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303 results about "Ketoconazole" patented technology

Ketoconazole is used to treat certain serious fungal infections in the body. Ketoconazole belongs to the class of drugs called azole antifungals. It works by stopping the growth of the fungus.

Topical antifungal treatment

A topical mycological treatment composition for medical, veterinarian, or dental use contains as active ingredients clotrimazole, ketoconazole, micanazole, nystatin, tolnaftate, propionic acid, sodium propionate, undecelynic acid, and zinc undecelynate. These ingredients are contained in a natural cream base, and the base may also contain an anti-inflammatory agent and an antibacterial agent.
Owner:AYON COVARRUBIAS BLAS

Antifungal phenylethylene

The antifungal and cancer cell growth inhibitory activities of 1-(3′,4′,5′-trimethoxyphenyl)-2-nitro-ethylene (TMPN) were examined. TMPN was fungicidal for the majority of 132 reference strains and clinical isolates tested, including those resistant to fluconazole, ketoconazole, amphotericin B or flucytosine. Minimum fungicidal concentration / minimum inhibitory concentration (MFC / MIC) ratios were ≦2 for 96% of Cryptococcus neoformans clinical isolates and 71% of Candida albicans clinical isolates. TMPN was fungicidal for a variety of other basidiomycetes, endomycetes and hyphomycetes, and its activity was unaffected by alterations in media pH. TMPN was slightly cytotoxic for murine and human cancer cell lines (GI50=1-4 μg / ml), and weakly inhibited mammalian tubulin polymerization (IC50=0.60 μg / ml). TMPN may also be used as a biochemical probe for tubulin and fungal dimorphism studies.
Owner:ARIZONA STATE UNIVERSITY

Compsns-and methods for trapping and inactivating pathogenic microbes and spermatozoa

Antimicrobial and contraceptive compositions and methods which prevent and/or reduce the risk of transmission of sexually transmitted diseases through sexual activity as well as prevent and/or reduce the risk of pregnancy are provided. The compositions contain (1) a matrix-forming agent, (2) a bio-adhesive agent, (3) a buffering agent, (4) optionally a humectant, (5) optionally a preservative, and (6) water; wherein the composition is suitable for application within the vagina; wherein the compositions form a semisolid matrix on contact with ejaculate (thereby trapping ejaculated microbes and spermatozoa); wherein the composition causes hardening of cervical mucus (thereby decreasing the probability of sperm entry); wherein the composition forms a bio-adhesive layer over vaginal surfaces (thereby preventing or reducing the risk of contact of STD-causing microbes with the vaginal surfaces); wherein the composition maintains an acidic vaginal pH of less than about 5 in the presence of semen ejaculated from the male; and wherein the composition does not significantly impair the natural microbiological balance within the vagina. The antimicrobial and contraceptive compositions may also contain additional antimicrobial and/or contraceptive agents (e.g., nonoxynol-9, octoxynol-9, benzalkonium chloride, phosphorylated hesperidins, sulfonated hesperidins, polystyrene sulfonates, substituted benzenesulfonic acid formaldehyde co-polymers, H2SO4-modified mandelic acids, povidone iodine, itraconazole, ketoconazole, metronidazole, clotrimazole, fluconazole, teraconazole, miconazole, tinidazole, iconazole, chloramphenicol, nystatin, cyclopiroxolamine, and the like).
Owner:RUSH UNIV MEDICAL CENT

External-use medicament for treating tinea manus and pedis

ActiveCN101502580AQuick killImprove the ability to penetrate the epidermal keratinous tissueBiocidePowder deliveryDiseaseCuticle
The invention provides an externally applied medicament for treating tinea of hands and feet, consisting of three parts of powders A, electuary B and spray C, and the main ingredients comprise lightyellow sophora root, giant knotweed rhizome, dark plum fruit, salicylic acid, ketoconazole and the like, thereby having the effects of clearing heat, removing toxin, sterilization and anti-inflammation. The medicament is different from the previous simple treatment proposals for treating the tinea of hands and feet, the powers A is firstly used for rapidly killing pathogens at the skin surface, changing the infected lesion skin tissue structure of the surface, leading the structure to be loose and forming a smooth channel which is conductive to the penetration of the medicament, then the electuary B is used under the premise of the channel for dredging the penetration of the medicament, thereby rapidly and thoroughly killing the pathogens in skin, the spray C is used for powerful sterilization, keeping a clean environment for the skin and achieving the effect of no recurrence. The medicament carries out multi-level three-dimensional treatment, simultaneously realizes the treatment of external and internal diseases, combines the prevention with the treatment and simultaneously treats both principal and secondary aspect of disease, thereby realizing the special treatment method and reliable efficacy.
Owner:安徽世龙生物医药科技有限公司

Compositions and methods using direct MMP inhibitors for inhibiting photoaging of skin

