303 results about "Ketoconazole" patented technology

A topical mycological treatment composition for medical, veterinarian, or dental use contains as active ingredients clotrimazole, ketoconazole, micanazole, nystatin, tolnaftate, propionic acid, sodium propionate, undecelynic acid, and zinc undecelynate. These ingredients are contained in a natural cream base, and the base may also contain an anti-inflammatory agent and an antibacterial agent.

The invention discloses an externally used preparation for household pet disinsection and sterilization, which employs ketoconazole or/and chlorhexidine acetate as the active constituents, and balancing auxiliary materials. wherein the effective composition of bactericide in the external preparation comprises 0.1-20.0% of ketoconazole and 0.04% of chlorhexidine acetate, the effective composition of pesticide in the external preparation comprises 0.001-20.0-% of natural insecticidal cyhalothrin and balancing additive auxiliary materials, the effective composition of sterilizing complexing agent in the external preparation comprises 0.001-20.0úÑ of natural insecticidal cyhalothrin, 0.04% of chlorhexidine acetate, and 0.1-20.0% of ketoconazole.

Antimicrobial and contraceptive compositions and methods which prevent and/or reduce the risk of transmission of sexually transmitted diseases through sexual activity as well as prevent and/or reduce the risk of pregnancy are provided. The compositions contain (1) a matrix-forming agent, (2) a bio-adhesive agent, (3) a buffering agent, (4) optionally a humectant, (5) optionally a preservative, and (6) water; wherein the composition is suitable for application within the vagina; wherein the compositions form a semisolid matrix on contact with ejaculate (thereby trapping ejaculated microbes and spermatozoa); wherein the composition causes hardening of cervical mucus (thereby decreasing the probability of sperm entry); wherein the composition forms a bio-adhesive layer over vaginal surfaces (thereby preventing or reducing the risk of contact of STD-causing microbes with the vaginal surfaces); wherein the composition maintains an acidic vaginal pH of less than about 5 in the presence of semen ejaculated from the male; and wherein the composition does not significantly impair the natural microbiological balance within the vagina. The antimicrobial and contraceptive compositions may also contain additional antimicrobial and/or contraceptive agents (e.g., nonoxynol-9, octoxynol-9, benzalkonium chloride, phosphorylated hesperidins, sulfonated hesperidins, polystyrene sulfonates, substituted benzenesulfonic acid formaldehyde co-polymers, H2SO4-modified mandelic acids, povidone iodine, itraconazole, ketoconazole, metronidazole, clotrimazole, fluconazole, teraconazole, miconazole, tinidazole, iconazole, chloramphenicol, nystatin, cyclopiroxolamine, and the like).

The invention provides an externally applied medicament for treating tinea of hands and feet, consisting of three parts of powders A, electuary B and spray C, and the main ingredients comprise lightyellow sophora root, giant knotweed rhizome, dark plum fruit, salicylic acid, ketoconazole and the like, thereby having the effects of clearing heat, removing toxin, sterilization and anti-inflammation. The medicament is different from the previous simple treatment proposals for treating the tinea of hands and feet, the powers A is firstly used for rapidly killing pathogens at the skin surface, changing the infected lesion skin tissue structure of the surface, leading the structure to be loose and forming a smooth channel which is conductive to the penetration of the medicament, then the electuary B is used under the premise of the channel for dredging the penetration of the medicament, thereby rapidly and thoroughly killing the pathogens in skin, the spray C is used for powerful sterilization, keeping a clean environment for the skin and achieving the effect of no recurrence. The medicament carries out multi-level three-dimensional treatment, simultaneously realizes the treatment of external and internal diseases, combines the prevention with the treatment and simultaneously treats both principal and secondary aspect of disease, thereby realizing the special treatment method and reliable efficacy.

Compositions and methods are provided for ameliorating various effects of UVA and UVB radiation from the sun. The compositions include an ingredient that prevents photoaging from MED and subMED radiation, namely a direct acting MMP (matrix metalloproteinase) inhibitor. The compositions can include another, indirect MMP inhibitor, such as a retinoid, certain other compounds (such as N-acetylcysteine, 2-furildioxime, and vitamin C), tetracyclines, and if a retinoid is used then in addition optional compounds that inhibit the CYP-26 (chytochrome P-450) mediated metabolism of retinoids such as ketoconazole and other azole compounds. In the method, the composition is applied prior to exposure to the sun; for direct acting MMP inhibitors, application should be just prior to exposure, and if indirect inhibitors such as retinoids are used in addition, then application of the indirect inhibitor should be at least about seven hours prior to exposure. Compounds that prevent erythema (skin reddening, sunburn) do not necessarily protect against UV-mediated elevation of MMP levels and activity, and similarly compounds that prevent UV-mediated elevation of MMP levels and activity are not necessarily effective against UV-induced erythema.

