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Dosage control for drug delivery system

a drug delivery and drug technology, applied in the field of drug delivery systems, can solve the problems of clinicians err on the over-anesthetized side, varying the depth of anesthesia, and more procedures

Inactive Publication Date: 2007-08-16
ETHICON ENDO SURGERY INC
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This technique results in varying depths of anesthesia throughout the procedure.
A patient responding to pain is uncooperative, making the procedure more difficult.
As a result, the clinician tends to err on the over-anesthetized side.
In addition to placing the patient at greater risk for adverse events, over-anesthetizing causes the patient's recovery from anesthesia to be much longer.
However, this rapid action presents additional concerns for someone using an intermittent bolus technique, as typically done by non-anesthesiologists.
However, non-anesthesiologists are not familiar with pharmacokinetic (PK) principals, and will have difficulty determining a Loading Dose / Maintenance Rate combination that will both rapidly achieve and maintain the desired level of anesthesia.

Method used

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  • Dosage control for drug delivery system
  • Dosage control for drug delivery system
  • Dosage control for drug delivery system

Examples

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Embodiment Construction

[0015] For the purposes of illustration, the invention is explained using the delivery of propofol to achieve and maintain a level of anesthesia referred to as conscious sedation. However, the invention can be applied to any intravenous drug where it is appropriate to deliver a loading dose followed by a maintenance infusion. The equations will be adjusted for different pharmacokinetics (loading dose / maintenance rate relationships) for these other drugs. Examples of classes of drugs in addition to sedation drugs that can be administered in accordance with the invention are antibiotics, pain management drugs, cardiovascular drugs, anticancer drugs, and others.

[0016] A. Initiation of Sedation

[0017] An anesthetic drug such as propofol provides labeling recommendations for initiating sedation (loading dose)—0.0 to 0.5 mg / kg, and infusion rates for maintaining the patient's level of sedation (maintenance rate)—0.0 to 75 μg / kg / min. DC is designed to correlate these two ranges, such that...

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Abstract

A method for delivering intravenous drugs to a patient comprising programming a drug delivery system, including a controller and an infusion pump, with a maintenance rate or a loading dose for a drug and causing the drug delivery system to (a) calculate a loading dose based on the maintenance rate or a maintenance rate based on the loading dose, (b) administer the loading dose of the drug to the patient to rapidly achieve a desired level of effect, and (c) administer the drug at a first maintenance rate to maintain the level of effect.

Description

CROSS REFERENCE TO RELATED PATENT APPLICATION [0001] This is a continuation of U.S. patent application Ser. No. 10 / 886,255, filed on Jul. 7, 2004.FIELD OF THE INVENTION [0002] The present invention relates generally to drug delivery systems, and more particularly to a method of calculating a drug infusion profile for a drug delivery system. While the invention can be used in administering a variety of intravenous drugs it is particularly useful as an anesthetic delivery system. BACKGROUND OF THE INVENTION [0003] Three conditions or objectives control the administration of an anesthetic, namely, to rapidly produce the desired pharmacologic effect (hypnosis, analgesia, etc.); to maintain the desired effect throughout the medical procedure; and to enable the patient to recover quickly from the effect following completion of the procedure. [0004] In order to achieve the objective of rapidly inducing the desired anesthetic effect, the anesthesiologist typically delivers a so called “Load...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K9/22G16H20/17
CPCA61M5/142G06F19/3468A61M2005/14208A61M5/1723G16H20/17A61M5/14A61M5/168A61M31/00A61M5/00
Inventor MARTIN, JAMES F.
Owner ETHICON ENDO SURGERY INC
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