63 results about "Loading dose" patented technology

A protective sleeve for a catheter assembly comprising a tubular member composed of a first material. The first material having a first predetermined modulus of elasticity. The tubular member having at least one stripe of a second material engaged thereto. The second material having a greater modulus of elasticity than the first material. The tubular member having a loading state and being crimpable to a reduced state. In the loading state the tubular member being sized to disposingly engage the balloon of a catheter assembly wherein the balloon has a first diameter. When the tubular member is in the reduced state the tubular member is disposingly and retainingly engaged to the balloon. When the tubular member is in the reduced state the balloon has a second diameter which is less than the first diameter.

A protective sleeve for a catheter assembly comprising a tubular member composed of a first material. The first material having a first predetermined modulus of elasticity. The tubular member having at least one stripe of a second material engaged thereto. The second material having a greater modulus of elasticity than the first material. The tubular member having a loading state and being crimpable to a reduced state. In the loading state the tubular member being sized to disposingly engage the balloon of a catheter assembly wherein the balloon has a first diameter. When the tubular member is in the reduced state the tubular member is disposingly and retainingly engaged to the balloon. When the tubular member is in the reduced state the balloon has a second diameter which is less than the first diameter.

The perforated roll dispensing system comprises a hinged cradle within a housing enclosure with easily releasable latch lock. The semi-circular cradle trough provides a stable storage means for perforated roll products. The textured surface of the trough gives useful braking from the friction with the rotating roll for controlled metering and provides adequate resistance to tear and extract unity of the sheet material from the dispenser without unraveling. The hinge and latch feature make it easy to deploy and retract the cradle trough to the loading mode or the dispensing mode. The right angled top enclosure and back panel of the housing can be mounted on a vertical and horizontal surface.

The invention provides a hydraulic adjusting loading device for a self-weight type slide slope physical model experiment. The hydraulic adjusting loading device comprises a base, a sliding surface adjusting mechanism and a thrust force loading mechanism; the sliding surface adjusting mechanism is arranged on the base, the sliding surface adjusting mechanism comprises a sliding panel, a front support plate, at least one pair of front hydraulic telescopic links, a back support plate and at least one of back hydraulic telescopic links, the front hydraulic telescopic links are supported at the front of the base, the top ends of the front hydraulic telescopic links are connected with the front support plate, the back hydraulic telescopic links are supported at the back of the base, the top ends of the back hydraulic telescopic links are connected with the back support plate, the front end of the sliding panel is hinged with the front support plate, and the back end of the sliding panel is supported on the back support plate; and the thrust force loading mechanism comprises a loading platform for bearing heavy substances, and the bottom surface of the loading platform is in sliding fit with the top surface of the sliding panel, and can slide along the sliding panel front and back. According to the hydraulic adjusting loading device, the loading size and direction of the back-edge thrust force of the slide slope physical model experiment can be conveniently and quickly adjusted, so that the applied thrust force accords with the practical boundary condition, and the hydraulic adjusting loading device is stable in a loading force.

The invention discloses an experiment table for detecting static rigidity of a rolling linear guide rail pair. The experiment table comprises a guide rail pair installation plate, left and right support seats, and a test guide rail, wherein the guide rail pair installation plate and the left and right support seats are installed on a T-shaped groove platform, the test guide rail is installed on the guide rail pair installation plate, a pressing plate is fixed on a sliding block of the test guide rail to avoid crushing the sliding block during direct loading, a force application beam stretches across and is fixed on the left and right support seats and is loaded through a loading bolt, a loading force is controlled and measured by a weighing sensor, and the deformation is measured by an inductance measuring head. Three screw holes are formed in the force application beam and the left support seat and can apply a vertical load, a rolling moment and a horizontal load respectively, and the sliding block and the pressing plate of the mobile test guide rail can apply a capsizing moment and a rotation moment. By means of the experiment table, detection of static rigidity of the rolling linear guide rail pair under five kinds of loading actions is achieved, meanwhile, practical installation working conditions of the guide rail are met, and the loading manner is simple and reliable.

