137 results about "Ichthyosis" patented technology

This invention relates to certain sugar esters of phytosterols of formula (I). These esters are useful for topical application, and for the treatment of skin condition, including age spots, acne, loss of cellular antioxidants, collagen loss, loss of skin pliability, loss of skin suppleness, skin wrinkles including fine lines, oxidation, damage from radiation, malfunction of matrix metalloproteases, malfunction of tyrosinases, damage from free radicals, damage from UV, dry skin, xerosis, ichthyosis, dandruff, brownish spots, keratoses, melasma, lentigines, liver spots, pigmented spots, dark circles under the eyes, skin pigmentation including darkened skin, blemishes, oily skin, warts, eczema, pruritic skin, psoriasis, inflammatory dermatoses, topical inflammation, disturbed keratinization, skin changes associated with aging, nail or skin requiring cleansers, conditioning or treatment, and hair or scalp requiring shampooing or conditioning, and combinations thereof;Wherein,n=0, 1, 2, or 3; andR=H, —CH2OH, —CH(OH)—CH2OH, —CH(OH)—CH(OH)—CH2OH; andR1=Substituent selected from a sapogenin, steroid, or terpenoid.

An external preparation composition used for preventing or treating symptoms or diseases related to dermatopathy caused by dryness, UV rays and aging such as wrinkles and sags of the skin, pigmentation of the skin, skin roughness and coarse texture and skin diseases such as psoriasis, lichen, ichthyosis, keratosis, Darier's disease, pustulosis, acne, eczema and atopic dermatitis. The external preparation composition comprises at least one of acyl glucosamine derivatives represented by the following Formula (I): wherein R1, R2, R3, R4 and R5 are defined; and X is any one of groups represented by the following Formulas (A) to (C): wherein Y, n and R6 are also defined.

A Chinese medicine for treating psorinsis, ichthyosis, tinea, neurodermatitis, urticaria, eczema, flat wart, etc is composed of the orally taken capsules prepared from 19 Chinese-medicinal materials including dahurian angelica root, etc. the exterior-applied component A prepared from 6 Chinese-medicinal materials including cloves, etc. and the exterior-applied component B prepared from said component A and 14 Chinese-medicinal materials including dahurian angelica root, etc.

This invention relates to certain sugar esters of phytosterols of formula (I). These esters are useful for topical application, and for the treatment of skin condition, including age spots, acne, loss of cellular antioxidants, collagen loss, loss of skin pliability, loss of skin suppleness, skin wrinkles including fine lines, oxidation, damage from radiation, malfunction of matrix metalloproteases, malfunction of tyrosinases, damage from free radicals, damage from UV, dry skin, xerosis, ichthyosis, dandruff, brownish spots, keratoses, melasma, lentigines, liver spots, pigmented spots, dark circles under the eyes, skin pigmentation including darkened skin, blemishes, oily skin, warts, eczema, pruritic skin, psoriasis, inflammatory dermatoses, topical inflammation, disturbed keratinization, skin changes associated with aging, nail or skin requiring cleansers, conditioning or treatment, and hair or scalp requiring shampooing or conditioning, and combinations thereof;Wherein,n=0, 1, 2, or 3; andR=H, —CH2OH, —CH(OH)—CH2OH, —CH(OH)—CH(OH)—CH2OH; andR1=Substituent selected from a sapogenin, steroid, or terpenoid.

