41results about How to "High phototoxicity" patented technology

The present invention relates to compounds of formula (I),wherein R1-R5 and L are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.

The invention discloses a method for preparing a medicament-nanometer calcium phosphate composite system taking a fat soluble photosensitizer as a framework, which comprises the following steps of: under the condition that phosphoryl-containing organic matters exist or do not exist, adding distilled water and aqueous solution of calcium salt, and stirring uniformly to prepare a system A; adding the distilled water and aqueous solution of phosphate, and stirring uniformly to prepare a system B; and adding fat soluble photosensitizer solution into the system A or the system B or adding the fat soluble photosensitizer solution into the systems A and B simultaneously, stirring uniformly, and mixing the system A and the system B to obtain the medicament-nanometer calcium phosphate composite system taking the fat soluble photosensitizer as the framework. The administration system prepared by the method is high in water solubility and dispersibility and can promote the effective transmission of the fat soluble photosensitizer in blood, and the medicine loading rate of the administration system is increased. Simultaneously, the preparation method is simple, easy to operate, high in stability and low in cost. The invention also relates to application of the administration system prepared by the method in the preparation of medicaments for photodynamic therapy.

The invention relates to a preparation method and application in the preparation of photodynamic therapy medicines of a fat-soluble photosensitizer loaded on inorganic salt carrier or modified surface inorganic salt carrier. The preparation method comprises the following steps: in or without the presence of surfactant, firstly adding distilled water, DMSO solution of fat-soluble photosensitizer, chloride solution and phosphate solution, performing magnetic stirring, and obtaining calcium phosphate nanoparticles with the grain size less than 100nm of fat-soluble photosensitizer after the reaction, wherein the molar ratio of chloride solution to phosphate solution is 1:10-10:1. The preparation method of the invention is simple, is easy to operate and has high stability and low cost; the diameter of the prepared nanoparticles is about 70nm, thus facilitating the preparation and storage of the product; the nanoparticles have high water-solubility and good dispersity, and can be used to promote the effective transmission of the fat-soluble photosensitizer in blood and eliminate the toxic or side effects of the fat-soluble photosensitizer which is used alone; and the nanoparticles have low toxicity in the dark and high phototoxicity.

The invention belongs to the technical field of high polymer materials, biomedical materials and photodynamic therapy, and relates to a preparation method and application of a polymeric porphyrin compound. The preparation method comprises the following steps: dissolving tetracarboxylic acid modified tetraphenylporphyrin in an organic solvent, wherein the concentration is 0.1-1M; adding a thioketalcomonomer with terminal diamino into a reaction system, and finally adding 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride and 4-dimethylaminopyridine; heating the reaction system to 50-100 DEG C, and reacting for 24-72 hours; and after the reaction is finished, cooling to room temperature, settling and centrifuging, dialyzing an obtained crude product by using deionized water, and freeze-drying to obtain the polymeric porphyrin compound pPS.

A preparation method for upconversion NaYF4: yb3+, Tm3+ nanocrystals-hypocretin complex, using a hydrothermal method to synthesize upconversion NaYF4: yb3+, Tm3+ nanocrystals with an excitation wavelength of 980nm and an upconversion fluorescence wavelength of 470nm, and removing them under acidic conditions The surface modifier of the nanocrystal, obtain the nanocrystal aqueous solution, add the hypocretin solution, incubate, dialyze to remove the unadsorbed hypocrellin and solvent, and obtain the nanocrystal-hypocretin composite thing. The method of the present invention loads hypocrellin on the surface of up-conversion nano crystals to form a complex, so as to achieve the purpose of long-wave sensitization of hypocrellin, and overcomes the shortcomings of short hypocretin excitation wavelength and shallow tissue penetration depth of the treatment light source. Thereby promoting its application in the treatment of solid tumors in vivo. The invention also relates to the application of the complex prepared by the method in the preparation of photosensitive therapeutic drugs.

The invention discloses the application of a highly charged cationic porphyrin in the preparation of a PDT nano-photosensitizer. The invention utilizes an eight-charged water-soluble porphyrin compound——octaiodide 5,10,15,20-tetra{4-[2- [1,4‑Dimethyl‑4‑(2‑hydroxyethyl)piperazin‑1‑yl]ethoxy]phenyl}porphyrin (OMHEPzEOPP) 8+ 8I ‑ (hereinafter referred to as OMHEPzEOPP) combined with polypeptide nano-carriers, and applied to prepare nano-PDT photosensitizers that can specifically recognize tumor cells.

The invention discloses a polypyridine ruthenium complex, which has the structure described in the following formula I: wherein, X ‑ Represents a charge-balancing monovalent anion. The complex has high phototoxicity and low dark toxicity, can be preferably used in the preparation of photoactivated antitumor drugs, and can overcome the defect of large toxic and side effects of traditional chemotherapy drugs. The invention also discloses the preparation method and application of the polypyridine ruthenium complex.