A hydraulic prop having an anchoring force energy-absorbing buffering function comprises a prop main body part. An anchoring force energy-absorbing buffering mechanism part is arranged at the end of a movable column of the prop main body part, so as to overcome the shortcoming that an existing hydraulic prop is weak in impact resistance. When the hydraulic prop is subjected to impact of an external load and when the loading force is not enough to break open a clamping pin in an anchoring force supporting state, the impact load can be resisted through the rigid supporting of the clamping pin; and when the loading force exceeds the anchoring force supporting force of the clamping pin, the clamping pin cannot support an outer sleeve any longer and is obliged to retract towards an inner sleeve. While the clamping pin retracts, an energy-absorbing block is compressed in first time to absorb energy, precious buffering time is provided for the opening of a hydraulic prop safety valve, the safety valve is prevented from being damaged in an instant by huge impact force, the occurrence probability of cylinder explosion, sealing ring crushing and prop instability and bending is reduced, the impact resistance of the hydraulic prop is improved, and the safety factor of the hydraulic prop and a supporting system where the hydraulic prop is located is improved.

The invention discloses a non-strobe non-isolated LED constant-current driving circuit which comprises an alternating-current source, a rectifier bridge, a capacitor and two constant-current driving units. The alternating-current side of the rectifier bridge is connected with the alternating-current source, the direct-current side of the rectifier bridge is connected with an anode of an LED, one end of the capacitor and the power ends of the two constant-current driving units, and the negative end of the direct-current side is grounded. A cathode of the LED is connected with the input end of the first constant-current driving unit, the output end of the first constant-current driving unit is connected with the other end of the capacitor and the input end of the second constant-current driving unit, and the output end of the second constant-current driving unit is grounded. According to the LED constant-current driving circuit, the charging current of an AC input source to the capacitor is controlled to be constant, the circuit is made to achieve the effect that an LED load dose not have strobe, meanwhile, above 80 percent of power factors can be achieved, and therefore the product certification requirements are met.

The invention relates to a slow-release preparation of ticagrelor. Specifically, the slow-release preparation of the ticagrelor, provided by the invention, is suitable for being orally taken one timeevery day; meanwhile, a rapid drug releasing effect can be realized after tablets are damaged. The releasing tablets which are administrated one time every day can reduce the number of times of oral administration, so that the oral drug taking compliance of patients can be improved and risks that myocardial infarction or stroke is caused when acute thrombus formation is caused by the fact that thepatients forget to orally take the ticagrelor are reduced; meanwhile, when the tablets provided by the invention are orally taken for the first time, the tablets can be opened to meet the requirementof giving a load dosage to the patients, so as to rapidly take effect.

The invention provides a drug delivery device adapted to receive a cartridge, the cartridge being adapted to receive a needle assembly. The drug delivery device comprises a front-loaded cartridge holder adapted to receive and hold a cartridge in a mounted state and being actuatable between an open loading state and a closed operational state. The drug delivery device is further provided with blocking means configured to prevent the cartridge holder from being actuated between the closed and the open state when a cartridge with a mounted needle assembly is held in a mounted position.

The present invention discloses a paper chip gravity / capillary flow chemiluminescence method, and specifically discloses a paper chip for driving fluid by coupled gravity / capillary force, and a preparation method and application thereof in detection of heavy metal ions. The paper chip of the invention is divided into a hydrophobic region and a hydrophilic region; and the hydrophilic region is divided into a loading zone, a detection zone and a fluid passage zone. For usage, the paper chip is closely placed on a stand, and the slanted surface of the stand and the horizontal plane form an angle; and after placement, the loading zone and the fluid passage zone are on an inclined surface of the stand, and the detection zone is on the horizontal portion of the stand. Compared with the conventional flow chemiluminescence, the paper chip and detection method do not use any expensive pumping unit (precision syringe pump, peristaltic pump, etc.) to drive the liquid flow. The method only uses the natural gravity of liquid and capillary force of paper fiber voids to drive the flow of liquid.

Apparatus (40) for compressing a transcatheter cardiac stent-valve (10) comprises: a first compressor stage (100) including a hollow channel (42) with a tapered interior surface configured for compressing a stent-valve in response to longitudinal advancement of the stent-valve within the channel; and a second compressor stage (102) comprising a crimper for compressing a portion of the stent-valve without longitudinal advancement.

The invention relates to a static compliance performance testing device applied to an industrial robot. The static compliance performance testing device applied to the industrial robot comprises a loading direction adjusting assembly and a loading force adjusting assembly; the force applying end of the loading direction adjusting assembly is connected with a tail end mechanical joint of the industrial robot, and is used for adjusting a force direction of the tail end mechanical joint; the loading force adjusting assembly includes a lever, a first-stage weight and a second-stage weight, and thelever is provided with a fixed part and can rotate around the fixed part; the force bearing end of the loading direction adjusting assembly is connected with the lever, the first-stage weight is suspended on the lever, the second-stage weight is suspended on the lever and can move along the lever, and the weight of the first-stage weight is larger than the weight of the second-stage weight; and the first-stage weight and the second-stage weight both are located on one side of the force bearing end of the loading direction adjusting assembly.

