35results about How to "Avoid photodamage" patented technology

The invention relates to a nano probe for copper ion fluorescence imaging in cells and a preparation method for the nano probe. The preparation method comprises the following steps: firstly, synthesizing up-conversion nana particles with core-shell structures, CS-UCNPs for short; then, by taking a CTAB (cetyltrimethyl ammonium bromide) as a template agent and a surfactant, coating a layer of mesoporous SiO2 on the surfaces of the CS-UCNPs to obtain mesoporous coated nano particles CS-UCNPs@mSiO2 with compounding functions; finally, performing covalent bond assembly on functional modified rhodamine organic dye RHB precursors capable of identifying metal copper ions in a singular manner and the CS-UCNPs@mSiO2 to construct an organic-inorganic hybrid nano probe CS-UCNPs@mSiO2-RBH, thereby realizing fluorescence detecting and living cell fluorescence imaging of copper ions in an aqueous solution. The preparation method disclosed by the invention has the advantages of being simple in process, convenient to operate and easy to control structure. The prepared nano fluorescence probe has the characteristics of a uniform dimension, a stable structure, low toxicity and good biocompatibility, and a potential application value in the fields of up-conversion fluorescence labeling, fluorescence detecting and the like of cells or tissues.

The invention relates to an optical fiber living body fluorescent excitation spectral imaging device which comprises interference modulated light source unit, a microscopic imaging unit, an optical fiber bundle endoscopic unit and a computer, wherein light of the interference modulated light source unit is coupled into the optical fiber bundle endoscopic unit through the microscopic imaging unit, the light output by the optical fiber bundle endoscopic unit irradiates on a sample, the sample emits a fluorescent signal after being irradiated, the fluorescent signal is collected by the optical fiber bundle endoscopic unit and returns and enters the microscopic imaging unit, one end port of the microscopic imaging unit is connected with the computer, and the computer is used for processing the electric signal of the microscopic imaging unit so as to obtain an objective fluorescence excitation spectral imaging device. The optical fiber body fluorescence excitation spectral imaging device has the advantages of being capable of not only providing the form distribution of a sample imaging space, but also providing accurate fluorescence excitation spectral imaging information of each point of the imaging space, achieving simultaneous observation of different biochemical constituents of a biological sample self or varieties of exogenous fluorescent marker excitation spectrums, and providing a novel experimental instrument for the visualization of functional studies of living cells.

The invention discloses a fluoro phenylindole compound which adopts a structure shown in formula I, application of the fluoro phenylindole compound as a red organic luminescent material, and a preparation method of the fluoro phenylindole compound. The fluoro phenylindole compound is obtained through a reaction between cyclohexanone and 3-(3-(4-fluorophenyl)-1-isopropyl-1H-indole-2-yl) acrolein under an alkaline condition. The preparation method is simple to operate, convenient for synthesis and easy for purification; the obtained fluoro phenylindole compound is stable in structure and can be utilized for fluorescence conversion on a strong red color displayed under 800-nm laser excitation, thereby having potential application values in such fields as luminescent equipment, anti-counterfeit technologies, laser dye and fluorescence sensing; the research field of the fluoro phenylindole compound is expanded.

The present invention relates to a modified surface capable of having bacteriostatic and bactericidal activity when it is light irradiated, thus converting the surface of the substrate into a bacteriostatic and a bactericidal surface as many times as it is desired, and for a long time. According to the invention, the modified surface upon light irradiation avoids the attachment of a microorganism to this surface, inhibits the formation of a biofilm on this surface and destroys an already formed biofilm on this surface. These effects can be achieved as many times as it is desired, and for indefinite time.