Oral and topical pharmaceutical compositions, kits and methods of treatment thereof for treating various skin disorder including acne, psoriasis, ichthyosis, photoaging, photodamaged skin, and, skin cancer. Exemplary vitamin D analogs as active pharmaceutical ingredients include 2-methylene-19-nor-20(S)-1α-hydroxy-bishomopregnacalciferol, 19-nor-26,27-dimethylene-20(S)-2-methylene-1α,25-dihydroxyvitamin D3, 2-methylene-1α,25-dihydroxy-(17E)-17(20)-dehydro-19-nor-vitamin D3, 2-methylene-19-nor-(24R)-1α,25-dihydroxyvitamin D2, 2-methylene-(20R,25S)-19,26-dinor-1α,25-dihydroxyvitamin D3, 2-methylene-19-nor-1α-hydroxy-pregnacalciferol, 1α-hydroxy-2-methylene-19-nor-homopregnacalciferol, (20R)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol, 2-methylene-19-nor-(20S)-1α-hydroxy-trishomopregnacalciferol, 2-methylene-23,23-difluoro-1α-hydroxy-19-nor-bishomopregnacalciferol, 2-methylene-(20S)-23,23-difluoro-1α-hydroxy-19-nor-bishomopregnancalciferol, (2-(3′hydroxypropyl-1′,2′-idene)-19,23,24-trinor-(20S)-1α-hydroxyvitamin D3, 2-methylene-18,19-dinor-(20S)-1α,25-dihydroxyvitamin D3, a stereoisomer thereof, a prodrug thereof in oral compositions, a salt thereof, and / or a solute thereof. Compounds that activate retinoic acid receptors, such as retinoyls and retinoyl esters, include 13-cis-retinoic acid, all-trans-retinoic acid, (2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexeneyl)nona-2,4,6,8-tetraenoic acid, 9-(4-methoxy-2,3,6-trimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid, 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-napthoic acid, 4-[1-(3,5,5,8,8-pentamethyl-tetralin-2-yl)ethenyl]benzoic acid, retinobenzoic acid, ethyl 6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl]pyridine-3-carboxylate, retinoyl t-butyrate, retinoyl pinacol, retinoyl cholesterol, an isomer thereof, a prodrug thereof for oral compositions, an ester thereof, a salt thereof, and / or, a solute thereof. Combinations of such active ingredients demonstrate synergistic efficacy.

A composition and method for the prevention and therapeutic treatment of skin conditions and disorders are disclosed. The composition and method of the invention are particularly directed to the treatment and prevention of dermal irritations. These irritations include, for example, psoriasis, eczema, ichthyosis, pruritus, dryness and dermatitis, which may cause skin to crack, chap or chafe. The composition and method are particularly useful in treating and preventing diaper dermatitis. A therapeutic composition according to the invention includes an agent, which is an enzyme constituent, promoting the synthesis of collagen and the reproduction of cells, particularly skin cells. Such therapeutic agents include, for example, zinc oxide. This agent is generally nonprescription and capable of effectively preventing and treating diaper dermatitis through local or topical application. Therapeutic compositions according to the invention also include both natural and synthetic components, which aid in application, use and treatment.

A composition and method for the prevention and therapeutic treatment of skin conditions and disorders are disclosed. The composition and method of the invention are particularly directed to the treatment and prevention of dermal irritations. These irritations include, for example, psoriasis, eczema, ichthyosis, pruritus, dryness and dermatitis, which may cause skin to crack, chap or chafe. The composition and method are particularly useful in treating and preventing diaper dermatitis. A therapeutic composition according to the invention includes an agent, which is an enzyme constituent, promoting the synthesis of collagen and the reproduction of cells, particularly skin cells. Such therapeutic agents include, for example, zinc oxide. This agent is generally nonprescription and capable of effectively preventing and treating diaper dermatitis through local or topical application. Therapeutic compositions according to the invention also include both natural and synthetic components, which aid in application, use and treatment.

