47 results about "Clotrimazole" patented technology

It relates to a single-dose packaging unit which is a blow-fill-seal (BFS) container which comprises a sterile pharmaceutical or veterinary liquid composition which is a solution, wherein a) the composition comprises a therapeutically effective amount of clotrimazole or a pharmaceutically or veterinary acceptable salt thereof, together with one or more pharmaceutically or veterinary acceptable excipients or carriers, and b) the container has a volume from 0.05 to 8 mL, with the condition that the water content of the composition is equal to or lower than 4% by weight with respect to the total composition weight. It also relates to a secondary packaging comprising one or more single-dose packaging units.

Methods of treating infections caused by free-living amoeba are disclosed. The methods generally include systemic administration of an effective amount of miltefosine, such as an oral or intravenous formulation, and optionally local administration of an effective amount of miltefosine, such as a topical formulation of miltefosine. The methods may further include administration of one or more secondary agents. Exemplary secondary agents include steroids, polyhexamethylene biguanide (PHMB), chlorhexidine, propamidine isethionate, dibromopropamidine isethionate, neomycin, paromomycin, polymyxin B, clotrimazole, ketoconazole, miconazole, and itraconazole. The methods may be used to treat patients with infections caused by a free-living amoeba such as Naegleria fowleri, Balamuthia mandrillaris, Sappinia diploidea, and Acanthamoeba species. Exemplary infections include Acanthamoeba keratitis, granulomatous amoebic encephalitis, cutaneous acanthamoebiasis, primary amoebic meningoencephalitis, Sappinia amoebic encephalitis, or a disseminated disease associated with a free-living amoeba.

The invention relates to a Shuangzotai vaginal expansive suppository. The expansive suppository includes an active ingredient composed of clotrimazole, metronidazole and chlorhexidine acetate, a fat-soluble matrix and an expansive carrier. The drug layer is in full contact with the inner wall of the vagina to prevent the drug liquid from flowing out; the expansion plug is an inner and outer layer expansion plug, and the active ingredient is mixed with different substrates to form two layers, which can achieve dual effects of quick release and sustained release; The Shuangzotai vaginal expansion suppository provided by the present invention adopts seven original leading technologies, and the Shuangzotai vaginal expansion suppository has the functions of preventing the outflow of medicinal liquid, quick effect, long drug action time, and prevention of secondary infection, etc. Beneficial effect.

The invention discloses a mixing device and method for clotrimazole cream production, comprising a kettle body, the top of the kettle body is fixedly connected with a mixing motor, the inner cavity of the kettle body is provided with a stirring rod, and the stirring rod is provided with a power chamber and the chute, the outer side of the stirring rod is provided with a stirring plate matched with the kettle body, the stirring plate is provided with a sleeve hole, and the sleeve hole is provided with a slide bar matched with the chute, the The top wall of the inner cavity of the power chamber is fixedly connected to the electric telescopic device, and the bottom end of the telescopic rod on the electric telescopic device penetrates the bottom wall of the power chamber and is fixedly connected to the slide rod; the present invention stretches out the telescopic rod through the electric telescopic device, Then use the telescopic rod to push the slide bar down along the chute, and then push the stirring plate down along the inner cavity wall of the kettle body, and then use the stirring plate to squeeze the cream in the inner cavity of the kettle body and discharge it from the discharge pipe, which can effectively It prevents the cream from adhering to the inner wall of the kettle body, can completely discharge the cream in the kettle body, and can effectively ensure the output of the cream.

The invention relates to a pharmaceutical composition containing metronidazole and particularly relates to a pharmaceutical composition. The pharmaceutical composition contains metronidazole, clotrimazole, chlorhexidine acetate, sodium carboxymethyl starch, sodium carboxymethylcellulose, glycerine and water. The pharmaceutical composition disclosed by the invention has favorable pharmaceutical properties.