The invention relates to the technical field of medicaments, in particular to novel application of kaempferol as a synergist of anti-fungal medicaments. The anti-fungal medicaments are azole-type or polyene-type anti-fungal medicaments and based on the effective concentration of the anti-fungal medicaments, the adding ratio of the kaempferol is 0.5 to 16 mu g/ml. Tests show that when the kaempferol and the anti-fungal medicaments such as fluconazole, ketoconazole, miconazole and amphotericin B are used together, not only the anti-fungal effect is guaranteed on the premise of lowering the consumption of the anti-fungal medicaments, but also the anti-fungal medicaments can restore the function of killing the drug-resistant fungi, so that the kaempferol can be used as a synergist of the anti-fungal medicaments. The kaempferol used as the synergist of the anti-fungal medicaments can lower the consumption of the azole-type or polyene-type anti-fungal medicaments so as to reduce the toxic and side effects of the medicaments; and the kaempferol can make the anti-fungal medicaments restore the function of killing the drug-resistant fungi, so that the kaempferol can effectively treat mycotic infection, particularly drug-resistant t mycotic infection, and has quite important clinical application values.

A method for treating hair loss caused by androgenic alopecia and/or male pattern baldness. The method, which not only slows hair loss but causes hair re-growth, includes approximately daily application to a subject's scalp of a novel composition comprising finasteride (Propecia® or Proscar®), dutasteride (Avodart®), and minoxidil (Rogaine®) as active ingredients in a hypoallergenic cream-based vehicle, preferably coupled with daily ingestion of 1 mg per day of finasteride (Propecia® or Proscar®), application to the scalp of 5% minoxidil (Rogaine®) foam approximately once per day, and use of a ketoconazole-containing shampoo (e.g., Nizoral®) approximately 2-3 times per week. The method described herein also resolves scalp dermatitis in atopic subjects suffering therefrom. A method for making the novel composition is also provided.

Pharmaceutical compositions comprising the 2S,4R ketoconazole enantiomer or its pharmaceutically acceptable salts, hydrates, and solvates are useful to increase cardiolipin synthesis and for the treatment of Barth Syndrome, diabetic myopathy, cardiomyopathy associated with aging, mitochondrial disease, and other conditions and disorders where cardiolipin deficiency plays a causative or symptomatic role.

The invention provides a ketoconazole foaming agent and a preparation method thereof, which are used for treating fungal infective diseases, such as seborrheic dermatitis and the like.

The invention discloses an externally-used medicament for treating skin mycosis diseases, which is prepared from the raw materials of (by weight percent) terbinafine hydrochloride or miconazole or ketoconazole 0. 5-2%, Clobetasol Propionate 0. 01-0. 2%, neomycin sulphate 0. 3-1%, bee glue 5-25%, and balancing distilled water.

The invention discloses a whitening, acne removal and freckle removal cosmetology medicine which is prepared by the following raw materials in parts by weight: 2-5 parts of chloramphenicol injection, 5-7 parts of akafen powder, 14-16 parts of lincomycin hydrochloride gel and 6-8 parts of compound ketoconazole cream. The chloramphenicol injection, the akafen powder, the lincomycin hydrochloride gel and the compound ketoconazole cream are put into a container according to the weight parts, then are uniformly mixed and stirred and are finally bottled and packaged. The whitening, acne removal and freckle removal cosmetology medicine can effectively remove skin acnes and whelk and solve the problems of hyperpigmentation and the like which are caused by chloasma, freckles, physical machinery or chemical burn and is low in cost, easy to manufacture and convenient to use.

The invention discloses a solution for removing dandruff and its preparing process, wherein the solution is prepared from rhubarb horsetails, flavescent sophora root, Chinese dittany bark, poria cocos, rough gentian, boneol, menthol, ketoconazole, Clobetasol Propionate, propylene glycol, glycerin, azone, polysorbate -80 and sodium benzoate through charging the first five Chinese herbs into water, boiling, concentrating the filtrate, charging ketoconazole, Clobetasol Propionate, boneol, menthol and auxiliary materials, finally keeping constant volume by charging ethanol.

