genital mucosal tissues.

Propylene oxide is formed in a two step reaction wherein in a first step oxygen and hydrogen are reacted in the absence of propylene to form hydrogen peroxide and in a second step propylene is reacted with the formed hydrogen peroxide to form propylene oxide, the same solid noble metal on TS-1 catalyst being used to catalyze the reaction in each step.

A novel matrix composition for pharmaceutical use. The matrix composition has been designed so that it is especially suitable in those situation where an improved bioavailability is desired and / or in those situation where a slightly or insoluble active substance is employed. Accordingly, a controlled release pharmaceutical composition for oral use is provided in the form of a coated matrix composition, the matrix composition comprising i) a mixture of a first and a second polymer that have plasticizing properties and which have melting points or melting intervals of a temperature of at the most 200° C., the first polymer being selected from the group consisting of polyethylene glycols and polyethylene oxides, and the second polymer being selected form block copolymer of ethylene oxide and propylene oxide including poly(ethylene-glycol-b-(DL-lactic acid-co-glycolic acid)-b-ethylene glycol (PEG-PLGA PEG), poly((DL-lactic acid-co-glycolic acid)-g-ethylene glycol) (PLGA-g-PEG), poloxamers and polyethylene oxide-polypropylene oxide (PEO-PPO), ii) a therapeutically, prophylactically and / or diagnostically active substance, the matrix composition being provided with a coating having at least one opening exposing at one surface of said matrix, wherein the active substance is released with a substantially zero order release.

The invention discloses a dual-functional catalyst composition and an integrated process for production of olefin epoxides including propylene oxide by catalytic reaction of hydrogen peroxide from hydrogen and oxygen with olefin feeds such as propylene. The epoxides and hydrogen peroxide are preferably produced simultaneously in situ. The dual-functional catalyst comprises noble metal crystallites with dimensions on the nanometer scale (on the order of <1 nm to 10 nm), specially dispersed on titanium silicalite substrate particles. The dual functional catalyst catalyzes both the direct reaction of hydrogen and oxygen to generate hydrogen peroxide intermediate on the noble metal catalyst surface and the reaction of the hydrogen peroxide intermediate with the propylene feed to generate propylene oxide product. Combining both these functions in a single catalyst provides a very efficient integrated process operable below the flammability limits of hydrogen and highly selective for the production of hydrogen peroxide to produce olefin oxides such as propylene oxide without formation of undesired co-products.

The exemplary embodiments of the present invention providing new slurry compositions suitable for use in processes involving the chemical mechanical polishing (CMP) of a polysilicon layer. The slurry compositions include one or more non-ionic polymeric surfactants that will selectively form a passivation layer on an exposed polysilicon surface in order to suppress the polysilicon removal rate relative to silicon oxide and silicon nitride and improve the planarity of the polished substrate. Exemplary surfactants include alkyl and aryl alcohols of ethylene oxide (EO) and propylene oxide (PO) block copolymers and may be present in the slurry compositions in an amount of up to about 5 wt %, although much smaller concentrations may be effective. Other slurry additives may include viscosity modifiers, pH modifiers, dispersion agents, chelating agents, and amine or imine surfactants suitable for modifying the relative removal rates of silicon nitride and silicon oxide.

Two (or more), -component, body-implantable, absorbable, biocompatible, putty, and non-putty hemostatic tamponades for use in surgery. Component 1 is a finely powdered bulking material, preferably less than 50 microns, e.g. the calcium, magnesium, aluminum, or barium salts of saturated or unsaturated carboxylic acids containing about 6 to 22 carbon atoms, hydroxyapatite, DBM, polyglycolide, polylactide, poldioxinones, polycaprolactones, absorbable glasses, gelatin, collagens, mono, and polysaccharides starches. Component 2, a dispersing vehicle, may be esters of C8-C18 monohydric alcohols with C2-C6 aliphatic monocarboxylic acids; C2-C18 monohydric alcohols with polycarboxylic acids; C8-C30 monohydric alcohols; tocopherol and esters thereof with C2-C10 aliphatic monocarboxylic acids or polycarboxylic acids; absorbable 10-14C hydrocarbons; free carboxylic acids such as oleic, capric, and lauric; dialkyl ethers and ketones; alkyl aryl ethers and ketones, polyhydroxy compounds and esters and ethers thereof; (ethylene oxide / propylene oxide copolymers), oils e.g. olive oil, castor oil and triglycerides.

