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Method for detecting 15 forbidden azoles in children cosmetics

A detection method and technology of cosmetics, applied in the field of detection, to achieve high sensitivity, multiple types of detection, and strong pertinence

Pending Publication Date: 2022-06-07
GUANGDONG TESTING INST OF PROD QUALITY SUPERVISION
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, no liquid chromatography-mass spectrometry method has been used to simultaneously detect econazole, clotrimazole, ketoconazole, fluconazole, miconazole, neoconazole, bennimidazole, clometrazole, Detection method of 15 kinds of azole antibiotics such as metronidazole, ornidazole, tinidazole, isoprinidazole, ronidazole, hydroxymetronidazole, bifonazole

Method used

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  • Method for detecting 15 forbidden azoles in children cosmetics
  • Method for detecting 15 forbidden azoles in children cosmetics
  • Method for detecting 15 forbidden azoles in children cosmetics

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Experimental program
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Embodiment Construction

[0044] The present invention will be further described with reference to the embodiments and accompanying drawings, which should not be construed as limiting the protection scope of the present invention.

[0045] 1 Reagent material

[0046] The water is the first grade water specified in GB / T6682.

[0047] 1.1 Methanol, chromatographically pure.

[0048] 1.2 Acetonitrile, chromatographically pure.

[0049] 1.3 50% acetonitrile solution: Mix acetonitrile (1.2) and water in a volume ratio of 1:1, and shake well.

[0050] 1.4 Formic acid, chromatographically pure

[0051] 1.5 sodium chloride, analytical grade

[0052] 1.6 Saturated sodium chloride solution: Weigh 40g of sodium chloride (1.5), put it in 250mL

[0053] In a ground conical flask, add 100 mL of water, and sonicate for 15 minutes.

[0054] 1.7 0.1% formic acid solution: take 1000 mL of water, add 1 mL of formic acid (1.4), and mix well.

[0055]1.8 Standard products: econazole, clotrimazole, ketoconazole, fluc...

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Abstract

The invention relates to a method for detecting 15 forbidden azoles in children cosmetics. According to the method, 15 azole substances such as econazole, clotrimazole, ketoconazole, fluconazole, miconazole, neoconazole, benznidazole, metronidazole, metronidazole, ornidazole, tinidazole, isometronidazole, lornidazole, hydroxy metronidazole and bifonazole in the children cosmetics can be efficiently and rapidly detected by adopting a liquid chromatography-mass spectrometry method. The detection method fills the blank of children cosmetic detection standards, is high in pertinence, high in sensitivity and multiple in detection types, and protects children cosmetics.

Description

technical field [0001] The invention belongs to the technical field of detection, in particular to a detection method for 15 prohibited azoles in children's cosmetics. Background technique [0002] On September 30, 2021, the "Regulations on the Supervision and Administration of Children's Cosmetics" were passed and will come into force on January 1, 2022. The "Regulations on the Supervision and Administration of Children's Cosmetics" stipulate that the formula design of children's cosmetics should follow the principle of safety first, the principle of efficacy and extreme formula. The principle of simplicity, and stipulates that children's cosmetics should evaluate the scientificity and necessity of the raw materials used in terms of the safety, stability, function and compatibility of raw materials, combined with the physiological characteristics of children. Healthy substances must not be added. [0003] The skin of children is thinner than that of adults, and is more sen...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/72G01N30/86
CPCG01N30/02G01N30/72G01N30/86G01N30/8624G01N2030/027
Inventor 李聪郦明浩綦艳伍志航陈海燕刘辉唐穗平万春艳罗美芬霍丽斯罗敏婷陈启镌许庆鹏胡腾鑫孙魁魁
Owner GUANGDONG TESTING INST OF PROD QUALITY SUPERVISION
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