Methods for treating prostate cancer, including advanced prostate cancer, in a subject in need thereof, include administering once-daily to the subject, at least 80 mg of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4- tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N′-methoxyurea, or a corresponding amount of a pharmaceutically acceptable salt thereof. Another method includes: administering once-daily to the subject in need thereof, an oral load dose formulation having from 240 mg to 480 mg of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N′-methoxyurea, or a corresponding amount of a pharmaceutically acceptable salt thereof; and thereafter administering once-daily to the subject, an oral maintenance dose formulation having 80 mg to 160 mg of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N′-methoxyurea, or a corresponding amount of a pharmaceutically acceptable salt thereof.

The invention provides a single shaft air floating table balance adjusting method and system, and belongs to the technical field of air floating table balance adjusting. The method includes the following steps: tilting a single shaft air floating table with a loading disk at a first preset angle; determining a position when a unbalance quality on the loading disk reaches the maximum motion speed as a balance position, and stopping the load disk to a balance position; rotating the loading disk with a second preset angle so as to enable the loading disk to swing freely, and determining a first single pendulum period; determining a first unbalance quality value of the loading disk under the second preset angle condition, placing a first quality block corresponding to the first unbalance quality value to a position where the loading disk has maximum height with respect to a horizontal plane; if the first single pendulum period of the loading disk is greater than a first critical single pendulum period, then considering that the single shaft air floating table is adjusted to balance. According to the invention, the method can adjust the balance of all types of air floating tables, and is advantaged by simple structure and operation and high precision in adjusting balance.

A loading ledge to be used in transport and storing and a system for creation of load units. The loading ledge has an upper leg and a lower leg forming a substantially L-shaped cross section. The lower leg is furnished with one or more projections to make it possible to use handling equipment. One or more locking units are integrated in the loading ledge to grip straps or the like. The load unit is created in that two or more loading ledges are used together with straps to fixate the goods on the loading ledges.

The invention discloses a novel test loading device based on the lever principle. According to the novel test loading device, a counterweight is suspended at one end of a steel plate; the other end of the steel plate is connected with one end of a steel tube; a bearing plate is suspended at the other end of the steel tube; and a loading object is arranged on the bearing plate. A notch a is opened in the upper surface of the steel plate; the bottom of a rotating shaft is connected with the notch a in a rotating manner; and a force sensor is arranged on the top of the rotating shaft. A notch b is formed in the lower surface of the steel plate and is opened in the top of a support column. Two threaded rods are anchored on the ground; and a steel casing tube sleeves each threaded rod and is screwed on the corresponding threaded rod by a nut. Steel brackets are welded to the inner sides of the steel casing tubes; and support bases for supporting a test beam are arranged at the bottoms of all steel brackets. According to the provided novel test loading device, on the basis of the reverse loading mode and the graded loading mode, the deformation and carrying capacity restoration effects of the reinforced test beam can be observed under the loaded condition due to the rotatability of the lever.

The invention discloses a rock true triaxial test method capable of realizing the external loading of a test specimen. An X-direction loading framework is moved out; a specimen assembly is installed; the specimen assembly is pushed into a Z-direction loading work table of a host machine, and is subjected to true triaxial loading by combining a Y-direction loading work table; in the loading process, micro displacement and applied loading force can be measured; after the loading test is completed, the loading work tables sequentially quit; the specimen assembly arranged on an installing trolley is dismounted; pipelines of equipment are closed, and power supplies of the equipment are turned off. The rock true triaxial test method has the advantages that a four-post structure is used in the perpendicular direction of a host machine; integrally cast loading frameworks are used in two horizontal directions; the device is stable in structure nd has high rigidity; the loading frameworks adopt a sliding design; the specimen loading and the debugging can be performed at the outside; the moving space is large; the installation and the operation are convenient.

The invention relates to an in-situ cup drawing device, comprising a base, a cylinder arranged on the base in an inclined way, a compression part, a transitional press rod and a loading part, wherein the bottom of the transitional press rod is contacted with the loading part; a sample piece is arranged on the top end of the cylinder and is compressed by the compression part, and the bottom end of the cylinder pushes the transitional press rod into the cylinder by means of the rotation of the loading part. The in-situ cup drawing device can control the loading condition and maintain a loading state by controlling the precession amount and precession speed, thus being suitable for experiments in sample rooms with narrow electron microscopes.