Two (or more), -component, body-implantable, absorbable, biocompatible, putty, and non-putty hemostatic tamponades for use in surgery. Component 1 is a finely powdered bulking material, preferably less than 50 microns, e.g. the calcium, magnesium, aluminum, or barium salts of saturated or unsaturated carboxylic acids containing about 6 to 22 carbon atoms, hydroxyapatite, DBM, polyglycolide, polylactide, poldioxinones, polycaprolactones, absorbable glasses, gelatin, collagens, mono, and polysaccharides starches. Component 2, a dispersing vehicle, may be esters unsubstituted and N-substituted pyrrolidones of C8-C18 monohydric alcohols with C2-C6 aliphatic monocarboxylic acids; C2-C18 monohydric alcohols with polycarboxylic acids; C8-C30 monohydric alcohols; tocopherol and esters thereof with C2-C10 aliphatic monocarboxylic acids or polycarboxylic acids; absorbable 10-14C hydrocarbons; free carboxylic acids such as oleic, capric, and lauric; dialkyl ethers and ketones; alkyl aryl ethers and ketones, polyhydroxy compounds and esters and ethers thereof; (ethylene oxide / propylene oxide copolymers), oils e.g. olive oil, castor oil and triglycerides.

Provided is particulate of an anode active material for a lithium battery, comprising one or a plurality of anode active material particles being embraced or encapsulated by a thin layer of a high-elasticity polymer having a recoverable tensile strain no less than 5%, a lithium ion conductivity no less than 10−6 S / cm at room temperature, and a thickness from 0.5 nm to 10 μm, wherein the polymer contains an ultrahigh molecular weight (UHMW) polymer having a molecular weight from 0.5×106 to 9×106 grams / mole. The UHMW polymer is preferably selected from polyacrylonitrile, polyethylene oxide, polypropylene oxide, polyethylene glycol, polyvinyl alcohol, polyacrylamide, poly(methyl methacrylate), poly(methyl ether acrylate), a copolymer thereof, a sulfonated derivative thereof, a chemical derivative thereof, or a combination thereof.

(Salph or methoxy salph) Co (initiating ligand) catalyze homopolymerizing rac-PO to produce pure highly isotactic PPO and rac-1-butylene oxide to produce pure isotactic poly(butylene oxide). A product is unfractionated isotactic PPO of m-dyad content >81%, normally at least 99%.

According to a process for production of alkylene oxide polymers offered by the present invention, an alkylene oxide is subjected to a polymerization reaction under presence of a catalyst in a solvent containing an aliphatic hydrocarbon having from five to seven carbon atoms and a branched structure. The aliphatic hydrocarbon is provided preferably by 2-methyl pentane, 3-methyl pentane, 2,3-dimethyl pentane, 2,4-dimethyl pentane, etc. The alkylene oxide is provided preferably by ethylene oxides and / or propylene oxides.

The present invention relates to a composite prosthesis including a coated mesh having at least one opening through a first surface and a second surface of the coated mesh; the coated mesh comprising a mesh and a biocompatible coating substantially surrounding each filament of the mesh, wherein the biocompatible coating is formed by coating the mesh with a polyol prepolymer and curing the prepolymer, the prepolymer comprising a polyalkylene oxide polyol end capped with isocyanate, the polyalkylene oxide polyol having from about 70% to about 95% ethylene oxide groups and the remainder propylene oxide; and a barrier material comprising a biocompatible membrane constructed and arranged to cover at least one surface of the coated mesh, wherein the barrier material comprises a biologic material.