Preventing skin aging by targeting multiple causes by a single bullet is of primal scientific and consumer interest. A treatment based on compositions of compound (I) for cellular senescence to control cellular degradation offers such a solution to multiple skin ailments including skin degradation from cancer, diabetes, radiation treatments, chemotherapy, and sun-burn; mitochondrial dysfunction, age spots, acne, loss of cellular antioxidants, collagen loss, loss of skin pliability, loss of skin suppleness, skin wrinkles including fine lines, oxidation, damage from radiation, damage from free radicals, damage from UV, dry skin, xerosis, ichthyosis, dandruff, brownish spots, keratoses, melasma, lentigines, liver spots, pigmented spots, dark circles under the eyes, skin pigmentation including darkened skin, blemishes, oily skin, warts, eczema, pruritic skin, psoriasis, inflammatory dermatoses, topical inflammation, disturbed keratinization, skin changes associated with aging, scalp dryness, skin depigmentation, intracellular dehydration, and combinations thereof;

The invention relates to a kind of compound collagen gel, which is the mixture of collagen and antibiotics. For every gram gel, there is 1-100mg collagen, which is extracted from tendon of the rat tails, swine, or ox, 1-100mg antibiotics, 0.1-1.0mg medical antiseptics, 10-500mg thickening agents, and water. The antibiotics and collagen act cooperatively to be used in the treatment of the following diseases: different kinds of open wound, anabrosis caused by diabetes, skin damage because of venereal disease, hyperkeratesis, cuticularized skin problems such as keratosis palmaris ET plantaris, winter cutitis and ichthyosis. Since the collagen protein in the gel can be easily absorbed to provide threpsis to the diseased region, so it can promote the agglutination very effectively as well as extend the time of releasing time of the antibiotics.

The present invention relates to novel compounds, pharmaceutical compositions and methods for treating tumors, cancer and hyperproliferative diseases including psoriasis, genital warts and hyperproliferative cell growth diseases, including hyperproliferative keratinocyte diseases such as hyperkeratosis, ichthyosis, keratoderma or lichen planus. These compounds are described according to the chemical structure:where R1 is H, OH, F, Cl, Br, I, a C1-C6 optionally substituted alkyl or alkenyl group, an optionally substituted aryl group or a group;Ra is a H, OH, C1-C10, optionally substituted alkyl or alkenyl group, an optionally substituted O—(C1-C7 alkyl group) or O-aryl group, an amine group which is optionally substituted with at least one C1-C10 alkyl group which may be optionally substituted, or a single optionally substituted aryl group, biphenyl group, (C1-C6) alkylenearyl group, (C1-C6) alkylenebiphenyl group, heteroaryl group, heterocyclic group, (C1-C6) alkylene heteroaryl group or (C1-C6) alkylene heterocyclic group;R2 is a group;Rb is a H, OH, C1-C10, optionally substituted alkyl or alkenyl group, an optionally substituted O—(C1-C7 alkyl group) or O-aryl group, an amine group which is optionally substituted with at least one C1-C10 alkyl group which may be optionally substituted, or a single optionally substituted aryl group, biphenyl group, (C1-C6) alkylenearyl group, (C1-C6) alkylenebiphenyl group, heteroaryl group, heterocyclic group, (C1-C6) alkylene heteroaryl group or (C1-C6) alkylene heterocyclic group;R3 and R6 are each independently selected from H, OH, F, Cl, Br, I, a C1-C6 optionally substituted alkyl or alkenyl group, an optionally substituted aryl group, a carbamate, alkylene carbamate, urethane or alkylene urethane;R4 is a group, wherein Rb is as described above; andR5 is a group, wherein Rb is as described above,with the proviso that at least one of R1 and R2 or R4 and R5 contains an Ra or Rb group which is an amine group which is optionally substituted with at least one C1-C10 alkyl group which may be optionally substituted, or a single optionally substituted aryl group, biphenyl group, (C1-C6) alkylenearyl group, (C1-C6) alkylenebiphenyl group, heteroaryl group, heterocyclic group, (C1-C6) alkylene heteroaryl group or (C1-C6) alkylene heterocyclic group;or a stereoisomer, pharmaceutically acceptable salt, solvate, and polymorph thereof.

