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Green light response polymer nano-drug carrier and preparation method thereof

A nano-drug carrier and polymer technology, applied in the field of biomedical materials, can solve problems that limit the clinical application of polymer nano-drug carriers

Active Publication Date: 2021-05-18
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, UV light itself has certain phototoxicity, which limits the clinical application of UV-responsive polymeric nano-drug carriers.

Method used

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  • Green light response polymer nano-drug carrier and preparation method thereof
  • Green light response polymer nano-drug carrier and preparation method thereof
  • Green light response polymer nano-drug carrier and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032](1) Preparation of furan derivatives: 1.51 g is acid or Babi acid and 0.961 g of furfural is dissolved in 30 ml of water, and the reaction is 16 h at room temperature; after completion of the completion, it is filtered, water washing and other means to obtain a yellow solid. The yellow solid was redissolved in dichloromethane and washed sequentially with saturated sodium hydrogen sulfite solution, ultra-pure water, saturated sodium carbonate solution and saturated sodium chloride solution. Finally, dried over anhydrous magnesium sulfate Waiting for the means to obtain furan derivatives;

[0033](2) Polyethylene glycol -b- Poly (Acrylate -CO - Preparation of pentafluorophenyl methacrylate: 1 part of 2- (dodecyl trikarcarbonate group) -2-methylpropylene polyethylene glycol monomethyl ether, 0.05 parts of two Isobutyronitrile, 4 parts of methacrylate, 40 parts of acrylate, hexyl acrylate, dissolved in 1 ml dioxane, 60 ° C reaction 2 h; after the reaction is completed, the means of d...

Embodiment 2

[0038](1) Preparation of furan derivatives: 1.51 g is acid or Babi acid and 0.961 g of furfural is dissolved in 30 ml of water, and the reaction is 16 h at room temperature; after completion of the completion, it is filtered, water washing and other means to obtain a yellow solid. The yellow solid was redissolved in dichloromethane and washed sequentially with saturated sodium hydrogen sulfite solution, ultra-pure water, saturated sodium carbonate solution and saturated sodium chloride solution. Finally, dried over anhydrous magnesium sulfate Waiting for the means to obtain furan derivatives;

[0039](2) Polyethylene glycol -b- Poly (Acrylate -CO - Preparation of pentafluorophenyl methacrylate: 5 parts of 2- (dodecyl trikarcarbonate) -2-methacol polyethylene glycol monomethyl ether, 0.1 parts Isobutyronitrile, 5 parts of methacrylate, 60 parts of acrylate (adherehex) dissolved in 5 ml dioxane, 15 h at 75 ° C; after the reaction is completed, the polyethylene glycol is treated by dialys...

Embodiment 3

[0044](1) Preparation of furan derivatives: 1.51 g is acid or Babi acid and 0.961 g of furfural is dissolved in 30 ml of water, and the reaction is 16 h at room temperature; after completion of the completion, it is filtered, water washing and other means to obtain a yellow solid. The yellow solid was redissolved in dichloromethane and washed sequentially with saturated sodium hydrogen sulfite solution, ultra-pure water, saturated sodium carbonate solution and saturated sodium chloride solution. Finally, dried over anhydrous magnesium sulfate Waiting for the means to obtain furan derivatives;

[0045](2) Polyethylene glycol -b- Poly (Acrylate -CO - Preparation of pentafluorophenyl methacrylate: 10 parts of 2- (dodecyl trikarcarbonate) -2-methylpropylene polyethylene glycol monomethyl ether, 0.2 parts Isobutyronitrile, 8 parts of methacrylate, 80 parts of acrylate (adherene) dissolved in 10 ml dioxane, 90 ° C reaction 30 h; after completion, treatment, polyethylene glycol -b- Poly (Acry...

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Abstract

The invention discloses a green light response polymer nano-drug carrier and a preparation method thereof. The preparation method is characterized by comprising the following steps of firstly, synthesizing a green light response amphiphilic (hydrophilic and oleophylic) polymer containing donor-acceptor Stenhouse adducts, then, self-assembling the polymer and a drug in a solution to form vesicles, and finally, obtaining the green light response nano-drug carrier entrapped with a hydrophilic / hydrophobic drug. According to the nano-drug carrier prepared by the invention, low-energy green light is used as a response switch, so that the problem of light damage to biological tissues caused by an excitation light source is avoided; and compared with the traditional polymer micelle drug carrier, the polymer vesicle drug carrier prepared by the method has larger drug loading capacity and more drug loading and releasing modes.

Description

Technical field[0001]The present invention generally relates to a green light response polymer nano-drug carrier and a preparation method thereof, belonging to the field of biomedical materials.Background technique[0002]In recent years, since the stimulus response nano-drug carrier can realize the enrichment of anticancer drugs in the lesion site, it has been approved to enter the clinical development of the corresponding drugs, and has become an important development direction in the field of nanomechanics. Up to now, a pH response, an oxidative response, a light response, a thermal response, and an enzyme response, and an enzyme response are throttled in the nano-drug carrier. Among them, the light response polymer nano-drug carrier is widely studied due to its unique advantage. First, the light response polymer nano drug carrier has the advantages of extremely designed, non-toxic and long cyclicity, and can improve the drug concentration of the lesion, reduce the amount of inject...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/127A61K31/337A61K31/513A61K31/52A61K31/704A61K31/7068A61K47/32A61P35/00C08F293/00C08F8/32C08F8/00C08F8/30
CPCA61K9/1273A61K41/0042A61K47/32A61K31/704A61K31/337A61K31/513A61K31/7068A61K31/52A61P35/00C08F293/00C08F8/32C08F8/00C08F8/30A61K2300/00
Inventor 向均林建勋范浩军陈意颜俊马浩
Owner SICHUAN UNIV
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