The invention discloses a preparation method of a core-shell structured
synthetic polymer-natural
polymer composite
fiber, and the method comprises the steps of: (1) selecting one or several of synthetic polymers to dissolve in a
solvent, and conducting stirring until complete
dissolution; (2) selecting a natural
polymer to dissolve in a
solvent, or adding a
spinning assistant, and carrying out stirring until complete
dissolution; and (3) taking the solution prepared in step (1) as an outer tube
spinning solution, adopting the solution prepared in step (2) as an inner tube
spinning solution, injecting them into the inner tube and the outer tube of a coaxial spinneret, and performing
coaxial electrospinning at
room temperature. The core-shell structured nano-
fiber prepared by the invention selects the
synthetic polymer as the shell layer, and can inhibit water molecules from penetrating the natural
polymer as the core layer. The natural polymer as the core layer can more effectively encapsulate active substances to avoid inactivation of the active substances in the presence of an
organic solvent, so that the core-shell structured composite
fiber can play a good
drug sustained release role in the
drug carrier field, and an integral activity can be maintained.