The invention provides a composition of garlic total polysaccharide and sulfur-containing amino acid. The composition mainly comprises garlic water-soluble macromolecule effective components, has good effects on inhibiting scurf and relieving itching, is applicable to various skin desquamation, scurf, ichthyosis, and various skin itching symptoms, and has the functions of supporting right, dispelling evil, and reducing toxicity. The composition has wide application prospects, and can be prepared into medicaments or cosmetics for preventing and treating desquamation and relieving itching with significant curative effect and less toxic or side effects. The invention also provides a method for preparing the composition, which comprises: extracting garlics, performing centrifugation or filtration to remove superfluous impurities so as to obtain the composition meeting the requirements; or purifying the extract through an ion exchange chromatographic column to obtain garlic sulfur-containing amino acid; then performing concentration and alcohol precipitation of an eluate to obtain garlic total polysaccharide, or adding the extract into an organic solvent such as alcohol and the like, and performing precipitation to obtain garlic polysaccharide; finally combining the garlic sulfur-containing amino acid with the polysaccharide according to a weight ratio to obtain the composition meeting the requirements. The preparation method is simple in operation, low in cost, controllable in quality, and suitable for industrialization.

The Chinese medicine Jingfuling for treating psoriasis and ichthyosis is prepared with 19 kinds of Chinese medicinal materials, including antelope horn, buffalo horn, dragon's blood, cantharides, toad cake, rehmannia root, etc. The Chinese medicine is especially suitable for treating psoriasis and ichthyosis and has the features of high curative effect and no recurrence. It may be also used in treating eczema.

The active biological enzyme composite medicine includes nerve repairing factor nutrient liquid, which is prepared with placenta, umbilical cord and protein of hatched fowl egg as main material and Chinese medicinal materials as supplementary material and for treating Parkinson's disease and other nerve diseases as well as cancer; ichthyosis lotion, which is prepared with yolk and amniotic fluid of hatched fowl egg as main material and Chinese medicinal materials as supplementary material and for treating ichthyosis and squama cancer; and burn and scald curing lotion, which is prepared with hatched fowl egg as main material and Chinese medicinal materials as supplementary material and for treating various burns and scalds as well as other injuries.

A Chinese medicine for treating ichthyosis by fumigation is prepared from 18 Chinese-medicinal materials including fleece flower root, cordyceps, earthworm, Chinese angelica root, etc through mixing, grinding and loading in gauge bags. Its advantages are quick acting, sure curative effect (98% or more for cure rate), and no recurrence.

The invention relates to an emollient composition for topical use that comprises a combination of glycerol, Vaseline and liquid paraffin as an active principle, in the form of an oil-in-water or water-in-oil emulsion. The invention also relates to: the use thereof for preparing a drug for treating dry skin conditions associated with certain dermatoses such as atopic dermatitis, ichthyosis conditions and psoriasis; the use thereof for preparing a drug for treating small superficial burns; and the use thereof for preparing a drug for preventing and / or treating and / or reducing the frequency and intensity of eczema attacks observed in patients suffering from atopic dermatitis.

The invention relates to a method for controlling the quality of a Chinese medicine composition for treating ichthyosis, which belongs to the field of quality control of Chinese medicine. The Chinese medicine composition consists of dittany bark, pericarpium zanthoxyli, radix rehmannia, Chinese atractylodes, divaricate saposhnikovia root, cicada slough, safflower, hemp seed, cassia twig, angelica, szechwan lovage rhizome, liquorice, lightyellow sophora root, Chinese ephedra and broom cypress fruit. The method is characterized in that the content of one or a plurality of compositions in the medicine composition can be determined by high performance liquid chromatography; and one or the plurality of the compositions in the medicine composition can be distinguished by thin layer chromatography. The method makes up the deficiency of the prior art, improves the quality control standard of the medicine composition, and has the advantages of simple and convenient method, accurate result and excellent reproducibility.

The present invention relates to the prevention / treatment of ichthyosis vulgaris (IV), atopy and potentially other disorders associated with loss-of-function mutations in the filaggrin gene sequence. The prevention / therapy is based on the use of agents which enable the host's translational machinery to read through a nonsense mutation found in a mutant allele of the filaggrin gene.

