63 results about "Loading dose" patented technology

A protective sleeve for a catheter assembly comprising a tubular member composed of a first material. The first material having a first predetermined modulus of elasticity. The tubular member having at least one stripe of a second material engaged thereto. The second material having a greater modulus of elasticity than the first material. The tubular member having a loading state and being crimpable to a reduced state. In the loading state the tubular member being sized to disposingly engage the balloon of a catheter assembly wherein the balloon has a first diameter. When the tubular member is in the reduced state the tubular member is disposingly and retainingly engaged to the balloon. When the tubular member is in the reduced state the balloon has a second diameter which is less than the first diameter.

Apparatus (40) for compressing a transcatheter cardiac stent-valve (10) comprises: a first compressor stage (100) including a hollow channel (42) with a tapered interior surface configured for compressing a stent-valve in response to longitudinal advancement of the stent-valve within the channel; and a second compressor stage (102) comprising a crimper for compressing a portion of the stent-valve without longitudinal advancement.

The invention relates to a static compliance performance testing device applied to an industrial robot. The static compliance performance testing device applied to the industrial robot comprises a loading direction adjusting assembly and a loading force adjusting assembly; the force applying end of the loading direction adjusting assembly is connected with a tail end mechanical joint of the industrial robot, and is used for adjusting a force direction of the tail end mechanical joint; the loading force adjusting assembly includes a lever, a first-stage weight and a second-stage weight, and thelever is provided with a fixed part and can rotate around the fixed part; the force bearing end of the loading direction adjusting assembly is connected with the lever, the first-stage weight is suspended on the lever, the second-stage weight is suspended on the lever and can move along the lever, and the weight of the first-stage weight is larger than the weight of the second-stage weight; and the first-stage weight and the second-stage weight both are located on one side of the force bearing end of the loading direction adjusting assembly.

The invention relates to a triaxial test apparatus and method suitable for weak rocks. The apparatus mainly comprises a pedestal, and the pedestal is fixedly connected with a support; the top of the support is fixedly connected with a Z-axial stress loading mechanism; the lower portion of the support supports an X-axial stress loading mechanism and a Y-axial stress loading mechanism; the X-axial stress loading mechanism is positioned above the Y-axial stress loading mechanism; and the X-axial stress loading mechanism and the Y-axial stress loading mechanism are respectively provided with pressurizing plates driven by a leading screw pair. The structure of the apparatus is brand new, and triaxial pressurization is carried out in a mono-axial oil cylinder and biaxial oil cylinder loading mechanism combination form o realize very accurate control of the loading force, so the mechanical attribute researches of the soft rocks are realized.

Methods for treating prostate cancer, including advanced prostate cancer, in a subject in need thereof, include administering once-daily to the subject, at least 80 mg of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4- tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N′-methoxyurea, or a corresponding amount of a pharmaceutically acceptable salt thereof. Another method includes: administering once-daily to the subject in need thereof, an oral load dose formulation having from 240 mg to 480 mg of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N′-methoxyurea, or a corresponding amount of a pharmaceutically acceptable salt thereof; and thereafter administering once-daily to the subject, an oral maintenance dose formulation having 80 mg to 160 mg of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N′-methoxyurea, or a corresponding amount of a pharmaceutically acceptable salt thereof.

The embodiment of the invention discloses a multi-degree-of-freedom dynamic loading device for simulating wind power and ocean current load. One group of left axial loading pressurized cylinders is distributed on the left end of the loading bearing disk of a loading device along the axial direction; one group of right axial loading pressurized cylinders is distributed at the right end of the loading bearing disk along the axial direction; meanwhile, one group of radial loading pressurized cylinders is distributed on the main shaft at the left end of the loading bearing disk; the loading circuit of the hydraulic system is controlled by a computer control system to control the loading force of the left axial loading pressurized cylinders, the right axial loading pressurized cylinders and the radial loading pressurized cylinders; meanwhile, the loading force is transferred to a hydrostatic bearing by the loading pressurized cylinders and is transferred to a hydrostatic loading disk by the hydrostatic oil film of the hydrostatic bearing; and five-degree-of-freedom load (Fx, Fy, Fz, My and Mz) loading is finished by the combination of each loading force and loading bending moment. The multi-degree-of-freedom dynamic loading device is used for accurately simulating the wind power under the real working condition and various load situations borne the ocean current energy power generation device and each part in the transmission cabin of ocean current energy power generation device.