The present invention discloses a medicinally and edibly homologous solid beverage capable of improving eyesight of astronauts. The medicinally and edibly homologous solid beverage is composed of thefollowing components in weight percentages: 10%-30% of cassia seeds, 5%-30% of rhizoma polygonati, 5%-25% of blueberries, 5%-25% of Chinese wolfberry fruits, 5%-20% of chrysanthemum, 5%-20% of mulberry leaves, 5%-15% of maltodextrin and 1%-10% of xylitol. The provided medicinally and edibly homologous solid beverage is prepared from the natural raw materials and has functions on protecting eyesight, relieving eye fatigue and preventing light damage. According to a theory of millennium traditional Chinese medicine compatibility in our country, the medicinally and edibly homologous plants with human eyesight-protecting functions are used as the raw materials; and the medicinally and edibly homologous solid beverage is safe, free of side effects, relatively remarkable in effect, good in mouthfeel and very suitable for the particular populations of the astronauts to eat.

The invention discloses a green light response polymer nano-drug carrier and a preparation method thereof. The preparation method is characterized by comprising the following steps of firstly, synthesizing a green light response amphiphilic (hydrophilic and oleophylic) polymer containing donor-acceptor Stenhouse adducts, then, self-assembling the polymer and a drug in a solution to form vesicles, and finally, obtaining the green light response nano-drug carrier entrapped with a hydrophilic / hydrophobic drug. According to the nano-drug carrier prepared by the invention, low-energy green light is used as a response switch, so that the problem of light damage to biological tissues caused by an excitation light source is avoided; and compared with the traditional polymer micelle drug carrier, the polymer vesicle drug carrier prepared by the method has larger drug loading capacity and more drug loading and releasing modes.

Certain embodiments of the invention provide antioxidant-based diacids and polymers comprising glycol groups as described herein, and methods of use thereof. In certain embodiments the polymers described herein are formulated as microspheres or hydrogels. Described herein is the chemical incorporation of antioxidants, e.g., coumaric acid, ferulic acid, and sinapic acid, into a polymer backbone for use, e.g., in applications for localized release and rapid delivery. As provided, the chemical composition of the linker molecules used (of which hold together two bioactives via ester linkages) may be used to vary the hydrophilicity of the polymer. The bioactive release rate may also be altered for a tunable release delivery system, allowing for increased bioactive release compared to other linkers previously utilized.

The invention discloses an up-conversion luminescent nanoparticle and a preparation method and application thereof. The preparation method comprises the steps that core-shell-shell structure nanoparticles are prepared from ytterbium acetate, neodymium acetate, thulium acetate, gadolinium acetate, oleic acid and 1-octadecene through a coprecipitation method, and oleic acid (OA) coated up-conversionluminescent nanoparticles (UCNPs) are prepared. The inert shell structure on the outermost layer can greatly reduce luminescence quenching caused by surface defects of outer-layer ligands and nanocrystals and enhance the up-conversion luminescence intensity. Polyacrylic acid (PAA) is adopted to functionalize the surfaces of the nanoparticles, so that the upconversion nanoparticles have good dispersing capacity in an aqueous solution, and directional recognition of copper ions in an aqueous phase system is realized. The up-conversion luminescence intensity obtained by adopting 980nm or 808nm excitation has a good linear relationship with the copper ion concentration. The nanoparticle has the characteristics of good selectivity, low luminescence detection limit and wide linear range. Ethylene diamine tetraacetic acid (EDTA) is added, so that the luminescence of the up-conversion nanoparticles is recovered, and the up-conversion nanoparticles can be recycled.