Provided is lithium secondary battery comprising a cathode, an anode, and an electrolyte or separator-electrolyte assembly disposed between the cathode and the anode, wherein the anode comprises: (a) a foil or coating of lithium or lithium alloy; and (b) a thin layer of a high-elasticity polymer disposed between the foil / coating and the electrolyte (or separator-electrolyte assembly), having a recoverable tensile strain no less than 2%, a lithium ion conductivity no less than 10−6 S / cm at room temperature, and a thickness from 1 nm to 10 μm, wherein the high-elasticity polymer contains a cross-linked network of polymer chains having an ether linkage, nitrile-derived linkage, benzo peroxide-derived linkage, ethylene oxide linkage, propylene oxide linkage, vinyl alcohol linkage, cyano-resin linkage, triacrylate monomer-derived linkage, tetraacrylate monomer-derived linkage, or a combination thereof in the cross-linked network of polymer chains.

An anti-settling additive, composition containing the anti-settling additive, and methods for use in coating compositions or formulations. A HASE thickener with improved resistance to surfactants and anti-sag properties, compositions containing the thickener and methods for use of the thickener in coating compositions or formulations and the like. The anti-settling additive and the thickener being a polymer synthesized using a specialized associative monomer that contains C1-C4 alkyl, propylene oxide, ethylene oxide and a polymerizable group.

The invention discloses a hydrophilic polyvinylidene fluoride hollow fiber microporous membrane and the preparation method thereof. The main composition and the mass content of the membrane are 70% to 90% of polyvinylidene fluoride, amphiphilic poly-(propylene oxide-oxirane), 5% to 29% of poly-(methacrylic acid- acrylic acid) or poly-(methacrylic acid methyl ester-vinyl alcohol) copolymer and 1% to 5% of nano-silicon dioxide. The membrane preparation method is that all the components are mixed and dissolved with aperture regulator, thickener and solvent to obtain the membrane preparation liquid; after that, the hollow fiber forming is carried out through a dry-wet spinning technique, and finally cleaning and drying are implemented. The obtained membrane has adjustable internal diameter and external diameter, 60% to 80% of porosity and the aperture ranging from 0.01micron to 0.2micron. As a water disposal separating membrane material with excellent performance, the invention has the advantages of being able to be fully humid, organic adsorption resistance and great water flux, etc.

A membrane which can be used in membrane filtration processes and which has a reduced tendency to fouling is a polysulphone or a plyether sulphone and a polyethylene oxide / polypropylene oxide substituted diamine and can be made by a phase inversion process in the presence of pore modifying agents such as an alcohol, glycerol or glycol to give a membrane which has a pore size of 0.1.mu. to 1 micron and is hydrophilic.

The present invention is one kind of thick oil demulsifier and its preparation process, and belongs to the field of petrochemical technology. The present invention features that phenol-amine resin as the initial material is block polymerized with epoxy propane ad epoxy ethane under the action of catalyst to obtain stereo netted macromolecular polyether as the thick oil demulsifier. The polyether as the thick oil demulsifier may be further chain expanded for even high demulsifying effect. The thick oil demulsifier can reach the oil-water interface fast to lower the elasticity and viscosity of the interface film, speed the aggregation of liquid drops and demulsify effectively. The thick oil demulsifier has simple preparation process, is suitable for industrial production, and may be used in the efficient dewatering of oil field produced liquid with different water contents.

Provided herein are polyurethane foams which may be prepared by spray techniques. The foams of the invention are prepared using conventional isocyanates and a novel Mannich condensate polyol having a hydroxy number in the range of 250-340 and a viscosity of 3500 cps or less, and wherein the Mannich condensate polyol is derived from nonylphenol, formaldehyde, an alkanolamine, and propylene oxide as the sole alkoxylating agent. Polyurethane foams prepared according to the invention possess superior physical properties over sprayed polyurethane foams prepared using Mannich condensate polyols which are made using mixtures of propylene oxide and ethylene oxide.