The invention provides a saliva preservation solution, and a preparation method and application thereof. The saliva preservation solution comprises a DNA stabilizer including disodium edentate, tartaric acid and at least one selected from a group consisting of nitrilotriacetic acid and dihydroxyethylglycine; a microbial inhibitor including penicillin, streptomycin, geneticin and at least one selected from a group consisting of potassium sorbate, sodium benzoate, ethylparaben sodium, ketoconazole and puromycin; and a buffer solution including a TE buffer solution and at least one selected from a group consisting of a PBS buffer solution and a sodium chloride glucose buffer solution. According to the invention, through preparation of the saliva preservation solution, the morphology of cells in a saliva swab is maintained and prevented from disruption, and the growth of microorganisms in the saliva swab and the saliva preservation solution is inhibited.

The invention discloses a kit for determining four antifungal drugs in a dry blood spot at the same time, comprising extracting solution, diluent, a mobile phase, a standard substance and a quality control material; the standard substance contains ketoconazole, voriconazole, itraconazole and posaconazole; the extracting solution is composed of an isotope internal standard, water and an organic solvent; the organic solvent is methanol and/or acetonitrile; and the mobile phase comprises an organic phase and an aqueous phase, the organic phase is methanol and/or acetonitrile, and the aqueous phase is ammonium formate/acetate-formic/acetic acid aqueous solution. The invention also discloses a method for determining the four antifungal drugs in the dry blood spot at the same time by using the kit. The kit disclosed by the invention is applicable to simultaneous determination of contents of the four antifungal drugs in a dry blood spot sample, sample detection specificity is high, sensitivity is high, and stability is good.

The invention discloses benzopyrone-phenyl-oxazolidone compounds with the following structural general formulas shown in the specification. The compounds have better inhibiting and killing effects on various germs, and some of the benzopyrone-phenyl-oxazolidone compounds have higher bacteriostatic activity than positive control penicillihe G, kalamycin and ketoconazole, so that the benzopyrone-phenyl-oxazolidone compounds can be used for preparing anti-infective drugs. The invention also discloses preparation methods of the benzopyrone-phenyl-oxazolidone compounds.

A composition for treating skin conditions includes sulfur combined with a carrier vehicle such as, VASELINE®, petroleum jelly, lard or the like. At least fifty % by weight of the sulfur is used in combination with the VASELINE®, petroleum jelly or lard to create an effective skin cream for curing skin conditions such as, tinea versicolor, sebhorrheic keratosis and other kinds of dermatitis. The skin cream generally requires one application, unless the condition is severe, thereby avoiding daily and multi-daily expensive regimens. Additional components such as pyrithione zinc, selenium sulfide and ketoconazole, in varying weight proportions, typically between 1% and 2.5%, and in various combinations of each, may also be combined with sulfur in the carrier vehicle to provide enhanced treatment of various skin conditions.

The invention provides application of magnolol and azole medicines to preparation of antifungal combined medicines. The application indicates that azole medicines such as fluconazole, ketoconazole, itraconazole, miconazole and voriconazole are used together with magnolol to generate a synergetic antifungal effect; the magnolol serving as an efflux pump Cdrlp substrate is utilized to compete with the azole medicines for an efflux system, so that the concentration of efflux medicines can be reduced, and the curative effect of medicines can be improved. Furthermore, magnolol acts on the synthetic pathway of ergosterol and is combined with azole medicines to form a double-edged sword to inhibit synthesis of ergosterol together.

The present invention is a topical skin preparation for treatment of fungal infections of the skin and nails. The preparation comprises triacetin in combination with one or more antifungal agents. In a preferred form, the preparation comprises a combination of the antifungal agents tolnaftate and grisiofulvin are used in combination with triacetin. The concentrations of these constituents are 40 to 50% concentration triacetin, 30 to 50% acetone, 0.5-3.0% concentration tolnaftate and 0.5-4.0% concentration grisiofulvin, in one preferred embodiment. Other compounds, such as ethyl alcohol, acetone, amino acids such as n-acetylcysteine, and herbal additives may also be added to the preparation. Further, other antifungal agents such as nystatin, clortimazole, econazole, ketoconazole, miconazole, solconazole, oxiconizole, naftifine, terbinafine, and butenafine, for example, may be substituted for the antifungal agents tolnaftate and grisiofulvin. The preparation of the present invention is effective in treating immune compromised patients and those with diabetes, as well as relatively healthy persons.

