The invention relates to the medical technical field, in particular to a
paeonol micro-
emulsion preparation and a preparation method thereof. The
paeonol micro-
emulsion preparation consists of components with the weight percentage as follows: 0.1 percent to 2 percent of
paeonol, 10 percent to 25 percent of surfactant, 5 percent to 30 percent of cosurfactant, 5 percent to 15 percent of
oil phase and 40 percent to 70 percent of deionized water. The mouse
percutaneous experiment
in vitro shows that the paeonol micro-
emulsion prepared by the invention has obviously higher capacity of penetrating through the
horny layer than the
saturated aqueous solution of paeonol (p is less than 0.05), and the paeonol micro-emulsion can penetrate into the
skin deeply to take
curative effect within a short time and also has certain sustained and
controlled release function. At the same time, the paeonol micro-emulsion improves the
solubility of the paeonol obviously, increases the
drug loading quantity of the preparation and reduces the
drug administration times and the dosage. The paeonol micro-emulsion preparation has simple preparation method and uniform grain
diameter of the preparation, has the advantages of being safe, stable and efficient and, can be used for preparing dermal medication preparation or cosmetic.