An external-use curing and nursing traditional Chinese medicine for ichthyosis and xerodermia include, in parts by weight, for curing: 6-10 Cortex Dictamni, 5-8 Herba Lycopodii, 3-8 Flos Carthami, 3-8 Herba speranskiae tuberculatae, 6-10 Herba Menthae, 4-8 Folium Artemisiae Argyi, 3-6 GONGGUI, 3-6 Fructus Kochiae, 3-6 Cortex erythrinae, 3-6 Herba Artemisiae, 3-6 Ramulus Mori, 3-6 Bletilla striata, 3-8 Radix Paeoniae Rubra, 3-6 Rhizoma Atractylodis, 3-6 Asarum sieboldi, 2-4 Herba Leonuri, 3-5 Radix Ginseng Rubra, and 4-8 Radix Bupleuri; and include, in parts by weight, for nursing: 3-6 Rehmannia glutinosa Libosch, 3-6 Rehmannia glutinosa, 3-6 Paeonia suffruticosa Andr., 3-5 Alisma plantago aquatica, 3-8 Ophiopogon japonicus, 3-8 aloes, 10-30 Astragalus membranaceus, 3-5 Poria cocos, 5-14 FRUCTUS CORNI, 5-14 Rhizoma Dioscoreae, 3-6 peach kernel, 3-6 tremella, and 1-3 Panax. It is convenient to use, pain free, no side effect, no anti-medicine reaction is produced, and it operates quickly and has significant therapeutic effect.

The invention provides a drink containing corn stigma and ginseng and a preparation method of the drink. Each ton of the products is prepared from components as follows: 10-15Kg of xylitol, 0.5-1 L of a corn stigma extracting solution, 0.1-0.15 L of a ginseng extracting solution and water serving as an edible auxiliary material. The drink contains much total flavonoids in terms of rutin. The drink can be taken much or little each time, can be taken for a long time and can strengthen the body and prolong the longevity if often taken. The health-care drink has a good treatment effect on skin diseases such as dermatitis, urticaria, ichthyosis and the like and has an auxiliary treatment effect on obesity and blood sugar.

The present invention is Chinese medicine for treating leukoderma, psoriasis and ichthyosis, and includes orally taken preparation and externally applied medicine liquid and ointment. The orally taken preparation is prepared with gromwell, ephedra, ligusticum and other four kinds of Chinese medicinal materials; the externally applied medicine liquid has the materials including wolfberry bark, burdock-seed fructus arctii and eight kinds of Chinese medicinal materials; and the externally applied medicine ointment is prepared with black bean oil and Jiazhiluke. The present invention treats various kinds of tinea, especially leukoderma, psoriasis and ichthyosis, through the combination of orally taken Chinese medicine and externally applied Chinese medicine, and has the features of determined healing effect, short healing period and less recurrence.

The invention discloses a formula for medicinal ink. The formula comprises components as follows: 15 g of buffalo horn concentrated powder, 30 g of antelope horns, 100 g of musk, 100 g of borneol, 120 g of pearls, 15 g of toad venom, 15 g of calculus bovis, 24 g of cinnabar, 5 oxgall bladders, 10 g of bear gall, 10 snakes' gall bladders, 15 pigs' gall bladders, 100 g of ligusticum wallichii, 10 black carps' gallbladders, 150 g of lotus rhizome nodes, 70 g of safflower, 150 g of field thistle herbs, 150 g of Japanese thistle herbs, 400 g of lalang grass rhizomes, 200 g of common selfheal fruit-spike, 100 g of tree peony bark, 70 g of cloves, 20 g of gelatin, 200 g of water chestnut starch and 200 g of China wood oil soot. The formula is significant in curative effect on various skin, mouth and throat chronic diseases such as ichthyosis, chronic eczema, chronic urticarial, herpes zoster, neurodermatitis, stubborn dermatitis, acne, rosacea, innominate inflammatory, chronic pharyngitis, and recurrent dental ulcers.