Compositions and methods are provided for ameliorating various effects of UVA and UVB radiation from the sun. The compositions include an ingredient that prevents photoaging from MED and subMED radiation, namely a direct acting MMP (matrix metalloproteinase) inhibitor. The compositions can include another, indirect MMP inhibitor, such as a retinoid, certain other compounds (such as N-acetylcysteine, 2-furildioxime, and vitamin C), tetracyclines, and if a retinoid is used then in addition optional compounds that inhibit the CYP-26 (chytochrome P-450) mediated metabolism of retinoids such as ketoconazole and other azole compounds. In the method, the composition is applied prior to exposure to the sun; for direct acting MMP inhibitors, application should be just prior to exposure, and if indirect inhibitors such as retinoids are used in addition, then application of the indirect inhibitor should be at least about seven hours prior to exposure. Compounds that prevent erythema (skin reddening, sunburn) do not necessarily protect against UV-mediated elevation of MMP levels and activity, and similarly compounds that prevent UV-mediated elevation of MMP levels and activity are not necessarily effective against UV-induced erythema.
Owner:RGT UNIV OF MICHIGAN

Application of kaempferol as synergist of anti-fungal medicaments

The invention relates to the technical field of medicaments, in particular to novel application of kaempferol as a synergist of anti-fungal medicaments. The anti-fungal medicaments are azole-type or polyene-type anti-fungal medicaments and based on the effective concentration of the anti-fungal medicaments, the adding ratio of the kaempferol is 0.5 to 16 mu g/ml. Tests show that when the kaempferol and the anti-fungal medicaments such as fluconazole, ketoconazole, miconazole and amphotericin B are used together, not only the anti-fungal effect is guaranteed on the premise of lowering the consumption of the anti-fungal medicaments, but also the anti-fungal medicaments can restore the function of killing the drug-resistant fungi, so that the kaempferol can be used as a synergist of the anti-fungal medicaments. The kaempferol used as the synergist of the anti-fungal medicaments can lower the consumption of the azole-type or polyene-type anti-fungal medicaments so as to reduce the toxic and side effects of the medicaments; and the kaempferol can make the anti-fungal medicaments restore the function of killing the drug-resistant fungi, so that the kaempferol can effectively treat mycotic infection, particularly drug-resistant t mycotic infection, and has quite important clinical application values.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY

Method for preparing standard substance for detecting scurf removing agent in cosmetics

The invention discloses a method for preparing a standard substance for detecting a scurf removing agent in cosmetics. The method comprises a step of mixing propylene glycol solution of the scurf removing agent and cosmetic emulsion to form the standard substance, wherein the cosmetic emulsion comprises the following components in percentage by weight: A phase: 68 to 72 percent of deionized water, 4.5 to 5.5 percent of glycerol, 3 to 3.5 percent of propylene glycol and 0.45 to 0.5 percent of xanthan gum; B phase: 4 to 4.5 percent of stearate, 2 to 4 percent of cetyl alcohol and stearyl alcohol and 10 to 14 percent of No. 26 white oil; and C phase: 1.25 to 1.3 percent of phenoxyethanol and ethylhexylglycerin. The concentration of the scurf removing agent in the standard substance reaches 0.5 percent. The method has the advantages that: the scurf removing agent and the cosmetic emulsion are mixed to form the standard substance for detecting the scurf removing agent such as climbazole, piroctone olamine and ketoconazole; and the standard substance is the same as the cosmetics containing the scurf removing agent in actual use so that the detection of the scurf removing agent in the cosmetics is more accordant with the actual use state and the detection is more accurate.
Owner:SHANGHAI INOHERB COSMETIC +1

Kit for determining four antifungal drugs in dry blood spot at same time as well as application thereof

The invention discloses a kit for determining four antifungal drugs in a dry blood spot at the same time, comprising extracting solution, diluent, a mobile phase, a standard substance and a quality control material; the standard substance contains ketoconazole, voriconazole, itraconazole and posaconazole; the extracting solution is composed of an isotope internal standard, water and an organic solvent; the organic solvent is methanol and / or acetonitrile; and the mobile phase comprises an organic phase and an aqueous phase, the organic phase is methanol and / or acetonitrile, and the aqueous phase is ammonium formate / acetate-formic / acetic acid aqueous solution. The invention also discloses a method for determining the four antifungal drugs in the dry blood spot at the same time by using the kit. The kit disclosed by the invention is applicable to simultaneous determination of contents of the four antifungal drugs in a dry blood spot sample, sample detection specificity is high, sensitivity is high, and stability is good.
Owner:易达精准(杭州)科技有限公司

Antifungal agent and preparation and use method

The present invention provides new medicinal compositions of pyrrole antimicrobial medicines, such as itraconazole, cypconazole, ketoconazole and fluoroconazole. These medicinal compositions are made into the form of pill preparation, including core, medicine emulsion layer and randomly-selected protective layer, and the described medicine emulsion layer includes medicine, emulsifier, adhesive and absorption adjuvant, and the optimized emulsifier is vitamin E polyglycol succinic acid ester, and the optimized adhesive is hydroxypropyl methyl cellulose, the optimized absorption adjuvant is DL malic acid, said medicine is dissolved in organic solvent, and the optimized organic solvent is ethyl alcohol and dichloromethane, and the described protective layer contains polyglycol (PEG) 20000, and is coated on the medicine emulsion layer.
Owner:YUNG SHIN PHARMACEUTICALS INDUSTRIAL CO LTD