The invention discloses a nutritional health-care product for adjusting visual performance, and in particular relates to a nutritional health-care product for preventing and treating occurrence and development of myopia and cataract. The nutritional health-care product is prepared by a conventional method from the following raw materials in total weight of 100 grams by weight proportion: 1 to 10g of eyeseryl (ocustilla), 0.005 to 0.2g of lutein, 0.001 to 0.05g of vitamin B, 0.04 to 0.15g of vitamin C, 0.005 to 3g of beta-carotene, and the balance of toothpaste raw materials. In the method, the toothpaste is used as a basic raw material, and the eyeseryle (ocustilla), the lutein, the vitamin B, the vitamin C, the beta-carotene and other visual protective trophic factors are added, so a user is ensured to absorb trace visual protective trophic factors required for visual performance adjustment by means of contacting trace eyeseryl (ocustilla) and various vitamins for a long term and absorbing trace eyeseryl (ocustilla) and various vitamins through buccal mucosa in a daily tooth brushing process. Therefore, the occurrence and development of the myopia and the cataract can be prevented, treated and retarded, and meanwhile, clinical information proves that the nutritional health-care product has an excellent treatment effect on canker sores.

The invention discloses a multidirectional-turbulence and efficient-mixing novel runway pond microalgae cultivation system which comprises a runway pond. A turbulence carbon dioxide supplement device, an algae cell harvesting device utilizing microbubble back flushing, a flow retaining device and two paddle wheels are disposed in the runway pond, and a groove structure is disposed below each paddle wheel. The multidirectional-turbulence and efficient-mixing novel runway pond microalgae cultivation system is communicated with an algae cell settling pond, a disinfecting pond and a nutritive salt blending pond. The multidirectional-turbulence and efficient-mixing novel runway pond microalgae cultivation system has the advantages that water circulation in the runway pond can be accelerated, and air exchanging frequency between liquid surface and atmosphere is increased; primary concentration of algae cells can be achieved in real time and effectively, and centrifuging efficiency is increased; escaping of dispersed carbon dioxide can be prevented, carbon dioxide utilization rate can be increased, and algae liquid pH can be adjusted fast; convection between the upper layer and the lower layer of the algae liquid can be promoted effectively; continuous microalgae cultivation can be achieved.

The invention discloses a cosmetic preparation rich in cell growth factors. The cosmetic preparation is prepared from the following components: 0.01 to 0.2 percent of STP, 0.01 to 0.1 percent of cellgrowth factors, 1 to 10 percent of fish oil, 1 to 10 percent of surfactant, 1 to 15percent of humectant, 0.1 to 1 percent of antioxidant, 0.1 to 3 percent of pH modifier, 3 to 5 percent of emulsifier,0.1 to 5 percent of natural plant extract and deionized water. The invention provides the cosmetic preparation rich in the cell growth factors; the cosmetic preparation has the advantages that aged cells can be constantly replaced with new cells, so that the effects of preventing and removing wrinkles are generated through skin rejuvenation; skin wrinkles, dryness, sagging, aging and light damagecan be prevented, or the texture and smoothness of the skin are improved; the emulsification effect of cosmetics can be enhanced and the stability of cosmetics is improved. The invention also provides the preparation method of the cosmetic preparation rich in the cell growth factors; the preparation method has the advantages of simple operation, simplicity and easiness in obtaining materials, lowcost and worthiness of being popularized.

The invention belongs to the technical field of marine organisms, particularly to a keep-alive conveying and seed preservation method of rubber production tropical seaweed eucheuma denticulatum. The eucheuma denticulatum and moisturizing materials are placed into a 17.0 to 23.0 DEG C of storage device together under the dark condition and the 80 plus or minus 20% of relative humidity after water-leaving treatment is performed on the eucheuma denticulatum and accordingly the storage time can be extended and the long time keep-alive conveying of the eucheuma denticulatum can be achieved. The keep-alive conveying and seed preservation method of the eucheuma denticulatum is simple and practicable, the keep-alive period is long, the keep-alive conveying and seed preservation method is suitable for long-distance conveying of seedlings of the eucheuma denticulatum, farmers can harvest the seedlings ahead of time in a typhoon period, the seedlings can be safely stored, and losing of the seedlings can be avoided.