The invention provides a dry material bulk machine which comprises a telescopic device, a winding device, a control system and a dedusting system. The telescopic device comprises a bulk head, a telescopic joint and a steel wire rope. The dry material bulk machine is characterized in that a negative pressure detection device and a light projection module are arranged on the bulk head and both can feed back data to the control system; and the control system controls the loading state and the stopped state according to feedback data. According to the dry material bulk machine, the pressure state and the discharging condition of a discharging position are fed back to the control module, automatic recognition and disposition of unsmooth discharging, or material overflowing, exhaust fan faults and other problems are achieved, and the situation that a level indicator gives out an alarm signal by mistake, and thus, misjudgment and mistaken response of the dry material bulk machine are caused can be effectively avoided.

The invention discloses a melt containment retention system. The system comprises a retention portion and a cooling system for cooling the retention portion, the cooling system comprises a cooling source device and a cooling water circuit which are connected, the cooling water circuit is connected to the retention portion, the retention portion comprises a melt extending chamber which sleeves outside a pressure vessel and extends downwardly, the melt extending chamber is formed by a first container prepared by a cooling plate surrounding the outer periphery of the pressure vessel, the melt extending chamber has at least one first curved section buffer zone for buffering the melt flow rate, at least one second curved section retarding zone for extending a flow passage and narrowing the flowpassage and one loading zone at the bottom of the melt extending chamber in the melt flow direction, and the first curved section buffering zone and the second curved section retarding zone are oriented in the opposite direction. The system can effectively buffer the impact of a high temperature melt.

The invention discloses a micro mechanical property test clamping device for a material under a combined loading mode. The clamping device comprises a pedestal capable of being fixed on the top surface of a working table, a lower connection main shaft connected with the top of the pedestal, a lower fan-shaped flange disk connected with the top of the lower connection main shaft, an upper fan-shaped flange disk which is located above the lower fan-shaped flange disk and is separated from the lower fan-shaped flange disk and an upper connection main shaft connected with the upper fan-shaped flange disk, and further comprises a clamping structure for clamping a test piece. Compared with the prior art, the micro mechanical property test clamping device for the material under the combined loading mode has the advantages that by conversion of a through hole bolting position between the upper connection main shaft and the upper fan-shaped flange disk as well as a through hole bolting position between the lower connection main shaft and the lower fan-shaped flange disk, and cooperation with the test piece clamping structure with different clamping modes, a tester can conveniently complete a fracture property test of different types of materials, such as tensile failure, shear fracture, tear fracture, tensile shear combined fracture and tensile tear fracture.

The invention relates to a hip joint angle measurement apparatus. The hip joint angle measurement apparatus comprises a machine frame, an acquisition fine tuning module, a motion module and a motion control module, wherein the acquisition fine tuning module is connected with a base plate on the machine frame through a connecting plate, the motion control module is fixed on the base plate of the machine frame through a fixation side bearing, and the motion module is connected with a mobile plate on the motion control module through a bearing unit. The acquisition fine tuning module is internally provided with a force transducer and a three-dimensional slide unit, for online determination of a loading force and a fine tuning loading force; and a handle on the motion control module can adjust a slide leading screw so as to adjust the size of the loading force. The measurement apparatus provided by the invention can test and determine angle performance of a biomedical hip joint and can test biological motion features of an orthopaedic implantation apparatus under different load conditions; and the manufacturing and maintenance cost is low, the operation is convenient, and the promotion and application are easy.

The invention discloses a longitudinal steel rail constraining force test method for rail traffic. The method comprises the following steps: loading set loading force to steel rails, maintaining the loading force for a certain period of time, and measuring the loading force and the longitudinal displacement, relative to sleepers, of the steel rails from the beginning of loading; then continuously reloading to set loading force and maintaining for a certain period of time, and carrying out circulation in sequence for multistage loading; when the steel rails slide in buckles or the loading force exceeds or is equal to a set value, quickly reducing the load to zero, continuously measuring the displacement change of the steel rails for a certain period of time, then repeating the loading process again and again at an interval between every two times of loading, and drawing a force-displacement curve in each loading cycle; calculating the longitudinal elastic displacement before the steel rails slide; determining the amplitude of force F completely used for generating elastic deformation in each curve, abandoning an F value obtained in the first time, and calculating an average value of remaining F values to obtain the amplitude of longitudinal constraining force of the buckles for the steel rails. Accurate test result can be obtained, and the test process is simple and easy in operation.