An electrode and a battery coverable of improving cycle characteristics by forming an effective coat are provided. A cathode (21) and an anode (22) are wound with a separator (23) impregnated with an electrolytic solution inbetween. On the surface of the cathode (21) or the anode (22), a coat containing a compound, which has a smaller surface tension than of the electrolytic solution and is insoluble into the electrolytic solution, specifically, a coat containing siloxane such as poly (dimethyl siloxane), poly (methyl hydro siloxane), and poly (methyl phenyl siloxane), or perfluoro polyether such as poly (hexafluoro propylene oxide), or perfluoro alkane such as perfluoro pentadecane is provided. Thereby, without using a great deal of the compound for forming the coat, the coat effective to inhibit decomposition reaction of the electrolytic solution is formed.

A mixture of propylene oxide and methanol is separated by liquid / liquid extraction using water and a hydrocarbon such as n-octane as extractive solvents.

The invention relates to a preparation method of an efficient deemulsifier for naphthenic extra heavy oil and a product thereof, belonging to the technical field of petroleum processing. The efficient deemulsifier is prepared by polymerizing alkylphenol, polyethylene polyamine and formaldehyde to obtain thermoplastic phenol-amine resin as an initiator, polymerizing the initiator with oxirane and epoxypropane to generate polyether blocked copolymer, and then esterifying the polyether blocked copolymer with acrylic acid and other unsaturated acids to generate a modified polyether product by grafting olefine acid. The product prepared by the method has the characteristics of quick dehydration and low dosage. The efficient deemulsifier of the invention is suitable for dehydrating the naphthenic extra heavy oil of Karamay oil fields, meeting the requirements of proper temperature, quick dehydration, high dehydration rate, clear water color, and tidy oil-water interface, and has high efficiency demulsification and dehydration performance.

Demulsifiers containing an anionic surfactant selected from alkylsulfosuccinates, alkylphosphonic acids, and their salts; a nonionic surfactant selected from ethylene oxide / propylene oxide copolymers, ethoxylated fatty acids of polyethylene glycol, terpene alkoxylates, and modified alkanolamides; and solvent bases comprising blends of dibasic esters. Methods for breaking emulsions using such demulsifiers and solvent bases are also disclosed.

The invention relates to an energy-saving and emission-reducing technique for producing propane epoxide by using hydrogen peroxide epoxidation propylene, belonging to the field of petrochemical technology. The technique comprises a reaction part, a separation part and a tail gas treatment part, and is characterized in that propylene and hydrogen peroxide have an epoxidation reaction through a Ti-Si molecular sieve at medium pressure and low temperature; the propylene and solvent have higher recovery rate, the propane epoxide meeting the requirement of commercial-grade purity can be obtained by extractive distillation, and the joint product of propylene glycol monomethyl ether can be prepared by azeotropic distillation and purification; after part of tail gas is condensed and absorbed and the propylene is recovered, the tail gas reaches the standard and is discharged; extracting agent, absorbing agent and entrainer which are needed by the technique are in closed cycle in the process flow; and medium-pressure operation is adopted by a propylene tower to ensure water-cooling on the top of the tower, and thermal energy can be recovered by multiple-effect rectification and matching of streams. The technique has the effect and the advantage that the new energy-saving and environment-friendly technique for producing the propane epoxide can generate remarkable economic and social benefits.

The exemplary embodiments of the present invention providing new slurry compositions suitable for use in processes involving the chemical mechanical polishing (CMP) of a polysilicon layer. The slurry compositions include one or more non-ionic polymeric surfactants that will selectively form a passivation layer on an exposed polysilicon surface in order to suppress the polysilicon removal rate relative to silicon oxide and silicon nitride and improve the planarity of the polished substrate. Exemplary surfactants include alkyl and aryl alcohols of ethylene oxide (EO) and propylene oxide (PO) block copolymers and may be present in the slurry compositions in an amount of up to about 5 wt %, although much smaller concentrations may be effective. Other slurry additives may include viscosity modifiers, pH modifiers, dispersion agents, chelating agents, and amine or imine surfactants suitable for modifying the relative removal rates of silicon nitride and silicon oxide.