Composition and method for treating skin disorders

A composition for treating skin conditions includes sulfur combined with a carrier vehicle such as, VASELINE®, petroleum jelly, lard or the like. At least fifty % by weight of the sulfur is used in combination with the VASELINE®, petroleum jelly or lard to create an effective skin cream for curing skin conditions such as, tinea versicolor, sebhorrheic keratosis and other kinds of dermatitis. The skin cream generally requires one application, unless the condition is severe, thereby avoiding daily and multi-daily expensive regimens. Additional components such as pyrithione zinc, selenium sulfide and ketoconazole, in varying weight proportions, typically between 1% and 2.5%, and in various combinations of each, may also be combined with sulfur in the carrier vehicle to provide enhanced treatment of various skin conditions.
Owner:PENICK BRIAN

Application of magnolol and azole medicines to preparation of antifungal combined medicines

The invention provides application of magnolol and azole medicines to preparation of antifungal combined medicines. The application indicates that azole medicines such as fluconazole, ketoconazole, itraconazole, miconazole and voriconazole are used together with magnolol to generate a synergetic antifungal effect; the magnolol serving as an efflux pump Cdrlp substrate is utilized to compete with the azole medicines for an efflux system, so that the concentration of efflux medicines can be reduced, and the curative effect of medicines can be improved. Furthermore, magnolol acts on the synthetic pathway of ergosterol and is combined with azole medicines to form a double-edged sword to inhibit synthesis of ergosterol together.
Owner:SOUTHEAST UNIV

Topical antifungal treatment

InactiveUS20080200539A1BiocideAntimycoticsImmune compromisedNystatin G
The present invention is a topical skin preparation for treatment of fungal infections of the skin and nails. The preparation comprises triacetin in combination with one or more antifungal agents. In a preferred form, the preparation comprises a combination of the antifungal agents tolnaftate and grisiofulvin are used in combination with triacetin. The concentrations of these constituents are 40 to 50% concentration triacetin, 30 to 50% acetone, 0.5-3.0% concentration tolnaftate and 0.5-4.0% concentration grisiofulvin, in one preferred embodiment. Other compounds, such as ethyl alcohol, acetone, amino acids such as n-acetylcysteine, and herbal additives may also be added to the preparation. Further, other antifungal agents such as nystatin, clortimazole, econazole, ketoconazole, miconazole, solconazole, oxiconizole, naftifine, terbinafine, and butenafine, for example, may be substituted for the antifungal agents tolnaftate and grisiofulvin. The preparation of the present invention is effective in treating immune compromised patients and those with diabetes, as well as relatively healthy persons.
Owner:BOMMARITO ALEXANDER A

Quick screening method for illegally-added ketoconazole in scurf removing shampoo cosmetics

The invention provides a quick screening method for illegally-added ketoconazole in scurf removing shampoo cosmetics. The steps of the method are as follows: first, according to the characteristic that the ketoconazole is soluble to both organic solvent and inorganic acid solution, components possibly containing the ketoconazole are extracted by ethyl acetate from a shampoo product and are then extracted by the inorganic acid solution to dissolve the ketoconazole in the inorganic acid solution so as to further separate the ketoconazole from other interfering substances; second, according to the characteristic that the ketoconazole can react with an alkaloid precipitator to generate precipitation, saturated water solution of trinitrophenol is dripped into the inorganic acid solution possibly dissolved with the ketoconazole; the ketoconazole is possibly contained in a detected sample if the precipitation is generated, and vice versa. With high sensitivity, good accuracy, simple as well as easy operation, strong specificity, reliable detecting result and low analyzing cost, the quick screening method does not need a special instrument and is particularly suitable for quickly screening the illegally-added ketoconazole in the cosmetics on the scene.
Owner:广东省汕头市药品检验所

Method for detecting ketoconazole based on SERS of nano-silver colloid

ActiveCN109342387ASuperhydrophobicAct as a concentrateRaman scatteringThiolSilver colloid
The invention discloses a method for detecting ketoconazole based on the SERS of nano-silver colloid, wherein a hydrophobic substrate prepared by a grafted thiol compound is used as a material. The method comprises the following steps of: mixing the ketoconazole solution of different concentrations with the nano-silver colloid, carrying out centrifugal separation, and testing by a laser Raman spectrometer to obtain the SERS spectrum of the ketoconazole; acquiring a relationship between the Raman spectrum absorption intensity and the concentration of the ketoconazole of a certain wave number, and establishing a mathematical relationship between the Raman spectrum absorption intensity and the concentration of the ketoconazole; and using the laser Raman spectrometer to test a ketoconazole solution of unknown concentration, and calculating the concentration of the ketoconazole according to the mathematical relationship between the Raman spectrum absorbance intensity and the concentration of the ketoconazole of the certain wave number. The method for detecting ketoconazole based on the SERS of nano-silver colloid solves the problems that the cost of ketoconazole detection is high, a sample needs to be separated in multiple steps, and the like, has the advantages of being easy to operate, high in sensitivity, and capable of saving a lot of economic and time cost, and has wide application prospects.
Owner:FUJIAN ACAD OF FORESTRY
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