The present invention discloses a therapeutic face mask having a plurality of light emitting diodes. The therapeutic face mask substantially accommodates a user's face. Light of a particular color and intensity is projected on to the facial region of the user for facial therapy. The light emitting diodes (LEDs) are covered by a sheet of transparent silicone material to avoid direct contact of LEDs with the user's facial skin. The therapeutic face mask has a communication module in order to control the intensity, frequency, and color of the light emitting diodes when used by the user.

The invention discloses formula milk powder capable of protecting eyesight for children and a preparation method of the formula milk powder for the children. The formula milk powder contains whole milk powder, desalted whey powder, isomaltooligosaccharide, xanthophyll, zeaxanthin, docosahexaenoic acid (DHA) powder, lactoferrin, compound minerals, multivitamins, calcium carbonate, blueberry powder,huckleberry powder, wolfberry powder and chrysanthemum flower powder. The formula milk powder for the children can provide rich nutrients for growth and development of the children, effectively relieve visual fatigue and prevent occurrence of myopia.

Certain embodiments of the invention provide antioxidant-based diacids and polymers comprising glycol groups as described herein, and methods of use thereof. In certain embodiments the polymers described herein are formulated as microspheres or hydrogels. Described herein is the chemical incorporation of antioxidants, e.g., coumaric acid, ferulic acid, and sinapic acid, into a polymer backbone for use, e.g., in applications for localized release and rapid delivery. As provided, the chemical composition of the linker molecules used (of which hold together two bioactives via ester linkages) may be used to vary the hydrophilicity of the polymer. The bioactive release rate may also be altered for a tunable release delivery system, allowing for increased bioactive release compared to other linkers previously utilized.

The invention discloses a bioactive anti-oxidation polysalicylic acid hydrogel and its preparation method and application. The method comprises: 1) preparation of PSa polymer, 2) preparation of FPSa polymer, and 3) preparation of FPSa hydrogel ; 4) Characterize the physical and chemical properties of the FPSa hydrogel and apply it in biology. The FPSa polymer has good biocompatibility and degradability, and the synthesis method of the polymerization reaction and catalytic reaction used is environmentally friendly, easy to operate and cheap in raw material cost. FPSa hydrogel has good ultraviolet shielding properties, preventing ultraviolet rays from damaging the skin. The appeal results demonstrate that FPSa hydrogels have important potential applications in the prevention of skin photodamage, providing a strategy for designing multifunctional single-component bioactive hydrogels for biomedical applications.

The invention discloses a coaxial axial modulation high-resolution photoacoustic microscopic imaging method and an imaging system, belongs to the field of microscopic imaging, and particularly establishes a set of complete coaxial axial modulation high-resolution photoacoustic microscopic imaging system to avoid the problem of poor axial resolution in an orthogonal axial structure light modulation photoacoustic signal scheme. Meanwhile, the invention further provides a set of axial modulation photoacoustic signal method, the axial structure light modulation principle is combined with ultrasonic detection, the limitation that the axial resolution of the PAM system is limited by the detection bandwidth of an ultrasonic probe is broken through, the axial high-resolution PAM system imaging result is obtained, and meanwhile, the defect that light damage exists when the axial resolution of an existing PAM system is improved is overcome. In the method for axially modulating the photoacoustic signal, a coaxial axial structured light implementation scheme is provided on the basis of a double circular seam method, the three-dimensional light field distribution of circular seam masks with different initial phase differences near the rear focal plane of the lens can be easily obtained by changing an input light field, and the calculation is simple.

The invention discloses bioactive antioxidant polysalicylic acid hydrogel as well as a preparation method and theapplication thereof. The method comprises the following steps: (1) preparing a PSa polymer; (2) preparing an FPSa polymer; and (3) preparing FPSa hydrogel. and 4) characterizing the physical and chemical properties of the FPSa hydrogel and performing biological application. The FPSa polymer has good biocompatibility and degradability, the synthesis method of polymerization reaction and catalytic reaction is environment-friendly, the operation is simple, and the raw material cost is low. The FPSa hydrogel has good ultraviolet shielding performance and can prevent ultraviolet rays from damaging the skin. The result shows that the FPSa hydrogel has important potential application value in the aspect of preventing skin light damage, and a strategy for designing multifunctional single-part bioactive hydrogel is provided for biomedical application.