High explosives suitable for filling very small volume loading holes in micro-electric initiators for micro-electro-mechanical mechanisms, used as safe and arm devices, are prepared from slurries of crystalline energetic materials including organic liquid and applied using various methods. These methods include swipe loading, pressure loading and syringe loading. The organic liquid serves as a volatile mobile phase in the slurry so as to partially dissolve the energetic material so that, upon evaporation of the mobile phase, the energetic material precipitates and adheres to the loading hole.

The invention provides a two-stage loading consolidation testing method of normal consolidated undisturbed foundation soil. The method comprises the following steps: preparing and arranging a soil sample, determining an initial void ratio e0; applying 1 kPa of pro-load pressure for better contacting the sample and a device; performing two-stage loading with load of p1 and p2 in a loading test, determining the load values of p1 and p2 according to soil burial depth, respectively recording the deformation amount of the sample under two stage loading, conversing the deformation amount to the void ratio e1 and e2, obtaining a Harris function parameter A shown in a specification, a function parameter N shown in the specification, and a function parameter B shown in the specification, finally obtaining a relation which is shown in the specification between the soil void ratio e and overburden pressure p, wherein, the parameters are shown in the specification, and performing the loading consolidation tests of the normal consolidated undisturbed foundation soil. The method greatly reduce the loading stages of the consolidating tests, test time is shortened, test efficiency is increased, and the test result precision can satisfy the engineering practice requirement.

Methods for treating prostate cancer, including advanced prostate cancer, in a subject in need thereof, include administering once-daily to the subject, at least 80 mg of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N′-methoxyurea, or a corresponding amount of a pharmaceutically acceptable salt thereof. Another method includes: administering once-daily to the subject in need thereof, an oral load dose formulation having from 240 mg to 480 mg of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N′-methoxyurea, or a corresponding amount of a pharmaceutically acceptable salt thereof; and thereafter administering once-daily to the subject, an oral maintenance dose formulation having 80 mg to 160 mg of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N′-methoxyurea, or a corresponding amount of a pharmaceutically acceptable salt thereof.

The embodiment of the invention discloses a multi-degree-of-freedom dynamic loading device for simulating wind power and ocean current load. One group of left axial loading pressurized cylinders is distributed on the left end of the loading bearing disk of a loading device along the axial direction; one group of right axial loading pressurized cylinders is distributed at the right end of the loading bearing disk along the axial direction; meanwhile, one group of radial loading pressurized cylinders is distributed on the main shaft at the left end of the loading bearing disk; the loading circuit of the hydraulic system is controlled by a computer control system to control the loading force of the left axial loading pressurized cylinders, the right axial loading pressurized cylinders and the radial loading pressurized cylinders; meanwhile, the loading force is transferred to a hydrostatic bearing by the loading pressurized cylinders and is transferred to a hydrostatic loading disk by the hydrostatic oil film of the hydrostatic bearing; and five-degree-of-freedom load (Fx, Fy, Fz, My and Mz) loading is finished by the combination of each loading force and loading bending moment. The multi-degree-of-freedom dynamic loading device is used for accurately simulating the wind power under the real working condition and various load situations borne the ocean current energy power generation device and each part in the transmission cabin of ocean current energy power generation device.

Methods including novel dosing methods and / or dosage forms and compositions of Vitamin D compounds and / or mimics thereof alone and / or in combination with other agents for the treatment of proliferative conditions and / or cancers in humans.

The invention belongs to the technical field of space breeding, in particular relates to a seed processing technology in the space breeding, and the technology includes seed selection, package, storage, space loading and mutagenicity of seed, seed culture after the space loading and mutagenicity, and seedling selection, wherein, a syncopation processing is performed after seed selection and before package: a part with an embryo occupying one third of the whole seed is reserved, and the rest parts are ablated. Through the reasonable syncopation processing for the seed, the method of the invention greatly lightens the weight of the loading seed, at the same time, reserves the vitality of the seed and reduces the loading cost; in addition, the problem that sowing cannot be performed in season is solved through improving the breeding technology of the seed after space loading and mutagenicity; thereby providing fine support for the wide range of application of the space breeding technology.