1814results about How to "Diffusion fast" patented technology

The invention generally relates to compositions and methods for transporting substances across mucosal barriers. The invention also relates to methods of making and using such substances.

The present invention generally relates to reducing the mucoadhesive properties of a particle. In some embodiments, the particle is coated with and / or associated with a (poly(ethylene glycol))-(poly(propylene oxide))-(poly(ethylene glycol)) triblock copolymer. Methods for preparing inventive particles using a poly(ethylene glycol)-vitamin E conjugate as a surfactant are also provided. In some embodiments, methods are provided comprising administering to a subject a composition of particles of the present invention. Such particles with reduced mucoadhesive properties are useful in delivering agents to mucosal tissues such as oral, ophthalmic, gastrointestinal, nasal, respiratory, and genital mucosal tissues.

The invention discloses a micro-needle array chip, which comprises a micro-needle and a substrate. The micro-needle consists of a needle head, a needle rod and a needle base; the top of the needle head is provided with a needle point; the micro-needle is fixed on the substrate through the needle base; the needle rod of the micro-needle is cylindrical or conical; the needle rod is inclined to the substrate at a set angle; and the needle head is conical or the upper surface of the needle point is an elliptical plane which is parallel to the substrate or inclined to the substrate at a set acute angle. The metal micro-needle in the micro-needle array chip is firm in structure and cannot rupture; the needle point is sharp and convenient to puncture; the maximum puncture depth of the micro-needle is easily regulated and controlled; the micro-needle in the array has good consistency and are safe and reliable to use; and the hollow micro-needle has a side opening similar to that of the traditional needle. Therefore, the micro-needle array chip can effectively avoid the phenomenon that the skin blocks the infusion hole, is more favorable for rapid diffusion and absorption of medicaments, and has obvious curative effect.

An absorbent article is provided having an absorbent core with an absorbent pledget adhered to the body-facing side of the core between the core and the body-facing surface of the article. The pledget has a greater structural stiffness and a reduced surface area relative to the core. The absorbent article has a fluid permeable coverstock including a bi-component fiber. An hourglass-shaped absorbent pledget is disposed between the core and the coverstock. The pledget includes airlaid material adhered to the body-facing side of the absorbent core. The pledget further includes a three-dimensional apertured film mounted to the airlaid material, which engages the coverstock. The absorbent core is configured to fold about the hourglass shape of the pledget and resist undesired deformity of the absorbent article. The coverstock includes adhesive-coated elastic members disposed adjacent the longitudinal sides. The longitudinal sides are folded about a backsheet to enclose the core and pledget.