The present invention relates to a modified surface capable of having bacteriostatic and bactericidal activity when it is light irradiated, thus converting the surface of the substrate into a bacteriostatic and a bactericidal surface as many times as it is desired, and for a long time. According to the invention, the modified surface upon light irradiation avoids the attachment of a microorganism to this surface, inhibits the formation of a biofilm on this surface and destroys an already formed biofilm on this surface. These effects can be achieved as many times as it is desired, and for indefinite time.

The invention discloses a preparation method of a lithospermum root extract with stable color, which comprises the following steps: mixing lithospermum roots and an ethanol solution with the volume fraction of 50% according to the solid-liquid ratio of 1g: 30mL, and carrying out high-pressure treatment and filtration to obtain a crude lithospermum root extract; uniformly mixing petroleum ether, ethyl acetate, methanol and water according to a volume ratio of (5-7): (3-5): (4-6): (4-6), and standing for layering to prepare a stationary phase and a mobile phase; respectively pumping the stationary phase, the mobile phase and the radix arnebiae crude extract into a high-speed counter-current chromatograph to obtain a high-purity radix arnebiae extract; preparing the high-purity alkanet root extract into alkanet root extract freeze-dried powder; and mixing the freeze-dried powder of the alkanet root extract with octyldodecanol myristate to obtain the alkanet root extract for cosmetics. The preparation method disclosed by the invention has the characteristics of simplifying steps and saving time, and the obtained extract has the characteristics of lasting and stable color, higher active matter purity and better anti-aging effect.

The invention relates to a composition for protecting eyes as well as a health-protection food and a preparation method thereof. The composition for protecting eyes is prepared from the following raw material components in parts by weight: 2-8 parts of haematococcus pluvialis astaxanthin microcapsule powder, 20-40 parts of lutein ester microcapsule powder and 8-15 parts of zeaxanthin microcapsule powder. The composition for protecting eyes contains rich eye protection components, can effectively relieve eyestrain, improve eye microcirculation and prevent eyes from photic injury and inflammation injury, and can effectively prevent various eye problems such as visual impairment, cataract, glaucoma and macular degeneration. The composition is especially suitable for people with uncomfortable symptoms such as eye soreness, ophthalmodynia, eye dryness and impaired vision caused by eye overuse due to various reasons, as well as eye postoperative nursing.

The invention discloses a novel binuclear ion-type phosphorescence iridium complex, a preparation method thereof, and an application of the complex in bio-imaging. The chemical structure of the complex can be represented by a formula I: [Ir(C^N)2(tpphz)Ir(C^N)2]+Y-2, wherein tpphz represents tetrapyridinophenazine, C^N ligand is phenylpyridine (ppy), 2,4-difluorophenylpyridine (dfppy), thiophene quinoline (tpq) and 2-(4-dimesitylborylphenyl)quinoline (bpq), and the counter ion Y is PF6<-> and Cl<->. The iridium complex has the advantages of long phosphorescence lifetime , large Stokes shift, good optical stability, low toxicity, and good biocompatibility, and is an excellent probe for cell imaging.

The invention discloses a difunctional solid-state broadband red light emission organic light-emitting material having a structure shown in a formula I and a preparation method thereof. According to the solid-state broadband red light emission organic light-emitting material and the preparation method thereof disclosed by the invention, novel solid-state broadband red light emission piperidone organic light-emitting material with upconversion fluorescence characteristic are formed by combining piperidone with fluoro-phenylindole functional structure units through polyene bridged bonds. The difunctional solid-state broadband red light emission organic light-emitting materials provided by the invention have the characteristics of solid-state broadband red light emission and upconversion fluorescence, stable molecular structure, multiple functions, convenience in use and high practicality. (The formula I is shown in the description).