The invention provides a quick screening method for illegally-added ketoconazole in scurf removing shampoo cosmetics. The steps of the method are as follows: first, according to the characteristic that the ketoconazole is soluble to both organic solvent and inorganic acid solution, components possibly containing the ketoconazole are extracted by ethyl acetate from a shampoo product and are then extracted by the inorganic acid solution to dissolve the ketoconazole in the inorganic acid solution so as to further separate the ketoconazole from other interfering substances; second, according to the characteristic that the ketoconazole can react with an alkaloid precipitator to generate precipitation, saturated water solution of trinitrophenol is dripped into the inorganic acid solution possibly dissolved with the ketoconazole; the ketoconazole is possibly contained in a detected sample if the precipitation is generated, and vice versa. With high sensitivity, good accuracy, simple as well as easy operation, strong specificity, reliable detecting result and low analyzing cost, the quick screening method does not need a special instrument and is particularly suitable for quickly screening the illegally-added ketoconazole in the cosmetics on the scene.

The invention relates to an emulsifiable paste for treating acne, which comprises the following raw materials by weight: 70-150 parts of ketoconazole, 70-150 parts of lincomycin, 1200-2400 parts of metronidazole, 300-1200 parts of moroxydine hydrochloride, 35-90 parts of viaminate, 5-20 parts of tretinoin, 200-350 parts of vitamin E, 80-200 parts of vitamin B6, 50-100 parts of lidocaine, 600-2000 parts of aloe extract product, 1000-2000 parts of coconut meat powder and 100-800 parts of collagen powder with molecular weight lower than 2KD. The emulsifiable paste has the advantages of antibacterial function, antifungal function and anti-virus function, can promote epidermal cell differentiation and shedding, epidermal cell proliferation and differentiation can be adjusted, cornification is avoided, sebum secretion is adjusted, the emulsifiable paste has the effects of relieving pain, relieving itching, mitigating pockmark and whitening skin, and can help luster recovery for skin.

The invention provides a hybridoma cell strain secreting a ketoconazole monoclonal antibody and application of the hybridoma cell strain. The hybridoma cell strain of the invention has preserved in the China General Microbiological Culture Collection Center, Institute of Microbiology, Chinese Academy of Sciences, No. 3, Academy 1, Beichen West Road, Chaoyang District, Beijing, on May 13, 2021, with a preservation number of CGMCC No.22327, and the hybridoma cell strain is classified and named as a monoclonal cell strain. The ketoconazole monoclonal antibody secreted by the hybridoma cell strain of the invention has high specificity and high detection sensitivity (an IC50 value is 0.7 ng/mL, and the cross-over rate for a ketoconazole analogue is less than 1%) on the ketoconazole, the detection limit of the ketoconazole in a sample is 0.1 ng/g, and a detection linear range is 0.1-2.5 ng/g. The hybridoma cell strain can be used for establishing an immunological detection method of ketoconazole to detect ketoconazole residues in foods.

The invention discloses a method for detecting ketoconazole based on the SERS of nano-silver colloid, wherein a hydrophobic substrate prepared by a grafted thiol compound is used as a material. The method comprises the following steps of: mixing the ketoconazole solution of different concentrations with the nano-silver colloid, carrying out centrifugal separation, and testing by a laser Raman spectrometer to obtain the SERS spectrum of the ketoconazole; acquiring a relationship between the Raman spectrum absorption intensity and the concentration of the ketoconazole of a certain wave number, and establishing a mathematical relationship between the Raman spectrum absorption intensity and the concentration of the ketoconazole; and using the laser Raman spectrometer to test a ketoconazole solution of unknown concentration, and calculating the concentration of the ketoconazole according to the mathematical relationship between the Raman spectrum absorbance intensity and the concentration of the ketoconazole of the certain wave number. The method for detecting ketoconazole based on the SERS of nano-silver colloid solves the problems that the cost of ketoconazole detection is high, a sample needs to be separated in multiple steps, and the like, has the advantages of being easy to operate, high in sensitivity, and capable of saving a lot of economic and time cost, and has wide application prospects.