A Chinese medicine for treating psoriasis is prepared from more than 10 Chinese- medicinal materials including centipede, ground beetle, fleece flower root, red sage root, etc.

The present invention relates to hydrazide derivatives of Formula I notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such hydrazide derivatives. Said hydrazide derivatives are useful in the treatment of preterm labor, dysmenorrhea, fertility disorders, asthma, hypertension, undesired blood clotting, preelampsia, eclampsia, an eosinophil disorder, undesired bone loss, renal dysfunction, an immune deficiency disorder, ichthyosis, elevated intraocular pressure, infertility, sexual dysfunction, gastric ulcers and inflammatory disorders.

The invention relates to an antipruritic Chinese medicine composition and a preparation method thereof. The antipruritic Chinese medicine composition is prepared by mixing cortex dictamni, fructus kochiae, fructus cnidii, schizonepeta, unprepared rehmannia root, angelica sinensis, smoked plum, schisandra chinensis, periostracum cicada and liquorice which are as medicament raw materials in reasonable proportions, adding an appropriate amount of water and boiling. The antipruritic Chinese medicine composition has certain curative effects on psoriasis, ichthyosis, urticaria, acute and chronic dermatitis and diseases which are not healed after long treatment and have medicine resistance on certain medicines.

The invention relates to an ichthyosys-treating medicine and its preparing process, which is prepared from the following medicinal herbs (by weight ratio) as raw material, Chinese dittany bark 60-70 parts, Clematis chinensis 60-70 parts, dried rehamnnia root 80-90 parts, atractylodes rhizome 60-70 parts, ledebouriella root 40-50 parts, cicada skin 40-50 parts, safflower 40-15 parts, hemp seeds 40-50 parts, sweet osmanthus flower 40-50 parts, Chinese angelica root 60-70 parts, rhizome of Sichuan lovage 40-50 parts, licorice root 40-50 parts, flavescent sophora root 40-50 parts, Chinese ephedra 40-50 parts, broom cypress fruit 60-70 parts.

The present invention relates to a Chinese patent medicine capsule preparation, which has the advantages of short treatment cycle and low recurrence rate in treating psoriasis, vitligo, dermatoses, black and white hyperpigmented macule, ichthyosis, tinea manuum, etc., and the biggest characteristic of the Chinese patent medicine capsule preparation is as follows: the Chinese patent medicine capsule preparation can treat a large variety of dermatoses and has no any side effect. The Chinese patent medicine capsule preparation is prepared with twelve Chinese medicine components including cicada shell, lightyellow sophora root, etc., and the functions of the Chinese patent medicine capsule preparation include dehumidifying and sterilizing, eliminating blood stasis and promoting tissue regeneration, dispersing pathogenic wind and detoxifiying and enhancing immunity.

The invention relates to a plaster used for curing various dermatosis, which is a miracle plaster to treat skin diseases such as ichthyosis, psoriasis, and various ringworm, etc. and a preparation method thereof. The plaster is a combination of Traditional Chinese Medicine and western medicine, wherein, the components of Chinese Medicine are that (by weight percentage): 15-25 percent of pseudolarix, 15-25 percent of fructus cnidii, and 5-15 percent of dictamni cortex; while the components of western medicine are that (also by weight percentage): 15-25 percent of neomycin sulfate cream, 15-25 percent of urea cream and 15-25 percent of clotrimazole cream. The preparation method is that: the pseudolarix, the fructus cnidii and the dictamni cortex are weighed according to the weight percentage, mixed and soaked in water for 1-2h, and oiled by bloom fire and cooked for 1-2h by mild fire, and then the medicated liquor is poured out and filtered and dehydrated by mild fire to obtain thick liquid; next, the neomycin sulfate cream, the urea cream and the clotrimazole cream are mixed and well stirred to form a mixed cream; finally, the thick liquid and the mixed cream are mixed in a proportion of 1:1 (by weight) and then well stirred to get the finished product. The plaster is characterized by simple preparation method, easily obtained raw materials, low cost and easy production.