The invention relates to a fruit jelly capable of relieving asthenopia, comprising 0.1-15wt% of L-arabinose, 0-0.001wt% of vitamin A, 0.0001-0.0003wt% of xanthophylls, 0-0.01wt% of zinc element and 0.1-30wt% of filler and / or flavouring additive, and the balance of water. The invention realizes ice cream fruit jelly capable of relieving asthenopia in the prior art, and conventional substances for producing fruit jelly are adopted, thus solving the technical problems that the effect for reliving asthenopia of the fruit jelly ice cream is limited and commodity value is reduced, thereby being a fruit jelly which can effectively relieve asthenopia and has good taste.

The invention discloses a fluoro phenylindole compound which adopts a structure shown in formula I, application of the fluoro phenylindole compound as a red organic luminescent material, and a preparation method of the fluoro phenylindole compound. The fluoro phenylindole compound is obtained through a reaction between cyclohexanone and 3-(3-(4-fluorophenyl)-1-isopropyl-1H-indole-2-yl) acrolein under an alkaline condition. The preparation method is simple to operate, convenient for synthesis and easy for purification; the obtained fluoro phenylindole compound is stable in structure and can be utilized for fluorescence conversion on a strong red color displayed under 800-nm laser excitation, thereby having potential application values in such fields as luminescent equipment, anti-counterfeit technologies, laser dye and fluorescence sensing; the research field of the fluoro phenylindole compound is expanded.

The invention discloses a runway pool microalgae culture system using micro-bubble continuous gas flotation to harvest algal cells; the system includes a runway pool, the runway pool is internally provided with a turbulent flow carbon supplementing device, a device using micro-bubble continuous gas flotation to collect the runway pool algal cells, a flow blocking device, a double-paddle-wheel device and a groove structure which is arranged at the lower side. The system has the following advantages: (1) the circulation of a water body in the runway pool can be accelerated, and the gas exchange frequency between a liquid surface and the atmosphere is improved; (2) preliminary concentration on the algal cells can be achieved effectively in real time, the centrifugal efficiency is improved, the centrifugal energy consumption is reduced and the harvesting cost is decreased; (3) distributed carbon dioxide can be prevented from escaping, the utilization rate of carbon dioxide is improved, and the pH of an algal liquid is more rapidly adjusted; (4) exchange between an upper layer and a lower layer of the algae liquid can be effectively promoted, not only can the algae cells on the surface layer be prevented from being damaged by light, but also the total effective light energy quantity received by the algae cells of the unit water body is increased; and (5) the runway pool can realize continuous cultivation of microalgae, and an extremely small amount of waste water generated in the cultivation process can be recycled after the waste water is introduced to a disinfection pool and a nutrient salt blending pool through a pipeline and is treated.

The invention relates to the technical field of high polymer materials, biological medicines and nano materials, in particular to a preparation method and application of a novel fluorescent nano material with photodynamic therapy and sterilization functions. The preparation method comprises the following steps: dissolving an aniline compound and amino acid with deionized water, adding concentrated sulfuric acid after dissolving, and uniformly stirring and mixing; and transferring the uniformly mixed solution to a polytetrafluoroethylene reaction kettle, and carrying out hydrothermal reaction to obtain the novel macromolecular fluorescent nano material with the spiral structure. The fluorescent nano material can immediately generate hydroxyl free radicals, singlet oxygen and superoxide anion radical free radicals after being illuminated by ultraviolet light, visible light, laser and the like, and has extremely strong oxidation characteristics; when free radicals are generated, body color and fluorescence are changed, the generation of the free radicals can be judged according to the body color and fluorescence characteristics, and according to the characteristics of the photosensitizer, the photosensitizer can be applied to the fields of photodynamic therapy, photodynamic bacteriostasis and the like.